Standard Clinical Guidelines Research Articles

Bone Health Deterioration in Transfemoral Prosthetic Users: An Analytical Biomechanical Explanation.

There is a five-decade recorded history indicating that persons with transfemoral amputation experience bone loss in their amputated femur at levels seen in bedridden and post-menopausal individuals, irrespective of age or mobility levels. We used computer simulation to recreate the mechanical environment created by the mechanical design of a prosthetic device in the surviving femur of individuals with transfemoral amputations. Finite element models of gait instances were developed from the hip joint computerized tomography scan of a subject along with a coupled ischial containment prosthetic socket fitted as per standard clinical guidelines. Accompanying mirror models, assembled similarly but without the prosthetic socket were used for stimulus comparison. Simulation showed that more than 90% of the trabecular bone volume in the amputated femur with an ischial containment socket registered compressive strain magnitudes below 300με. These strain magnitudes are below the threshold for bone maintenance as per mechanotransduction theory (i.e., they lie within the disuse window). Only 50% of the bone was in the disuse window for the mirror model for the gait instances considered. These results are consistent with reported invivo evidence which shows that transfemoral prosthesis users may lose bone mass irrespective of age or mobility levels when using traditional socket designs. Clinically, this study shows that prosthetic sockets that support load through the ischium alter the kinetic chain and preclude application of mechanical stimulus that sustains healthy levels of bone mass in the proximal femur. The study also shows that femur length, prosthetic alignment and tissue tone influence this stimulus.

Evidence-Based Surgical Guidelines for Treating Children With Rhabdomyosarcoma.

Surgery remains the cornerstone of treatment for rhabdomyosarcoma (RMS) in children. However, there is considerable variation in surgical management practices worldwide, highlighting the need for standardized Clinical Practice Guidelines (CPG). The CPG development involved assembling a multidisciplinary group, prioritizing 10 key topic areas, conducting evidence searches, and synthesizing findings. Recommendations were voted on using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) methodology. The panel recommended regional lymph node evaluation for patients with paratesticular RMS who are more than 10years old and extremity RMS. Other suggestions included pretreatment re-excision for incompletely resected RMS, preoperative radiation therapy for unresectable tumors, maintaining a 0.5cm resection margin, and tumor bed marking with surgical clips. The panel also suggests resection of residual metastatic disease following chemotherapy, resection of relapsed disease, and the least invasive approach for managing patients presenting with obstruction. This CPG provides evidence-based surgical management recommendations for RMS that can be adapted to diverse resource settings.

Patient safety is our business! Staff perspectives on implementing hospital falls prevention education.

Providing patients with falls prevention education reduces falls in hospitals, yet there is limited research on what influences successful implementation at the staff, ward and hospital levels. We engaged hospital-based health professionals to identify multi-level barriers and enablers to patient falls education that could influence the implementation of a Safe Recovery program. Purposive sampling was used to recruit hospital staff (n = 40) for focus groups and one-on-one interviews. Data were analysed using content analysis and categorized using a socio-ecological framework to understand the micro, meso and macro level influences of hospital falls prevention. We identified five overarching themes, on the barriers and enablers to implementation of the Safe Recovery program. The enablers to falls prevention education included sharing the responsibility to implement the program, setting clear goals for staff, showing the impact of delivering the program, involving family to reinforce the messaging, using falls champions to upskill staff and making the resources (video and booklet) readily available to patients at all times. Barriers included insufficient time for staff to deliver falls prevention education, lack of falls prevention training for staff during their clinical training, absence of standardized protocols and clinical guidelines across hospital settings and insufficient hospital marketing to promote the program. Using a systems thinking approach, this study showed that implementation requires more advocacy and support for patient falls prevention across different tiers of the hospital system to integrate into usual care.

Tracheostomy Practice in the Italian Intensive Care Units: A Point-Prevalence Survey.

