The construction industry holds remarkable benchmarks of aptitude and creativity; however, it is among the most lethal industries when it comes to occupational health and safety (OHS). This study incorporates a detailed analysis of the key OHS issues within the construction sector with a special regard for developing countries such as Nigeria. The paper discusses different physical, chemical, biological, and psychological risks within the industry and highlights the importance of compliance with OHS requirements aimed at avoiding mishaps, incidents, and even fatalities. Moreover, it discusses the issues relating to poor training, funding limitations, and project pressures while highlighting the significance of maintaining a strong safety culture, workers' awareness, and compliance in enhancing OHS results. In addition to that, the review also examines current safety measures, identifies gaps, and suggests improvements, drawing on global best practices to inform future policies and strategies. This study serves as a valuable resource for policymakers, construction stakeholders, and employers to minimize health risks and optimize construction workers’ productivity and well-being.