ST Wave Research Articles

Cardioprotective effect of chelidonic acid against doxorubicin-induced cardiac toxicity in rats

Introduction and objectivesThe current study evaluates the effect of chelidonic acid on doxorubicin-induced cardiac toxicity. Chelidonic acid (CA) is a natural pyran-skeleton heterocyclic compound found in rhizomes of the perennial plant, celandine (Chelidonium majus). MethodsWistar rats were given an intraperitoneal injection of doxorubicin (1.25 mg/kg, cumulative dose of 20 mg/kg) four times per week for a duration of four weeks to induce cardiotoxicity. CA treatment (10, 20, and 40 mg/kg orally for four weeks) was started together with doxorubicin. ResultsCA treatment reduced myocardial damage and improved cardiac dysfunction in doxorubicin-treated rats. It improved blood pressure, restored ST wave height and normalized the QTc interval compared to the rats treated only with doxorubicin. Administration of CA for four weeks reduced left ventricular end-diastolic pressure. Moreover, CA treatment decreased the level of cardiac markers such as creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and cardiac troponin-T. Masson's trichrome, hematoxylin, and eosin staining of heart tissue revealed that CA attenuated the deleterious effects of doxorubicin and prevented further damage and fibrosis in rats. ConclusionThe study findings confirm that CA treatment can protect the myocardium against doxorubicin-induced cardiotoxicity.

“备案制”转变对会计师事务所证券审计市场的影响——以*ST浪奇为例

“备案制”转变对会计师事务所证券审计市场的影响——以*ST浪奇为例

THE CHATTERJEE PHENOMENON: A DEMONSTRATION OF CARDIAC MEMORY IN PACED RHYTHMS.

While T-wave inversions (TWI) are associated with various pathologies, they are rarely associated with cardiac memory, termed the Chatterjee phenomenon. A 76-year-old man with sick sinus syndrome with a pacemaker presented with chest tightness and new onset TWI in his precordial leads. On admission, he tested positive for COVID-19, but remained stable and only required minimal supplemental oxygen. His troponin was only slightly elevated, and EKG showed TWI throughout his precordial leads. A previous EKG had shown normal sinus rhythm without a paced rhythm or ST wave abnormalities. Interrogation of his pacemaker revealed an AV-paced rhythm. Given his chest tightness without dynamic changes in his troponin or EKG, the symptoms were considered more likely related to his COVID-19 infection, and he was discharged home. Aberrancies in normal cardiac conduction can result in altered electrical activation, especially for those with AV pacemakers, leading some patients to develop cardiac memory, manifesting as TWI. AV-paced rhythm and narrow QRS complexes with TWI localized to precordial leads without evidence of active cardiac ischaemia may suggest cardiac memory, termed the Chatterjee phenomenon, requiring no invasive interventions. In patients with T-wave inversions, various conditions should considered in the differential diagnosis, including left bundle branch block and sick sinus syndrome, although T-wave inversions in V1-V3 are non-specific and benign.Cardiac memory, termed the Chatterjee Phenomenon, is one of the causes of T-wave inversions which is sometimes ignored.No invasive interventions are needed for T-wave inversions with the Chatterjee phenomenon.

Observation of Ultrabroadband Striped Space-Time Surface Plasmon Polaritons

Because surface plasmon polaritons (SPPs) are surface waves characterized by one free transverse dimension, the only monochromatic diffraction-free spatial profiles for SPPs are cosine and Airy waves. Pulsed SPP wave packets have been recently formulated that are propagation-invariant and localized in the in-plane dimensions by virtue of a tight spectral association between their spatial and temporal frequencies, which have thus been dubbed “space-time” (ST) SPPs. Because of the spatiotemporal spectral structure unique to ST-SPPs, the optimal launching strategy of such novel plasmonic field configurations remains an open question. We present here a critical step toward realizing ST-SPPs by reporting observations of ultrabroadband striped ST-SPPs. These are SPPs in which each wavelength travels at a prescribed angle with respect to the propagation axis to produce a periodic (striped) transverse spatial profile that is diffraction-free. We start with a free-space ST wave packet that is coupled to a ST-SPP at a gold-dielectric interface, and unambiguously identify the ST-SPP via an axial beating detected in two-photon fluorescence produced by the superposition of incident ST wave packet and the excited surface-bound ST-SPP. These results highlight a viable approach for efficient and reliable coupling to ST-SPPs and, thus, represent the first crucial step toward realization of the full potential of ST-SPPs for plasmonic sensing and imaging.