Background and Objectives: A tracheostomy is a frequently performed surgical intervention in intensive care units (ICUs) for patients requiring prolonged mechanical ventilation. This procedure can offer significant benefits, including reduced sedation requirements, improved patient comfort, and enhanced airway management. However, it is also associated with various risks, and the absence of standardized clinical guidelines complicates its implementation. This study aimed to determine the prevalence of tracheostomy among ICU patients, while also evaluating patient characteristics, complication rates, and overall outcomes related to the procedure. Materials and Methods: We conducted an observational, cross-sectional, point-prevalence survey across eight ICUs in Italy. Data were collected over two 24 h periods in March and April 2024, with a focus on ICU characteristics, patient demographics, the details of tracheostomy procedures, and associated complications. Results: Among the 92 patients surveyed in the ICUs, 31 (33.7%) had undergone tracheostomy. The overall prevalence of tracheostomy was found to be 9.1%, translating to a rate of 1.8 per 1000 admission days. The mean age of patients with a tracheostomy was 59.5 years (SD = 13.8), with a notable predominance of male patients (67.7%). Neurological conditions were identified as the most common reason for ICU admission, accounting for 48.4% of cases. Tracheostomy procedures were typically performed after a mean duration of 12.9 days of mechanical ventilation, primarily due to difficulties related to prolonged weaning (64.5%). Both early and late complications were observed, and 19.35% of tracheostomized patients did not survive beyond one month following the procedure. The average length of stay in the ICU for these patients was significantly extended, averaging 43.0 days (SD = 34.3). Conclusions: These findings highlight the critical role of tracheostomy in the management of critically ill patients within Italian ICUs. The high prevalence and notable complication rates emphasize the urgent need for standardized clinical protocols aimed at optimizing patient outcomes and minimizing adverse events. Further research is essential to refine current practices and develop comprehensive guidelines for the management of tracheostomy in critically ill patients.

Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review.

Hematopoietic stem cell transplantation (HSCT) is a key therapeutic approach for pediatric patients with hematologic and non-hematologic disorders. However, post-transplant pulmonary complications remain a significant cause of morbidity and mortality. Pulmonary Function Tests (PFTs) are essential for the early detection of pulmonary dysfunction, yet their application in pediatric HSCT recipients has yielded inconsistent results. This review aims to assess the variations in pulmonary function post-HSCT and explore their clinical implications for pediatric patients. A systematic review was conducted by analyzing studies published between 2000 and 2024, sourced from PubMed, Web of Science, CNKI, and Wan Fang databases. The review included cohort studies, randomized controlled trials, and case-control studies that assessed pulmonary function using standardized PFTs. Pulmonary dysfunction, particularly obstructive and restrictive ventilatory disorders, is common in pediatric HSCT recipients. Significant changes in PFT parameters, such as FEV1/FVC ratio and FEF25-75%, were observed. However, trends in post-transplant pulmonary function vary due to factors such as pre-transplant lung conditions, patient age, and treatment protocols. Innovative diagnostic methods, such as parametric response mapping (PRM) and multiple breath washout (MBW), show promise in enhancing early detection and management of pulmonary complications. Monitoring pulmonary function is critical for the early identification of complications in pediatric HSCT recipients. Although standardized clinical guidelines are available, variability in PFT trends underscores the need for more refined diagnostic tools. Advanced diagnostic methods, like PRM and MBW, may improve early detection and help optimize the management of pulmonary dysfunction, ultimately improving long-term outcomes for pediatric patients.

Changes in Emergency Department Practices After Implementation of a Standardized Heavy Menstrual Bleeding Guideline.

The aim of the study is to assess the effect of an emergency department (ED) standardized clinical guideline for adolescent heavy menstrual bleeding on the rate of return ED visits and ED provider history-taking and management of this condition. This was a retrospective cohort study. Patients less than 18 years old presenting to a single academic children's hospital ED between 2010 and 2020 with a chief complaint of heavy menstrual bleeding were included. Patient demographics were collected, along with a 10-point scale of provider documentation of specific medical and menstrual history components and required laboratory workup. Planned treatment plans were collected, as well as hospital admissions and return ED visits (within 3 weeks). Total number of patients was 267 (n = 106 pre- and n = 161 post-), with similar distribution of age ranges between groups (14.6 [2.2] and 14.5 [2.0], P = 0.73). On the 10-point scale of required history and laboratory evaluations, postimplementation patients received 1.9 more points than the precohort (P < 0.001). Age (-0.22 [95% confidence interval {CI} -0.36 to -0.08]) and evaluation by a trainee physician (0.75, [95% CI 0.09 to 1.41]) were also associated with significant differences in point totals. Documentation of outpatient follow-up with primary care physician or an adolescent medicine/gynecology specialist significantly increased (50% and 90% P < 0.001). Implementation was associated with a decrease in ED return visits in multivariate analysis (odds ratio 0.27, [95% CI 0.08 to 0.92], P = 0.036). Implementation of a clinical guideline pathway improved provider documentation and history taking, increased referrals to specialist care, and significantly decreased return ED visits within 3 weeks for heavy menstrual bleeding complaints.

