AbstractBackgroundA pathological Hallmark of Alzheimer’s Disease (AD) is the significant deposition of amyloid beta (Aβ) plaques in the brain. Several studies were reported to inhibit the Aβ fibrillation using nanoparticles, nanoclusters and bioconjugate nanomaterials for Alzheimer’s treatment. In recent years, natural compound (phytochemicals) have been largely used to study and identified as promising agents for the prevention and treatment of neurodegenerative diseases including AD.MethodGold nanoparticle with appropriate surface conjugates with higher affinity has been studied and acknowledge the interaction between Bio‐Nano interfaces. The surface covering or anchoring conjugates will play a major role in vitro and in vivo. Herein, we reported Epigallocatechin gallate (EGCG) stabilized gold nanoparticle (AuNps) were synthesised as a Aβ inhibitor.ResultThe synthesised EGCG‐AuNps Characterized using UV‐Vis Spectroscopy, DLS, XRD, SEM (EDAX) and TEM (SAED) and the biocompatibility were studied by using MTT and scratch assay. The synthesised EGCG‐AuNPs inhibiting Aβ aggregation, dissociation Aβ fibrils which lead to prevent plaque formation, which confirmed using Thioflavin T‐assay and TEM studies.ConclusionThis work provides new insights into the synthesised AuNps as functional therapeutic agent for AD.