Stable Link Research Articles

Virtual screening and network pharmacology-based synergistic coagulation mechanism identification of multiple components contained in compound Kushen Injection against hepatocellular carcinoma

BackgroundHepatocellular carcinoma (HCC) is a primary liver malignancy commonly encountered in the setting of chronic liver disease and cirrhosis. Compound Kushen Injection (CKI) has been widely used in HCC, however, the underlying mechanisms are scarce. ObjectiveTo explore the molecular mechanisms of CKI for HCC.To explore the molecular mechanisms of CKI for HCC. Materials and MethodsThe chemical ingredients of CKI were reviewed from published articles and the potential targets were got from Herbal Ingredients’ Targets Platform. Coagulation-related targets were from Kyoto Encyclopedia of Genes and Genomes and HCC-related targets were from Therapeutic Target Database, Gene Expression Omnibus, and The Cancer Genome Atlas. Then the CKI-Herb-Target and CKI-Herb-Target-HCC networks were built. The shared targets between CKI and HCC were used for functional enrichment through Metascape and the shared coagulation-related target was used for molecular docking and survival analysis. ResultsA total of 23 chemical ingredients and 41 potential targets shared between CKI and HCC were obtained. The results of functional enrichment indicated that several canonical pathways of CKI mostly participated in the treatment of HCC. Furthermore, a chemical ingredient of CKI formed a stable hydrogen bond link with the ASN-189 on PLG, with a best binding energy of −4.7 kcal/mol. Finally, PLG was confirmed as the shared coagulation-related target and interrelated with the prognosis of HCC. ConclusionCKI probably improves HCC prognosis through PLG. Our research undoubtedly deepened the understanding of the molecular mechanism of CKI anti-HCC.

РОЛЬ МІЖНАРОДНИХ ТРАНСПОРТНИХ КОРИДОРОВ У ПРОЦЕСІ ІНТЕГРАЦІЇ АЗЕРБАЙДЖАНУ У СВІТОВУ ЕКОНОМІКУ

The article discusses the concept, purposes of creation and general characteristics of international transport corridors. The authors provide a brief description of the prerequisites for the formation and development of international transport corridors, and also consider the contribution of international transport corridors to the development of the national economy of the state-participants of the transport system from the point of view of micro- and macroeconomic indicators. The purpose of the article is to analyze the role of international transport corridors in the process of integration of Azerbaijan into the world economy. The object of the research is logistic principles of international transport corridors in the process of integration of Azerbaijan into the world economy. The methods used in the research. Here are used methods of categorical analysis and synthesis to study theoretical approaches to determining the essence and features of omnichannel loyalty programs. In addition, the description of the transformation of loyalty programs required the use of the observation method to display market trends and vectors of their influence on the specified process, as well as specification - to highlight and characterize relevant digital tools. Research hypothesis. The construction of new international transport corridors in the process of integration of Azerbaijan into the world economy will be a guarantee of the development of this region and its economic opportunities. Presenting main material. The conclusions contained in this article on the importance of international transport corridors for the economy of the state can be used in the future to assess the need to develop transport and logistics infrastructure within the framework of already functioning international transport corridors, to determine new strategic directions for the formation of new international transport corridors in the context of changing macroeconomic prerequisites and redistribution of traffic flows, including due to the introduction of sanctions, as well as to assess the prospects for the formation of new transport corridors. The originality and practical significance of the research. International transport corridors (ITC) in the context of global integration processes and the global division of labor are one of the most important factors in the development of the world economy. International transport corridors ensure the creation and functioning of stable transport links between various foreign participants in international economic relations. Conclusions and perspectives of further research. Of course, it is difficult to deny the importance of international transport corridors for the development of the global economy. At the same time, scientific interest arises in relation to what prerequisites lie behind the formation of international transport corridors and what contribution they make to the development of national economies of states through whose territory the national part of international transport corridors passes.