Rehabilitation Assessment of Post Intensive Care Syndrome

The awareness of symptoms experienced after intensive care seems to have been extensively studied since the pandemic wave in 2019. The persistence or new occurrence of symptoms after intensive care is diagnosed as post-intensive care syndrome (PICS). The syndrome encloses multiple system disorders and therefore requires thorough utilization of assessment tools, which unfortunately have no standard clinical practice guidelines. Several subdomains that are crucial for assessment include physical, cognitive, and mental functions. Other aspects to be observed include quality of life, physical examination, and functional tests, particularly those related to reduced cardiorespiratory endurance. This review aimed to highlight the most notable list of tools to be used in the outpatient assessment setting of PICS. The feasibility was also tested in a recent workshop session for physical medicine and rehabilitation specialists, and it was possible to accomplish this in 30 min. Until a consensus is reached on the PICS assessment, it is strongly suggested that practitioners exercise these tools and use them in daily practice.

Recent advances in the prevention and treatment of dental erosion: a narrative review.

Dental erosion is a progressive and irreversible loss of dental tissues caused by chemical processes from intrinsic or extrinsic acids without bacterial involvement. This condition, categorized as part of tooth wear, has gained increasing attention due to its rising prevalence, particularly among children and adolescents. Teeth erosion is often linked to modern dietary habits, including consuming acidic foods, beverages, and certain medications. The impact of dental erosion varies, from localized damage to the entire dentition, with factors such as acid exposure, pH, and the type of acid contributing to its severity. Prevention strategies focus on oral health education, dietary modifications, and remineralization with fluoride-based products, while emerging biomimetic technologies, such as nanomaterials and bioactive polymers, show promise. Restorative treatments, including composite restorations and veneers, are used for advanced cases but lack standardized guidelines for optimal application. Thirty-four studies were included in this article, focusing on fluoride-based products, innovative varnishes, and minimally invasive restorative techniques like CAD-CAM and injection molding. The review highlights the need for further research on the long-term effectiveness of these interventions and the development of standardized clinical guidelines to improve treatment outcomes.

Surgical Management of Vertebral Body Fractures in Proximal Junctional Kyphosis: A Case Series Utilizing Intravertebral Reduction Devices and Hardware Extension

