Stabilizer Agent Research Articles

Effect of stabilizer agent type on the characteristics of Pd–Ni nanoparticles deposited on reduced graphene oxide as electrocatalysts for the oxygen reduction reaction

Effect of stabilizer agent type on the characteristics of Pd–Ni nanoparticles deposited on reduced graphene oxide as electrocatalysts for the oxygen reduction reaction

Involvement of Molecular Mechanism and Biological Activities of Pemirolast: A Therapeutic Review

: This review paper aims to investigate the therapeutic benefits of pemirolast across different medical conditions, including asthma, allergic rhinitis, cancer, conjunctivitis, etc. The prevalence of allergic conditions has risen in recent decades, primarily attributed to environmental factors. This paper explores the role of pemirolast in managing and mitigating these diseases, shedding light on its potential applications in the context of evolving environmental influences. : This review paper investigates the diverse biological activities exhibited by pemirolast, encompassing its roles as an antimicrobial, analgesic, antiviral, anti-inflammatory, antioxidant, antihistamine, mast cell stabilizer, anti-tubercular, anticancer, anti-asthmatic, anti-malarial, diuretic, antianxiety, and antifungal agent. The positive outcomes of pemirolast application in various diseases are highlighted, showcasing its potential across a spectrum of medical conditions. : The pharmacological impact of pemirolast extends to diverse inflammatory mediators, enzymes, and hormones associated with various diseases. Pemirolast demonstrates inhibitory effects on key elements such as eosinophil activation, histamine, leukotriene, IgE, mast cells, basophils, prostaglandin, interleukin, T-helper cells, macrophage T-cells, neutrophils, tryptase, T-lymphocytes, interferons I-III, Amyloid β (Aβ) peptide, dsRNA transcription, GABA, dopamine, serotonin, and norepinephrine. This comprehensive exploration underscores pemirolast inhibitory actions across disorders, emphasizing its potential therapeutic relevance in diverse pathological conditions. : This review paper illuminates pemirolast potassium's versatile biological and therapeutic applications across various diseases. The potential synergies of combining pemirolast with buspirone, ritanserin, theophylline, and capreomycin are explored, showcasing its ability to elicit beneficial responses in addressing diverse ailments.

Study on the preparation of bimetallic silver-copper nanoparticles by electron beam irradiation

Silver and copper nanoparticles are well-known as good antimicrobial agents. In this study, we reported the preparation and characterization of bimetallic silver-copper nanoparticles (Ag-CuNPs) prepared by the electron beam (EB) irradiation method. Chitosan (CTS) was used as a stabilizer agent. The obtained Ag-CuNPs were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), and UV-Vis spectrophotometry. The influence of the different concentrations in the range of 100–1,000 ppm of Ag+ and Cu2+ ions at the mass ratio of [Ag+]:[Cu2+] = 1/1 on the particle size and particle size distribution of the Ag-CuNPs was investigated. The TEM results showed that the average size of the Ag-CuNPs was 11.02–13.73 nm when the total concentration of Ag+ and Cu2+ ions was 250 – 1,000 ppm, respectively. The EB-irradiation method can be applied in the production of Ag-CuNPs on a large scale.

Stabilizing microtubules aids neurite structure and disrupts syncytia formation in human cytomegalovirus-infected human forebrain neurons.

