Stability Of Ring Research Articles

Mejora significativa de la estabilidad a carga axial con el fijador externo pélvico pretensado: análisis biomecánico en un modelo con lesión Tile tipo C

ObjectiveThe aim of our work is to check if the use of a pre-tensed bar connected to 2supra-acetabular Schanz pins is more stable in a pelvic with a tile C1 injury. Material and methodsWe used synthetic pelvis (N=5) with a unstable vertical injury, stabilized with both the standard and the pre-tensed system. They both were submitted to axial loading. We measured applied forces and the position of markers that were positioned in the sacroiliac and symphysis joints. We determined the relative movements between injured surfaces, rigidity, resistance and when each system failed. ResultsWhen using the pre-tensed fixator, the rigidity was much higher in the sacro-iliac joint (P=.043) being 3.45 times higher, being also 2.06 times higher in pubic symphysis (P=.043). The resistance against failure was 2 times higher too (P=.043). DiscussionThe increased axial stability with the pre-tensed external fixator accords with its ability to make active compression in both posterior and anterior elements of the pelvic ring, which was previously demonstrated. This result supports the preliminary clinic outcomes that were obtained. ConclusionsThe pre-tensed external fixator increases the axial stability of the pelvic ring's posterior elements in a synthethic pelvis with a Tile C1 injury, without decreasing it's capacity to achieve an anterior stability.

Infected pseudarthrosis of the symphysis with persisting instability : Revision osteosynthesis with tantalum cage and silver ionized ITS plate after peri-implant infection with MRSE after osteosynthetic stabilization of atypeC pelvic injury

Overall symptomatic pseudathrosis after pelvic ring fracture is rare. A pseudarthrosis of the dorsal pelvic ring often leads to persisting pain due to instability and needs a consequent treatment strategy. Often a bacterial infection can be found in persisting pseudarthrosis notably in the anterior pelvic ring region. It is assumed that the peculiar anatomical site of the surgical approach - pubic region and abdominal skinfold - in particular accompanied with adipositas is predestined. Often patients with pseudathrosis and proof of bacterial infection show no symptoms. In these cases treatment is not mandatory. Patients however who complain about persisting pain limited treatment options exist.The following case report demonstrates atreatment strategy to achieve pelvic ring stability and infection eradication using a silver ionised plate and screws as well as a tantalum cage.

Assembly dynamics of FtsZ and DamX during infection-related filamentation and division in uropathogenic E. coli

During infection of bladder epithelial cells, uropathogenic Escherichia coli (UPEC) can stop dividing and grow into highly filamentous forms. Here, we find that some filaments of E. coli UTI89 released from infected cells grow very rapidly and by more than 100 μm before initiating division, whereas others do not survive, suggesting that infection-related filamentation (IRF) is a stress response that promotes bacterial dispersal. IRF is accompanied by unstable, dynamic repositioning of FtsZ division rings. In contrast, DamX, which is associated with normal cell division and is also essential for IRF, is distributed uniformly around the cell envelope during filamentation. When filaments initiate division to regenerate rod cells, DamX condenses into stable rings prior to division. The DamX rings maintain consistent thickness during constriction and remain at the septum until after membrane fusion. Deletion of damX affects vegetative cell division in UTI89 (but not in the model E. coli K-12), and, during infection, blocks filamentation and reduces bacterial cell integrity. IRF therefore involves DamX distribution throughout the membrane and prevention of FtsZ ring stabilization, leading to cell division arrest. DamX then reassembles into stable division rings for filament division, promoting dispersal and survival during infection.

Sacral fractures in geriatric patients

Sacral fractures in geriatric patients are increasing and form a distinct entity. Clinical findings can be unspecific, which is why they are easily overlooked. It is mandatory to analyze the whole pelvic ring for evaluation of pelvic stability and for making treatment decisions. The primary diagnostics are made using plain X‑radiography; however, for assessment of the posterior pelvic ring an examination using sectional imaging is regularly necessary. The fragility fractures of the pelvis (FFP) classification is suitable as a guideline for the surgical treatment to be used. Stable fractures without relevant displacement after initial mobilization should be treated conservatively. Instability, failure of mobilization and persistent pain are, however, common reasons for surgical treatment. Fracture displacement determines if minimally invasive procedures for posterior and anterior pelvic ring stabilization are possible. Otherwise, complex open procedures such as spinopelvic fixation may be necessary.