Vertebral body fracture is the most common manifestation of proximal junctional failure (PJF), a frequent complication following adult spinal deformity surgery and a leading cause of reoperation(1). In the absence of established consensus regarding optimal revision techniques for PJF, this case report presents two patients with non-traumatic vertebral fractures secondary to PJF, successfully managed with intravertebral reduction device (SpineJack®) and bone cement augmentation, combined with the extension of previous instrumentation. While the etiology of PJF in these two cases remains undetermined, this report aims to contribute to the evolving literature on surgical revision strategies for PJF, particularly in the context of vertebral fractures. The first case involves a 62-year-old female with degenerative scoliosis, flat back deformity, adult idiopathic scoliosis, coronal malalignment, and degenerative disc disease with lateral listhesis underwent lateral lumbar interbody fusion (LLIF) at L2-3, L3-4, and L4-5 with titanium interbody devices and posterior L1 to pelvis instrumentation and fusion. Following L1 compression fracture at the proximal end of the instrumentation, the patient underwent surgical revision at 6 weeks postoperative. The pedicle screws at L1 were explanted, and the pedicle tracks were utilized for open placement of SpineJack® implants under fluoroscopic guidance to reduce and elevate the compressed L1 vertebra, restoring anterior vertebral height. The postoperative course was unremarkable, and the patient exhibited significant clinical improvement. The second case involves a 60-year-old female patient with a history of painful thoracolumbar scoliosis who underwent a T8-Pelvis posterior spinal fusion (PSF) with multiple Smith-Petersen osteotomies (SPOs) and L4-S1 transforaminal lumbar interbody fusion (TLIF) with right-sided instrumentation. Following discovery of a T8 vertebral compression fracture at 8 weeks postoperative, existing hardware at the fracture level was removed, and SpineJack® implants were inserted bilaterally into T8, under fluoroscopic direction. The patient’s postoperative course was unremarkable with significant clinical improvement in pain and neurological function. This report aims to contribute to the literature on surgical strategies for managing vertebral fractures associated with PJF. The use of SpineJack® with cement augmentation appears effective in restoring vertebral body height and spinal alignment while offering a less invasive alternative to more extensive procedures like vertebral column resection (VCR). This technique may offer promising results for spine surgeons addressing vertebral fractures in the context of PJF. While the limitations inherent to case reports preclude establishment of intravertebral reduction devices with cement augmentation as a standard clinical practice guideline for vertebral fractures in the setting of proximal junctional kyphosis and/or failure (PJK/PJF), the successful treatment of two patients with this combined approach aims to contribute to the existing literature by presenting the safety and efficacy of such a technique. It suggests its potential utility for spine surgeons encountering this PJF vertebral fractures moving forward.

A Literature Review of the Educational Gaps and Needs in Migraine Management: An Asian Perspective Within a Global Context.

Migraine is a common neurological disorder that presents considerable challenges to healthcare systems worldwide. These changes are especially relevant in rapidly developing regions such as Asia, with an increasingly productive population and ongoing advancements in healthcare systems and infrastructure. Despite its substantial impact, migraine management remains inadequate, potentially due to deficiencies in medical education. We hypothesized that significant gaps in basic and advanced medical training and continuing professional education contribute to the suboptimal management of migraine in various healthcare settings across Asia. A comprehensive literature review was conducted using PubMed and Google databases. The search focused on cross-sectional studies published in English from inception until September 2024 that examined educational needs among medical trainees and clinicians and clinical gaps in migraine management in Asia. These studies were then contextualized within a global perspective. The review identified significant shortcomings in migraine education at all levels of educational training in Asia, which also translated to poor management of migraines in clinical practice. Undergraduate medical curricula in Asia inadequately address headache disorders, while postgraduate training programs provide insufficient guidance in headache management, especially for complex cases. Primary care clinicians exhibited variable levels of understanding and frequently incorrectly diagnosed and managed migraine.Additionally, many Asian countries lack standardized clinical practice guidelines (CPGs) and specialized training programs for headache management. A multidimensional approach is required to tackle the pre-existing educational and clinical practice limitations. The approach should include improving the medical school curriculum, providing focused continuing medical education programs or developing migraine modules for primary care physicians (PCPs), and developing region-specific CPGs. Besides educational initiatives, integrating and coordinating systems of care, where primary and specialist services complement each other, are crucial for improving patient care. Robust education combined with comprehensive referral and linkage protocols ensures continuity of care across healthcare levels. Moreover, collaboration, communication, and cooperation among healthcare providers (HCPs) and organizations are vital to enhancing the quality of life and productivity of migraine patients in the region.A synergistic approach that combines robust collaboration with innovative educational delivery can catalyze the widespread adoption of evidence-based medicine (EBM).

Diagnostic and therapeutic challenges in implementing hypertension management after kidney transplantation.

