Stability Parameters Research Articles

The Causal Relationship Between Stocks, Gold, Crude Oil, and Bond Returns in Poland

Theoretical background: Capital investments involve taking risks to achieve a favourable rate of return. Investors are offered various options, including stocks, bonds, and commodities. The aforementioned investment opportunities are considered alternatives due to their varying price volatility and risk levels. Bonds and gold demonstrate a low or negative correlation with equities. On the other hand, crude oil and gold are positively correlated. An essential issue in analysing financial markets is to capture the dynamic behaviour of the financial time-series data, i.e. variables such as prices and returns on investments in assets mentioned above. In decision-making, investors should consider the causal relationship between asset classes, as some variables may contain important information about the future dynamics of other variables. The ability to predict future outcomes is crucial to reduce uncertainty. Vector autoregression (VAR) models are regarded as a useful modelling tool in investigating interrelations between financial instrument prices and returns. Purpose of the article: The paper aims to evaluate the linkages between stock, gold, crude oil, and bond returns in Poland. We focus on analysing both the long term equilibrium between logarithmic financial asset prices and the Granger causality between logarithmic returns in the short term. Research methods: The causal relationships between the stocks, gold, crude oil, and bond logarithmic returns are investigated based on the VAR/VECM estimates. The empirical data cover the period from December 2006 to January 2023. We use the following market data to measure the interrelations between the considered assets: WIG Index, gold and crude oil spot prices, and bond index reflecting the price movements on the Polish financial market. We carry out the test for stationarity employing the ADF and Phillips–Perron tests. The pre-estimation process also involves identifying the number of lags and conducting the Johansen cointegration test since variables are integrated of order one to examine the existence of the long-term equilibrium between the logarithmic prices of assets mentioned above. We use the Wald test for the models’ parameters to indicate the type of Granger causality between logarithmic returns. The forecast error variance decomposition (FEVD) and impulse response functions (IRF) analysis is also applied. Moreover, the post-estimation procedure includes a test for parameters stability and white noise of residuals. All calculations are performed using Stata’s standard software package. Main findings: The results suggest that the markets we examined in Poland are cointegrated, meaning a long-term relationship exists between the prices of financial assets. Additionally, we prove that gold logarithmic prices have a negative impact on the stock index, indicating an inverse relationship between their price developments. We also discover that crude oil and bonds’ effects on the stock market are positive. Although all β coefficients of the error correction equation are statistically significant, the short-term adjustment to equilibrium did not occur based on the α coefficients of the short-term equations. According to the Granger causality analysis related to the VAR in first differences, gold price changes have a short-term impact on stock returns. In contrast, stock returns cause crude oil returns. However, we find no causal linkages in the remaining cases, suggesting that the variables are independent. Changes in asset prices are mainly attributed to their shocks, while observed impacts described by IFR function patterns die out quite quickly. Overall, results confirm that investors can combine gold and stocks in their portfolios, as these interrelated assets have alternative investment properties. Additionally, it is worth noting that the correlation between stock returns and crude oil or bonds is undesirable when constructing portfolios.

Precessing non-axisymmetric ellipsoids: bi-stability and fluid instabilities

This study explores precession-driven flows in a non-axisymmetric ellipsoid spinning around its medium axis. Using an experimental approach, we focus on two aspects of the flow: the base flow of uniform vorticity and the development of fluid instabilities. In contrast to a preceding paper (J. Fluid. Mech., vol. 932, 2022, A24), where the ellipsoid rotated around its shortest axis, we do not observe bi-stability or hysteresis of the base flow, but a continuous transition from small to large differential rotation and tilt of the fluid rotation axis. We then use the model developed by Noir & Cébron (J. Fluid. Mech., vol. 737, 2013, pp. 412–439) to numerically determine regions in the parameter space of axial and equatorial deformations for which bi-stability may exist. Concerning fluid instabilities, we use three independent observations to track the onset of both boundary layer and parametric instabilities. Our results clearly show the presence of a parametric instability, yet the exact nature of the underlying mechanism (conical shear layer instability, shear instability and elliptical instability) is not unambiguously identified. A coexisting boundary layer instability, although unlikely, cannot be ruled out based on our experimental data. To make further progress on this topic, a new generation of experiments at significantly lower Ekman numbers (ratio of rotation and viscous time scales) is clearly needed.

Cerebral haemodynamics and intracranial pressure during haemorrhagic shock and resuscitation with total endovascular balloon occlusion of the aorta in an animal model.