Human cytomegalovirus (HCMV) is a prolific human herpesvirus that infects most individuals by adulthood. While typically asymptomatic in adults, congenital infection can induce serious neurological symptoms including hearing loss, visual deficits, cognitive impairment, and microcephaly in 10-15% of cases. HCMV has been shown to infect most neural cells with our group recently demonstrating this capacity in stem cell-derived forebrain neurons. Infection of neurons induces deleterious effects on calcium dynamics and electrophysiological function paired with gross restructuring of neuronal morphology. Here, we utilize an iPSC-derived model of the human forebrain to demonstrate how HCMV infection induces syncytia, drives neurite retraction, and remodels microtubule networks to promote viral production and release. We establish that HCMV downregulates microtubule associated proteins at 14 days postinfection while simultaneously sparing other cytoskeletal elements, and this includes HCMV-driven alterations to microtubule stability. Further, we pharmacologically modulate microtubule dynamics using paclitaxel (stabilize) and colchicine (destabilize) to examine the effects on neurite structure, syncytial morphology, assembly compartment formation, and viral release. With paclitaxel, we found improvement of neurite outgrowth with a corresponding disruption to HCMV-induced syncytia formation and Golgi network disruptions but with limited impact on viral titers. Together, these data suggest that HCMV infection-induced disruption of microtubules in human cortical neurons can be partially mitigated with microtubule stabilization, suggesting a potential avenue for future neuroprotective therapeutic exploration.

Microstructural Analysis of Stabilized Rammed Earth Using XRD And SEM Methods

The microstructure analysis of stabilized rammed earth (SRE) is crucial for understanding its mechanical properties, durability, and long-term performance. This literature review paper investigates the application of X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) in analyzing the microstructural characteristics of SRE. XRD is employed to identify the crystalline phases present in the material, providing insights into the mineralogical composition and the effects of stabilization agents. SEM offers high-resolution images that reveal the surface morphology, particle distribution, and bonding mechanisms within the stabilized matrix. By synthesizing recent studies, this review highlights the advancements in microstructural analysis techniques and their implications for the optimization of SRE in construction. The findings from XRD and SEM analyses are integrated to present a comprehensive understanding of the microstructure-property relationships in SRE. The literature suggests that stabilization methods, such as the addition of cement, lime, or other additives, significantly influence the crystallinity, particle interlocking, and pore structure of the rammed earth. This review discusses the correlation between microstructural features observed through XRD and SEM and the resulting mechanical properties, such as compressive strength and durability. The paper concludes by identifying gaps in the current research and proposing directions for future studies, emphasizing the need for standardized testing protocols and the exploration of novel stabilization materials to enhance the performance of SRE. Keywords: X-Ray Diffraction, Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis

CMAS corrosion resistance of scandia, ceria, yttria‐stabilized zirconia ceramic

AbstractSc2O3–CeO2–Y2O3– stabilized zirconia (ScCeYSZ) nanoparticles with different percentages of stabilizer agents [sample1: 1.8 wt.% (Sc2O3) 8.3 wt.% (CeO2) 1.9 wt.% (Y2O3), sample 2: 1.1 wt.% (Sc2O3) 9.0 wt.% (CeO2) 1.9 wt.% (Y2O3), sample 3: .5 wt.% (Sc2O3) 9.6 wt.% (CeO2) 1.9 wt.% (Y2O3) stabilized zirconia] were synthesized with Pechini method and consolidated by spark plasma sintered method. The results showed that despite the [(sample)1: 1.8 wt.% (Sc2O3) 8.3 wt.% (CeO2) 1.9 wt.% (Y2O3)] had lower density and higher porosity percentage compared to other samples, it had better calcium–magnesium–alumina–silicate (CMAS) corrosion resistance compared to other samples and the yttria‐stabilized zirconia nanopowders (nano‐YSZ) sample. It was due to the higher acidic nature and tetragonality of the (sample)1 sintered body compared to other samples and YSZ ceramic in the CMAS corrosive medium. Moreover, the results of phase and microstructural analysis following CMAS corrosion revealed the formation of the monoclinic phase and rod‐shaped CaAl2Si2O8 particles on the surface of the sampled sintered sample. However, the nano‐YSZ sample corroded homogenously and delamination occurred after the CMAS corrosion test.