Evidence for blood pressure (BP) measurement and hypertension management in kidney transplant recipients (KTR) remains lacking. Accurate BP measurement technique is a critical component of hypertension management, and 24-h ambulatory BP monitoring remains the gold standard for diagnosis of hypertension in KTR. BP target at different periods posttransplant is uncertain, but likely higher than that in nontransplant patients given factors related to long-standing uremic milieu and kidney transplantation such as vascular calcification altering transplant renal hemodynamic and allograft perfusion and immunosuppression. Dividing BP target into immediate, early, and late posttransplant periods can guide differential diagnoses of hypertension and BP control with a target SBP less than 160 mmHg in general and BP 115-135/65-85 mmHg for adult KTR receiving pediatric kidneys during the immediate posttransplant period, 130/80 mmHg during early and late posttransplant periods. Calcium channel blockers were shown to have favorable graft outcomes. Novel antihypertensive medications for resistant and refractory hypertension and device-based therapies are limited due to KTR's ineligibility for participating in clinical trials. In KTR, BP measurement and monitoring practice should follow the standard clinical practice guideline for nontransplant patients by considering posttransplant factors and immunosuppressive state. Novel treatment options required further studies.

How are different traditional Chinese medicine modalities deployed by clinical practitioners in China? Findings from a national survey

ObjectiveTraditional Chinese medicine (TCM) incorporates traditional diagnostic methods and several major treatment modalities including Chinese herbal medicine, Chinese patent medicine, and non-pharmacological methods such as acupuncture and tuina. Even though TCM is used daily by more than 70,000 healthcare facilities and over 700,000 clinical practitioners in China, there is a poor understanding of the extent to which TCM diagnostic methods are used, how different treatment modalities are deployed in general, and what major factors may affect the integration of TCM and Western medicine. This study aimed to fill this void in the literature. MethodsIn the 2021 National Healthcare Improvement Evaluation Survey, we included three questions gauging the perception and practices of TCM amongst physicians working in TCM-related facilities, investigating the frequency of their deployment of TCM diagnostic methods, and predominant TCM treatment methods. Our empirical analysis included descriptive statistics, intergroup chi-square analysis, and binary logistic regression to examine the association between different types of facilities and individual characteristics and TCM utilization patterns. ResultsA total of 7618 clinical physicians comprised our study sample. Among them, 84.27% have integrated TCM and Western medicine in their clinical practice, and 80.77% of TCM practitioners used the 4 diagnostic methods as a tool in their clinical practice. Chinese herbal medicine was the most widely utilized modality by Chinese TCM physicians (used by 88.49% of respondents), compared with the Chinese patent medicine and non-pharmacological TCM methods, which were used by 73.14%, and 69.39%, respectively. Herbal tea as an out-of-pocket health-maintenance intervention is also a notable practice, recommended by 29.43% of physicians. Significant variations exist across certain institutions, departments, and individual practitioners. ConclusionGiven that most of the surveyed physicians integrated TCM with Western medicine in their clinical practices, the practice of “pure TCM” appears to be obsolete in China’s tertiary healthcare institutions. Notably, remarkable variation exists in the use of different TCM modalities across institutions and among individuals, which might be related to and thus limited by the practitioners’ experience. Future research focusing on the efficacy and safety of TCM interventions for specific diseases, the development of standardized clinical guidelines, and the enhancement of TCM education and training are called for to optimize TCM-Western medicine integration.

Prevalence and Correlates of Cannabis Use among Cancer Survivors

Abstract Background Delaware has legalized marijuana use for both medical and recreational use. This study identified factors associated with cannabis use among adults with chronic relative to individuals without a history of cancer in the First State. Methods Combined data (2020, 2021 and 2022) from the Behavioral Risk Factor Surveillance System (BRFSS) were analyzed for Delaware. Multivariable logistic regression examined individual-level demographic, socio-economic, clinical, and behavioral predictors associated with marijuana use stratified by history of cancer. Results Cannabis use was lower among cancer survivors compared to individuals with no history of cancer (6.76% vs. 13.43%). However, a higher proportion of cancer survivors reported use for medical purposes (75.13% vs. 64.28%). Marijuana use prevalence decreased with age among cancer survivors. After adjusting for sex, age, educational attainment, self-reported race/ethnicity, mental health status and physical health status, current smoking (odds ratio [OR], 4.24 vs. 2.74) and binge drinking (OR, 2.45 vs. 1.75) were associated with cannabis use in both groups. Conclusions Adults with cancer were more likely to use marijuana. Marijuana use prevalence decreased with age. Public perceptions of marijuana is becoming more acceptable. Risk of medical conditions such as cancer increase with age. As such, older adults might also become consumers of marijuana. Clinicians should screen for marijuana use among patients and initiate open discussions with patients about the benefits and risks associated with marijuana. Key messages • Need for ongoing cannabis research to better understand and inform its use for medical purposes. • Development of high-quality standardized education materials and clinical practice guidelines for marijuana use.

