Standard Error Of Mean Research Articles

A GIS-based Binary Logistic Regression Model for the Inundation Analysis; A Case Study on Elapatha DS Division, Ratnapura District, Sri Lanka


 
 
 Flood susceptibility analysis (FSA) is a prerequisite for adopting flood mitigation and adaptation techniques. A number of technologies and models have emerged through time, and this study focuses on the Binary Logistic Regression Model (BLRM) to investigate flood vulnerability of Elapatha Divisional secretariat (DS), Ratnapura District, Sri Lanka where has high impact from inundation. Rainfall, land use and land cover (LULC), elevation, slope, slope aspect, distance to the river, topographic wetness index (TWI), and stream power index (SPI) were the factors used in the model construction. These components were investigated in terms of their contribution to flood susceptibility using all location data and field plotting of responsible parameters in the study area using Geographic Information System (GIS) software, and all extracted data points were 96489, of which 50% were used for BLRM development using SPSS statistical software and remaining 50% for model validation. The coefficient of rainfall parameters, log value of elevation in meters, the tan value of slope in degrees, radiant value of aspect in degrees, (distance from the river)0.1, the ratio between SPI and TWI (SPI/TWI) and LULC band values of built-up area, water bodies and vegetations were 0.023, -2.254, -1.018, -0.005, -0.164, -0.003, 2.707, -.067 and -0.004 respectively. The accuracy was validated using Mean standard error (MSE) and area under curve (AUC) analysis, with values of 0.031 and 0.724 respectively. The Built-up area, elevation, and slope had the most impact on the inundation Elapatha DS division, and model performance represents 72.4% accuracy. Therefore, mitigation of inundation problems can be achieved through proper landscaping in the area.
 Keywords: Binary logistic Regression, Flood susceptibility Analysis, GIS software, Spatial analysis
 
 

Is there a link between the inflammatory potential of a diet and mental health among patients with migraine? Findings from a cross-sectional survey

ABSTRACT Aims In this study, we aimed to evaluate the relationship between the dietary inflammatory index (DII) and mental health outcomes among patients with migraine headaches. Methods In this cross-sectional study, 262 subjects were included. The dietary intakes were collected using a validated 168-item semi-quantitative food frequency questionnaire. Items were scored according to their inflammatory potential, so a higher DII indicated a more pro-inflammatory diet. The association between DII and the mental health of participants was investigated using multinomial logistic regression and odds ratio (OR) with a corresponding 95% confidence interval (CI) was reported. Results Overall, 224 women and 38 men, with a mean (standard error) DII of −2.96 (0.06), age of 36.1 (0.53) years, and BMI of 25.55 (0.21) kg/m2, comprised our study population. DII was positively associated with a higher risk of depression in patients with the highest adherence to a pro-inflammatory diet compared to those with the lowest adherence (OR = 1.76; 95%CI: 1.04, 3.00; Ptrend = 0.035). Adjustments for age, sex, marital status, smoking status, migraine headache index score, number of family members, mean arterial pressure, medication, physical activity, and BMI intensified the association in a way that the risk of depression was 2.03 times higher in patients with the highest adherence to a pro-inflammatory diet compared to those with the lowest adherence to a pro-inflammatory diet (OR = 2.03; 95%CI: 1.18, 3.49; Ptrend = 0.011). Conclusion Our findings suggest that depression was positively associated with adherence to a pro-inflammatory diet. However, no significant association was observed between anxiety and stress with DII.

Dosimetric Impact of Voluntary Deep Inspiration Breath Hold (DIBH) in Mediastinal Hodgkin Lymphomas: A Comparative Evaluation of Three Different Intensity Modulated Radiation Therapy (IMRT) Delivery Methods Using Voluntary DIBH and Free Breathing Techniques.

