Stable Solid Lipid Nanoparticles Research Articles

Glyceryl Behenate and Its Suitability for Production of Aceclofenac Solid Lipid Nanoparticles

AbstractThe aim of this study was to explore the use of glyceryl behenate (GB) as a candidate lipid for the production of solid lipid nanoparticles (SLN) using the anti‐inflammatory drug, aceclofenac, as an example. SLN were produced using the Gasco microemulsion method with three different lipids, namely GB, glyceryl palmitostearate (GP) and cetyl alcohol (CA). The prepared SLN were subjected to determination of entrapment, zeta potential, particle size, in vitro dissolution, entrapment efficiency and biodistribution. Stable SLN of GB having size 245 ± 5 nm were prepared with a polydispersity index of 0.470. The size range was higher with other lipids i.e., CA and GP. It was found that as the drug lipid molar concentration was raised, particles with a smaller size were obtained irrespective of the nature of the lipid. The surfactant poloxamer 188 gave best results when used at a concentration of 2.5% w/v of dispersion. The study recommends GB as a suitable candidate for the production of SLN.

Optimization of Preparation Variables for Trimyristin Solid Lipid Nanoparticles

Solid lipid nanoparticles (SLNs) have been regarded to behave similar to the vegetable oil emulsions because emulsions of lipid melts are formed before lipid droplets being solidified to turn into SLNs. Compared to lipid emulsion, however, it has been more difficult to obtain stable SLNs and needs more extensive considerations on stabilizer and manufacturing process. In the present study, we tried to prepare phosphatidylcholine-based trymyristin (TM) SLNs using high pressure homogenization method and optimize the manufacturing variables such as homogenization pressure, number of homogenization cycles, cooling temperature, co-stabilizer and freeze-drying with cryoprotectants. Nano-sized TM particles could be Prepared using egg Phosphatidylcholine and pegylated phospholipids (PE) as stabilizers. Based on the optimization study, the dispersion was manufactured by homogenization under the pressure of 100 MPa for more than 5 cycles, and solidifying the intermediately formed lipid melt droplets by dipping in liquid nitrogen followed by thawing at room temperature. In addition, TM SLNs could be freeze-dried and then redispersed easily without significant particle size changes after freeze drying with 10% and 12.5% sucrose or trehalose. The TM SLNs established in this study can be used as delivery system for drugs and cosmetics.

Surface modification of resorcinarene based self-assembled solid lipid nanoparticles for drug targeting

Prolyl-bearing amphiphilic resorcinarenes, e.g. tetrakis(N-methylprolyl)tetraundecylcalix[4]resorcinarene, self-assemble as stable solid lipid nanoparticles; these fully characterized systems could be further functionalized at their surface with proteins, and interact with specific antibodies bound on a sensor surface.