Based on the current scientific understanding regarding COVID-19, this article presents the results of new studies (Tests 4, 5, 6), conducted by the Institute of Museum and Library Services (IMLS) and the Online Computer Library Center (OCLC), in partnership with Battelle. The purpose of the experiments is to determine how long frequently circulated library, museum and archival materials should be quarantined before being put back into public circulation.Each test has been conducted by applying the virulent SARS-CoV-2 virus on various materials held at standard room temperature and relative humidity conditions, and then examining the rate of natural attenuation of the virus. The items were not sterilized before testing. Battelle propagated the clinical isolate of the SARS-CoV-2 virus in-house, followed by characterization and testing to establish a certified titer. The materials in Test 4 included binding and cover items placed in a stacked configuration to imitate the common practice that libraries employ when handling book/DVD returns, as well as expanded polyethylene foam, which is typically used in museums for storage and shipping. Test 5 focused on textiles, while Test 6 included building materials (glass, marble, brass, laminate, and powder-coated steel). Test coupons cut from the materials were inoculated with active virus, and then allowed to dry. The test coupons were then examined at the following timepoints: on the second, third, fourth and sixth day (Test 4); on the second, fourth, sixth and eighth day (Tests 5 and 6). The results of the tests showed how much virus was detectable at the selected timepoints. In Test 4, the virus was still detected on all the five materials after six days. In Test 5, the virus was still detected on leather and synthetic leather publication after eight days. In Test 6, the virus was not detected on the tested materials after six days.This publication is provided for informational purposes only, and readers are encouraged to review federal, regional, and local guidance. The authors, sponsors and researchers are not liable for any damages resulting from use, misuse, or reliance upon this information, or any errors or omissions herein.