Triglyceride-glucose index correlates with the occurrence and prognosis of acute myocardial infarction complicated by cardiogenic shock: data from two large cohorts

BackgroundTriglyceride-glucose (TyG) index, a dependable indicator of insulin resistance, has been identified as a valid marker regarding multiple cardiovascular diseases. Nevertheless, the correlation of TyG index with acute myocardial infarction complicated by cardiogenic shock (AMICS) remains uncertain. Our study aims for elucidating this relationship by comprehensively analyzing two large-scale cohorts.MethodsUtilizing records from the eICU Collaborative Research Database and the Medical Information Mart for Intensive Care IV, the link between TyG and the incidence and prognosis of AMICS was assessed multicentrally and retrospectively by logistic and correlation models, as well as restricted cubic spline (RCS). Propensity score matching (PSM), inverse probability of treatment weighting (IPTW), and overlap weighting (OW) were employed to balance the potential confounders. Subgroup analyses were performed according to potential modifiers.ResultsOverall, 5208 AMI patients, consisting of 375 developing CS were finally included. The TyG index exhibited an apparently higher level in AMI populations developing CS than in those who did not experienced CS [9.2 (8.8–9.7) vs. 9.0 (8.5–9.5)], with a moderate discrimination ability to recognize AMICS from the general AMI (AUC: 0.604). Logistic analyses showed that the TyG index was significantly correlated with in-hospital and ICU mortality. RCS analysis demonstrated a linear link between elevated TyG and increased risks regarding in-hospital and ICU mortality in the AMICS population. An increased mortality risk remains evident in PSM-, OW- and IPTW-adjusted populations with higher TyG index who have undergone CS. Correlation analyses demonstrated an apparent link between TyG index and APS score. Subgroup analyses presented a stable link between elevated TyG and mortality particularly in older age, females, those who are overweight or hypertensive, as well as those without diabetes.ConclusionsElevated TyG index was related to the incidence of CS following AMI and higher mortality risks in the population with AMICS. Our findings pointed a previously undisclosed role of TyG index in regard to AMICS that still requires further validation.

Design, modeling, and validation of a 0.5 kWh flywheel energy storage system using magnetic levitation system

The flywheel energy storage system (FESS) has excellent power capacity and high conversion efficiency. It could be used as a mechanical battery in the uninterruptible power supply (UPS). The magnetic suspension technology is used in the FESS to reduce the standby loss and improve the power capacity. First, the whole system of the FESS with the magnetic levitation system is introduced, and the control diagrams of the charging/discharging processes are developed. Moreover, the force modeling of the magnetic levitation system, including the axial thrust-force permanent magnet bearing (PMB) and the active magnetic bearing (AMB), is conducted, and results indicate that the magnetic forces could stably levitate the flywheel (FW) rotor. The stator part and the FW rotor are analyzed using the FEM model, and the results could satisfy the requirements on stress and strength of the FESS at the rated speed. Then, the control models are established to accomplish the rapid charging/discharging functions of the FESS. Finally, experiments are performed to test the charging/discharging ability, and the results show that an excellent control current could enhance the charging/discharging efficiency so the stable DC link voltage could be outputted at the discharge process. Therefore, the test results prove that the designed FESS could be used as an auxiliary power supply for the UPS when the grid power fails.

Ultra-Wideband Circular Polarized Implantable Patch Antenna for Implantable Blood Glucose Detection System Applications.

To address the current demands for antenna miniaturization, ultra-bandwidth, and circular polarization in advanced medical devices, a novel ISM band implantable antenna for blood glucose monitoring has been developed. This antenna achieves miniaturization by incorporating slots in the radiation patch and adding symmetric short-circuit probes, resulting in a compact size of only 0.054λ0 × 0.054λ0 × 0.005λ0 (λ0 is the wavelength in free space in respect of the lowest working frequency). By combining two resonance points and utilizing a differential feed structure, the antenna achieves ultra-broadband and circular polarization. Simulations indicate a |S11| bandwidth of 1.1 GHz (1.65-2.75 GHz) and an effective axial ratio (based on 3 dB axis ratio) bandwidth of 590 MHz (1.89-2.48 GHz), able to cover both the ISM frequency band (2.45 GHz) and the mid-field frequency band (1.9 GHz). The antenna exhibits CP gains of -20.04 dBi at a frequency of 2.45 GHz, while it shows gains of -24.64 dBi at 1.9 GHz. Furthermore, a superstrate layer on the antenna's radiating surface enhances its biocompatibility and minimizes its impact on the human body. Simulation and experimental results indicate that the antenna can establish a stable wireless communication link for implantable continuous blood glucose monitoring systems.