Biosynthesis of ZnO-NPs from mycoendophyte Alternaria alternata

Fungi-mediated biosynthesis of nanoparticles is a potentially beneficial strategy for large-scale production. In this study, ZnO-NPs were synthesized biogenically using a cell free broth from mycoendophyte Alternaria alternata inhabiting Piper cubeba as a reducer and stabilizer agent. ZnO-NPs appeared to be spherical in transmission electron microscopy, Histogram reveals the nanoparticle size between 20 and 60 nm, and FTIR experiments were employed to analyze the structure, shape, and physicochemical characteristics of the ZnO-NPs. The biosynthesized nanoparticles exhibited an absorption peak at 346 nm in the UV–visible spectrum, which corresponded to the plasmon resonance of ZnO-NPs. The X-ray diffraction spectra of the nanoparticles revealed the formation of crystal planes and hexagonal crystal geometry metal oxides of zinc. In experiments, biosynthesised ZnO-NPs were proven to be exhibit broad spectrum antimicrobial activity. Based on antimicrobial studies bacteria were found to be more susceptible when compare to fungi exhibiting antibacterial activity equal that of co-assayed standard (18–21 mm zone of inhibition). As a result, ZnO-NPs could be mass-produced sustainably, with the potential to be used in a range of biological processes.

Predictors of valproic acid steady-state serum levels in adult and pediatric psychiatric inpatients: a comparative analysis.

Valproic acid (VPA) is commonly used as a second-line mood stabilizer or augmentative agent in severe mental illnesses. However, population pharmacokinetic studies specific to psychiatric populations are limited, and clinical predictors for the precision application of VPA remain undefined. To identify steady-state serum VPA level predictors in pediatric/adolescent and adult psychiatric inpatients. We analyzed data from 634 patients and 1,068 steady-state therapeutic drug monitoring (TDM) data points recorded from 2015 to 2021. Steady-state VPA levels were obtained after tapering during each hospitalization episode. Electronic patient records were screened for routine clinical parameters and co-medication. Generalized additive mixed models were employed to identify independent predictors. Most TDM episodes involved patients with psychotic disorders, including schizophrenia (29.2%) and schizoaffective disorder (17.3%). Polypharmacy was common, with the most frequent combinations being VPA + quetiapine and VPA + promethazine. Age was significantly associated with VPA levels, with pediatric/adolescent patients (< 18 years) demonstrating higher dose-adjusted serum levels of VPA (β = 7.6±2.34, p < 0.001) after accounting for BMI. Women tended to have higher adjusted VPA serum levels than men (β = 5.08±1.62, p < 0.001). The formulation of VPA (Immediate-release vs. extended-release) showed no association with VPA levels. Co-administration of diazepam exhibited a dose-dependent decrease in VPA levels (F = 15.7, p < 0.001), suggesting a potential pharmacokinetic interaction. This study highlights the utility of population-specific pharmacokinetic data for VPA in psychiatric populations. Age, gender, and co-administration of diazepam were identified as predictors of VPA levels. Further research is warranted to establish additional predictors and optimize the precision application of VPA in psychiatric patients.

A novel green reducing agent for the synthesis of chromium oxide nanoparticles (Cr2O3 NPs) based on saffron by-products: Characterization and antioxidant activity

The production of nanomaterials using safe, biological and environmentally friendly methods is attracting increasing attention. In the present study, aqueous extracts of Moroccan saffron (Crocus sativus L) by-products were used for the first time as a green stabilizer and reductant agent to synthesize chromium oxide nanoparticles (Cr2O3NPs). The aqueous extract of saffron by-products was analyzed for phytochemical screening, while the green synthesized Cr2O3NPs were analyzed using high-resolution scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The antioxidant activity of Cr2O3NPs, aqueous chromium nitrate solution (Cr (NO3)), and aqueous extract of saffron by-products have been also investigated using 1,1-Diphenyl-2-picrylhydrazyl (DPPH) method. The results showed that the aqueous extract of saffron by-products used for the synthesis of Cr2O3NPs appeared to be rich in phenolic (2.32 mg GA / g dry weight), flavonoid (2.28 mg RE / g dry weight), and anthocyanin compounds (33.67 mg Delphinidin / L extract). The XRD analysis confirmed that the Cr2O3NPs have a particle size of 31 nm with a hexagonal crystal structure. SEM micrographs of Cr2O3NPs showed a homogenous distribution and spherical shape, while the EDX spectrum confirmed that Cr2O3NPs contain significant amount of Chromium (61,90 %), and oxygen atoms (36,55 %). Moreover, the presence of absorption bands characteristic of the alcohol group (3451 cm−1) and the aromatic rings (1639 cm−1) in the infrared spectrum of Cr2O3NPs, indicates that the secondary metabolites of the saffron plant were successfully active in reducing chromium ions to Cr2O3NPs. Besides, the antioxidant activity results showed that the biosynthesized Cr2O3NPs exhibited strong inhibition percentages (63 %) compared to the aqueous extract of saffron by-products (74 %), and the aqueous solution of chromium nitrate (30 %) at 1,30 mg/mL. The study suggests that saffron by-products extract can be used as a natural reducing agent in the synthesis of Cr2O3NPs. Furthermore, the environmentally friendly synthesis process for Cr2O3NPs and their antioxidant effect make them suitable for use in various fields.