To assess changes of cerebral haemodynamic and intracranial pressure (ICP) in animals, with or without elevated ICP, during controlled haemorrhagic shock and resuscitation with Total REBOA (tREBOA). In 22 anaesthetized and normoventilated pigs, after placement of catheters for monitoring invasive proximal blood pressure (pMAP), ICP, and vital parameters, and 60min stabilisation phase, a controlled haemorrhagic shock (HS), was conducted. In 11 pigs (EICPG), an elevated ICP of 25-30 mmHg at the end HS was achieved by simulating an epidural mass. In 11 pigs (NICPG), the ICP was normal. tREBOA was then applied for 120min. The changes of pMAP and ICP were followed, and cerebral perfusion pressure (CPP) calculated. The integrity of the autoregulation was estimated using a calculated Modified-Long Pressure Reactivity Index (mL-PRx). After stabilisation, hemodynamics and physiological parameters were similar and normal in both groups. At the end of the HS, ICP was 16 mmHg in NICPG vs. 32 in EICPG (p = 0.0010). CPP was 30 mmHg in NICPG vs. 6 mmHg in EICPG (p = 0.0254). After aorta occlusion CPP increased immediately in both groups reaching after 15min up to104 mmHg in NICPG vs. 126 mmHg in EICPG. Cerebrovascular reactivity seems to be altered during bleeding and occlusion phases in both groups with positive mL-PRx. The alteration was more pronounced in EICPG, but reversible in both groups. tREBOA is lifesaving by restoration the cerebral circulation defined as CPP in animals with HS with normal or elevated ICP. Despite the observation of short episodes of cerebral autoregulation impairment during the occlusion, mainly in EICPG, tREBOA seems to be an effective tool for improving cerebral perfusion in HS that extends the crucial early window sometimes known as the "golden hour" for resuscitation even after a traumatic brain injury.

Identifying vehicle characteristic target based on subjective ratings from drivers

In virtual tire development, defining vehicle characteristic target is crucial to achieving the desired vehicle performance with the equipped tires. Vehicle performance is generally evaluated through subjective ratings by skilled drivers following SAE J1441 guidelines, as well as the objective performance metrics obtained via vehicle dynamics analysis. However, due to the scarcity and bias in real-world testing dataset, the vehicle characteristic target cannot be determined definitively. To address this issue, we propose a recommendation system that searches the unexplored vehicle characteristic domains. This suggested method provides virtual subjective ratings to enrich the limited real-world dataset from the skilled drivers. Moreover, we highlight the correlation between subjective and objective data using vehicle and tire dynamics simulation software. Based on this augmented data, we predict the vehicle characteristic target according to the subjective rating requirements. The proposed approach was validated through various experiments involving skilled drivers and various vehicle-tire combinations, showing 91.26% to 96.2% consistency in generated steering parameter domains. Domains of stability parameters show that one fewer domain was generated by a conservative driver compared to more lenient driver, which confirms the robustness of the proposed approach in accommodating individual driver preferences.

Insights into Stable Apple Genotypes for Fruit Yield in Himachal Pradesh: An Assessment Using Parametric and Non-parametric Stability Measures

Insights into Stable Apple Genotypes for Fruit Yield in Himachal Pradesh: An Assessment Using Parametric and Non-parametric Stability Measures

63 Utilization of vasopressin and norepinephrine in neonates with cardiorespiratory compromise: A multicenter retrospective cohort study in Canada

