The intention of the current study was to investigate the Physico-chemical characteristics of Dexibuprofen loaded nanoparticles. Dexibuprofen is an NSAID - non-steroidal anti-inflammatory drug intended for the treatment of rheumatoid arthritis related symptoms. In current market trends, the tablets and capsule dosage forms captures major market contribution. A systematic evaluation of physico chemical characteristics of the drug powder, it’s characteristics was performed as a basic step at the start of formulation development of the dosage form. The formulation development approach is decided based on the above data. Dexibuprofen nanoparticles was developed by an Ionotropic pre gelation technique comprising Chitosan, Calcium chloride and Sodium alginate as coating material. The preformulation evaluation of Dexibuprofen and it’s compatibility with selected excipients was performed to design an appropriate strategy for the development of Dexibuprofen modified release nanoparticles. The parameters like melting point, pKa, solubility, dissolution and assay method development, solid state stability, solution stability, flow properties, bulk density, microscopical assessment, entrapment efficiency, excipients compatibility, and nanoparticles release profile were evaluated. The results of this study, along with the experimental values, will be discussed in detail.