Longitudinal Dynamic Relationships Between Videogame Use and Symptoms of Gaming Disorder and Depression Among Chinese Children and Adolescents.

Although previous studies have shown a close relationship between gaming disorder and depressive symptoms, few have measured normal videogame use, symptoms of gaming disorder, and depressive symptoms concurrently. The longitudinal dynamics between these variables remain unclear. This study used two demographic cohorts to examine the longitudinal relationship between gaming and depressive symptoms: children (n = 1513, 46.9% girls, Mage ± SD = 9.63 ± 0.58 years) and adolescents (n = 1757, 48.5% girls, Mage ± SD = 12.55 ± 0.70 years). Random intercept cross-lagged panel models (RI-CLPMs) were employed to distinguish between within- and between-person levels of gaming and depressive symptoms. The RI-CLPM results showed a stable link between symptoms of gaming disorder and depression at the between-person level for both children and adolescents. At the within-person level, among children, depressive symptoms positively predicted subsequent gaming disorder symptoms, but gaming disorder symptoms were not a significant predictor of depressive symptoms at this level. Among adolescents, there was no significant cross-lagged effect between symptoms of gaming disorder and depression at the within-person level. Additionally, there was no significant cross-lagged effect between normal videogame use and depressive symptoms in either cohort. These results highlight the different effects of normal videogame use and gaming disorder symptoms associated with depressive symptoms. The different effects on children and adolescents underscore the importance of considering the different developmental stages in the study of gaming and mental health outcomes.

Properties of an optical event timer for satellite laser ranging

The resolution and above all the stability of the geodetic reference frames is crucially important when global change, such as the sea level rise is observed. In this context systematic errors are still presenting a significant challenge to the measurement techniques of space geodesy. In order to overcome this unfortunate situation for the satellite laser ranging technique, we have utilized the injection of a mode-locked laser to provide a stable low-noise link between the optical domain, where the measurements are carried out, and the microwave regime in which the station clock is defined. We obtained a considerably enhanced measurement delay stability by 10–20 ps over several days, albeit with some experimental challenges. The implementation of waveform scans required us to revisit the issue of target structure and intensity variation in satellite laser ranging.

Development, democracy, and dependence in the Southern Cone: political coalitions, stabilizing mechanisms, and their hazards

This article explores the challenge of sustaining development-oriented political coalitions in ‘dependent intermediate democratic economies’ (IDDEs). Scholars have pointed out that the absence of upgrading coalitions in IDDEs, particularly in Latin America, results from weak economic and political institutions and fragmented political support, as well as from the political and social turbulences introduced by economic dependency. Our argument, however, is that some Latin American IDDEs have managed to craft semi-stable political configurations capable of sustaining development and reform processes with relative success. These intermediate coalitions pivot on context-specific stabilization mechanisms that balance institutional, political, and economic fragilities and tensions. To support this argument, we take issue with three countries in Latin America’s Southern Cone – Argentina, Chile, and Uruguay – and distinguish three different types of stabilization mechanism at play in each of these cases: an Argentine-style variant based on the hegemonic role played by a dominant political party, a Chilean-style variant based on elite consensus and the atomization of collective organization, and a Uruguayan-style variant sustained by stable links between and within economic and social sectors. Additionally, we explore how each of these configurations, due to their structure, carry inherent hazards that envision specific trajectories of destabilization.