Abstract Background Data regarding neonatal clinical experience with Vasopressin (VA) and Norepinephrine (NE) are limited to small studies. The lack of large-scale studies with safety and efficacy data is preventing the widespread adoption of these agents. Objectives To describe epidemiological data on utilization of NE and VA in neonates including their indications, effectiveness and overall outcomes across 3 tertiary Neonatal Intensive Care Units (NICU) in Canada. Design/Methods This retrospective cohort study involved neonates who received NE or VA between January 1, 2015-December 31, 2020 at 3 tertiary NICUs. Data regarding demographic information, indications of use, dosing details, and clinical outcomes were described using mean, standard deviations (SD), frequencies and percentages. When appropriate, a comparative analysis was performed using Mann-Whitney U tests or the chi-square test as appropriate. Post-initiation changes in physiological variables and laboratory parameters over time were analyzed using repeated measure ANOVA. Results 133 neonates (VA:70, NE:63) were included in this study. Baseline demographic features, clinical characteristics at initiation, indication of use, dosing details and clinical response in neonates exposed to both agents are summarized in Table 1. VA was commonly used for oxygenation failure due to persistent pulmonary hypertension of the newborn (PPHN), while NE was commonly used for hypotension due to septic shock. NE was frequently used as a 1st line inotropic agent, whereas VA was used more as an additive agent [30 (47.6%) vs 12 (18.6%); p=<0.001]. During treatment, lower sodium levels were recorded in the VA group vs the NE group [126.5 (8.6) vs 132 (7); p=.035], but other safety parameters were similar. The time to reach predefined stability parameters were similar in both groups. Significant improvement in physiological parameters were seen over time with both agents (Figure 1). Mortality within 7 days of use was high in the cohort, but comparable between VA and NE groups [18 (25.7%) vs 22 (34.9%), p=0.206]. Other neonatal morbidities were comparable between groups (Table 1). Conclusion This multicenter study provides pragmatic insights into the current use of NE and VA in neonates. Our study reports the effective use of each agent in distinct patient subgroups. This cohort represented neonates with high illness severity; however, exposure to either agent did not independently increase the risk of mortality or adverse outcomes. Further prospective studies exploring its optimal use and cardiopulmonary effects would be interesting.

A fault location method for DC transmission line based on the distributed parameter model considering line parameter uncertainty

Addressing the impact of whether line parameters can be accurately obtained and the errors due to environmental influences on the accuracy of fault location for DC transmission line, this paper proposes a fault location method based on the distributed parameter model that accounts for uncertainty in line parameter. To address the challenge of accurately obtaining DC transmission line parameters, a high-order derivative-based parameter estimation method is introduced to determine unknown equivalent parameters of the DC transmission line. Additionally, an optimization algorithm is incorporated to dynamically correct parameter errors, thereby enhancing parameter stability and constructing an accurate line model. Based on this, theoretical derivations confirm the applicability of the Tellegen's quasi-power theorem in the normal operation and internal fault equivalent models of DC transmission line. A fault location function is established based on the relationship between the line's Tellegen quasi-power characteristic and fault distance. The proposed method's effectiveness and accuracy are validated using a DC system model built on the PSCAD/EMTDC simulation platform. Simulation results indicate that the proposed method can locate faults under different fault conditions.

First high-power helicon results from DIII-D

Abstract More than 0.6 MW of rf power at 476 MHz has been coupled to DIII-D plasmas by launching helicon (whistler) waves with a traveling-wave antenna (comb-line) in the fast-wave polarization (Van Compernolle et al 2021 Nucl. Fusion 61 116034) which resulted in the observation of electron heating of the core plasma with single-pass absorption based on ray-tracing in L-mode discharges. The coupling performance of the 1.5 m wide 30-element comb-line traveling-wave antenna has been consistent with expectations based on the 2015–2016 experiments on DIII-D with a low-power 12-element prototype (Pinsker et al 2018 Nucl. Fusion 58 106007). The conditioning process that was necessary to carry out high-power experiments is discussed; rf-specific impurities have not been observed. Parametric decay instabilities have been observed and are being investigated as a potential edge absorption mechanism (Porkolab et al 2023 AIP Conf. Proc. 2984 070004).

Utilizing parametric instabilities to diagnose edge density fluctuations in TCV

Abstract Two-plasmon decay instabilities (TPDIs) are a class of parametric instabilities where a gyrotron beam, polarized in X-mode, decays nonlinearly into two upper hybrid waves at approximately half frequency. Here, we present the design of a simple radiometer that was installed at Tokamak á configuration variable to diagnose TPDIs as well as a novel technique that was used to calibrate the radiometer using thermal electron cyclotron emissions. We show examples of measured radiation from TPDIs that occur when the gyrotron beam intersects blob filaments in the scrape-off layer and demonstrate that the frequency separation of the TPDI daughter waves can be used to assess the densities of the blob filaments. This technique could be utilized to diagnose density fluctuations due to both blobs, ELMs, and rotating magnetic islands.

Speciation studies of binary and ternary complexes formed with fe(II) ion 2,6-pyridinedicarboxylic acid and several amino acids

The chemical speciation of ternary systems involving Fe(II), 2,6-pyridinedicarboxylic acid (H2Dipi), and various amino acids (glycine, β-alanine, α-alanine, leucine, methionine, lysine, phenylalanine, threonine, serine, proline, valine, and histidine) was investigated in this work. Potentiometric titrations were conducted for each system in aqueous solution at 25 °C using 1 mol dm−3 NaCl solution as the ionic medium. The resulting data were analyzed using the least-squares program LETAGROP. Additionally, the binary system of Fe(II)-2,6-pyridinedicarboxylic acid in aqueous solution at 25 °C with NaCl 1.0 mol dm−3 as the ionic medium was also examined. Species distribution diagrams were generated, and the relative stability parameter Δlog K was calculated.