Role of Zr3+ in excitation of Eu3+ ions in stabilized ZrO2:Eu nanoparticles

Microwave hydrothermal technique has been applied to crystallize ZrO2 nanoparticles with the sizes below 10 nm and activated with Eu. Trivalent europium ions acted also as the stabilization agent of the high temperature ZrO2 polymorphs at the room temperature. To achieve this, high concentrations - up to 20 % of Eu3+ - were introduced to the zirconia host lattice. Reference samples of ZrO2 containing yttrium were synthesized to obtain pure cubic, tetragonal and monoclinic phases at constant europium concentration. Eu3+ ions have not been reduced to divalent form, however, we have observed reduction of Zr4+ ions by means of luminescence spectroscopy and electron paramagnetic resonance (EPR). The variation of Zr3+ concentration in the samples with increasing Eu3+ content seems to support the concept of trivalent ion pairs as charge compensation centers in ZrO2. Excitation of Eu3+ ions was conducted via low and high symmetry sites. Trivalent zirconium ions have been found to play a role in the excitation of Eu3+ ions at low symmetry sites.

Improving cell viability with protective agent, carrier support and stability agent of Candida tropicalis TISTR 5922 starter powder

A pure culture of Candida tropicalis TISTR 5922 was used as a starter culture in Ka - nom Tuay - fu production which is a Thai traditional food. The objective of this research was to improve the viability of C. tropicalis TISTR 5922 starter powder by 15% glucose (w/v) with a different protective agent (milk powder, skim milk powder and sweet whey powder) at 5, 10 and 15% (w/v)), carrier supports (rice flour, corn flour, wheat flour and cassava flour), which can enhance the survival by stability agents (gelatin, Arabic gum and maltodextrin at 1, 2 and 3% (w/v)), and drying at 40°C. The results showed that 15% glucose with 10% skim milk powder for protective agents, rice flour for carrier support and 3% Arabic gum as for stability agent were well processed. It also showed high cell viability of 8.45 log CFU/g. The starter powder had the moisture content and water activity at 7.15±0.48% and 0.40±0.04, respectively. The results indicated that good physical properties of starter powder were obtained.

Feasibility and mechanism of high alumina cement-modified chlorine saline soil as subgrade material

Soil salinization is a serious problem during ground improvement and foundation construction around the coastal region. This study used high alumina cement (HAC) as a soil stabilisation agent to modify the coastal chlorine saline soil as roadbed backfilling materials. In addition, Ordinary Portland cement (OPC), slaked lime (SL) and fly ash (FA) were used to better the understanding of the chlorine fixation and roadbed performance. The microstructures of different hydration products were investigated through the utilization of the X-ray diffraction and scanning electron microscope equipped with an energy dispersion spectrometer. The HAC-SL-modified soil depicts that the aluminium and calcium phases are beneficial to the formation of Friedel’s salt and hydration products. The optimal chlorine fixation is approximately 20.5% at 6% HAC-SL incorporation (3% of HAC and 3% SL). At the early stage of curing, the strength of the HAC-treated soil is high. However, with a prolonged curing period, there is a slight decrease in the strength because the porosity will increase during the transformation of metastable CAH10 and C2AH8 into stable and dense C3AH6. This evolution can be prevented by incorporating SL to enrich calcium silicate hydrate (C-S-H) and calcium aluminate hydrate (C-A-H). Furthermore, it is of key importance to mention that HAC reaction is quick, therefore, the compaction should be undertaken instantly to ensure the road performance.