Hodgkin lymphomas are radiosensitive and curable tumors that often involve the mediastinum. However, the application of radiation therapy to the mediastinum is associated with late effects including cardiac and pulmonary toxicities and secondary cancers. The adoption of conformal IMRT and deep inspiration breath- hold (DIBH) can reduce the dose to healthy normal tissues (lungs, heart and breast). We compared the dosimetry of organs at risk (OARs) using different IMRT techniques for two breathing conditions, i.e., deep inspiration breath hold (DIBH) and free breathing. Twenty-three patients with early-stage mediastinal Hodgkin lymphomas were accrued in the prospective study. The patients were given treatment plans which utilized full arc volumetric modulated arc therapy (F-VMAT), Butterfly VMAT (B-VMAT), and fixed field IMRT (FF-IMRT) techniques for both DIBH and free breathing methods, respectively. All the plans were optimized to deliver 95% of the prescription dose which was 25.2 Gy to 95% of the PTV volume. The mean dose and standard error of the mean for each OAR, conformity index (CI), and homogeneity index (HI) for the target using the three planning techniques were calculated and compared using Student's t-test for parametric data and Wilcoxon signed-rank test for non-parametric data. The HI and CI of the target was not compromised using the DIBH technique for mediastinal lymphomas. The mean values of CI and HI for both DIBH and FB were comparable. The mean heart doses were reduced by 2.1 Gy, 2.54 Gy, and 2.38 Gy in DIBH compared to FB for the F-VMAT, B-VMAT, and IMRT techniques, respectively. There was a significant reduction in V5Gy, V10Gy, and V15Gy to the heart (p < 0.005) with DIBH. DIBH reduced the mean dose to the total lung by 1.19 Gy, 1.47 Gy, and 1.3 Gy, respectively. Among the 14 female patients, there was a reduction in the mean right breast dose with DIBH compared to FB (4.47 Gy vs. 3.63 Gy, p = 0.004). DIBH results in lower heart, lung, and breast doses than free breathing in mediastinal Hodgkin Lymphoma. Among the different IMRT techniques, FF-IMRT, B-VMAT, and F-VMAT showed similar PTV coverage, with similar conformity and homogeneity indices. However, the time taken for FF-IMRT was much longer than for the F-VMAT and B-VMAT techniques for both breathing methods. B-VMAT and F-VMAT emerged as the optimal planning techniques able to achieve the best target coverage and lower doses to the OARs, with less time required to deliver the prescribed dose.

Associations of minimally processed and ultra-processed food intakes with cardiovascular health in Korean adults: the Korea National Health and Nutrition Examination Survey (KNHANES VI), 2013-2015.

Although recent studies have suggested the adverse effects of processed foods on cardiovascular disease, few studies have been conducted on the effects of food processing on cardiovascular health (CVH) in Koreans. This study aimed to investigate the associations of minimally processed foods (MPF) and ultra-processed foods (UPF) intakes with CVH. We used the data of 6945 adults (≥19) from the sixth Korea National Health and Nutrition Examination Survey. MPF and UPF intakes were based on the NOVA food classification. Using Life's simple 7 (LS7) proposed by the American Heart Association, the CVH indicator was estimated as the sum (0-12) of the scores of six components. Multiple linear and multinomial logistic regressions were used to estimate the associations between processed food intakes and CVH. The mean (standard error) of MPF and UPF intake was 61.28 (0.28) and 20.27 (0.24) %kcal/day, respectively. After adjusting for sex, age, household income, educational attainment, family history of CVD, and stress, we found significant positive associations between MPF intake and CVH (p value < 0.001), while associations between UPF intake and CVH were significantly negative (p value < 0.001). Moreover, the magnitude of the observed association was more distinctive in females (p-interaction < 0.01) and with increasing age (p-interaction < 0.001). A high intake of MPF is associated with improved CVH, while a high intake of UPF is associated with poorer CVH in Korean adults. Therefore, public health policies should be established to promote the choice of less processed foods to improve CVH among South Korean adults. In modern society, processed foods have become ubiquitous and South Korea's consumption of processed foods is very high. This study had shown that the more processed a food is, the more negative impact it can have on cardiovascular health. Therefore, researching the effects of processed foods on the human body can increase understanding of population health and aid in the development of prevention and treatment strategies.

Evaluation of the Effectiveness of Disinfectants on Impression Materials.