25 Genomic medicine in paediatric care for neurodevelopmental disorders: An assessment of practices, attitudes and education needs of Ontario paediatricians

Abstract Background Non-geneticist healthcare professionals are increasingly responsible for delivering genetics-informed care to individuals and their families affected by neurodevelopmental disorders (NDDs). Developing education tools to support their continuing education will require an understanding of physicians’ current approaches, attitudes and desired resources regarding genomic medicine, in the context of their specialty and healthcare system. Objectives Our goal was to assess paediatricians’ current practices, attitudes, and education needs regarding the provision of genomic medicine to individuals with NDDs in Ontario. Design/Methods We distributed an anonymous electronic questionnaire between April 2023 and June 2023 using online dissemination strategies. Inclusion criteria were paediatricians who self-identify as providing care to patients with NDDs. A multi-disciplinary team of genetic and non-genetic experts and a family partner developed the questionnaire. It had four sections: 1) demographic and clinical practice information, 2) experience with providing genomic medicine, 3) attitudes about providing genomic medicine, 4) education needs. Results One hundred and thirty paediatricians completed the questionnaire (estimated response rate of 10%, based on estimated 1300 Ontario paediatricians with varied practices). General paediatricians comprised 76% of responders; 50% of responders practiced outside a large urban centre. In terms of experience with genomic medicine: 58% of responders always/often discuss genetic testing options with families. Barriers to ordering genetic testing included lack of knowledge, confidence, access to lab services and time. Rates of ordering genetic testing varied by NDD and genetic test. Some paediatricians endorsed outdated testing practices (e.g., 9% order karyotype for patients with autism). Paediatricians also order genetic tests outside of standard clinical guidelines (e.g., 38% order a genetic test for patients with isolated language delay). In terms of attitudes regarding genomic medicine: majority believe that it is important to become educated about delivering genetic services to patients with NDDs. Over 60% strongly agree/agree that a genetic diagnosis may offer improved health management and research access, and about 50% strongly agree/agree that it may offer improved access to medical services and positive psychological impact for families. Commonest barriers to integrating genomic medicine in paediatric care were concerns about unanticipated genetic results, lack of local resources/logistical challenges, and competing psychosocial considerations. In terms of genetic education needs: paediatricians expressed strongest interest in learning about genetic testing (e.g. utility, interpretation, management) and advances in genomic technologies. Conclusion Ontario paediatricians integrate aspects of genomic medicine in the care of individuals with NDDs, though sometimes outside of clinically recommended contexts. They desire more support in optimizing this integration as genomic technologies and information evolve. Our study provides valuable information to guide the creation of genetic education tools to enhance collaborative healthcare for children and youth with NDDs.

Emergency imaging protocols for pregnant patients: a multi-institutional and multi- specialty comparison of physician education