Biocompatible Thermally Responsive Vinyl Sulfone Silica Nanocapsules as Stabilizing and Softening Agents for Metal-Free Leather Production

Biocompatible Thermally Responsive Vinyl Sulfone Silica Nanocapsules as Stabilizing and Softening Agents for Metal-Free Leather Production

Mucoadhesion, Rheology, Swelling Behavior, and Immunomodulatory Properties of Polysaccharides of Gum Exudates Obtained from Astracantha echidnaeformis (Sirj.) Podlech as a Formulary Excipient Candidate

AbstractThe physicochemical, rheological, and mucoadhesive characteristics of gum derived from Astracantha echidnaeformis are investigated. It's polysaccharides are isolated using chromatography techniques, and their immunomodulatory characteristics are evaluated by subjecting Jurkat cells to the WST‐1 assay. The composition of these polysaccharides is analyzed using gas chromatography‐mass spectrometry (GC‐MS). The viscosity and shear‐thinning behavior of gum are directly influenced by its concentration and the presence of NaCl, whereas they are inversely affected by temperature. The gum has strong potential as a thickening agent for dispersed systems. The mucoadhesion strength of the gum insoluble fraction is 109 ± 4.58 g cm−2, indicating excellent adhesiveness for application to mucoadhesive formulations. Cells’ proliferation enhancement is found for the isolated manno‐arabinoglucan (MW: ≤1.27 kDa) and galacto‐arabinan (MW: ≥667.8 kDa) at concentrations lower than 400 µ mL−1, but at higher concentrations they inhibited the proliferation. The isolated pectic galacto‐arabinan (MW: 669.58 kDa) exhibited a proliferative effect at 250 µg mL−1, but the isolated manno‐galactoglucan (MW: 80.90 kDa) showed cytotoxicity at higher doses. The isolated proteoglycans has mostly galacto‐arabinan backbones with immunomodulatory properties. The gum can be used as a thickening agent for the physical stabilization of suspensions and gels, specifically those needing to be stored at cold temperatures.

Nanochannel Stability of Chemically Converted Graphene Oxide Membranes.

Chemically converted graphene oxide laminate membranes, which exhibit stable interlayered nanochannels in aqueous environments, are receiving increasing attention owing to their potential for selective water and ion permeation. However, how the molecular properties of conversion agents influence the stabilization of nanochannels and how effectively nanochannels are stabilized have rarely been studied. In this study, mono-, di-, and tri-saccharide molecules of glucose (Glu), maltose (Glu2), and maltotriose (Glu3) are utilized, respectively, to chemically modify graphene oxide (GO). The aim is to create nanochannels with different levels of stability and investigate how these functional conversion agents affect the separation performance. The effects of the property differences between different conversion agents on nanochannel stabilization are demonstrated. An agent with efficient chemical reduction of GO and limited intercalation in the resulting nanochannel ensures satisfactory nanochannel stability during desalination. The stabilized membrane nanochannel exhibits a permeance of 0.69 L m-2 h-1 bar-1 and excellent Na2SO4 rejection of 96.42%. Furthermore, this optimized membrane nanochannel demonstrates enhanced stability under varying external conditions compared to the original GO. This study provides useful information for the design of chemical conversion agents for GO nanochannel stabilization and the development of nanochannel membranes for precise separation.