Evaluating the Utility of High Sensitivity Troponin in Blunt Cardiac Injury

IntroductionScreening for blunt cardiac injury (BCI) includes obtaining a serum troponin level and an electrocardiogram for patients diagnosed with a sternal fracture. Our institution has transitioned to the use of a high sensitivity troponin I (hsTnI). The aim of this study was to determine whether hsTnI is comparable to troponin I (TnI) in identifying clinically significant BCI. Materials and methodsTrauma patients presenting to a level I trauma center over a 24-mo period with the diagnosis of sternal fracture were screened for BCI. Any initial TnI more than 0.04 ng/mL or hsTnI more than 18 ng/L was considered positive for potential BCI. Clinically significant BCI was defined as a new-bundle branch block, ST wave change, echocardiogram change, or need for cardiac catheterization. ResultsTwo hundred sixty five patients with a sternal fracture were identified, 161 underwent screening with TnI and 104 with hsTnI. For TnI, the sensitivity and specificity for detection of clinically significant BCI was 0.80 and 0.79, respectively. For hsTnI, the sensitivity and specificity for detection of clinically significant BCI was 0.71 and 0.69, respectively. A multivariate analysis demonstrated the odds ratio for significant BCI with a positive TnI was 14.4 (95% confidence interval, 3.9-55.8, P < 0.0001) versus an odds ratio of 5.48 (95% confidence interval 1.9-15.7, P = 0.002) in the hsTnI group. ConclusionsThe sensitivity of hsTnI is comparable to TnI for detection of significant BCI. Additional investigation is needed to determine the necessity and interval for repeat testing and the need for additional diagnostic testing.

Prevalence and Associated Factors of Electrocardiogram Abnormalities in Patients With Systemic Lupus Erythematosus: A Machine Learning Study.

Electrocardiogram (EKG) abnormalities are predictive of subsequent cardiovascular events. Cardiac involvement is common in systemic lupus erythematosus (SLE). We aimed to determine the prevalence of EKG abnormalities in SLE patients and to examine the factors associated with EKG abnormalities with machine learning approaches. Consecutive SLE patients' records were retrieved from the database of the hospital for the cross-sectional study. Abnormal EKGs with clinical significance were grouped by the presence of tachyarrhythmias, atrioventricular block, nonspecific ST segment changes, T wave abnormalities, ventricular hypertrophy, axis deviation, bundle branch block, and QT interval prolongation. Associated factors of the most common EKG abnormalities were assessed by comparing logistic regression and 4 other machine learning approaches. In the present study, 299 patients were enrolled, with 128 showing clinically significant abnormalities on EKG. T wave changes (52.3%), nonspecific ST segment-T wave (ST-T) changes (26.6%), and prolonged QT interval (8.6%) were the most prevalent abnormalities among patients with abnormal findings on EKG. Random forests models had the best performance in the discovery of associated factors. Age, disease duration, antinuclear antibody titer, disease activity (as measured by the Systemic Lupus Erythematosus Disease Activity Index 2000) were associated with nonspecific ST-T changes, prolonged QT interval, and T wave changes. Hypertension, positivity for anti-SSA antibodies, and secondary Sjögren's syndrome were influential factors for nonspecific ST-T changes, prolonged QT interval, and T wave changes, specifically. ST-T and T wave changes were the most common abnormalities seen on EKGs of SLE patients. Our finding suggests that age, longer disease duration, higher disease activity, hypertension, anti-SSA antibody positivity, and secondary Sjögren's syndrome are important and influential factors in these EKG abnormalities.

Diagnostic and prognostic implications of right ventricular-arterial coupling in cardiac amyloidosis and in genetic and non-genetic cardiomyopathies with hypertrophic phenotype

