In this paper, the effects of coolant flow rate, location of film holes, tip clearance height, and density ratio on blade tip film cooling effectiveness were experimentally investigated using pressure-sensitive paint. And numerical simulation was used to analyze the flow characteristic. Three different turbine blade tips were studied under a mainstream Reynolds number of 6.7 × 105. The pressure ratio was 1.7 and the blowing ratio ranged from 0.4 to 2.2. The results indicated that the cooling effectiveness gradually increased as the blowing ratio increased. The film tends to lift off under a larger blowing ratio, resulting in a decrease in the cooling effectiveness. The squealer tip with an inclined pressure side rim exhibited better film cooling effectiveness under the design conditions. The film cooling effectiveness on the pressure-side rim was lower than that on the suction-side rim under the same operating conditions. The analyses also indicated that an increase in the density ratio effectively enhances film cooling. Compared with the most published investigations conducted in a low-speed wind tunnel, these studies can be better applied to turbine blade cooling design.