Infancy Stage Research Articles

Surface-dominant micro/nanofluidics for efficient green energy conversion.

Green energy conversion in aqueous systems has attracted considerable interest owing to the sustainable clean energy demand resulting from population and economic growth and urbanization, as well as the significant potential energy from water resources and other regenerative sources coupled with fluids. In particular, molecular motion based on intrinsic micro/nanofluidic phenomena at the liquid-solid interface (LSI) is crucial for efficient and sustainable green energy conversion. The electrical double layer is the main factor affecting transport, interaction between molecules and surfaces, non-uniform ion distribution, synthesis, stimulated reactions, and motion by external renewable resources in both closed nanoconfinement and open surfaces. In this review, we summarize the state-of-the-art progress in physical and chemical reaction-based green energy conversion in LSI, including nanoscale fabrication, key mechanisms, applications, and limitations for practical implementation. The prospects for resolving critical challenges in this field and inspiring other promising research areas in the infancy stage (studying chemical and biological dynamics at the single-molecule level and nanofluidic neuromorphic computing) are also discussed.

Moving Towards Industry 5.0 in the Pharmaceutical Manufacturing Sector: Challenges and Solutions for Germany

Emergence of industry 5.0 facilitates real-time synchronisation of production processes, which helps with the production of customized products. Although industry 5.0 can revolutionize the landscape of goods production, still its adoption is in the infancy stage. Hence, the purpose of this article is to examine barriers that impede the adoption of industry 5.0, and to propose solution initiatives (SIs). After an in-depth literature review and interviews with German industry experts in pharmaceutical sector, barriers and SIs are ranked using an integrated Analytical hierarchy process-elimination and choice expressing reality-decision-making trial and evaluation laboratory (AHP-ELECTRE-DEMATEL) approach. “Linking virtual reality and reality” is found to be the most critical deterrent to the adoption of industry 5.0, and falls into a causal group, which signifies their influence on other deterrents. “Measures for better connectivity with patients” is of utmost importance for German firms to ensure secure communication and safeguard patient data. The findings also highlight the problems with the adoption of high-tech innovations due to lack of standardization and fair benchmarking policies on industry 5.0. This article concludes by proposing an industry 5.0 framework. The inhibitors to adopting industry 5.0 were investigated in this article, the results of which will assist practitioners and decision makers to understand the issues with industry 5.0. The results of this article will help potential adopters of this technology to look for the SIs. This will therefore pave the path for effective adoption of industry 5.0 across the pharmaceutical manufacturing sector.

Risk indicators for the severity of erosive wear in deciduous dentition of Mexican schoolchildren aged 5 to 7 years.

The objective of this work was to estimate the prevalence and severity of erosive tooth wear (ETW), and to identify risk indicators of deciduous dentition of a group of schoolchildren from public schools in Tlalnepantla de Baz, State of Mexico. A cross-sectional study was carried out in 352 schoolchildren from 5 to 7 years old. The severity of the ETW was evaluated using the Basic Erosive Wear Examination (BEWE). Risk indicators were evaluated through a survey which included food and beverage consumption, consumption habits, vitamin C consumption, gastroesophageal reflux, heartburn, belching, xerostomia, vomiting and teeth grinding. Multinomial logistic regression models were fitted. The prevalence of ETW was 99.7% (n = 351). Regarding severity, 46.6% were at a null/mild level, 27.3% moderate, and 26.1% severe. Males were more likely to present severe ETW (odds ratio (OR) = 2.23, 95% confidence interval (CI), 1.27-3.93; p = 0.005). The risk indicators for the severity of ETW were the frequent consumption of citrus fruits (OR = 2.09, 95% CI, 1.12-3.89; p = 0.021), fruit juice (OR = 1.99, 95% CI, 1.06-3.75; p = 0.033), processed beverages (OR = 2.15, 95% CI, 1.23-3.78; p = 0.008) and hot sauce (OR = 1.82, 95% CI, 1.03-3.20; p = 0.036). The prevalence of ETW in the deciduous dentition was very high (99.7%) and ~1/3 for severe ETW. The dietary factors associated with severe ETW are part of the regular consumption of Mexican school-age children, which impact their oral health condition. It is important to establish intervention strategies from the infant stage, focused on both children and their caregivers.

Exposures to great Chinese Famine during embryo, foetal or infant stages link differently with risks of cardiovascular diseases in late middle age.