Abstract Funding Acknowledgements Type of funding sources: None. BACKGROUND &amp; PURPOSE. Right ventricular (RV) dysfunction in cardiomyopathies is a consequence of chronic overload (i.e. aortic stenosis, AS) or direct involvement of systemic disorders (i.e. cardiac amyloidosis, CA). The Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure (TAPSE/sPAP) ratio has been recently proposed as a surrogate of RV-arterial coupling (RVAC). This study aims to compare RVAC between CA subgroups and between CA and other forms of genetic and non-genetic cardiomyopathies with hypertrophic phenotype. METHODS. We enrolled 50 patients with CA (26 AL and 24 wtATTR) and 75 cardiomyopathies with hypertrophy phenotype (LVH group) [25 pts with hypertrophic cardiomyopathy (HCM), 25 hypertensive pts(HypCM), and 25 pts with AS]. Besides routine echocardiographic measurements, we analysed right chambers dimensions and classical and novel parameters of RV function [TAPSE, TAPSE/sPAP, St wave, global (RVGLS) and free-wall (RVFWS) strain]. RESULTS. Compared to AL, the ATTR group showed higher right chambers dimensions, without differences in all RV systolic parameters. Compared to the LVH group, CA patients showed no differences in RV dimensions while RV systolic parameters, including the TAPSE/sPAP ratio, were significantly reduced in the presence of significantly higher LV filling pressures. At ROC curve analysis, TAPSE (AUC 0.877; 95% CI: 0.811-0.943; p &amp;lt; 0,0001) and TAPSE/sPAP ratio (AUC 0.859; 95% CI: 0.783-0.935; p &amp;lt; 0,0001) showed the best ability in discriminating CA among other forms of LVH (cut-off 20.5 mm for TAPSE with sensibility of 80.5% and specificity of 78.8%, respectively; cut-off 0.62 for TAPSE/sPAP ratio with sensibility of 85.4% and specificity 81.8%). At 24 months follow-up, there were 15 deaths in CA (30%) and 4 in LVH group (5%). At Kaplan-Meier estimation, the TAPSE/sPAP ratio showed progressively a significantly reduced survival in the lowest interquartile ranges. Moreover, at multivariate analysis, TAPSE/sPAP was the only independent prognostic factor (β -5,644; 95% IC: 0,000-0,522; p &amp;lt; 0,027). CONCLUSIONS. The RVAC is significantly impaired in CA compared to the LVH group but not between CA subgroups. Its reduction seems attributable to both increase LV filling pressure, due to the restrictive nature of the infiltrative cardiomyopathy, and reduced RV systolic function, due to either indirect RV chronic overload and direct myocardial infiltration. The TAPSE/sPAP ratio is a surrogate of RVAC and proved to be a novel echocardiographic parameter useful in both discriminating CA among genetic and non-genetic forms of LVH, and stratifying the prognosis. Abstract Table 1 Abstract Figure 1

COMPARISON OF CLINICAL OUTCOMES AND MORTALITY IN COVID 19 PATIENTS ADMITTED DURING THE FIRST VERSUS SECOND WAVE IN THE ICU OF A TERTIARY CARE CENTRE IN NORTH INDIA.

Background-India,like many countries,has experienced two surges of the COVID 19 pandemic.Empirical data shows a difference in the effects of the virus between the two periods.We decided to compare the behaviour of the disease in its two major outbreaks in critically ill patients so as to obtain a better understanding and improve clinical outcomes. Methods- This was a retrospective study conducted by obtaining patients data from hospital records during the first st wave from 1 April 2020 to 30 June 2020 and comparing it to the records in second wave 15 March 2021 to 15 June 2021. Patient demographics,clinical presentation,mechanical ventilation and overall ICU outcomes were compared. Results- 89 patients admitted during first wave and 100 patients admitted during second wave during the chosen period were selected for the purpose of this study. Second wave predominantly involved the young and middle aged while majority of patients during first wave belonged to older age group with co morbidities. The most frequent signs and symptoms during both waves were fever,cough,pneumonia and tachypnea. Conclusion- The second wave was characterised by higher infectivity in a comparatively younger age group whereas first wave showed older age groups being primarily infected. However, the case fatality rate during first wave was higher than second wave.

Noninvasive Predictors of Coronary Slow Flow Phenomenon in Patients Presenting with Chronic Coronary Syndrome