Background The disinfection of dental impression materials is a cornerstone of infection control in dental practice. This study aimed to evaluate the effectiveness of two disinfectants, sodium hypochlorite and iodophor, on alginate and silicone impression materials, which are prone to microbial contamination. Methods The study was structured into two main groups based on the impression material: Group I (alginate) and Group II (addition silicone), each further subdivided into two subgroups for disinfection with sodium hypochlorite and iodophor. For each subgroup, initial microbial swabs were taken before any treatment, followed by a second swab after rinsing and a final swab after disinfection. The mean colony-forming unit (CFU) counts, standard deviations, and standard errors of the mean were calculated for each stage of treatment. Results Prior to disinfection, Group I had a mean CFU count of 2,529.40, while Group II had a lower mean CFU of 1,417.40. After rinsing, there was a significant decrease in CFUs in both groups, with Group I at 1,337.10 and Group II at 415.10. Post-disinfection, Group I showed a mean CFU count of 73.00 for sodium hypochlorite and 0.00 for iodophor. Similarly, Group II achieved a CFU reduction of 99.00 with sodium hypochlorite and 0.00 with iodophor, demonstrating a marked reduction in microbial presence. Conclusion Iodophor was exceptionally effective in disinfecting both alginate and silicone impression materials, eliminating all detectable CFUs. Sodium hypochlorite also significantly reduced microbial counts but was not as effective as iodophor. Rinsing prior to disinfection was instrumental in reducing the microbial load, underscoring its importance in the disinfection protocol.

Variability of time duration analysis for rainfall water using precipitation indexes in Hai town

Abstract Insufficient rainfall has an impact on a variety of natural resources. This work aims to determine the variability of rainfall and drought in Hai town depending on the standardized rainfall index (SRI), rainfall concentration index (RCI), index of wetness (IW), and coefficient of variation (CV). Rainfall series were taken from the Meteorological Station Directorate of Hai Town, Iraq for a period of 30 years (1989–2018). The results indicated that the years 1996 and 2014 had high SRI and were under extremely wet conditions (IW = 195.93 and 165.93, respectively). However, the lowest SRI value was in 2004, with a wetness index of 35.15, whereas the RCI was strongly irregular in rainfall distribution. Also, the CV was highly variable that ranged between 113.78 and 244.01. Mathematical models were created and confirmed for predicting the wetness index using data-fitting software. Model 1 generated best outcomes (R2 = 99.99%, relative error (RE) = 0.221, root mean square error (RMSE = 0.253) and standard error of estimates (SEE = 0.28). The results demonstrated that rain indicators have significant differences and alteration throughout the study period. Hence, the best model for estimating wetness and droughts in Hai town is recommended.

P571 The Effect of NLRX1 Activation on Eosinophils in Ulcerative Colitis and Inflammation: Translational Learnings Across Diseases and from Mouse to Human

Abstract Background Although the precise role of eosinophils in IBD is debated, elevated eosinophils may influence response to therapy and clinical outcomes1. Thus, therapeutic agents which affect both neutrophil and eosinophil recruitment may provide more robust clinical improvement in patients with UC. NLRX1 is an immunometabolic protein which reduces oxidative stress, shifts cellular metabolism, and decreases inflammation in multiple cell types implicated in ulcerative colitis (UC). Studies of NLRX1 agonists (gut-selective NX-13 &amp; systemic LABP-73) in diverse disease models identified novel cellular targets of NLRX1 activation. We compared NLRX1’s effect on eosinophils in 2 disease states, UC and the more prototypical eosinophilic disease, asthma, and evaluated the findings. Methods In the 4-week NX-13 Phase 1b, a double-blind trial of 36 patients with active UC (Total Mayo Score 4-10; Mayo endoscopic subscore 2-3) who were randomly assigned to NX-13 250mg Immediate Release (IR), 500mg IR, 500mg Delayed Release (DR) or Placebo QD for 4 weeks, histology was assessed using the Geboes score by a blinded pathologist2. For allergic asthma models, mice were immunized with ovalbumin or house dust mite followed by antigen challenge concurrent with LABP-73 or vehicle. Cells isolated from the lung were analyzed by flow cytometry using the BD FACS Celesta/Diva. Data are represented as means (standard error). Results In the 1b clinical trial, both the Geboes score and neutrophil subscores were reduced in the IR NX-13 group compared to placebo, consistent with the effects seen in preclinical IBD models. Upon examination, eosinophil infiltration was reduced in both the IR dose cohorts compared to placebo (Fig1A). In the subset of patients with active eosinophil infiltration at baseline (defined as Geboes subscore ≥2A.1), eosinophil reduction was seen in all NX-13 doses (Fig1B). Importantly, a numerically increased clinical response rate (decrease in total Mayo score of ≥3 or ≥30%) was seen in patients that demonstrated effective eosinophil reduction, compared to patients without improvement (75% versus 29%; Fisher’s Exact Test, p=0.08). In two allergic asthma models, NLRX1 activation by LABP-73 significantly reduced the fraction of eosinophils within the lung relative to vehicle control (n=7-8; p&amp;lt; 0.05), confirming NLRX1 activation can regulate eosinophilic inflammation in Th2-mediated responses. Conclusion Neutrophil and eosinophil infiltration were reduced in UC patients treated with the gut selective NLRX1 agonist, NX-13, and was coupled with better clinical outcomes. The effect of NX-13 on eosinophils will be evaluated further in the ongoing phase 2 NEXUS trial in patients with UC. 1 A Mookhoek, et al. JCC (16). 2 L Peyrin-Biroulet, et al. JCC (17) Supp