Perinatal malnutrition is a critical cause of diseases in offspring. Based on the different rates of organ development, we hypothesised that malnutrition at varying early life stages would have a differential impact on cardiovascular disease in middle-aged and older adults. This study sought to assess the long-term impact of exposure to the 1959-1961 Great Chinese Famine (GCF) during early developmental periods on risks of cardiovascular diseases in the late middle-aged offspring. A total 6, 662 individuals, born between 1958 and 1964, were divided into six groups according to the birth date. The generalised line model was used to control age and estimate differences with 95% confidence interval (CI) in blood pressure. Binary logistic regression was applied to evaluate the association between famine exposure and cardiovascular diseases. Compared to the unexposed late middle-aged persons, blood pressure was elevated in the entire gestation exposure group, regardless of postnatal exposure to GCF. Increased blood pressure was also found in the female offspring exposed to GCF during early and middle gestation. The early-childhood exposure was associated with the risk of bradycardia in the offspring. The risks of vertebral artery atherosclerosis were elevated in GCF famine-exposed groups except first trimester exposed group. The chronic influence of GCF in early life periods was specific to the developmental timing window, sexesand organs, suggesting an essential role of interactions among multiple factors and prenatal malnutrition in developmentally "programming" cardiovascular diseases.

Analysis of predictive factors related to long-term hearing and temporal bone development in congenital microtia

ObjectiveTo investigate the predictive factors of long-term hearing threshold and temporal bone development in children with congenital microtia (CM). Methods74 patients (92 ears) with CM enrolled, which all had auditory brainstem response (ABR) results during infancy or toddlerhood, pure tone audiometry (PTA) and high-resolution computed tomography (HRCT) results during childhood or adolescence, and had not undergone any surgery. We compared the relationship between ABR, auditory steady-state response (ASSR), the affected side, auricular morphology, presence of external auditory canal stenosis or atresia, PTA average, mastoid pneumatization, Jarhsdoerfer scores, and wether cholesteatoma exists. ResultsThe average age of ABR in 92 ears was 2.72 ± 3.52 years old, PTA was 7.26 ± 2.51 and HRCT was 6.91 ± 2.76 years old. ABR-AC was related to PTA average, mastoid pneumatization, Jarhsdoerfer scores, and wether cholesteatoma exists in CM. While ABR-ABG was related to all of these factors except Jarhsdoerfer score, and ABR-BC had no relationship with any of them. ASSR only showed correlation with frequencies of 1, 2kHz and was related to Jarhsdoerfer score, with no other correlations observed. The impaired ear side showed no relevance. However, auricular morphology was related to all of these factors except wether cholesteatoma exist. External auditory canal stenosis or atresia was related to PTA average, but unrelated to mastoid pneumatization. ConclusionThe ABR examination in the infant stage plays a crucial role in predicting the long-term hearing and temporal bone development in patients with CM.

Corporate Governance and Performance of Commercial Banks in Nepal

The purpose of this study was to examine the effect of corporate governance on performance of commercial banks in. It also examined the corporate governance practices of commercial banks. The study followed quantitative approach and descriptive research design. Multiple regression analysis was used to explore the causal relationship between corporate governance and financial performance of commercial banks. The study revealed a positive relationship of number of board meeting and foreign ownership and bank performance which shows higher the board meeting, foreign investment higher would be the bank performance. However, there was negative relationship of board size and capital adequacy ratio with bank performance indicating higher the board size, capital adequacy ratio would lead lower bank performance. Practices of corporate governance system of financial sector in Nepal is still infant stage however joint venture banks practices are more harmonizing rather than government banks and other banks.

Penilaian terhadap Potensi Proses Pembuatan Aditif bagi Pembaikan untuk Pembuatan Semula Menggunakan Kaedah AHP: Kajian Kes Angkup Brek Kereta

In line with technological advancements in the era of IR 4.0, it is crucial for remanufacturing process to shift towards the more sustainable automated process. One of the remanufacturing activities that is currently gaining significant interest is an additive repair process. The repair processes in remanufacturing are usually conducted conventionally which caused inherent defects on the used part due to the heat generation and residual stress exerted during the process. Therefore, additive repair processes through the metal additive manufacturing should be considered in remanufacturing which offers substantial benefits in terms of efficiency and environmental effects. However, the inclusion of additive repair is still at the infancy stage where thorough investigation is necessary to overcome the issues in the process. The raised issues include the printability, bonding behaviour between two metals and quality of the repaired part. It is important to ascertain the compatibility of the additive repair process with the certain type of defects. This study focuses on the evaluation of defects or failure in an automotive brake caliper component using the Analytic Hierarchy Process (AHP) decision-making method. The main objective is to consider both qualitative and quantitative aspects for selecting the suitable repair process by reflecting the potential defects as the criteria and sub-criteria. Three respondents were participated to provide the priority scores through paired comparisons for each criterion, sub-criterion, and alternative involved. The study found that the Directed Energy Deposition (DED) process is the primary choice of respondents with the potential to be considered as a repair process for additive manufacturing with the score of 0.65. Overall, an AHP method is able to evaluate subjective opinions to select the suitable repair process in remanufacturing application.

