The Standard Electronic Module, format E, (SEM-E) is extensively employed in navigation, control, tracking, guidance, and communications electronics. Thermal resistance of the junction between the guide rib of the SEM-E frame and the liquid-cooled chassis card rail to which the module is clamped is a principal contributor to overall thermal resistance in the heat rejection path. High resistance causes excessive operating temperatures and failure rates. The currently used configuration employs anodic coatings on contact surfaces and segmented wedge clamps to secure modules to the chassis. In the present investigation, the thermal performance of alternative configurations utilizing nickel and silver platings instead of the anodic coating on card rails and pneumatic bladder clamps instead of wedge clamps is experimentally determined. These results are compared to previously obtained results for the baseline condition. Results indicate that nickel and silver platings and bladder clamps provide no enhancement in performance in an ambient air environment (in which surface vessels and submarines operate) compared to anodic coatings and wedge clamps. In a vacuum environment (approximating operational surroundings for high-altitude aircraft and spacecraft), nickel plating increases junction thermal resistance by 300%, silver plating reduces resistance by 25-33%, and bladder clamps decrease resistance by 25-40%.