Unraveling the impact of energy demand and exports on environment and economy: A case study of South Asian Economies

<p class="MsoNormal" style="margin-top: 10pt; text-align: justify;"><span lang="EN-US" style="font-family: 'times new roman', times, serif; font-size: 14pt;">This study employs empirical analysis using an econometric model that examines the interdependence among environmental degradation, exports, and economic development with energy use. It also provides an environmental Kuznets curve (EKC) for selected South Asian economies utilizing time-series data. The findings reveal a long-term, stable equilibrium link between energy demand and pollution. There exists a positive relationship between structural factors and pollution. Moreover, this study constructs a model of exports and pollution from an interdependent perspective. The three perspectives are tested: the scale and structure of energy consumption considering the twin constraints of export-trade and pollution, and the scale of pollution in export-trade constraint. These results show that the increase in energy use leads to higher CO2 emissions amidst export volume. However, in the presence of income, the scale of effect lowers a little. The analysis also supports the presence of Kuznets curve for south-Asian economies. The results imply substantial scope for development in the energy use and pollution structure within South Asia's current export trade process. This development can be attained by regulating energy use and enhancing system efficacy without necessitating changes to the scale effect or structural effect.</span></p>

РАЗВИТИЕ ВАЛЮТНОГО РЕГУЛИРОВАНИЯ ЭКСПОРТНЫХ ОПЕРАЦИЙ В РФ

Export operations are of particular relevance because they are carried out under conditions of uncertainty and high risk. The sanctions economy is caused by a number of factors that have a direct impact on export-oriented enterprises, leading to a number of consequences. Today, export operations are the sector that is regulated by the state in order to develop stable infrastructural links between exporters' organisations and to reduce the sanctions impact on exporters' enterprises. The main task is to provide conditions for the development of export operations, building international cooperation of exporters' organisations, and on the other hand to carry out control functions, as well as to build transparency of information support, to ensure the reliability of foreign exchange operations in terms of export relations. The state has developed a number of measures to reduce risks, one of which is the system of currency regulation and control. Therefore, this topic is topical. The article presents a review of normative acts and highlights the main directions of regulation of export operations on the territory of the Russian Federation. The modern problems of exporters are formulated, the principles of currency regulation of currency control in terms of export operations in modern conditions through digital mechanisms are disclosed

Analysisof Beam Walk in Inter-Satellite Laser Link: Implications for Differential Wavefront Sensing in Gravitational Wave Detection

Achieving space-based gravitational wave detection requires the establishment of an interferometer constellation. It is necessary to establish and maintain stable laser interferometric links using the differential wavefront sensing (DWS) technnique. When the distant measurement beam experiences pointing jitter, it causes beam walk on the surface of the local detector. The reduced overlap between the local reference spot and the distant spot increases the nonlinear errors in the DWS technique, which need to be suppressed. Numerical analysis was conducted on the spatial beam interference signals of the DWS technique when the distant measurement beam experienced pointing jitter. An experimental measurement system was designed, and the beam walk was suppressed using a conjugate imaging system. The results show that within a range of 300 μrad, the optical path with the imaging system can reduce measurement errors by at least 83%. This way also helps to reduce pointing jitter noise in inter-satellite links, thereby improving laser pointing control accuracy.This method would provide a valuable reference for future DWS measurement systems.

A Flexible Topology Control Strategy for Mega-Constellations via Inter-Satellite Links Based on Dynamic Link Optimization

In large-scale satellite constellations, the efficiency of inter-satellite communication is paramount. Traditional topology control strategies, such as the Manhattan configuration, provide stable links but can result in indirect communication paths, affecting the efficiency of information transfer. This paper addresses this issue by proposing an innovative “3 + 1” dynamic topology control scheme. The scheme retains three static links determined by the relative angular velocity and acceleration while introducing a dynamic link based on distance and angular velocity constraints to optimize the link duration and overall network communication efficiency. To address the complexity of matching dynamic links, this paper introduces an elite strategy-based maximum weighted matching algorithm for general graphs. Compared to traditional greedy algorithms, our proposed algorithm significantly improves the link duration and topological stability. Through simulation experiments comparing communication delays between Xiamen and Los Angeles, our results show that the proposed dynamic link scheme substantially reduces the average delay, enhancing the efficiency and flexibility of inter-satellite communication. This research not only extends the duration of inter-satellite links but also provides new perspectives and methodologies for further studies on inter-satellite topology control strategies.