Synthesis and Isolation of a Kekulé Hydrocarbon with a Triplet Ground State.

Design, synthesis, and isolation of a Kekulé hydrocarbon with a triplet ground state is described. Its triplet ground state was unambiguously confirmed by ESR experiments, and the structure and fundamental physical properties were also revealed. The key feature of the molecular design is the decrease in the bonding interaction in the singlet state by aromatic stabilization of benzene rings and the increase of the exchange interaction of unpaired electrons which are favorable for the triplet state. These results contribute to the development of hydrocarbon-based organic magnetic materials.

Synthesis and Isolation of a Kekulé Hydrocarbon with a Triplet Ground State

AbstractDesign, synthesis, and isolation of a Kekulé hydrocarbon with a triplet ground state is described. Its triplet ground state was unambiguously confirmed by ESR experiments, and the structure and fundamental physical properties were also revealed. The key feature of the molecular design is the decrease in the bonding interaction in the singlet state by aromatic stabilization of benzene rings and the increase of the exchange interaction of unpaired electrons which are favorable for the triplet state. These results contribute to the development of hydrocarbon‐based organic magnetic materials.

What's New in Orthopaedic Trauma.

What's New in Orthopaedic Trauma.

Cement augmentation in pelvic ring fractures

Cement augmentation of sacroiliac (SI) screws in the posterior pelvic ring has been shown to provide greater biomechanical stability in cadaveric studies. Pelvic ring fractures are relatively rare compared to the total number of fractures. Nevertheless, the 1‑year mortality rate of up to 27% is very high, especially for geriatric pelvic ring fractures and is also largely associated with reduced mobility due to the fracture. The primary goal of treatment is therefore the restoration of patient mobility. This requires the achievement of sufficient stability of the pelvic ring. As osteoporosis is often acausative factor for the pelvic ring fracture, amore stable anchoring of the implants in the osteoporotic bone can be achieved by cement augmentation. This article presents the possibilities of cement augmentation of the pelvic ring and describes the technique of cement-augmented SI screws.

MP25-17 PELVIC INSUFFICIENCY FRACTURE—AN UNDERRECOGNIZED CAUSE OF PAIN AFTER PUBECTOMY

You have accessJournal of UrologyCME1 May 2022MP25-17 PELVIC INSUFFICIENCY FRACTURE—AN UNDERRECOGNIZED CAUSE OF PAIN AFTER PUBECTOMY Molly DeWitt-Foy, Ranveer Vasdev, and Sean Elliott Molly DeWitt-FoyMolly DeWitt-Foy More articles by this author , Ranveer VasdevRanveer Vasdev More articles by this author , and Sean ElliottSean Elliott More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002568.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Pubectomy is traditionally used in repair of complex pelvic fracture urethral injuries (PFUI) but is now increasingly used in the management of pubic osteomyelitis that results from prostate cancer treatment. Classically, pubectomy after PFUI is thought to not disrupt the stability of the pelvic ring. However, this has not been studied in detail in patients with osteomyelitis, who often have comorbid conditions that may alter said stability and increase risk of fracture.). Our aim is to document the incidence, presentation and risk factors of sacral insufficiency fracture (SIF) in patients who have undergone pubectomy for osteomyelitis. METHODS: Retrospective chart review was performed of patients undergoing pubectomy for osteomyelitis at a single institution from 2016-2021. Descriptive statistics and univariate analysis were performed using R. Wilcoxon rank-sum test and Fisher exact test were used as appropriate. RESULTS: Sixteen patients underwent pubectomy for osteomyelitis, all after prostate radiotherapy. Mean age was 68 years and mean BMI 28.5. Six (37.5%) underwent cystectomy with urinary diversion at the time of pubectomy, 4 (23.5%) had cystectomy prior to pubectomy. Eleven (68.7%) had postoperative cross-sectional pelvic imaging, of which 3 (25%) were found to have a new SIF; one additional patient had SIF prior to pubectomy. Three SIFs were detected on MRI and one on CT scan. All patients were symptomatic of SIF, most commonly with new pelvic or perineal pain. The median BMI of patients with SIF was significantly lower than those without SIF (22.4 v 30.5, p value=0.004). Age, chronic kidney disease, bone metastasis, hyperbaric oxygen, diabetes, and androgen deprivation therapy were not significantly associated with risk of SIF. CONCLUSIONS: Sacral insufficiency fracture is a rarely described sequela of pubectomy for osteomyelitis. Lower BMI is significantly associated with SIF, perhaps indicative of overall frailty. Source of Funding: NA © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e435 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Molly DeWitt-Foy More articles by this author Ranveer Vasdev More articles by this author Sean Elliott More articles by this author Expand All Advertisement PDF DownloadLoading ...