PurposePrevious studies have demonstrated that radiologists and other providers perceive the teratogenic risks of radiologic imaging to be higher than they actually are. Thus, pregnant patients were less likely to receive ionizing radiation procedures. While it is imperative to minimize fetal radiation exposure, clinicians must remember that diagnostic studies should not be avoided due to fear of radiation, particularly if the imaging study can significantly impact patient care. Although guidelines do exist regarding how best to image pregnant patients, many providers are unaware of these guidelines and thus lack confidence when making imaging decisions for pregnant patients. This study aimed to gather information about current education, confidence in, and knowledge about emergency imaging of pregnant women among radiology, emergency medicine, and OB/GYN providers.MethodsWe created and distributed an anonymous survey to radiology, emergency medicine, and OB/GYN providers to evaluate their knowledge and confidence in imaging pregnant patients in the emergent setting. This study included a questionnaire with the intent of knowing the correct answers among physicians primarily across the United States (along with some international participation). We conducted subgroup analyses, comparing variables by specialty, radiology subspecialty, and training levels. Based on the survey results, we subsequently developed educational training videos.Results108 radiologists, of which 32 self-identified as emergency radiologists, ten emergency medicine providers and six OB/GYN clinicians completed the survey. The overall correct response rate was 68.5%, though performance across questions was highly variable. Within our 18-question survey, four questions had a correct response rate under 50%, while five questions had correct response rates over 90%. Most responding physicians identified themselves as either “fairly” (58/124, 47%) or “very” (51/124, 41%) confident. Amongst specialties, there were differences in performance concerning the knowledge assessment (p = 0.049), with the strongest performance from radiologists. There were no differences in knowledge by training level (p = 0.4), though confidence levels differed significantly between attending physicians and trainees (p < 0.001).ConclusionThis study highlights deficiencies in knowledge to support appropriate decision-making surrounding the imaging of pregnant patients. Our results indicate the need for improved physician education and dissemination of standardized clinical guidelines.

Interpretation of a clinical practice guideline on the management of chronic pain associated with temporomandibular joint disorders

Temporomandibular disorders (TMD) are a heterogeneous group of diseases that affect the temporomandibular joint, chewing muscle system, dental occlusion, and even various structures throughout the body, with significant characteristics of biological-psychological-social pattern. TMD related chronic pain, as the most important clinical symptom, can result in negative emotions seriously affecting patients' quality of life and physical and mental health. Although a variety of therapies have been previously reported to treat TMD related chronic pain, there is a lack of widely recognized therapies. Professor Jason W Busse (from Michael G DeGroote National Pain Centre, McMaster University, Hamilton ON, Canada) took the lead and collaborated with multiple internationally renowned schools/hospitals of stomatology to develop an international consensus on the management of chronic pain associated with TMD, a clinical practice guideline, which took two years and was published in December 15th, 2023 in a global top journal of clinical research The British Medical Journal. This clinical practice guideline explored the comparative effectiveness of available therapies for chronic pain associated with TMD, conditionally recommended the specific intervention for different treatment or pain relief, proposed a comprehensive, agreed, and standardized clinical practice guideline. This present article describes the methodology and key elements of the clinical practice guideline to help clinicians fully understand and appropriately apply this guidance, which could provide the references for clinical practice of TMD associated chronic pain in China.

Precision Medicine: Utilizing Genomic Insights for Customized Therapeutic Strategies

Precision medicine represents a revolutionary shift in healthcare by utilizing genomic insights to develop customized therapeutic strategies tailored to an individual’s genetic makeup. This article explores the integration of genomic data into personalized treatment plans, focusing on how advances in genetic sequencing and bioinformatics are enabling more targeted and effective medical interventions. By analyzing a patient’s genome, precision medicine allows for more accurate diagnosis, prediction of disease risk, and optimization of treatment options, particularly in fields such as oncology, cardiology, and rare genetic disorders. The study highlights key advancements in pharmacogenomics, which plays a critical role in determining how individuals respond to specific drugs based on their genetic profiles. Case studies in cancer treatment illustrate the success of precision therapies like targeted gene therapy and immunotherapy, which have significantly improved patient outcomes. Despite these advancements, challenges such as the high cost of genomic sequencing, ethical considerations, and the need for standardized clinical guidelines remain barriers to widespread adoption. The article concludes by emphasizing the potential of precision medicine to transform healthcare by shifting from a one-size-fits-all model to a more individualized and efficient approach to disease management.

Implementing pharmacogenomic testing in Australian general practice: an exploratory qualitative study.

Aim: To explore general practitioners' (GPs) views on implementing pharmacogenomic testing in Australian general practice.Methods: Semi-structured interviews were conducted with nine GPs in Australia, recruited from primary care networks. Interviews were analyzed using thematic analysis. Themes were mapped onto the Consolidated Framework for Implementation Research domains.Results: Barriers to implementation included lack of knowledge, education, standardized pharmacogenomic reports and national clinical guidelines and financial inaccessibility. Facilitators included positive exposure to pharmacogenomics, peer influences, interdisciplinary collaboration and proven clinical utility. Current uptake was minimal; however, GPs shared positive perceptions of clinical use.Conclusion: Recommendations for successful implementation include building and disseminating clinical evidence, developing national guidelines and standardized reports, incorporation into formal education and increasing financial accessibility.