Elucidating the G X E Interaction Using AMMI, AMMI Stability Parameters and GGE for Cane Yield and Quality in Sugarcane

Elucidating the G X E Interaction Using AMMI, AMMI Stability Parameters and GGE for Cane Yield and Quality in Sugarcane

Turbulent Energy and Carbon Fluxes in an Andean Montane Forest—Energy Balance and Heat Storage

High mountain rainforests are vital in the global energy and carbon cycle. Understanding the exchange of energy and carbon plays an important role in reflecting responses to climate change. In this study, an eddy covariance (EC) measurement system installed in the high Andean Mountains of southern Ecuador was used. As EC measurements are affected by heterogeneous topography and the vegetation height, the main objective was to estimate the effect of the sloped terrain and the forest on the turbulent energy and carbon fluxes considering the energy balance closure (EBC) and the heat storage. The results showed that the performance of the EBC was generally good and estimated it to be 79.5%. This could be improved when the heat storage effect was considered. Based on the variability of the residuals in the diel, modifications in the imbalances were highlighted. Particularly, during daytime, the residuals were largest (56.9 W/m2 on average), with a clear overestimation. At nighttime, mean imbalances were rather weak (6.5 W/m2) and mostly positive while strongest underestimations developed in the transition period to morning hours (down to −100 W/m2). With respect to the Monin–Obukhov stability parameter ((z − d)/L) and the friction velocity (u*), it was revealed that the largest overestimations evolved in weak unstable and very stable conditions associated with large u* values. In contrast, underestimation was related to very unstable conditions. The estimated carbon fluxes were independently modelled with a non-linear regression using a light-response relationship and reached a good performance value (R2 = 0.51). All fluxes were additionally examined in the annual course to estimate whether both the energy and carbon fluxes resembled the microclimatological conditions of the study site. This unique study demonstrated that EC measurements provide valuable insights into land-surface–atmosphere interactions and contribute to our understanding of energy and carbon exchanges. Moreover, the flux data provide an important basis to validate coupled atmosphere ecosystem models.

Parametric Excitation and Instabilities of Spin Waves Driven by Surface Acoustic Waves

AbstractThe parametric excitation of spin waves by coherent surface acoustic waves in metallic magnetic thin film structures is demonstrated experimentally using Brillouin light scattering spectroscopy. Complementary micromagnetic simulations and analytical modeling reveal that, depending on the experimental conditions, the spin‐wave instabilities originate from different phonon‐magnon and magnon‐magnon scattering processes. This opens novel ways to create micro‐scaled nonlinear magnonic systems for logic and data processing that profit from the efficient excitation of phonons using piezoelectricity.

The Role of Oral Nutritional Supplements in Head and Neck Cancer Patients Undergoing Chemoradiotherapy.

This study aimed to assess the impact of oral nutritional supplements (ONS) on nutritional intake, body weight, and body composition in head and neck cancer (HNC) patients undergoing chemoradiotherapy. The study evaluated whether ONS could prevent treatment-related nutritional deterioration. This prospective observational pilot study included 30 HNC patients randomized into two groups: ONS (n = 15) and No ONS (n = 15). All participants underwent chemoradiotherapy, with the ONS group receiving 200 mL of a high-calorie, high-protein supplement twice daily. Nutritional status, including body weight, BMI, fat mass, fat-free mass, and bone mass, was assessed at three time points: baseline, mid-treatment, and end of treatment. Data were analyzed using the Mann-Whitney U test, with a p-value of ≤0.05 considered statistically significant. At baseline, there were no significant differences between the two groups in body weight, BMI, or body composition. By the end of radiotherapy, the No ONS group showed significant reductions in body weight (p < 0.001), BMI (p < 0.001), fat mass (p < 0.001), and fat-free mass (p < 0.001), while the ONS group maintained more stable nutritional parameters. Acute radiotherapy toxicities, including nausea, dysphagia, and oral mucositis, were not significantly different between the two groups. ONS effectively mitigates weight loss and preserves body composition in HNC patients undergoing chemoradiotherapy. While no significant reduction in radiation-induced toxicities was observed, the nutritional benefits of ONS support its use in preventing malnutrition in this patient population. Larger studies are needed to further validate these findings.