A Review on Stabilizing Clayey Soil Using Waste Materials

Infrastructural development on unstable clayey soil has resulted to the damage of buildings and roads, the loss of lives, and financial instability in many projects including both vertical and horizontal structures due to the incapability of clayey soil to withstand certain magnitude of loadings. Furthermore, the deposit of materials that are left-over in open areas has also become an environmental challenge for residents in many communities. This review elaborates on the effect of waste materials—SDA (sawdust ash), FA (fly ash), and RHA (rice hush ash)—on the shearing strength of clayey soil as agents for stabilization. The study covers significant books on stabilizing clayey soil with additives as well as high indexed research articles that were published from 1998 to 2023. The findings show that, mixing the ash of sawdust with natural clay soil at the peak values of four (4) percent to seven point five (7.5) percent carries up the UCS (Unconfined Compressive Strength), the MDD (Maximum Dry Density), the CBR (California Bearing Ratio), and lowers the soil’s swelling, Optimum Water Content or OMC and Liquid Limit (LL). Similarly, the mixture of FA and clay soil at the optimum values ranging from 9 to 25%, raises the clayey soil’s UCS, MDD, and CBR while lowering its swelling potential, OMC, and LL. Additionally, the UCS, MDD and CBR increases, and the swelling, OMC, and LL reduce at the optimum value of added rice hush ash ranging from 10 to 20%. Thus, it is established that the addition of sawdust, fly, and rice hush can enhance clayey soil’s engineering properties.

A new technique for using gamma irradiation to enhance silver nanoparticles synthesized by chemical reduction and their effect on tomato early blight disease under field conditions

Early blight disease causes a significant loss in tomato production. This study focuses on the effective suppression of Alternaria solani, which causes huge losses in tomato yield. This research was conducted at the Egyptian Atomic Energy Authority Nuclear Research Centre. Infected plants were treated with silver nanoparticles (AgNPs). Two chemical materials, sodium borohydride and trisodium phosphate, were used for the synthesized silver nanoparticles. 1% polyvinylpyridine (PVP) was used as a stabilizer agent. AgNPs were exposed to several doses of gamma irradiation (0, 1.5, 3, 6, 12, and 24) kilo Gray (kGy) in order to enhance and maximize the effect of AgNPs on Alternaria solani. UV–Vis spectroscopy (UV), Fourier-transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM) were used to characterize AgNPs; sodium borohydride and trisodium citrate were used for the chemical reduction. AgNPs and AgNPs + gamma irradiation led to increases in shoot fresh weight and shoot dry weight; they also elevated the antioxidant enzymes, as well as peroxides and catalase, when compared with control (untreated) plants. AgNPs and AgNPs + gamma irradiation decreased the disease severity compared with the control untreated. Our study not only corroborates established trends in nano-agriculture but also introduces novel insights into the specific effects of gamma irradiation on AgNP that led to a decrease in this size in the quantum dot range (3–10) nm, as shown in Tem. By drawing parallels with the work of esteemed researchers in the field.

Synthesis and antibacterial activity of metallic copper‐chitosan nanomaterial using environmentally friendly Cleistocalyx operculatus leaf extract as a reducing agent

AbstractThe copper‐chitosan nanomaterial (CuNPs‐CTS) was effectively produced through a chemical reduction process employing Cleistocalyx operculatus leaf extract (COLE) as a reduction agent and chitosan as a stabilization agent. Both COLE and chitosan were derived from natural sources and are environmentally friendly. Various techniques including XRD, SEM, TEM, and DLS were used to characterize the samples. The findings revealed the exclusive presence of CuNPs metal when COLE was used as the reducing agent, while the presence of both metallic Cu and Cu2O was the result of using NaBH4. The CuNPs‐CTS material synthesized with COLE displayed CuNPs particles with diameters varying from 10 to 30 nm. CuNPs‐CTS materials were tested for their antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria. CuNPs‐CTS materials effectively inhibited the growth of these bacteria, significantly expanding the bacterial inhibition zone compared to the control sample (distilled water). The CuNPs‐CTS material using COLE exhibited a bacterial inhibition zone diameter of around 20 and 18 mm against S. aureus and E. coli, respectively. This surpassed the antibacterial performance of the CuNPs‐CTS material employing NaBH4 against S. aureus (18 mm).