The Libido and Semen Quality of Bali Bulls Supplemented with Micro-Nutrients of Zinc, Selenium, Vitamin A and Vitamin E

Low quality and quantity of food intake of bulls in the tropics might adversely affect libido and semen quality through their effects on spermatogenesis process. The purpose of this study was to evaluate the effect of micro-minerals (Zn and Se) and vitamins (A and E) on the libido and semen quality of Bali bulls. 2 (two) Bali bulls, aged 4-5 years old with a body weight 300-350 kg. The study was divided into 2 periods and each period was conducted for 8 weeks. At the first period (control), the experimental bulls were fed with natural grasses and concentrates (1% of body weight). Furthermore, at the second period (treatment period), they were fed diet similar to that used in the first period with an additional of a mineral mix (Zn and Se) and vitamin (A and E). Evaluation of libido and semen quality were carried out simultaneously twice a week. Libido was measured by calculating the time required for the bulls from approaching the teaser until they mounted for the first time and from approaching until they ejaculated, respectively. Semen was collected by using an artificial vagina. The volume, colour, pH, and, viscosity, as were recorded. Evaluation of semen quality in the form of the sperm concentration, motility, viability and abnormality were done by using Computer Assisted Semen Analyser (CASA). Fresh semen was diluted by Andromed®. The diluted semen was preserved at the temperature 50C for 144 hrs. Motility, viability and abnormality were observed every 12 hrs. Data were reported as mean and standard error of mean analysed by using the paired student’s t-test. Mean interval between the bulls approaching and mounting the teaser for the first time and between approaching and ejaculation after the supplementation of micro-nutrients were significantly shorter (P&lt;0.05) in compared to those before the supplementation (2.68 vs. 6.52 and 5.09 vs. 10.06 minutes, respectively). The sperm viability after the supplementation of micro-nutrients was significantly higher in compared to that before supplementation. (82.25 vs. 87.50 %). Preservation of diluted bull semen at the temperature of 50C for 144 hrs showed that the sperm viability was significantly higher (P&lt;0.05) and sperm abnormality was significantly lower (P&lt;0.05) after the supplementation of micro-nutrients in compared to those before the supplementation. It can be concluded that the supplementation micro-nutrients in Bali bulls could increase libido, sperm viability and reduce the sperm abnormality.

Improving health literacy of passengers of cruise ships: readability of passenger-facing COVID-19 information provided by commercial cruise lines-an infodemiology study.

Readability of COVID-19 information from 35 cruise lines was examined. Mean Flesch Reading Ease and Flesch-Kincaid Grade Level scores (±standard error of mean) were 46.6 ± 1.3 (target ≥60) and 10.9 ± 0.3 (target ≤ 8.0), respectively. Two (6%) cruise lines met readability reference targets. Readability tools may aid in preparing more easily read passenger-facing health-related information on existing infections, including COVID-19, other respiratory infections, as well as gastroenteritis (e.g. norovirus), as well as providing a methodology for improving the readability of information prepared for newly emerging infectious diseases.

Estimating nutrient composition and polyphenol concentration using Near-Infrared Spectroscopy (NIRS) in tropical forages

Abstract. Parastiwi HA, Lestari NSH, Yanza YR, Niderkorn V, Ridwan R, Jayanegara A. 2023. Estimating nutrient composition and polyphenol concentration using Near-Infrared Spectroscopy (NIRS) in tropical forages. Biodiversitas 24: 6652-6660. This study aimed to evaluate the accuracy and precision of Near-Infrared spectroscopy (NIRS) in determining nutrient composition and total phenol concentration in tropical forages. A total of 48 tropical forages from 33 species were subjected to measurements using conventional methods and NIRS equipment for rapid determination. The measured variables included Dry Matter (DM), ash, Crude Protein (CP), Ether Extract (EE), Crude Fiber (CF), and Total Phenolic (TP). The values obtained from NIRS were then statistically evaluated to obtain their coefficient of determination (R2), Standard Error (SE), and Root Mean Square Error (RMSE). Each tropical forage was assessed with three scanning repetitions, where two were conducted to calibrate NIRS determination, and another was performed to validate the NIRS results. All values obtained from the measured samples using both methods in this study were statistically analyzed through Partial Least Square (PLS) regression model. The results showed that the accuracy of NIRS for estimating nutrient content and total phenolic among different tropical forages was varied. NIRS was precise and accurate for estimating crude protein and total phenolic contents of tropical forages but showed lower accuracy for estimating EE content.