Background: Patients with coronary slow flow phenomenon (CSFP) exhibit the following characteristics: Predominantly middle-aged males, the majority have mixed pattern angina, persistent chest pain sensations after therapy, and many have had repeated invasive and non-invasive examinations.&#x0D; Objectives: Our study aimed to determine the base of non-invasive predictors of coronary slow flow phenomenon in patients presenting with chronic coronary syndrome.&#x0D; Patients and Methods: This a case-control study included 100 participants of suspected coronary artery disease were divided into two groups matched in age and sex group I: 50 patients with primary CSFP and group II: 50 patients with normal coronary angiography. Each patient was undergoing to demographic data taking, physical investigation, good hydration, restrict fasting hours requested for coronary angiography, 12 lead-Electrocardiogram (ECG)s were obtained for each patient at rest, laboratory parameters, coronary angiography, treadmill exercise ECG, transthoracic echocardiography to assess the thickness of the left ventricle’s (LV) wall, its interior dimensions, as well as the LV’s ejection fraction (EF) using M-mood method and the aortic propagation velocity.&#x0D; Results: male sex and the Canadian Cardiovascular Society Angina grade’s (CCSA) class 3 were significantly decreased in group I compared to group II and male sex, Diabetes mellitus (DM), smoker and CCSA class 4 were substantially increase in group I compared to group II (P &lt;0.05). P wave max, P Wave dispersion (PWd), corrected QT dispersion (QTcd) at resting ECG, T wave inversion and ST Waves segment depression at stress ECG were significantly increase in group I compared to group II. QTc min was significantly lower in group I compared to group II (P &lt;0.05). LA diameter was significantly increased in group I than group II. Aortic propagation velocity was significantly decreased in group I than group II (P &lt;0.05). Hematocrit, total leucocytic count, mean platelet volume and High-sensitivity C-reactive protein (hsCRP) were significantly increase group I compared to group II (P &lt;0.05).&#x0D; Conclusions: Patients suspected of having a coronary artery disease who are diagnosed with coronary slow flow, male sex, dilated LA, CCSA class 3 or 4, elevated hematocrit value, elevated total leucocytic count, increased mean platelet volume, increased HsCRP, P max, PWd, QTcd, T wave inversion, ST segment depression, and decreased aortic propagation were statistically higher in CSFP patient compared to controls.

COVID-19 Pandemic Impact on Chronic Lymphocytic Leukemia (CLL) Patients' Preferences Towards Therapies: The Italian Experience (CHOICE Study)

COVID-19 Pandemic Impact on Chronic Lymphocytic Leukemia (CLL) Patients' Preferences Towards Therapies: The Italian Experience (CHOICE Study)

Electrocardiography can be a clue to underlying cardiomyopathy

Background: Electrocardiography (ECG) is an accessible, low cost diagnostic and prognostic tool. Recent studies have shown increased risk of deaths associated with cardiomyopathy and to study the patients with symptoms of cardiomyopathy on basis of ECG.Methods: A total of 50 patients were explained the procedure and the purpose of the study, informed consent was taken from the patient or the relative in a language they can understand. Required physical examination and necessary investigations were carried out. In our study, maximum subjects had normal voltage (80%) low voltage ECG findings were in 20%, normal QRS complex in 78%, wide QRS complex in 20% LBBB/RBBB in 24%. Evidence of ischemia like T wave changes in 34%, ST wave changes in 24% and tachycardia (26%). Thus ECG can give a clue for diagnosing cardiomyopathy and guide us for further managements but it is not a diagnostic marker for it since most of the patients had normal ECG findings.Results: In our study, electrocardiogram findings among patients are: Maximum subjects had normal voltage (80%). Low voltage ECG findings were in 20%. Normal QRS complex in 78%, wide QRS complex in 20% LBBB/RBBB in 24%. Evidence of ischemia in 58% and tachycardia (26%).Conclusions: ECG is an accessible, low cost diagnostic and prognostic tool. Most common findings in cardiomyopathy is biventricular hypertrophy and left bundle branch block with wide QRS complex, low voltage ECG and ST changes as also seen in present study. Thus, ECG can be initial investigation for cardiomyopathy and can give us clue for further investigations and management.

Isochronous space-time wave packets.

The group delay incurred by an optical wave packet depends on its path length. Therefore, when a wave packet is obliquely incident on a planar homogeneous slab, the group delay upon traversing it inevitably increases with the angle of incidence. Here, we confirm the existence of isochronous "space-time" (ST) wave packets: pulsed beams whose spatiotemporal structure enables them to traverse the layer with a fixed group delay over a wide span of incident angles. This unique behavior stems from the dependence of the group velocity of a refracted ST wave packet on its angle of incidence. Isochronous ST wave packets are observed in slabs of optical materials with indices ranging from 1.38 to 2.5 for angles up to 50° away from normal incidence.