Digital Professional Competence (DProCom) for Higher Education: A Systematic Review of Literature

The need to discuss and refine the concept of Digital Professional Competence (DProCom) has become vital in the rapidly advancing and extensively digitized information and knowledge society. The Coronavirus pandemic revealed the usage divide among teachers and its impact on learning outcomes, thus surfacing the need to explore DProCom in Higher Education (HE) for future researchers to use findings of this review for developing pragmatic research models and professional development initiatives for student teachers of all levels. The aim of this systematic literature review is to provide the scholarly community with an overview of the definition, range of attributes, and gaps in research on DProCom from 2012 to 2022 in the context of HE. The initial search yielded 3903 outcomes, which were iterated through inclusion criteria, and 39 research articles relevant to HE were thoroughly reviewed. The results assert a lack of consistency and uniformity in terminologies being used to denote the concept of DProCom and their description in the literature. The findings confirm that DProCom is in its infancy stage. There is a need to continue research on professional competence from a global perspective to predict changes in HE teaching, professional development and quality assessment of learning outcomes to respond to the needs of HE in a digital era.

Realization of Vitality Optimization in Traditional Village Human Settlement Environment Supported by Intelligent Sensor Technology

The vitality of traditional villages (VTV) is a reference indicator for measuring the hollowing out of traditional villages. Human settlements in the world are based on the access and availability to the chief vitality factors of the geographical region. The traditional villages of China are the potential candidates for improving vitality optimization, as their development is still in the stage of infancy. This work proposes a framework that integrates complex subsystems of the traditional village human settlements with the vitality factors. The issues in these traditional villages are analyzed under the umbrella of social life, domestic life and agriculture, which is the primary occupation of people in traditional villages. Further, the work identifies the contemporary computing technologies and communication technologies used in various applications of intelligent sensor technology. This work associates the various subsystems of the villages, namely strategic, social, economic, resource and environment subsystem, and information subsystem, with the factors influencing dimensions of development, namely resources, service chain, sustainability, technology and institution. This framework can be further extended to include more elements of vitality factors.

A qualitative perspective of the role of Malawi Library Association in developing librarianship in Malawi: opportunities and challenges

PurposeThe study aims to unpack the role of Malawi Library Association (MALA) in developing librarianship in Malawi. It also explores an array of opportunities and challenges that are present for MALA.Design/methodology/approachThe study applies the interpretivist paradigm for the research design. Qualitative data were collected from a purposeful sample totaling 24 practicing librarians and paraprofessionals in different work environments to inform the study phenomenon.FindingsThe study gathers that the role of MALA has been in its infancy stage for a long time. However, the apparent developments of MALA manifest in its pro-educational initiatives. Overall, MALA is impeded by a litany of obstacles such as financial constraints and a lack of advocacy strategy.Originality/valueThe study theorizes the role of MALA by triangulating the advocacy coalition framework, institutional theory and professionalization theory in the library and information practice.

ChatGPT: The catalyst for teacher-student rapport and grit development in L2 class

Language education as a dynamic field of study requires constant innovations to meet the L2 needs in the classroom milieu. Additionally, the surge of technological advancements warns us about the significance of studying the possible beneficial roles of artificial intelligence in language teaching and learning about which the field is in its infancy stage. In this vein, the present study examined the effectiveness of a four-staged ChatGPT-based rapport-building protocol (CGRBP) on teacher-student rapport and L2 grit to not only profile a non-correlational evidence to L2 emotion studies, but also to link the realm of artificial intelligence with positive psychology in order to find practical ways for cultivating an emotionally supportive learning context. To do so, 30 intermediate-level Iranian EFL learners participated in experimental (n = 15) and control (n = 15) groups in a 16-week instruction program. Data gathered from a pre-test post-test experimental design was analyzed by One-Way ANCOVA and the analyses showed that students who were taught English through CGRBP outperformed the students in control group on L2 grit. The results verified the mediating role of CGRBP in the L2 context by suggesting that the application of a well-structured and staged ChatGPT-based instruction would possibly lead to enhanced L2 grit. Since grit is an integral part of one's positive psycho-emotional network, several theoretical and pedagogical implications were discussed and directions for future explorations were suggested.