Design, fabrication and evaluation of a robot for plant nutrient monitoring in greenhouse (case study: Iron nutrient in spinach)

The regulation of nutrients intake in plant life is a critical factor in preserving the quality of crops, enhancing yield rates, and minimizing the fertilizer consumption. Consequently, this research presents the design of an intelligent robot for real-time monitoring of plant nutrients within greenhouse environments. The robot’s ability to detect and address iron deficiency in spinach plants was evaluated. To achieve this, the robot, equipped with a camera, captured visible imaging from surface of spinach plants including both the control group and the group subjected to iron deficiency stress. Statistical analysis of the data was performed at the probability level of 5 %, and genetic algorithm (GA) was utilized to select the most suitable features (G, Area, Energy, Entropy, R and L), from 41 extracted image parameters, including color, morphological, and texture features. An artificial neural network (ANN) was then employed to detect iron deficiency in plants, resulting in an accuracy of 96 %. Subsequently, the Gaussian kernel function of support vector regression (SVR) algorithm was used to predict spinach iron content, yielding the highest determination coefficient (R2 = 0.94) and the lowest values of mean absolute percentage error (MAPE = 5.92), root mean square error (RMSE = 0.43) and standard regression error (SRE = 2.66). The designed robot detected iron-deficient plants with precision, sensitivity, specificity and accuracy of 86 %, 82 %, 84 % and 83 %, respectively. The robot then took the necessary control actions to supply the deficiency of this nutrient by foliar spraying of more than 89 % of the crop area.

Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy

BackgroundThis study was performed to test the hypothesis that systemic leukocyte gene expression has prognostic value differentiating low from high seizure frequency refractory temporal lobe epilepsy (TLE).MethodsA consecutive series of patients with refractory temporal lobe epilepsy was studied. Based on a median baseline seizure frequency of 2.0 seizures per month, low versus high seizure frequency was defined as ≤ 2 seizures/month and > 2 seizures/month, respectively. Systemic leukocyte gene expression was analyzed for prognostic value for TLE seizure frequency. All differentially expressed genes were analyzed, with Ingenuity® Pathway Analysis (IPA®) and Reactome, to identify leukocyte gene expression and biological pathways with prognostic value for seizure frequency.ResultsThere were ten males and six females with a mean age of 39.4 years (range: 16 to 62 years, standard error of mean: 3.6 years). There were five patients in the high and eleven patients in the low seizure frequency cohorts, respectively. Based on a threshold of twofold change (p < 0.001, FC > 2.0, FDR < 0.05) and expression within at least two pathways from both Reactome and Ingenuity® Pathway Analysis (IPA®), 13 differentially expressed leukocyte genes were identified which were all over-expressed in the low when compared to the high seizure frequency groups, including NCF2, HMOX1, RHOB, FCGR2A, PRKCD, RAC2, TLR1, CHP1, TNFRSF1A, IFNGR1, LYN, MYD88, and CASP1. Similar analysis identified four differentially expressed genes which were all over-expressed in the high when compared to the low seizure frequency groups, including AK1, F2R, GNB5, and TYMS.ConclusionsLow and high seizure frequency TLE are predicted by the respective upregulation and downregulation of specific leukocyte genes involved in canonical pathways of neuroinflammation, oxidative stress and lipid peroxidation, GABA (γ-aminobutyric acid) inhibition, and AMPA and NMDA receptor signaling. Furthermore, high seizure frequency-TLE is distinguished prognostically from low seizure frequency-TLE by differentially increased specific leukocyte gene expression involved in GABA inhibition and NMDA receptor signaling. High and low seizure frequency patients appear to represent two mechanistically different forms of temporal lobe epilepsy based on leukocyte gene expression.

Rates and Predictors of Structural Valve Degeneration and Failure of Trifecta Bioprosthetic Valve Over a 5-year Follow-up Period: A Single-center Experience.