Elucidating the Dynamics and Selective Mechanistic Mode of Inhibition of a Novel Poly ADP-Ribose Polymerase-1 Inhibitor

: Poly ADP-ribose polymerase-1 (PARP-1), due to its role in DNA damage and repair, has been identified as a crucial therapeutic target to attenuate cancer development and progression. More so, selective inhibition has remained a focal point in PARP-1 targeting and has led to the development of numerous compounds, including the recently identified Cpd10n, a novel homoerythrina alkaloid derivative. To expound on the selective PARP-1 inhibition mechanisms by Cpd10n, we employed computational simulation methods in this study. Findings revealed that the inhibitor stabilized the characteristic motion of activated PARP-1 as evidenced by reductions in residual deviations and structural flexibility. Findings further revealed that Cpd10n was favorably bound at the active site PARP-1 as supported by the occurrence of strong hydrogen and halogen bonds based on complementarity. These were in addition to aromatic bonds with an enhanced ring to ring stability. Steady and high-affinity interactions between the fluorine atom of Cpd10n and Glu988 could potentiate the selective activity of the compound. Interaction analyses also revealed that inhibitor binding was strongly dependent on electrostatic effects over van der Waal contributions, which were relatively minimal. We believe findings from this study will further contribute to the rational structure-based design of highly selective PARP-1 inhibitors.

Stabilization of hexazine rings in potassium polynitride at high pressure.

Polynitrogen molecules are attractive for high-energy-density materials due to energy stored in nitrogen-nitrogen bonds; however, it remains challenging to find energy-efficient synthetic routes and stabilization mechanisms for these compounds. Direct synthesis from molecular dinitrogen requires overcoming large activation barriers and the reaction products are prone to inherent inhomogeneity. Here we report the synthesis of planar N62- hexazine dianions, stabilized in K2N6, from potassium azide (KN3) on laser heating in a diamond anvil cell at pressures above 45 GPa. The resulting K2N6, which exhibits a metallic lustre, remains metastable down to 20 GPa. Synchrotron X-ray diffraction and Raman spectroscopy were used to identify this material, through good agreement with the theoretically predicted structural, vibrational and electronic properties for K2N6. The N62- rings characterized here are likely to be present in other high-energy-density materials stabilized by pressure. Under 30 GPa, an unusual N20.75--containing compound with the formula K3(N2)4 was formed instead.

Biomechanical evaluation of seven fixation methods to treat pubic symphysis diastasis using finite element analysis

