Toothpaste is a paste or gel useful to maintain dental health and preventing dental disease like cavities and promote oral hygiene it is an abrasive that aids in removing dental plaque and food from the teeth, assists in suppressing halitosis. It contains surfactants and active ingredients (most commonly fluoride) to help prevent tooth decay (dental caries) and gum disease (gingivitis). Large amounts of swallowed toothpaste can be toxic. The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem leaves, Guava leaves. The plant extract ingredient posses the anti-bacterial and antiseptic properties. The herbal toothpaste formulated which can satisfy all the required condition to keep the mouth fresh and prevent tooth decay by bacteria. The formulated herbal toothpaste compared with marketed preparation. The formulated herbal toothpaste compared with marketed preparation. Physical examination: Colour-greenish green, smooth in nature, ph-8.2, spreadability- Good and stable formulation. The outcome of this research herbal toothpaste shows equal patronizing and engrossing passion over the marketed preparation it was consider after the comparing the marketed preparation(Colgate, Dabur Red, Dantkanti) with formulated herbal toothpaste. It has been good scope in future dental research and dental health of public.