Event Abstract Back to Event Proteome profiling of hippocampus during chronic hypobaric hypoxia exposure: Enriched environment as a therapeutic approach Vishal Jain1*, Shashi B. Singh1 and Govindasamy Ilavazhagan2 1 Defence Institute of Physiology and Allied Sciences, Department of Neurophysiology, India 2 Hindustan University, Research, India Hypobaric hypoxia (HH) is known to cause cognitive dysfunctions owing to the high oxygen dependency of the brain. Cognitive and motor deficits have been reported to occur on chronic exposure to HH. On the other hand enriched environment (EE) enhances learning and memory, reduces memory decline during different neurological disorders. Previously we have shown that enriched environment improves cognition and decreases neurodegeneration during chronic exposure to hypobaric hypoxia. Present study is designed to explore the effect of enriched environment on hypobaric hypoxia induced alteration in synaptic plasticity and strength. Sprague dawley rats (3 months old) were exposed to hypobaric hypoxia condition in an animal decompression chamber at an altitude of 25000 feet for continuous 7 days. Animals from control group were kept in standard cage whereas enriched group were kept in EE cage. Following exposure rats were sacrificed and hippocampi was dissected out and processed for different experimental protocols. MALDI following 2D electrophoresis was performed to study the global change in hippocampal protein expression. Further expression of different synaptic proteins was assessed through western blotting and immunohistochemistry. Golgi stain was performed to study dendritic arbrorization. Results of the present study showed that identified proteins belong to a diverse variety of functional classes including cell death, proteins involved in oxidative stress metabolism, synaptic proteins, growth factors and proteins associated with signalling. Hypobaric hypoxia decreases expression of synaptic proteins i.e. synaptophysin, PSD-95, synaptotagmin which further validated by western blotting whereas exposing them in enriched environment ameliorate this synaptic loss. Golgi staining reveals increased dendritic arborization, spine density and morphology on exposure to EE during HH. Present study also reveals the possible role of BDNF/TrkB signalling in enriched environment mediated modulation hippocampal synaptic plasticity. Therefore it can be concluded that enriched environment ameliorate HH induced synaptic loss through BDNF/TrkB signalling. Keywords: Synaptophysin, hypoxia, PSD-95, synaptotagmin, BDNF/TrkB signalling Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: YIC02: Young Investigator Colloquium 2 Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Jain V, Singh SB and Ilavazhagan G (2016). Proteome profiling of hippocampus during chronic hypobaric hypoxia exposure: Enriched environment as a therapeutic approach. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00059 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Dr. Vishal Jain, Defence Institute of Physiology and Allied Sciences, Department of Neurophysiology, Delhi, Delhi, India, vishal6784@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Vishal Jain Shashi B Singh Govindasamy Ilavazhagan Google Vishal Jain Shashi B Singh Govindasamy Ilavazhagan Google Scholar Vishal Jain Shashi B Singh Govindasamy Ilavazhagan PubMed Vishal Jain Shashi B Singh Govindasamy Ilavazhagan Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.