BackgroundPubic symphysis diastasis (PSD) hinders the connection between bilateral ischia and pubic bones, resulting in instability of the anterior pelvic ring. PSD exceeding 25 mm is considered disruptions of the symphyseal and unilateral/bilateral anterior sacroiliac ligaments and require surgical intervention. The correct choice of fixation devices is of great significance to treat PSD. This study aimed to evaluate the construct stability and implant performance of seven fixation methods to treat PSD using finite element analysis.MethodsThe intact skeleton-ligament pelvic models were set as the control group. PSD models were simulated by removing relevant ligaments. To enhance the stability of the posterior pelvic ring, a cannulated screw was applied in the PSD models. Next, seven anterior fixation devices were installed on the PSD models according to standard surgical procedures, including single plates (single-Plate group), single plates with trans-symphyseal cross-screws (single-crsPlate group), dual plates (dual-Plate group), single cannulated screws, dual crossed cannulated screws (dual-canScrew group), subcutaneous plates (sub-Plate group), and subcutaneous pedicle screw-rod devices (sub-PedRod group). Compression and torsion were applied to all models. The construct stiffness, symphyseal relative micromotions, and von Mises stress performance were recorded and analyzed.ResultsThe construct stiffness decreased dramatically under PSD conditions. The dual-canScrew (154.3 ± 9.3 N/mm), sub-Plate (147.1 ± 10.2 N/mm), and sub-PedRod (133.8 ± 8.0 N/mm) groups showed better ability to restore intact stability than the other groups (p < 0.05). Regarding regional stability, only single-plate fixation provided unexpected regional stability with a diastasis of 2.1 ± 0.2 mm (p < 0.001) under a compressive load. Under a rotational load, the single-crsPlate group provided better regional angular stability (0.31° ± 0.03°, p < 0.001). Stress concentrations occurred in the single-Plate, sub-Plate, and sub-PedRod groups. The maximum von Mises stress was observed in the single-plate group (1112.1 ± 112.7 MPa, p < 0.001).ConclusionThe dual-canScrew fixation device offers ideal outcomes to maintain stability and prevent failure biomechanically. The single-crsPlate and dual-Plate methods effectively improved single-Plate device to enhance regional stability and disperse stresses. The subcutaneous fixation devices provided both anterior pelvic ring stability and pubic symphysis strength.

Pelvic ring injuries: classification and treatment

This review article will focus on the classification and treatment options for pelvic ring fractures. The pelvic ring can be split into anterior and posterior supporting structures. Injury can result in mechanical pelvic instability, the significance of which is determined by the magnitude and direction of forces applied during injury. The typical fracture patterns of anteroposterior compression, lateral compression and vertical shear form the basis of the Young and Burgess classification. However, the logic of the Tile classification system is useful in determining the degree of pelvic instability and the optimal surgical stabilization options. Posterior pelvic ring stabilization is often performed percutaneous after closed fracture reduction with sacro-iliac screws. This avoids the soft tissue complications often associated with open posterior approaches. Alternative reduction techniques can be performed through an open anterior approach using the first ilio-inguinal window to approach sacro-iliac joint disruptions as well as crescent fractures of the posterior iliac wing. The anterior pelvic ring, traditionally stabilized with external fixation, can be well accessed with the open ‘STOPPA’ approach. This allows access to an area extending from the pubic symphysis around the pelvic brim to the anterior aspect of the sacro-iliac joint where plates can be applied. Other options for anterior ring stabilization include column screws and the use of the ‘In-fix’ (Internal Fixator).

Dynamics and Stability of the Contractile Actomyosin Ring in the Cell.

Contraction of the cytokinetic ring during cell division leads to physical partitioning of a eukaryotic cell into two daughter cells. This involves flows of actin filaments and myosin motors in the growing membrane interface at the midplane of the dividing cell. Assuming boundary driven alignment of the actomyosin filaments at the inner edge of the interface, we explore how the resulting active stresses influence the flow. Using the continuum gel theory framework, we obtain exact axisymmetric solutions of the dynamical equations. These solutions are consistent with experimental observations on closure rate. Using these solutions, we perform linear stability analysis for the contracting ring under nonaxisymmetric deformations. Our analysis shows that few low wave number modes, which are unstable during onset of the constriction, later on become stable when the ring shrinks to smaller radii, which is a generic feature of actomyosin ring closure. Our theory also captures how the effective tension in the ring decreases with its radius, causing significant slowdown in the contraction process at later times.

Starr frame-assisted minimally invasive internal fixation for pelvic fractures: Simultaneous anterior and posterior ring stability