The Trifecta bioprosthetic valve has been commonly used for surgical aortic valve replacement (SAVR). Multiple studies have been done to define the rate of structural valve degeneration (SVD) and failure (SVF), but the outcomes are still debatable. Therefore, we aim to conduct this single-center study to estimate the rate and predictors of SVD/SVF. This retrospective observational cohort single-center study was conducted between 2014 and 2019 among Trifecta SAVR patients. Data were patient's characteristics collected from electronic medical records at baseline and follow-up (3-5 years). Statistical analysis was performed with a significance level of P ≤ 0.05. A total of 271 eligible patients were identified. Most of our sample were males (57.9%), with a mean age of 71.1 ± 10.6 years. The mean baseline preoperative ejection fraction (EF) was 53.0%, with no change (P = 0.88) in the immediate postoperative EF (53.6%). A most recent follow-up EF revealed a significant increase of EF (55.2%), P = 0.01. Furthermore, there was a significant increase from peak velocity to PVMRE (mean difference [MD] ± standard error of mean (SEM) [0.15 ± 0.04], P < 0.01), an increase in pressure gradient (PGIPE) to PGMRE (MD ± SEM [1.70 ± 0.49], P < 0.01), and a decrease in Doppler velocity index (DVIIPE) to DVIMRE (MD ± SEM [-0.037 ± 0.01], P = 0.01). Regarding the SVF rate, 13 (4.8%) patients had failed valves requiring replacement throughout the study period. Over a 5-year follow-up period, 4.8% had SVF with an SVD of 23.2%, with the majority of SVD not being clinically significant except in six patients. These results corroborate with a previously published study suggesting a bad clinical outcome of Trifecta valve placement.

Prevalence and health risk evaluations of mycotoxins in drinking water sources in Nigeria.

Mycotoxins in drinking water are neglected pollutants that have serious health implications when ingested. Common mycotoxins with health concerns include deoxynivalenol (DON), ochratoxin A (OTA), and zearalenone (ZEN). This study considers the distribution and apparent health risks of these mycotoxins in drinking water sources (groundwater, surface water, bottled water, sachet water) in three Southwest Nigeria States: Osun, Oyo, and Lagos States, using the UHPLC-ESI-QTOF. ZEN and DON were found in all 95 water samples across all three states. ZEN in sachet water samples has the highest mean concentrations, with those from Osun, Oyo, and Lagos States having concentrations of 14.96 ± 4.46, 8.59 ± 3.86, and 10.56 ± 2.84 μg L-1, respectively. In contrast, the mean concentrations of all three mycotoxins (± Standard Error of Mean) in bottled water samples are the lowest across the three States. The mean concentrations of OTA in sachet water samples (2.93 ± 0.79, 1.24 ± 0.40, and 3.01 ± 1.50 μg L-1) are slightly higher than those in bottled water (1.47 ± 0.28, 1.53 ± 0.31, and 0.75 ± 0.31 μg L-1) for Osun, Oyo, and Lagos States, respectively. Groundwater samples across the three States had the lowest average pH values, below the WHO's lowest limit of 6.5. Principal Component Analysis studies indicate that all three mycotoxins in water samples are closely associated by source. Possible human exposure values for ZEN suggest some health concerns, especially with the use of sachet water type based on the estrogenicity of this mycotoxin. However, OTA values for all water samples analyzed, are much lower than the tolerable daily intake (TDI) of 4.73 μg kg-1 bw per day provided by European Food Safety Auhtority (EFSA). The levels of DON in all water sample types were of no serious health concern. However, human exposure levels to all three mycotoxins in bottled water fall within safe limits of health-based guidance values (HBGV) indicating that this drinking water type is better treated, unlike sachet water. Nevertheless, stakeholders need to re-examine water quality with respect to these mycotoxins and adopt stringent guidelines and new water treatment strategies to provide consumers with safe drinking water in line with the UN SDG #6.

Effectiveness of Vortioxetine in Working Patients with Major Depressive Disorder in China: A Subgroup Analysis of the RELIEVE China Study.