Evaluation of clinical effectiveness of blood stasis leaflet in patients with blood stasis: A prospective, randomized, and crossover trial.

Blood stasis (BS) refers to a pattern of symptoms resulting from circulatory dysfunction or stagnation in the human body. Due to its historical origin and diverse interpretations, communication between patients and doctors of traditional Korean medicine (DKMs) presents challenges. Efforts to improve patients understanding in traditional Korean medicine (TKM) have led to the development of disease-specific standard clinical practice guidelines. However, there is a limited focus on creating clinical practice guidelines or informative leaflet specifically addressing BS, which is a frequently encountered pattern of symptoms in TKM. This study aimed to bridge the gap between patients and DKMs by developing an informative leaflet focusing on BS for metabolic diseases. We assessed its appropriateness through expert advisory meetings and the Delphi process, and evaluated its clinical effectiveness. We conducted a prospective, randomized, crossover trial to compare the clinical effectiveness of using BS leaflets in TKM treatment. The hypothesis investigated whether the leaflet group would show higher scores in satisfaction of DKMs' explanations, understanding of DKMs' explanations, improving the reliability of TKM, satisfaction with treatment time, improvement in explanations compared to previous TKM experiences, and necessity of managing BS treatment, compared to the no-leaflet group. In a study involving 40 patients (mean age: 62.3 ± 7.8 years), symptoms persisted for an average of 16.75 ± 9.3 hours daily, with a severity rating of 2.53. The leaflet group exhibited significantly higher satisfaction scores than the no-leaflet group in all aspects (all P < .0001). After confirming the absence of sequence and period effects using a linear-mixed effect model, we were able to ascertain the presence of a treatment effect, as evidenced by statistically significant higher scores across all survey items in the leaflet group compared to the no-leaflet group (all P < .0001). Expert consensus on symptoms aligning with the BS pattern resulted in the development of an informative leaflet. Its utilization notably improved patient satisfaction, comprehension, and trust in TKM treatment, unaffected by temporal influences, thus demonstrating its clinical effectiveness. In summary, the BS leaflet significantly enhanced patient understanding and optimized treatment procedures.

Acute Coronary Syndrome: Treatment Strategies and Outcomes in Patients Admitted to a Tertiary Care Hospital in Palestine.

Acute coronary syndrome (ACS) is the leading cause of death worldwide despite advances in treatment and prevention measures. This study aimed to explore ACS treatment strategies (ischemia-guided vs early invasive) and risk factors among patients diagnosed with ACS in a tertiary care hospital in Palestine and to evaluate related outcomes regarding future events and standard clinical guidelines. This retrospective cohort study reviewed patient data from a Palestinian medical hospital. The study included 255 patients ≥ 18 years who were hospitalized between January 2021 and December 2021 and diagnosed with ACS. The data were analyzed using the Statistical Package for Social Science (SPSS). 71% of the participants were males. The mean age was 59.59±11.56 years. Smoking, diabetes, and hypertension were the most common risk factors. Unstable angina (UA) was the most prevalent ACS type, accounting for 43.1% (110) of cases, whereas NSTEMI accounted for 39.2% (100) and STEMI accounted for 17.6% (45) of cases. An ischemic-guided strategy approach was used in 71% (181) of the patients. Upon discharge, the most prescribed medication classes were antiplatelets (97.6%), statins (87.1%), PPIs (72.5%), and antihypertensives (71.8%). Treatment strategies were selected according to the clinical guidelines for most ACS types. ACS management in Palestine continues to evolve to overcome barriers, decrease patient mortality, and decrease hospital stay. UA and NSTEMI were the most common ACS diagnoses at admission, and the ischemic strategy was the most common modality. The findings of this study call for an increased awareness of CVD risk factors, resource availability, and adherence to clinical guidelines to improve patient outcomes and community health.