ObjectiveWe aimed to investigate the surgical techniques, efficacy, and safety of Starr frame-assisted minimally invasive internal fixation for simultaneous anterior and posterior ring stability in pelvic fractures. MethodsThe clinical data of 22 patients with anterior and posterior pelvic ring injuries who underwent Starr frame-assisted minimally invasive internal fixation were retrospectively collected. The anterior pelvic ring was fixed with an anterior subcutaneous internal fixator (INFIX), and the posterior pelvic ring was fixed with sacroiliac screws. The operative time, intraoperative blood loss, fluoroscopy times, number of assistants, complications, and weight-bearing time were analyzed. The Matta score was used to evaluate the fracture reduction. The Majeed score was used to evaluate clinical efficacy, and Gibbon's classification was used to estimate the occurrence of sacral nerve injury. ResultsAll 22 patients were treated with sacroiliac screws for posterior ring injuries, including 12 cases with single sacroiliac screws, nine with two sacroiliac screws, and one with three sacroiliac screws. INFIX was used for all anterior ring fixation, including two screws in seven cases, three screws in 13 cases, and four screws in two cases. The fracture reduction quality was excellent in 15 cases, good in four cases, and moderate in three cases by Matta scores. All patients were followed up for 6–20 (12.5 ± 5.7) months. Callus-formation time based on postoperative X-ray was 3–8 (4.3 ± 1.2) weeks. Weight-bearing time was 3–12 (6.3 ± 2.8) weeks after surgery. At the last follow-up, 15 patients were evaluated as excellent, five as good, and two as fair according to the Majeed score. Gibbons’ classification showed that one of the three patients with sacral nerve injury recovered completely and two did not recover. Complications occurred in six patients, including one with internal fixation loosening, two with anterolateral thigh paresthesia, one with malunion, one with nonunion, and one with heterotopic ossification. ConclusionsStarr frame-assisted minimally invasive internal fixation could stabilize the anterior and posterior pelvic rings simultaneously, overcoming the difficulty of fracture reduction. This technique can help patients with early postoperative weight-bearing and improved functional outcomes, providing a novel modality for the minimally invasive treatment of pelvic ring injuries.

Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.

The F-BAR protein Cdc15 mediates attachment of the cytokinetic ring (CR) to the plasma membrane and is essential for cytokinesis in Schizosaccharomyces pombe. While its N-terminal F-BAR domain is responsible for oligomerization and membrane binding, its C-terminal SH3 domain binds other partners at a distance from the membrane. We previously demonstrated that the essential cytokinetic formin Cdc12, through an N-terminal motif, directly binds the cytosolic face of the F-BAR domain. Here, we show that paxillin-like Pxl1, which is important for CR stability, contains a motif highly related to that in formin Cdc12, and also binds the Cdc15 F-BAR domain directly. Interestingly, Pxl1 has a second site for binding the Cdc15 SH3 domain. To understand the importance of these two Pxl1-Cdc15 interactions, we mapped and disrupted both. Disrupting the Pxl1-Cdc15 F-BAR domain interaction reduced Pxl1 levels in the CR, whereas disrupting Pxl1’s interaction with the Cdc15 SH3 domain, did not. Unexpectedly, abolishing Pxl1-Cdc15 interaction greatly reduced but did not eliminate CR Pxl1 and did not significantly affect cytokinesis. These data point to another mechanism of Pxl1 CR recruitment and show that very little CR Pxl1 is sufficient for its cytokinetic function.

Contributions of Pubic Rami Fracture Morphology and Fixation to Pelvic Ring Stability in Type 1 Lateral Compression Injuries: A Biomechanical Cadaveric Study.

Treatment of lateral compression type 1 (LC-1) injuries has historically been nonoperative with immediate weight-bearing. However, management of these injuries remains controversial, with reports of displacement at follow-up for nonoperatively managed LC-1 fractures. The goal of our study was to determine the effect of superior pubic ramus fracture morphology and fixation construct on pelvic stability. Ten fresh-frozen cadaveric were transected into hemi-pelvises. Incomplete Denis type 1 sacral fractures were made. Hemi-pelvises were randomized to receive a transverse-type or oblique-type superior pubic ramus fracture with the contralateral hemi-pelvis receiving the opposing morphology. A lateral load to 135N was applied with an Instron materials testing machine and lateral displacement of the hemi-pelvis was recorded. Deflection and stiffness were calculated. Statistical analysis was conducted using a t test assuming unequal variances with an alpha = 0.05. Oblique-type superior pubic ramus fractures allowed more deflection compared with transverse-type fractures in the absence of fixation (P = 0.018). The posterior-only and combined anterior and posterior fixation configurations on average reduced deflection more than no fixation or anterior fixation only. In all fixation configuration cases, the average deflection for transverse-type fractures was less than that of the oblique-type fractures. Our findings suggest that displacement of LC-1 pelvic injuries may be related to pubic rami fracture morphology. When looking at initial injury imaging, oblique-type pubic rami fractures may suggest an increased potential for displacement over time. In such cases, we recommend an examination under anesthesia to evaluate for underlying instability and consideration for fixation. Therapeutic Level V.