Spectrally recycling space-time wave packets

'Space-time' (ST) wave packets are propagation-invariant pulsed optical beams that travel rigidly in linear media without diffraction or dispersion at a potentially arbitrary group velocity. These unique characteristics are a result of spatio-temporal spectral correlations introduced into the field; specifically, each spatial frequency is associated with a single temporal frequency (or wavelength). Consequently, the spatial and temporal bandwidths of ST wave packets are correlated, so that exploiting an optical source with a large temporal bandwidth or achieving an ultralow group velocity necessitate an exorbitantly large numerical aperture. Here we show that `spectral recycling' can help overcome these challenges. 'Recycling' or `reusing' each spatial frequency by associating it with multiple distinct but widely separated temporal frequencies allows one to circumvent the proportionality between the spatial and temporal bandwidths of ST wave packets, which has been one of their permanent characteristics since their inception. We demonstrate experimentally that the propagation invariance, maximum propagation distance, and group velocity of ST wave packets are unaffected by spectral recycling. We also synthesize a ST wave packet with group velocity c/14.3 (c is the speed of light in vacuum) with a reasonable numerical aperture made possible by spectral recycling.

LABVIEW BASED ECG SIGNAL ACQUISITION AND ANALYSIS

The system “LabVIEW based ECG signal acquisition and analysis” is developed to assist patients and doctors in health care. An arrhythmia is an abnormal heart rhythm. It may be so brief that it doesn’t change the overall heart rate, but it can cause the heart rate to be too slow or too fast. When arrhythmias are severe or last long enough, the heart may not be able to pump enough blood to the body. This can cause the patient to feel tired, lightheaded or may make him pass out. It can also cause death. Before treatment, it’s important for the doctor to know where an arrhythmia starts in the heart and whether it’s abnormal. An electrocardiogram (ECG) is often used to diagnose arrhythmias. “LabVIEW based ECG signal acquisition and analysis” is meant to acquire ECG signals from the patient and analyze it to detect and classify its anomalies and abnormalities. This is achieved by extracting amplitudes and durations of parameters of ECG waveform such as P wave, QRS complex, RR interval, and PR durations. These parameters are compared with the normal values to determine the type of abnormality- Tachycardia or Bradycardia. The database of the patient is maintained for further use by the doctor. The objective of LabVIEW based ECG signal acquisition and analysis aims at acquiring and analyzing temporal parameters of ECG signal such as P wave, QRS complex, RR interval, PR durations and amplitudes of the P wave, ST wave, identification of cardiac arrhythmia using LabVIEW. The research work has helped us to explore various features of LabVIEW like signal processing and automated database generation.

Analysis of normal electrocardiographic patterns in mandarin ducks (Aix galericulata).

Background:Electrocardiographic (ECG) examination in birds is considered an inexpensive and noninvasive diagnostic aid for the recognition of infectious and metabolic diseases. Contrary to other bird species, studies describing normal ECG patterns for mandarin ducks (Aix galericulata) are lacking.Aim:The aim of this study was to describe and evaluate normal ECG patterns in A. galericulata.Methods:Ten clinically healthy mandarin ducks of both sexes, aged between 1 and 2 years and with body weight between 0.8 and 1.2 kg were included. Electrocardiograms were performed in a quiet room with animals conscious and manually restrained. All electrocardiographic parameters were recorded using standard (I, II, and III) and augmented (aVR, aVL, and aVF) limb leads. The paper speed was set at 50 mm/second. The amplitude was 1 mV = 20 mm. Morphological patterns of P, QRS, and T deflections were evaluated in all limb leads. The amplitude and the duration of waves and, their intervals were determined in lead II. The mean electrical axis (MEA) in the frontal plane was calculated using the Bailey hexaxial system.Results:In all birds examined, a regular sinus rhythm was observed. P waves were mainly positive in I, II, III, and aVF. A negative P wave was identified in aVR, while in aVL a great variability was present. The QRS complex was mainly isoelectric in lead I, while it was negative with rS or QS morphology in leads II, III, and aVF. A positive polarity of QRS was detected in aVL with R pattern, while it was negative or positive with QS or R morphology, respectively, in aVF. T waves were mostly positive in leads II, III, and aVF and, isoelectric in lead I. ST slurring and Ta wave were observed in 2/10 and 8/10, respectively. The mean heart rate was 246 ± 90 beats per minute and the MEA was −88.8° ± 9.57°.Conclusion:The ECG tracings of mandarin ducks show similarities and some differences with other avian species. The electrocardiographic values provided here can be used to assist in the interpretation of ECG in A. galericulata.

Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model.

Boric acid and omega-3 are used as essential elements for both animal and human health. Many researchers have shown these beneficial effects on cardiac and inflammatory markers. This study aims to evaluate cardiac protective effect of boric acid and omega-3 against MI (myocardial infarction), probably due to the suppression of pro-inflammatory cytokines of natriuretic peptides in rats. Fifty male Sprague-Dawley rats were randomly divided into five groups: control, MI, MI+boric acid, MI+omega-3, and MI+boric acid+omega-3. Saline solution (2ml/day), omega-3 (800mg/kg/day), and boric acid (100mg/kg/day)+omega-3 (800mg/kg/day) were orally administered to the relevant groups throughout the 28days. To constitute the MI model, the rats were exposed to isoproterenol-HCl (ISO) (200mg/kg, S.C.) on the 27th and 28th. In the MI group, serum levels of CK-MB, BNP, and TNF-α are increased significantly. Also, ST waves and heart rates were higher in the MI than the control. These results demonstrate that biochemical results healed in MI+boric acid, MI+omega-3, and MI+boric acid+omega-3 groups compared MI group. ECG and light microscope results supported the findings as well. The statistical analysis showed that boric acid and/or omega-3 has protective effects on cellular damage in MI.

Numeric Simulation of Acoustic-Logging of Cave Formations

The finite difference (FD) method of monopole source is used to simulate the response of full-wave acoustic-logging in cave formations. The effect of the cave in the formation of borehole full-waves was studied. The results show that the radius of cave is not only linearly related to the first arrival of the compressional wave (P-wave), but also to the energy of the shear wave (S-wave). The converted S (S–S wave) and P-waves (S–P wave) are formed when the S-wave encounters the cave. If the source distance is small, the S–S and S–P waves are not separated, and the attenuation of the S-wave is not large, due to superposition of the converted waves. The S–P wave has been separated from the S-wave when the source distance is large, so the attenuation of the S-wave increases. The amplitude of the P and S–waves changes most when the distance of the cave to the borehole wall reaches a certain value; this value is related to the excitation frequency. The amplitude of the Stoneley wave (ST wave) varies directly with the radius of cave. If the radius of the cave is large, the energy of ST wave is weak. The scattered wave is determined by the radius and position of the cave. The investigation depth of a monopole source is limited. When the distance of the cave to the borehole wall exceeds the maximum investigation depth, the borehole acoustic wave is little affected by the cave. In actual logging, the development of the cave can be evaluated by using the first arrival of the P-wave and the energy of the S and ST waves.

Agarwood Alcohol Extract Ameliorates Isoproterenol-Induced Myocardial Ischemia by Inhibiting Oxidation and Apoptosis.

Agarwood is a traditional medicine used for treating some diseases, including painful and ischemic diseases. This study was carried out to investigate the potential cardioprotective effect of the whole-tree agarwood-inducing technique-produced agarwood alcohol extract (WTAAE) on isoproterenol- (ISO-) induced myocardial ischemia (MI) in rats and explore the underlying molecular mechanisms. Compared to the MI group, WTAAE pretreatment significantly improved ST wave abnormal-elevation, mitigated myocardial histological damage; decreased creatinine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), and aspartate transaminase (AST) levels; reduced hydrogen peroxide (H2O2) and lipid peroxide (LPO) production; and increased total antioxidant capacity (T-AOC) and catalase (CAT) activities. Moreover, agarwood alcohol extracts (AAEs) markedly enhanced the mRNA levels of Nrf2-ARE pathway, and Bcl-2 reduced the apoptotic Bax family mRNA expressions. In addition, the effect of WTAAE was greater than that of wild agarwood alcohol extract (WAAE) and burning-chisel-drilling agarwood alcohol extract (FBAAE). All of these data indicate that WTAAE exerted the protective effects of MI, and its mechanism was associated with upregulating Nrf2-ARE and suppressing Bcl-2 pathways.

Classification of myocardial infarction based on hybrid feature extraction and artificial intelligence tools by adopting tunable-Q wavelet transform (TQWT), variational mode decomposition (VMD) and neural networks.