Early Famine Exposure Results in Left Ventricular Remodeled, Diastolic Dysfunction and Systolic Function Preserved in Adults

Introduction: Malnutrition during a critical window of development in a fetus or infant can result in abnormal cardiac remodeling and function. It is uncertain whether the contribution of these effects continues to impact the cardiac remodeling and function of adults over the course of several decades of growth. Our study examined the impact of early Chinese famine exposure on cardiac remodeling, left ventricular (LV) diastolic function, and LV systolic function in adults. Methods: Participants at high risk of cardiovascular disease from the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project (PEACE MPP) were enrolled. The famine in China lasted from 1959 to 1962. A total of three groups were formed based on the participants’ birth dates: pre-famine group, famine exposure group, and post-famine group. Logistic regression and linear mixed models were used to explore the association between famine exposure and cardiac remodeling, LV diastolic function and LV systolic function in adults. Results: The study included 2,758 participants, the mean age was 57.05 years, 62.8% were female, 26.4% had LV hypertrophy (LVH), 59.6% had LV diastolic dysfunction (LVDD), and 10.5% had reduced global longitudinal strain (GLS). Compared to post-famine exposure, participants had independently increased risk of LVH in the famine exposure group (OR: 2.02, 95% CI: 1.60–2.56) and pre-famine exposure (OR: 1.36, 95% CI: 1.06–1.76). Compared to post-famine exposure, the risk of LVDD remarkably increased in the famine exposure group (OR: 3.04, 95% CI: 2.49–3.71) and pre-famine exposure group (OR: 1.87, 95% CI: 1.52–2.31). Famine exposure had no significant impact on GLS but was associated with a significant increase in LV ejection fraction (LVEF) and LV end-diastolic diameter (LVEDD). Significant interactions were observed between the effects of famine exposure and other clinical/sociodemographic variables (gender, systolic blood pressure [SBP] ≥140 mm Hg or not, high school or above or not, and annual income <50,000 RMB or not) on these outcomes. Conclusion: Exposure to famine, particularly during fetal and infant stages, increases the risk of LVH and LVDD in adults. However, the LV systolic function remains preserved. These impacts are more pronounced in females, individuals with SBP ≥140 mm Hg, those with low income, or those with high educational status.

Artificial intelligence at the pen's edge: Exploring the ethical quagmires in using artificial intelligence models like ChatGPT for assisted writing in biomedical research.

Chat generative pretrained transformer (ChatGPT) is a conversational language model powered by artificial intelligence (AI). It is a sophisticated language model that employs deep learning methods to generate human-like text outputs to inputs in the natural language. This narrative review aims to shed light on ethical concerns about using AI models like ChatGPT in writing assistance in the health care and medical domains. Currently, all the AI models like ChatGPT are in the infancy stage; there is a risk of inaccuracy of the generated content, lack of contextual understanding, dynamic knowledge gaps, limited discernment, lack of responsibility and accountability, issues of privacy, data security, transparency, and bias, lack of nuance, and originality. Other issues such as authorship, unintentional plagiarism, falsified and fabricated content, and the threat of being red-flagged as AI-generated content highlight the need for regulatory compliance, transparency, and disclosure. If the legitimate issues are proactively considered and addressed, the potential applications of AI models as writing assistance could be rewarding.

Nano-Si for On-Demand H2 Production: Optimization of Yield and Real-Time Visualization of Si─H2O Reaction Using Liquid-Phase Transmission Electron Microscopy.

Hydrogen (H2), the most abundant element in the universe, has the potential to address the challenges of energy security and climate change. However, due to the lack of a safe and efficient method for storing and delivering hydrogen, its practical application is still in its infancy stages. To overcome this challenge, a promising solution is demonstrated in the form of on-demand production of H2 using nano-Silicon (Si) powders. The method offers instantaneous production of H2, yielding a volume of 1.3 L per gram of Si at room temperature. Moreover, the H2 production yield and the rate can be effectively controlled by adjusting the reaction pH value and temperatures. Additionally, liquid-phase transmission electron microscopy (LPTEM) is utilized in situ to demonstrate the entire reaction in real-time, wherein H2 bubble formation is observed and illustrated the gradual conversion of crystalline Si particles into amorphous oxides. Moreover, it is confirmed that the purity of the generated gas is 99.5% using gas chromatography mass spectrometry (GC-MS). These findings suggest a viable option for instant H2 production in portable fuel cells using Si cartridges or pellets.