Automatic determination of directional stability parameters of an electric vehicle with a two-motor scheme as part of the torque distribution controller

In case if the front and rear axle of the electric vehicle are not mechanically linked, the presence of automatic torque distribution to the axles or wheels becomes not only an addition to increase the level of consumer properties, but also a necessity. A method for determining the directional stability condition of an electric four-wheel drive vehicle is developed as part of the research by comparing the target and measured yaw rate, and is based on the formulated conditions of drift, skid, and counter steer registration. A method for detecting slipping of the driving wheels of an electric vehicle with a dual-motor scheme is developed, which is based on comparing the target and measured velocity differences of the front and rear axle and includes an auto oscillation detection function. A method for determining the target front and rear axle speed difference in a corner is described. Based on the tests performed, it is concluded that the proposed methods are applicable to the active torque distribution function between the axles of an all-wheel drive electric vehicle being developed by the authors of the paper, which provides improved directional stability and controllability, and counteracts slipping of the drive wheels.

The Effect of Magnesium Sulfate plus Ketorolac versus Morphine plus Ketorolac on Pain Relief in Patients with Renal Colic: A Double-blind Randomized Clinical Trial

Abstract Background: It seems that magnesium sulfate (MgSO4) can be useful in reducing acute pain caused by stone passing through the ureter by reducing ureteral smooth muscle contractions. Aim: This study aimed to evaluate the effect of MgSO4 plus ketorolac versus morphine plus ketorolac on pain relief in renal colic. Methods: The present double-blind randomized clinical trial was performed on 70 patients with renal colic divided into two groups. Patients in the first group received 30 mg intravenous ketorolac plus 5 mg intravenous morphine while patients in the second group received 30 mg/kg MgSO4 plus 30 mg intravenous ketorolac. Then, patients’ hemodynamic parameters and pain scores were evaluated before and 20, 40, and 60 min after the intervention. Results: Within 60 min of administration, systolic blood pressure was significantly reduced in the morphine plus ketorolac group (P &lt; 0.001) while there was no significant change in the MgSO4 plus ketorolac group in this regard (P = 0.576). In addition, the patients’ mean pain scores were not significantly different between the two groups in any of the studied times (P &gt; 0.05). Conclusion: Given that the addition of MgSO4 to ketorolac, as compared with the addition of morphine (as a drug) to ketorolac, has been associated with fewer complications and greater stability of hemodynamic parameters, it can be stated that the use of MgSO4 as an adjunct can be a good choice for further pain relief in patients with contraindications for drug administrations.

The influence of toe geometry on toe armour stability for conventional rubble mound breakwaters

Rubble mound breakwaters have toe structures that provide support to the armour layer and prevent damage to the structure from scouring. In this way, toe failure may be regarded as one of the primary failure modes of rubble mound breakwaters. Several formulae have been proposed for toe stability with conflicting results owing to the neglect of factors such as storm duration and armour layer slope. In the present study, a statically stable rubble mound with rock armoured toe was tested under irregular waves. The effects of wave height, wave period, armour layer slope, water height in front of the structure, water height above the toe, and toe width on the hydraulic stability of a toe structure are investigated. Toe width was found to be ineffective on toe stability, while the relative depth was found as an effective parameter for the toe stability. Greater toe damage was observed by increasing wave height and storm duration. The results highlighted the necessity for a new stability number involving the type of wave breaker on the armour slope with a critical Iribarren value of 4.1. Based on the data from the present study and the findings of another study, new formulae have been developed for estimating toe damage in rubble mound breakwaters. Evaluating the proposed formula using other researchers’ data and formulae highlighted its strengths.

First step toward designing effective real-time control systems in laser directed energy deposition

In-process monitoring and control are essential for quality assurance and consistency of laser-based directed energy deposition processes. Detection of irregularities during deposition in terms of defects or flaws is based on in situ monitoring of output process parameters such as temperature, melt-pool geometry, or deposition height. The real-time feedback of these output parameters allows the development of control strategies for real-time adjustment of input process parameters, such as laser power or scanning speed, to correct detected deviations from the desired output process parameters. Therefore, criteria such as sensitivity, stability, correlation, trends, and interactions of the input-output process parameters have a direct impact on controller design, establishing, for example, control limits or tolerance ranges of the output parameters. This paper focuses on the study of the characteristics of output process parameters to input process parameters. This research involves analyzing and comparing the deposition of single tracks under various input process parameters, including laser power and scanning speed. Melt-pool geometry and temperature are estimated from a visual camera and a hyperspectral line camera, whereas the final deposition geometry is obtained from a laser triangulation scanner. The results show the linearity between input and output process parameters, the steadiness of the output process parameters, the relation between melt-pool and final deposition, and offer insights to design effective in-process control systems.

Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries

BackgroundNeurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propagate BBB disruption. Oxidative damage results in an imbalance of mitochondrial homeostasis, which can further drive functional impairment of brain capillaries. To this end, we developed a method to track mitochondrial-related changes after oxidative stress in the context of neurovascular pathophysiology as a critical endophenotype of neurodegenerative diseases.MethodsTo study brain capillary-specific mitochondrial function and dynamics in response to oxidative stress, we developed an ex vivo model in which we used isolated brain capillaries from transgenic mice that express dendra2 green specifically in mitochondria (mtD2g). Isolated brain capillaries were incubated with 2,2’-azobis-2-methyl-propanimidamide dihydrochloride (AAPH) or hydrogen peroxide (H2O2) to induce oxidative stress through lipid peroxidation. Following the oxidative insult, mitochondrial bioenergetics were measured using the Seahorse XFe96 flux analyzer, and mitochondrial dynamics were measured using confocal microscopy with Imaris software.ResultsWe optimized brain capillary isolation with intact endothelial cell tight-junction and pericyte integrity. Further, we demonstrate consistency of the capillary isolation process and cellular enrichment of the isolated capillaries. Mitochondrial bioenergetics and morphology assessments were optimized in isolated brain capillaries. Finally, we found that oxidative stress significantly decreased mitochondrial respiration and altered mitochondrial morphology in brain capillaries, including mitochondrial volume and count.ConclusionsFollowing ex vivo isolation of brain capillaries, we confirmed the stability of mitochondrial parameters, demonstrating the feasibility of this newly developed platform. We also demonstrated that oxidative stress has profound effects on mitochondrial homeostasis in isolated brain capillaries. This novel method can be used to evaluate pharmacological interventions to target oxidative stress or mitochondrial dysfunction in cerebral small vessel disease and neurovascular pathophysiology as major players in neurodegenerative disease.

Experience of using multimodal opioid-saving anesthesia in children: single-center prospective randomized study

BACKGROUND: In the protocols of rapid recovery after surgery, it is recommended to avoid long-term administration and/ or high doses of opioids in order to reduce the severity of their adverse reactions in the postoperative period. In this regard, opioid-sparing anesthesia (OSA) may become a promising approach to the treatment of cancer patients. AIM. To evaluate the effectiveness of multimodal OSA in the scheme "dexmedetomidine+ketamine (in subanesthetic doses)+lidocaine (intravenous infusion)" in pediatric oncosurgery. MATERIALS AND METHODS: A single-center prospective randomized study involved 40 children aged 12 to 18 years. Patients were divided into 2 groups depending on the method of anesthesia: in group I (n=20), combined endotracheal anesthesia with opioids was performed, in group II (n=20) — multimodal OCA based on intravenous infusion of lidocaine, dexmedetomidine and subanesthetic doses of ketamine. The patients underwent extended operations in the head and neck area in the volume of thyroidectomy with fascial-sheath lymph dissection and excision of the central tissue of the neck from 2 sides. RESULTS: With stable intraoperative hemodynamic parameters, the median total intraoperative need for analgesics in group II was: for lidocaine— 351 (289.6; 418.5) mg (which is 1.75mg/kg per hour), for dexmedetomidine— 88.2 (38.5; 119.7) µg, for ketamine — 21.6 (17.4; 27.3mg. In group I, the median total intraoperative need for fentanyl was 273.7 (406; 240.9)µg. In addition, in group I, the median amount required for postoperative analgesia of the synthetic opioid analgesic tramadol was 419 (365.6; 479)mg (which is 7.8mg/kg; p=0.01). In group II, the median amount of lidocaine required for postoperative analgesia (1 mg/kg per hour) turned out to be 1377.3 (735.7; 1894)mg, while additional tramadol administration at a dose of 57.3 (28.5; 107.7)mg was required in only 7(35%) patients. CONCLUSION: Multimodal OSA based on dexmedetomidine, lidocaine, ketamine and sevoflurane is an effective and safe method of anesthesia in children from 12 to 18 years old, which is not inferior to opioid analgesics in the treatment of perioperative pain during surgical interventions on the thyroid and parathyroid glands in cancer patients, and also reduces the number of adverse reactions characteristic of opioids.