A non-isolated PFC bridgeless SEPIC-Cuk converter with adaptive PI controller for induction motor

In general, the induction motor (IM) is extremely nonlinear in nature and frequency dependent. In most cases, the power generated by the IM has a low power factor (PF), which exhibits detrimental effect on the extent to which the whole transmission and distribution system functions. Since there exists more current harmonics as an outcome of minimized PF, the efficiency of the power system suffers due to transmission line heating and voltage distortion characteristics. Therefore, this paper proposes a power factor correction (PFC) method to overcome the aforementioned issues. Here, by the utilization of AC-DC bridgeless SEPIC-Cuk converter, the power quality is improved by reducing reactive power consumption and enabling better control of voltage and current outputs. To maintain the stable DC link voltage with reduced ripples, the adaptive proportional-integral (PI) controller is used in this work. The three-phase voltage source inverter (VSI) transitioning function is controlled by cascaded fuzzy logic (CFL) controller, which is also utilized for regulating the speed of the three-phase IM. Implementing the proposed control strategy improves power quality significantly by reducing total harmonic distortion (THD). The proposed system is simulated in the MATLAB platform and the attained outcomes, it is clear that the proposed system is highly effective.

Performance evaluation of bridgeless isolated SEPIC-Luo converter for EV battery charging using PI and ANN controller

Electric vehicle (EV) rechargeable battery packs that employ traditional power factor correction (PFC) circuit design have performance limitations due to their substantial conductivity loss that ensures at the input of a diode bridge rectifier (DBR). This study suggests a bridgeless (BL) isolated single ended primary inductance converter (SEPIC) - Luo converter to address the problem. As a result, the input current exhibits a power factor operation of unity throughout the charging process. DBR elimination and current conduction through a remarkably small number of circuits both significantly reduce conduction losses. The use of an artificial neural network (ANN) and proportional integral (PI) controller enhances the converter's performance with a stable DC link voltage. The suggested converter overall operation is thoroughly described in terms of variety of operating modes and simulation-based effectiveness. Here, with the assistance of the hysteresis current controller (HCC), the input current disruptions are reduced. Constant current and voltage management is used to successfully charge the EV battery, resulting in improved efficacy and inherent PFC. By utilizing simulation outcomes achieved from MATLAB, the performance of proposed BL isolated SEPIC-Luo in boosting the power quality of EV charger system is examined.

An Adaptive Dual-Mode Task-Oriented Resource Management Strategy for GEO Relay Systems

With the fierce global competition on satellite networks, the building of satellite constellations grows explosively. Sharply increasing on-orbit data will face the challenge of satellite-ground data transmission. GEO satellites become the top choice for satellite data relay due to their stable satellite-ground link. Most existing spectrum resource management for GEO relays is equipment-oriented and benefit priority, which may lead to a waste of spectrum resources. In this paper, we propose a real-time task-oriented resource allocation strategy for GEO relay systems. We model the spectrum allocation problem as a distributed non-cooperative Stackelberg game process. We prove that when both sides of the game pursue the maximization of personal revenue, the system will enter a Nash equilibrium state, whereas spectrum resources are not fully used. Based on the maximization of individual utilities (U-prior) and spectrum utilization (S-prior) methods, we design an adaptive dual-mode pricing mode to maximize the spectrum resources within a certain loss of revenue. The simulation results show that the S-prior and U-prior have better performance than the baseline method and existing optimization methods. Our proposed dual-mode strategy is making more throughputs and has less delay with little loss of utility values than that of individual utility maximization.

Why put yourself on a pedestal? The pathogenic role of the A/E pedestal.

Certain Escherichia coli (E. coli) strains are attaching and effacing (A/E) lesion pathogens that primarily infect intestinal epithelial cells. They cause actin restructuring and polymerization within the host cell to create an actin-rich protrusion below the site of adherence, termed the pedestal. Although there is clarity on the pathways initiating pedestal formation, the underlying purpose(s) of the pedestal remains ambiguous. The conservation of pedestal-forming activity across multiple pathogens and redundancy in formation pathways indicate a pathogenic advantage. However, few decisive conclusions have been drawn, given that the results vary between model systems. Some research argues that the pedestal increases the colonization capability of the bacterium. These studies utilize A/E pathogens specifically deficient in pedestal formation to evaluate adhesion and intestinal colonization following infection. There have been many proposed mechanisms for the colonization benefit conferred by the pedestal. One suggested benefit is that the pedestal allows for direct cytosolic anchoring through incorporation of the established host cortical actin, causing a stable link between the pathogen and cell structure. The pedestal may confer enhanced motility, as enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are better able to migrate on the surface of host cells and infect neighboring cells in the presence of the pedestal. Additionally, some research suggests that the pedestal improves effector delivery. This review will investigate the purpose of pedestal formation using evidence from recent literature and will critically evaluate the methodology and model systems. Most importantly, we will contextualize the proposed functions to reconcile potential synergistic effects.