Is the economic uncertainty- human health relationship nonlinear? An empirical analysis for the China.

The health costs of economic uncertainty always remain a major concern among policymakers of China. The theoretical and empirical literature on the economic uncertainty-human health nexus is still in its infancy stage. This study is firmly rooted in the economic uncertainty theory advanced by Baker, Bloom, & Davis. In this study, the primary objective of the analysis is to estimate the asymmetric impact of economic uncertainty on human health in China's economy. In order to evaluate the short and long-run estimates of economic uncertainty on human health across various quantiles, we have employed the linear and nonlinear QARDL models. The linear QARDL model shows that the long-run relationship between economic uncertainty and the infant mortality rate is positive and significant at all quantiles, while the long-run relationship between economic uncertainty and the death rate is positive and significant at higher quantiles. The nonlinear QARDL model reveals that, in the long run, the relationship between the positive shock of economic uncertainty and the infant mortality rate is positive and significant at quantiles 0.30 to 0.95, while the long-run relationship between the positive shock of economic uncertainty and the death rate is positive and significant at higher quantiles. The relationship between the negative shock of economic uncertainty and the infant mortality rate is negative and significant at the highest quantiles, while the relationship between the negative shock of economic uncertainty and death rate is negative and significant at higher quantiles in the long run. The findings indicate a positive relationship between economic uncertainty in China and higher rates of infant mortality and death. Thus, adopting suitable policies for controlling economic uncertainty can help in improving human health in China.

Nexus between mandatory ESG disclosure regulation and abnormal stock returns: a study of an emerging economy

PurposeThis study aims to study the response of the stock market to the announcement of compulsory environmental, social and governance (ESG) disclosure regulation in the context of the Indian economy – one of the largest emerging economies. The study also examines the role of carbon sensitivity and pre-ESG disclosure.Design/methodology/approachDaily stock price data of 940 listed companies has been collected for 276 trading days to compute abnormal returns. The current study is based on event study methodology to analyze the announcement effect of disclosure regulations. Furthermore, to check the robustness of results, cross-sectional regression has been applied to correct for potential heterogeneity.FindingsResults of the event study signify that the equity share market has reacted positively and significantly to the mandatory ESG disclosure regulation. Furthermore, the study also confirms the mitigating role of carbon sensitivity and pre-ESG disclosure as carbon nonsensitive (non predisclosure) firms have witnessed a more intense effect of regulation as compared to sensitive (predisclosed) corporations.Practical implicationsCurrent findings assist managers in understanding investor perception toward nonfinancial disclosures. Corporate managers can use disclosure as a tool to enhance the firm value and reduce information asymmetry by providing relevant information. Furthermore, policymakers can use the findings of present research to disseminate the advantages of adopting ESG disclosure practices thereby improving the transparency and governance among business firms.Originality/valueTo the best of the author’s knowledge, this study is the first to provide empirical evidence on the market response to compulsory ESG disclosure framework in the emerging context of India. Furthermore, considering the infancy stage of ESG research, the present research contributes to the body of knowledge by empirically testing the disclosure theories.

Digitalization of Classrooms: A Comparative Study on Teachers’ Perceptions about the Use of Digital Teaching Materials in Early Childhood and Primary Education

The incorporation of digital didactic materials into the teaching and learning process of students, both in Early Childhood and Primary Education, inevitably entails changes. Some of them concern teacher training, others the interactions and roles of the members of the educational community, and others the innovation, a priori, of the educational process itself. In this context, characterized by the digitization of classrooms, questions arise that this research aims to answer: What vision do teachers have of the incorporation of these media? In what learning situations are they used and for what purposes? Are there differences between the use of digital resources in the infant and primary school stages? This article aims to analyze and compare the perceptions of teachers in two different contexts: the Autonomous Community of the Canary Islands and the Valencian Community. By means of a qualitative study, the focus is on knowing the teachers’ assessment of the usefulness of these resources and on identifying the uses given to them in classroom practices. The results show how, despite the widespread use of digital materials in both stages, some teachers are rethinking their use with students at an early age.

