SS OCT Research Articles

Assessment of Choroidal Thickness and Volume during the Water Drinking Test by Swept-Source Optical Coherence Tomography

To evaluate changes in peripapillary and macular choroidal thickness and volume after the water-drinking test (WDT) using swept-source optical coherence tomography (SS OCT). Prospective, cross-sectional, observational study. Fifty-six eyes of 28 healthy volunteers. Participants underwent a 3-dimensional optic disc and macula scanning protocol with a prototype SS OCT (Topcon, Inc., Tokyo, Japan) at baseline and 15, 30, 45, and 120 minutes after the start of the WDT. The WDT consisted of drinking 1000 ml of water within 5 minutes. Objective measurements of the choroid were obtained with automated segmentation of the choroidal boundaries. Choroidal thickness and volume. Mean age ± standard deviation of participants was 35.6 ± 9.1 years. Intraocular pressure (IOP) increased from 14.9 ± 2.7 mmHg at baseline to a peak of 16.8 ± 3.0 mmHg 15 minutes after the WDT (P < 0.001). Mean baseline choroidal thickness and volume were 181.3 ± 50.8 μm and 6.19 ± 1.80 mm(3), respectively, at the optic disc and 217.4 ± 43.6 μm and 7.83 ± 1.55 mm(3), respectively, at the macula. After the WDT, peripapillary and macular choroidal thickness increased by a maximum of 5.7% (P<0.001) and 4.3% (P<0.001), respectively. Choroidal volumes increased by 6.4% (P<0.001) and 3.9% (P<0.001), respectively. There was no association between change in IOP and peripapillary (P = 0.27) or macular (P = 0.09) choroidal thickness. Using automated segmentation of SS OCT measurements, significant increases in choroidal thickness and volume are observed after the WDT in healthy subjects.

Choroidal thickness changes determined by SS OCT following intravitreal bevacizumab

AbstractPurpose To report choroidal thickness (CT) changes using a SS OCT prototype following intravitreal bevacizumab injections.Methods Seventeen patients were treated by one single intravitreal 1.25 mg injection of bevacizumab (IVB). The macular area was examined using an SS‐OCT prototype system based on swept‐source OCT and was used to image the full‐thickness choroid and sclera. A CT profile of the macula was created by manually measuring CT (from the posterior edge of retinal pigment epithelium to the choroid/sclera junction) subfoveally, and three further determinations were performed every 750 μm temporal and nasal to the fovea. CT was determined immediately before and 24 hours after performing 1.25 mg IVB.Results Seventeen eyes from 17 patients (11 eyes with exudative age related macular degeneration, 4 eyes with retinal vein occlusion, 1 eye with myopic choroidal neovascularization, and 1 eye with diabetic macular edema) were examined. Nine patients were male and 8 were female. Mean age was 73 ± 11years range 53 to 88. Pearson correlation coefficient among observers averaged 0.90 (range 0.54 to 0.99). Changes in choroidal thickness were not significant for any of the determinations (Student t test for paired data). Changes in central foveal thickness were almost statistically significant (Student t test for paired data).Conclusion Our findings suggest that one single IVB does not seem to induce acute choroidal thinning.

Cataract, refractive and glaucoma surgery: anterior eye segment photo, clinical details, TD OCT, SD OCT and SS OCT scans, diagnosis and conclusion

AbstractAbstract not provided

In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance

The purpose of this study was to develop a dynamic tunable focal distance graded-refractive-index lens rod-based high-speed 3-D swept-source (SS) optical coherence tomography (OCT) endoscopic system and demonstrate real-time in vivo, high-resolution (10-microm) imaging of pleural-based malignancies in an animal model. The GRIN lens-based 3-D SS OCT system, which images at 39 fps with 512 A-lines per frame, was able to capture images of and detect abnormalities during thoracoscopy in the thoracic cavity, including the pleura, chest wall, pericardium, and the lungs. The abnormalities were confirmed by histological evaluation and compared to OCT findings. The dynamic tunable focal distance range and rapid speed of the probe and SS prototype OCT system enabled this first-reported application of in vivo 3-D thoracoscopic imaging of pleural-based malignancies. The imaging probe of the system was found to be easily adaptable to various sites within the thoracic cavity and can be readily adapted to other sites, including rigid airway endoscopic examinations.