ObjectiveTo describe fourteen years of experience of in the treatment of advanced stages of epithelial ovarian cancer in the National Cancer Institute of Colombia MethodsA retrospective observational case series including patients with epithelial ovarian cancer in stages III and IV, who received primary treatment in National Cancer Institute of Colombia between January 1st, 1997 and December 31th, 2011. ResultsA total of 119 patients were identified durin the study period. With a median age of 56 years, most patients showed functional status compromise (63.9%) and hypolbuminemia (82.4%). The most common histological type was serous adenocarcinoma (62.2%) and there was poorly differentiated histological grade in 63.3% of cases. Almost all (94.1%) patients had peritoneal surfaces compromise with involvement of the upper abdomen in 38.7% and extra-abdominal disease in 29.4%. Treatment with primary surgery plus adjuvant chemotherapy was performed on 89.1%, achieving optimal cytoreduction in 25.2%; 29% of cases showed progression during treatment, and 57% of them relapsed. The median disease-free survival was 16.61 months, and the overall survival was 28.93 months. ConclusionsIn our setting, patients with advanced epithelial ovarian cancer have a high tumor burden and aggressive behavior of the disease, reflected in a poor oncological outcome.