Scientific narrative as a factor of intensification of communicative relations of the «science — society» system

The article offers an analysis of communicative interaction in the modern academic field — among individual researchers, research teams and groups in conditions of high competition against the background of exponential growth of publication activity and digitalization of communications both within the professional community and taking into account the strengthening and transparency of interactions with the public. The author puts forward a working hypothesis, according to which it is the narrative attribute in the representation of the results of scientific research that can contain a reserve for evolutionary success within the framework of the systemic nature of communication and have a high potential for the formation of stable links between subsystems of science and other public actors, such as non-professional external observers.

Trajectory optimization for maximization of energy efficiency with dynamic cluster and wireless power for UAV‐assisted maritime communication

AbstractNowadays, the digital development of marine ranching requires a communication system with wide coverage, high transmission rate and stable communication links. It is known that fixed‐wing unmanned aerial vehicles (UAVs) have great advantages in long‐range applications. They have the potential to serve as low‐altitude communication platforms for maritime communication. In this study, with a developmental perspective, considering the intense growth of marine terminals in the future, a new clustering algorithm applied to cluster nonorthogonal multiple access (C‐NOMA) is proposed and its advantages are investigated. In addition, considering the limited energy of marine terminals, combining the wireless power communication (WPC) technology for the UAV to charge terminals, the charging and communication time are optimized with the Lagrange multiplier method and the bisection search method. After completing the above optimization content of charging and communication, combined with the optimization results, it is found the trajectory that maximizes the energy efficiency of the UAV with the convex optimization technique. Experimental results show that the proposed clustering algorithm has good throughput performance, better fairness and lower algorithm complexity, and the proposed trajectory optimization scheme has better energy efficiency.

Edge-Bound Change Detection in Multisource Remote Sensing Images

Detecting changes in multisource heterogeneous images is a great challenge for unsupervised change detection methods. Image-translation-based methods, which transform two images to be homogeneous for comparison, have become a mainstream approach. However, most of them primarily rely on information from unchanged regions, resulting in networks that cannot fully capture the connection between two heterogeneous representations. Moreover, the lack of a priori information and sufficient training data makes the training vulnerable to the interference of changed pixels. In this paper, we propose an edge-oriented generative adversarial network (EO-GAN) for change detection that indirectly translates images using edge information, which serves as a core and stable link between heterogeneous representations. The EO-GAN is composed of an edge extraction network and a reconstructive network. During the training process, we ensure that the edges extracted from heterogeneous images are as similar as possible through supplemented data based on superpixel segmentation. Experimental results on both heterogeneous and homogeneous datasets demonstrate the effectiveness of our proposed method.

High-precision ground simulator for laser tracking of gravity satellite.

Inter-satellite laser ranging is a key technology to improve the measurement precision of gravity satellites in future missions. However, it requires a stable laser link between satellites, which would be affected by external disturbances in space and internal couplings of satellite components. This paper presents a dynamic model to describe the tracking error and proposes a high-precision satellite simulator for the validation of inter-satellite laser tracking. Then, the noises of the sensors and actuators are tested to give the theoretical tracking performance of the simulator. Finally, the laser tracking performance is validated through two experiments: fixed-position tracking and motion tracking. The experimental results show that the measured tracking error of the satellite platform is better than 10 mrad/Hz in the fixed-position tracking and 50 mrad/Hz in the motion tracking. Furthermore, the optical platform can reduce the measured tracking error to 80 μrad/Hz in both two experiments. This work provides a theoretical foundation for optimizing laser tracking performance in space missions, and the proposed simulator has demonstrated a potential for mission simulation with laser tracking.