PurposeThe purpose of this study is to model and solve numerically the three-dimensional off-centered stagnation point flow and heat transfer of magnesium oxide–silver/water hybrid nanofluid impinging to a spinning disk.Design/methodology/approachThe applied effective thermophysical properties of hybrid nanofluid including thermal conductivity and dynamics viscosity are according to the reported experimental relations that would be expanded by a mass-based algorithm. The single phase formulations coupled with experimental-based hybrid nanofluid model is implemented to derive the governing partial differential equations which are then transferred to a set of dimensionless ordinary differential equations (ODEs) with the use of the similarity transformation method. Afterward, the reduced ODEs are solved numerically by bvp4c function from MATLAB that is a trustworthy and efficient code according to three-stage Lobatto IIIa formula.FindingsThe effect of spinning parameter and nanoparticles masses (mMgO, mAg) on the hydrodynamics and thermal boundary layers behavior and also the quantities of engineering interest are presented in tabular and graphical forms. The recent work demonstrates that the analysis of flow and heat transfer becomes more complicated when there is a non-alignment between the impinging flow and the disk axes. From computational results demonstrate that, the radial and azimuthal velocities are, respectively, the increasing and decreasing functions of the disk spinning parameter. Further, for the greater values of the spinning parameter, an overshoot of the radial velocity owing to the centrifugal forces of the spinning disk is observed. Besides, the quantities of engineering interest gently enhance with first and second nanoparticle masses, while comparing their absolute values illustrates the fact that the effect of second nanoparticle mass (mAg) is greater. Further, it is inferred that the second nanoparticle’s mass enhancement results in the amplification of the heat transfer; although, the high skin friction and the relevant shear stress should be controlled.Originality/valueThe combination of experimental thermophysical properties with theoretical modeling of the problem can be the novelty of the present work. It is evident that the experimental relations of effective thermophysical properties can be trustable and flexible in the theoretical/mathematical modeling of hybrid nanofluids flows. Besides, to the best of the authors’ knowledge, no one has ever attempted to study the present problem through a mass-based model for hybrid nanofluid.