This paper presents a numerical investigation into the fire endurance of carbon fiber reinforced polymer (CFRP)-strengthened columns, shielded with fire-resistant materials, in piloti-type reinforced concrete buildings. The strengthened column, equipped with a fire protection system, underwent exposure to the ASTM E119 standard time-temperature curve for a duration of 4 h. To comprehensively evaluate the thermal and structural performance of the strengthened column at elevated temperatures and substantiate the effectiveness of the fire protection system, a fully coupled thermal-stress analysis was conducted. The numerical modeling approach employed in this study was rigorously validated through previous experimental studies in conjunction with adherence to the ACI design guideline, specifically ACI 440.2R-17. Using the validated structural fire model, the thermal and structural behaviors of the RC column with an insulated CFRP strengthening system were investigated based on four key performance criteria: glass transition temperature, ignition temperature of polymer matrix, critical temperature of reinforcing bars, and the design axial load capacity at elevated temperatures. Furthermore, a comparative assessment of fire endurance was performed using diverse fire-resistant materials, including Sprayed Fire-Resistive Material (SFRM) and Sikacrete®-213 F, with insulation thicknesses ranging from 10 to 30 mm, during the 4-hour fire exposure period.