Phytochemical profile, anti-inflammatory analysis and cytotoxic activity of SmE-SeNPs against breast (MCF-7) cancer cells

Plant extract is inexpensive and does not need special conditions to produce nanoparticles quickly; it is an eco-friendly approach. Selenium nanoparticles have attracted a lot of attention because of their various applications and benefits in medicine. This investigation studied a bio-synthesis of selenium nanoparticles using Sonchus maritimus leaves aqueous extract (SmE-SeNPs) to evaluate their anti-inflammatory and anti-cancer properties. The presence of SmE-SeNPs in the sample was confirmed by ultraviolet–visible (UV–vis) spectroscopy at different stage of synthesis, and transmission electron microscope. The S. maritimus extract was analyzed by LC-ESI-MS technique. The anti-inflammatory proprieties of the extract and SmE-SeNPs was estimated using protein denaturation and membrane stabilization assays, and the antiproliferative activity of the synthesized nanoparticles was assessed against breast cancer cell line (MCF-7). LC-ESI-MS results revealed the richness of S. maritimus extract by various phenolic compounds including protocachuic acid, trans frulic acid, o-coumaric acid and luteolin. Physical characterizations of nanoparticle demonstrated that the SeNPs have a spherical and regular circle shape with very small size reach to 7.154 ± 0.47 nm. Both of S. maritimus extract and SmE-SeNPs presented a potential anti-inflammatory activities compared to standard, each against denaturation of protein with IC50 value (334.369 ± 29 μg/mL) and (163.393 ± 14.1 μg/mL) respectively, or against the hemolysis of red blood cells through protecting and stabilizing their membrane with IC50 value (89.044 ± 4.11 μg/mL) for SmE-SeNPs and (53.539 ± 4.64 μg/mL) for S. maritimus extract. Moreover, this study showed that exposure of SmE-SeNPs can inhibited MCF-7 cell proliferation, which observed in breast cancer. As conclusion, our research suggested that Sonchus maritimus leaves aqueous extract can be used as reducer and stabilizer agents for green synthesis of SmE-SeNPs which provided their anti-inflammatory and anticancer effects.

Evaluation of the effect of acid additives on rheological properties and technological efficiency of zwitterionic and anionic surfactant mixtures

Relevance. Various acid additives such corrosion inhibitors, iron stabilizers, demulsifiers, anti-precipitation agents are usually used to provide necessary technological properties to acid compositions. Adding the additives into the acid composition based on viscoelastic surfactants can have a significant impact on the efficiency of their subsequent use, since micelle formation and, consequently, rheology of their solutions are particularly sensitive to the presence of additional components in the system. Accordingly, determination of the acid additives influence on rheological properties and technological efficiency of acid compositions with surfactants is a vital task. Aim. To evaluate the effect of acid additives on rheological behavior of viscoelastic surfactants-based acid compositions (mixture of cocamidopropyl betaine and ethoxylated fatty alcohol sulfosuccinate). Object. Acidic composition based on viscoelastic surfactants (a mixture of anionic and zwitterionic surfactants) and a package of acidic additives – corrosion inhibitor, iron stabilizer, demulsifier and antisludge agent. Methods. Investigation of rheological properties using an MCR52 rheometer (Anton Paar GmBH) in the shear rate range from 1 to 100 s–1 at temperatures from 20 to 90°C, standard tests for selecting acid additives. Results. The authors have determined the effect of acid additives on rheological properties of the developed self-diverting acid solution based on the viscoelastic surfactant (a mixture of anionic and zwitterionic surfactants). The obtained results confirmed that adding the acid additives into solutions leads to a decrease in partially neutralized solution viscosity. However, it expands the range of manifestation of viscoelastic properties. This will increase the efficiency of the developed composition during acid treatment. Also, the addition of acid additives reduces the initial viscosity, which facilitates acid injection into formation. A viscoelastic gel is not formed with hydrocarbons, which indicates that the treatment is effective in cleaning up the area after acidizing. The temperature test showed that the additives do not affect the temperature range of acid solution application.