Cardiovascular diseases (CVD) is the leading cause of human mortality and morbidity around the world, in which myocardial infarction (MI) is a silent condition that irreversibly damages the heart muscles. Currently, electrocardiogram (ECG) is widely used by the clinicians to diagnose MI patients due to its inexpensiveness and non-invasive nature. Pathological alterations provoked by MI cause slow conduction by increasing axial resistance on coupling between cells. This issue may cause abnormal patterns in the dynamics of the tip of the cardiac vector in the ECG signals. However, manual interpretation of the pathological alternations induced by MI is a time-consuming, tedious and subjective task. To overcome such disadvantages, computer-aided diagnosis techniques including signal processing and artificial intelligence tools have been developed. In this study we propose a novel technique for automatic detection of MI based on hybrid feature extraction and artificial intelligence tools. Tunable quality factor (Q-factor) wavelet transform (TQWT), variational mode decomposition (VMD) and phase space reconstruction (PSR) are utilized to extract representative features to form cardiac vectors with synthesis of the standard 12-lead and Frank XYZ leads. They are combined with neural networks to model, identify and detect abnormal patterns in the dynamics of cardiac system caused by MI. First, 12-lead ECG signals are reduced to 3-dimensional VCG signals, which are synthesized with Frank XYZ leads to build a hybrid 4-dimensional cardiac vector. Second, this vector is decomposed into a set of frequency subbands with a number of decomposition levels by using the TQWT method. Third, VMD is employed to decompose the subband of the 4-dimensional cardiac vector into different intrinsic modes, in which the first intrinsic mode contains the majority of the cardiac vector's energy and is considered to be the predominant intrinsic mode. It is selected to construct the reference variable for analysis. Fourth, phase space of the reference variable is reconstructed, in which the properties associated with the nonlinear cardiac system dynamics are preserved. Three-dimensional (3D) PSR together with Euclidean distance (ED) has been utilized to derive features, which demonstrate significant difference in cardiac system dynamics between normal (healthy) and MI cardiac vector signals. Fifth, cardiac system dynamics can be modeled and identified using neural networks, which employ the ED of 3D PSR of the reference variable as the input features. The difference of cardiac system dynamics between healthy control and MI cardiac vector is computed and used for the detection of MI based on a bank of estimators. Finally, data sets, which include conventional 12-lead and Frank XYZ leads ECG signal fragments from 148 patients with MI and 52 healthy controls from PTB diagnostic ECG database, are used for evaluation. By using the 10-fold cross-validation style, the achieved average classification accuracy is reported to be 97.98%. Currently, ST segment evaluation is one of the major and traditional ways for the MI detection. However, there exist weak or even undetectable ST segments in many ECG signals. Since the proposed method does not rely on the information of ST waves, it can serve as a complementary MI detection algorithm in the intensive care unit (ICU) of hospitals to assist the clinicians in confirming their diagnosis. Overall, our results verify that the proposed features may satisfactorily reflect cardiac system dynamics, and are complementary to the existing ECG features for automatic cardiac function analysis.

Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat

The present study designed to investigate the protective effect of curcumin nanoparticles (CUR-NPs) on the cardiotoxicity induced by doxorubicin. Rats were divided into four groups; control, rats treated daily with CUR-NPs (50 mg/kg) for 14 days, rats treated with an acute dose of doxorubicin (20 mg/kg) and rats treated daily with CUR-NPs for 14 days injected with doxorubicin on the 10th day. After electrocardiogram (ECG) recording from rats at different groups, rat decapitation was carried out and the heart of each rat was excised out to measure the oxidative stress parameters; lipid peroxidation (MDA), nitric oxide (NO) and reduced glutathione (GSH) and the activities of Na,K,ATPase and acetylcholinesterase (AchE). In addition, the levels of dopamine (DA), norepinephrine (NE) and serotonin (5-HT) were determined in the cardiac tissues. Lactate dehydrogenase (LDH) activity was measured in the serum. The ECG recordings indicated that daily pretreatment with CUR- NPs has prevented the tachycardia (i.e. increase in heart rate) and ameliorated the changes in ST wave and QRS complex induced by doxorubicin. In addition, CUR-NPs prevented doxorubicin induced significant increase in MDA, NO, DA, AchE and LDH and doxorubicin induced significant decrease in GSH, NE, 5-HT and Na,K,ATPase. According to the present findings, it could be concluded that CUR-NPs have a protective effect against cardiotoxicity induced by doxorubicin. This may shed more light on the importance of CUR-NPs pretreatment before the application of doxorubicin therapy.