Instabilities of a vortex-ring-bright soliton in trapped binary three-dimensional Bose-Einstein condensates

Instabilities of vortex-ring-bright coherent structures in harmonically trapped two-component three-dimensional Bose-Einstein condensates are studied numerically within the coupled Gross-Pitaevskii equations and interpreted analytically. Interestingly, the filled vortex core with a sufficiently large amount of the bright component is observed to reduce the parametric interval of stability of the vortex ring. We have identified the mechanisms of several linear instabilities and one nonlinear parametric instability in this connection. Two of the linear instabilities are qualitatively different from ones reported earlier, to our knowledge, and are associated with azimuthal modes of $m=0$ and $m=1$, i.e., deviations of the vortex from the stationary ring shape. Our nonlinear parametric resonance instability occurs between the $m=0$ and $m=2$ modes and signals the exchange of energy between them.

Simple Multiuser Twin-Field Quantum Key Distribution Network

Twin-field quantum key distribution (TFQKD) systems have shown great promise for implementing practical long-distance secure quantum communication due to its measurement-device-independent nature and its ability to offer fundamentally superior rate-loss scaling than point-to-point QKD systems. A surge of research and development effort in the last two years has produced many variants of protocols and experimental demonstrations. In terms of hardware topology, TFQKD systems interfering quantum signals from two remotely phase-locked laser sources are in essence giant Mach-Zehnder interferometers (MZIs) requiring active phase stabilization. Such configurations are inherently unsuitable for a TFQKD network, where more than one user-pair share the common quantum measurement station, because it is practically extremely difficult, if not impossible, to stabilize MZIs of largely disparate path lengths, a situation that is inevitable in a multi-user-pair TFQKD network. On the other hand, Sagnac interferometer based TFQKD systems exploiting the inherent phase stability of the Sagnac ring can implement asymmetric TFQKD, and are therefore eminently suitable for implementing a TFQKD network. In this work, we experimentally demonstrate a proof-of-principle multi-user-pair Sagnac TFQKD network where three user pairs sharing the same measurement station can perform pair-wise TFQKD through time multiplexing, with channel losses up to 58 dB, and channel loss asymmetry up to 15 dB. In some cases, the secure key rates still beat the rate-loss bounds for point-to-point repeaterless QKD systems, even in this network configuration. It is to our knowledge the first multi-user-pair TFQKD network demonstration, an important step in advancing quantum communication network technologies.

Quantitative Resonance Theory Based on the Clar Sextet Model.

Despite its great explanatory power in understanding the chemistry of polycyclic aromatic hydrocarbons (PAHs) and related systems, the Clar sextet rule still remains an intuitive and qualitative model with notable exceptions in some cases. Here we develop a quantitative theory of chemical resonance based on semilocalized Clar-type resonance structures (named the Clar resonators) consisting of variable numbers of Clar sextets and C═C bonds. The constructed wave functions of the Clar resonators are used to expand the actual wave function of the π-conjugated system obtained from a DFT or Hartree-Fock calculation. The resultant weights and one-electron energies of the Clar resonators can serve as a quantitative measure of the importance of these resonators. Implementing the theory in our open-source python code EzReson and applying it to over a thousand PAH molecules of different sizes and shapes, we show that the weight of the Clar resonators increases exponentially with increasing number of sextets and that their energy decreases linearly with the latter, thus confirming the general validity of the Clar rule. On the basis of such a large-scale resonance analysis, we propose three extended Clar rules, along with a unified quantitative model, that are able to evaluate the importance of all Clar resonators and the ring aromaticity for PAHs. Using the present theories, we uncover the essential role that the minor Clar resonators may play in correctly understanding the resonance stabilization and local aromaticity of rings, which was totally overlooked in the original Clar model.