Major depressive disorder (MDD) causes significant functional impairments that impact on all aspects of patients' daily lives, including their ability to work, work productivity, and social life. To assess the real-world effectiveness of the multimodal antidepressant vortioxetine in working patients with MDD in China. RELIEVE China was an observational, prospective cohort study. Patients (aged ≥18 years) with MDD initiating treatment with vortioxetine in routine clinical practice settings were followed for 24 weeks. In this subgroup analysis, functioning was assessed using the Sheehan Disability Scale (SDS) in patients in full- or part-time work or education at baseline who remained on treatment at all follow-up visits (n=424). Depressive, cognitive, and anxiety symptoms were also assessed. For all endpoints, mean change from baseline at weeks 8 and 24 was analyzed using mixed models for repeated measures. Clinically relevant and sustained improvements in patient functioning and measures of work productivity were observed over the 24 weeks of vortioxetine treatment. The adjusted mean (standard error) reduction in SDS total score from baseline was 5.4 (0.3) points at week 8 and 8.7 (0.3) points at week 24 (both P<0.001 vs baseline). Significant improvements were observed across all SDS domains and in levels of absenteeism and presenteeism (P<0.001 vs baseline for all endpoints at both time points). Significant improvements in depressive, cognitive, and anxiety symptoms were also observed over the study period (all P<0.001 vs baseline). The proportion of patients in remission (ie, 17-item Hamilton Depression Rating Scale score ≤7) after 24 weeks of vortioxetine treatment was 65.4%. Vortioxetine was well tolerated; nausea was the most common adverse event, reported by 18.6% of patients. These findings support the effectiveness and tolerability of vortioxetine in working patients with MDD receiving treatment in routine clinical practice settings in China.

Results of XEN45 Gel Stent Implantation in the Treatment of Primary Open‐Angle Glaucoma Using 5, 10 or 20 μg Mitomycin C: A Pilot Study

Background: No consensus has been reached on the adequate dose of mitomycin C (MMC) in XEN45 gel stent implantation. Lower doses have the potential to reduce MMC‐linked side effects. This study aimed to evaluate treatment efficacy of ab interno XEN45 gel stent in primary open‐angle glaucoma (POAG) with three different MMC doses.Methods: This retrospective single‐centre nonrandomised trail included 54 patients (56 eyes) who underwent XEN45 gel stent implantation for POAG with above‐target intraocular pressure (IOP) under medical therapy. Eyes were grouped according to the received MMC dose: Group 1 (20 μg; n = 21), Group 2 (10 μg; n = 14) and Group 3 (5 μg; n = 21). The primary endpoint was the mean IOP change in the three MMC dose groups after 6, 12 and 24 months. Secondary endpoints included the success rate defined as lowering of baseline IOP ≥ 20% and below a cut‐off IOP set at three different levels: ≤ 18, ≤ 16 and ≤ 14 mmHg (Criteriums 1, 2 and 3), the mean number of ocular hypotensive medications and the frequency of needling procedures.Results: After 24 months, the overall mean (standard error) IOP was significantly reduced from 24.7 (0.9) mmHg to 15.2 (0.7) mmHg (p &lt; 0.0001). The average IOP change (standard error) in MMC dose groups 1, 2 and 3 was −8.6 (2) mmHg, −10.1 (2.1) mmHg and −10.4 (2.8) mmHg. Complete success (Criterium 1) was achieved in 50%, 62% and 43% of the eyes in groups 1, 2 and 3. No statistically significant difference was found within the first 24 months between the three MMC dose groups for IOP change, success rate, number of ocular hypotensive medications and the frequency of needling procedures.Conclusions: XE45 was effective in all three dose groups. As the success rate did not significantly differ between the MMC doses, these results may support the use of the lowest dose.Trial Registration: ClinicalTrials.gov identifier: 559/2016BO2

Effectiveness of digital health interventions for perinatal depression: a systematic review and meta-analysis

Abstract Pregnant women and new mothers within 1 year after delivery are at a high risk of depression, yet many do not get the help they need due to wide reasons heralding stigma, access, cost, time, and shortage of human resources. Hence, compelling the exploration of alternate and potentially cost-effective means of delivering care, including the leverage of digital tools. This review aimed to evaluate the effectiveness of digital health interventions in reducing depressive symptoms among perinatal women. Literatures were sought from seven academic databases alongside the references of previous reviews. Included studies were all quantitative study types involving the use of digital health interventions for perinatal women not more than 1-year post-delivery. Standardized mean difference and standard error were used to perform random-effect model meta-analysis. Sensitivity and subgroup analyses were performed to determine certainty and modifiers of the findings, respectively. Forty-eight studies were included in this review with 28 studies used for meta-analyses. Numerous digital channels were identified; however, none specified the use of a digital health theory in its development. The digital health interventions showed a small positive significant effect over the controls (standardized mean difference = 0.29, P = 0.003, I2 = 34%), and this was significantly influenced by intervention delivery and facilitation modes, time of initiation of the intervention, and period covered by the intervention. Although digital health interventions may hold some potential for perinatal depression, scaling the interventions may be challenging sequel to overlooked influences from the interactions within the human–computer–society complex.

Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data.

Osteoporosis, characterized by decreased bone density and increased fracture risk, imposes significant physical, psychosocial, and financial burdens. Early detection and prevention are crucial for managing osteoporosis and reducing the risk of fractures. To investigate the relationship between Hepatitis A seropositivity and bone mineral density (BMD) in adolescents and adults and to explore the potential link between Hepatitis A infection and osteoporosis risk. This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018 to evaluate the association between hepatitis A seropositivity and BMD in 15,693 participants. Multivariable regression analysis was used to calculate the mean BMD and standard error for adolescents and adults, followed by an independent z-test to determine whether there was a significant difference between the seropositive and seronegative groups. Hepatitis A seropositive adolescents and adults had lower BMD than their seronegative counterparts, with significant differences in lumber spine (mean difference = -0.03 g/cm2, P < 0.01 for both age groups) and pelvis BMDs (mean difference = -0.02 g/cm2, P < 0.01 for the adult age groups), after adjusting for various covariates. This study confirmed that both adolescent and adult individuals seropositive for Hepatitis A antibodies had reduced BMD among both adolescents and adults, especially in the adult group. This finding suggests a possible link between Hepatitis A infection and risk of osteoporosis.

An attempt to resolve no-wait flow shop scheduling problems using hybrid ant colony and whale optimization algorithms

The incentive for many developments and scientific progresses within the field of scheduling has emerged from industrial environments, and naturally, it could be utilized in expressing the scheduling concepts regarding terms used in the industry. Generally speaking, scheduling problems are known as limited optimization issues through which decisions related to the machines’ assignment and works processing sequence are probed. Thus, following a review of the related literature, the major goal of this research is to design a mathematical model and to solve it through a meta-heuristic for no-wait flow shop scheduling problem using different machines for the purpose of minimizing the time required to complete the work using whale and ant colony optimization (ACO) algorithms in Sanat-Gostar-e-Hamgam Shoe Company. The ACO and whale algorithm methods are used to compare and predict scheduling activities in manufacturing line of shoe industry. The results showed an ACO algorithm with two stages in mean ideal distance (MID) end amounting to 76.65 and 77.38, respectively. Also, regarding the amounts of standard error mean squares, it could be claimed that the model designed using the improved whale algorithm has a better prediction, and the minimum time required to complete works using the whale algorithm is estimated to be equal to 86.1071. This could lead to an optimal state in achieving the predetermined goals.

Development of Urdu version of Chronic Respiratory Disease Questionnaire Self-Administered Standardized (CRQ-SAS); validity and reliability analysis in COPD patients.

Chronic Respiratory Disease Questionnaire Self-Administered Standardized (CRQ-SAS) is a valid and reliable tool that evaluates the health-related quality of life among the adult population affected with chronic respiratory disorders (CRDs) and has been translated into many languages as per need. The main objective of this study was to translate the CRQ-SAS into the Urdu language and evaluate its psychometric properties. It was a two-staged study that consisted of translating the original version into Urdu language and then psychometric testing of the translated version. The reliability of the translated questionnaire was assessed by measuring its internal consistency, test-retest reliability, standard error of mean (SEM) & minimal detectable change (MDC). Validity was determined by evaluating its content for content validity, construct (convergent and discriminative) validity, and exploratory factor analysis. Data was analyzed using SPSS v 28 with an alpha level < 0.05 considered to be significant. CRQ-SAS U had an excellent internal consistency (Cronbach's Alpha α = 0.89), test-retest reliability (ICC2,1) = 0.91 of all items, and low SEM = 0.11 and MDC = 0.65. S-CVI was 0.9, with statistically significant difference across the response of COPD patients and healthy subjects, and a high degree of correlation with St Georges Respiratory Questionnaire (r = 0.7-0.9) proving CRQ-SAS U content, discriminant and convergent valid respectively. Exploratory factor analysis identified two factors responsible for 80% of the variance. CRQ-SAS U demonstrated optimal psychometric properties which renders it to be used in Urdu speaking populations with COPD.