Assessing the awareness and perception of waqf among business owners in Gombe State, Nigeria

PurposeThe literature about the dynamics of Muslims' awareness and perception of waqf has been generally scarce,especially in Nigeria. As renewed efforts are emerging to develop a new waqf regime in the country, this study examines this aspect in Gombe metropolis, Nigeria, with a view to identifying the key factors shaping people's perception and awareness towards waqf.Design/methodology/approachTo achieve the objective of this study, primary data were collected through a survey among 494 business owners in the Gombe metropolis. The data were then analysed using probit and Tobit regression models.FindingsThe study found that altruistic behaviour, religiosity level, educational level and young age are among the factors that determine people's perception and awareness towards donating to waqf among business owners in Gombe. Altruism and young age embolden businesspersons to recognise the effectiveness of waqf institutions in solving socioeconomic challenges.Practical implicationsThe findings of this study imply that waqf has huge potential in the study area and that with well-structured, organized waqf education programmes within the business community using diverse avenues, a robust waqf sector can be developed.Originality/valueAs far as the study area and the entire Nigerian Islamic economics and finance landscape is concerned, the study has explored a novel research area. Given the infant stage of empirical studies on waqf in Nigeria, there are virtually no previous attempts to examine the awareness and perception of businesspersons towards waqf; variables that are key to the development of an effective sector.

CAUTI Elimination: A Systematic Elimination of CAUTI in Long-Term Care Facility

Catheter-associated urinary tract infection (CAUTI) in nursing-home residents is commonly associated with multiple problems. Lack of proper intervention to prevent CAUTI in the elderly and frail nursing-home residents leads to sepsis, hospitalization, and antimicrobial use, ultimately causing the colonization with multidrug- resistant organisms (MDROs). Furthermore, it inflates the costs. The project aims to systematically determine an approach to eliminate CAUTI in long-term care facilities. There, the establishment of antibiotic stewardship is at its infancy stage. The CAUTI project contributes significantly to the wide-reaching efforts to reduce the threats posed by antimicrobial-resistant organisms. The crucial element of an impactful strategy is the prevention by utilizing evidence-based bundle of care education and evidence-based urinary catheter protocols (UCP), both funded by the Agency for Healthcare Research and Quality (AHRQ). The CAUTI project’s outcome is measured using National Healthcare Safety Network (NHSN) and the symptomatic definition of CAUTI provided by the Centers for Disease Control and Prevention (CDC) to identify and count the cases in the unit; the team uses the NHSN’s data for benchmarking. The qualitative and quantitative methodology approaches utilized to implement a CAUTI prevention strategy at Burbank Healthcare Center and Rehabilitation. Thirty participants were selected out of 172 populations during the study for the CAUTI project. The findings indicate that 11 out of 30 participants developed CAUTI, of which three acquired it at the facility and eight at the community. Further, although female participants were fewer than males, females seem to develop a CAUTI with higher frequency than male participants.

Pharmacogenomic Analysis of Combined Therapies against Glioblastoma Based on Cell Markers from Single-Cell Sequencing.

Glioblastoma is the most common and aggressive form of primary brain cancer and the lack of viable treatment options has created an urgency to develop novel treatments. Personalized or predictive medicine is still in its infancy stage at present. This research aimed to discover biomarkers to inform disease progression and to develop personalized prophylactic and therapeutic strategies by combining state-of-the-art technologies such as single-cell RNA sequencing, systems pharmacology, and a polypharmacological approach. As predicted in the pyroptosis-related gene (PRG) transcription factor (TF) microRNA (miRNA) regulatory network, TP53 was the hub gene in the pyroptosis process in glioblastoma (GBM). A LASSO Cox regression model of pyroptosis-related genes was built to accurately and conveniently predict the one-, two-, and three-year overall survival rates of GBM patients. The top-scoring five natural compounds were parthenolide, rutin, baeomycesic acid, luteolin, and kaempferol, which have NFKB inhibition, antioxidant, lipoxygenase inhibition, glucosidase inhibition, and estrogen receptor agonism properties, respectively. In contrast, the analysis of the cell-type-specific differential expression-related targets of natural compounds showed that the top five subtype cells targeted by natural compounds were endothelial cells, microglia/macrophages, oligodendrocytes, dendritic cells, and neutrophil cells. The current approach-using the pharmacogenomic analysis of combined therapies-serves as a model for novel personalized therapeutic strategies for GBM treatment.