Squamous Cell Carcinoma-related Antigen Research Articles

口腔悪性腫ようにおけるへん平上皮癌関連抗原（ＳＣＣ抗原）測定の臨床的意義

Squamous cell carcinoma (scc) is the most frequently type of oral cancer, but no reliable specific tumor markers of scc have been obtained. In this paper, the authors applied measurement of squamous cell carcinoma related antigen (scc antigen), a useful tumor marker of scc of the uterine cervix, to oral cancer patients and evaluated the clinical values of scc assay in diagnosis, follow-up and prognosis.The subjects were 29 cases of oral cancer and 23 cases of benign oral disease. The oral cancer cases included 12 cases of tongue cancer, 5 of buccal cancer, 4 of gingival cancer, 2 of cancer of the oral floor, 2 of cancer of the maxillary sinus and 4 cases of other cancers. Twenty one of these cases (about 72%) were histologically scc.Serum scc antigen levels were determined by the RIA KIT employing 125 I-labelled scc antigen as tracer. The cut off level was set as 2.3ng/ml.The following results were obtained.1) The subjects with oral cancer exhibited a higher scc antigen level than those of patients with non-bearing oral cancer or those of cases with benign oral diseases.2) The positive rate of the subjects with oral cancer was relatively high and 44% were at a level over 2.3ng/ml. Particularly in scc, 60% were at a level over 2.3ng/ml. Among 16 subjects with non-bearing oral cancer, on the other hand, only one subject showed positive. All subjects with benign oral disease were within normal range.3) As to the regions of oral cancer, tongue cancer and cancer of the oral floor showed relatively high scc antigen levels.4) There was no relationship between stages and scc antigen levels.5) Post-treatment scc antigen levels tended to decrease to within normal range in cases where the disease followed a good course, while they tended to increase in those that followed a poor course.6) The measurement of scc antigen levels appears to be especially useful for diagnosis, follw-up and evaluating prognosis in oral squamous cell carcinoma.

頭けい部がんにおける血清中へん平上皮がん関連抗原（ＴＡ‐４）量測定の臨床的意義

Serum levels of squamous cell carcinoma related antigen (TA-4) were measured by a RIA KIT in 34 patients with head and neck cancer. Eight of 13 patients (62%) with untreated head and neck cancer showed positive serum TA-4 levels, while only one of 10 control cases (10%) showed false-positive results. All patients with advanced stages (III and IV) showed detectable antigen levels. Five of 35 samples (14%) with treated cancer and 12 of 17 samples (71%) with recurrence were positive for the antigen. High pretreatment antigen levels declined to undetectable levels after surgery, irradiation and chemotherapy. The findings suggest that TA-4 is a good tumor marker for cancer of the head and neck, specially for squamous cell carcinoma.

Clinical evaluation of serum squamous cell carcinoma-related antigen levels in patients with malignant neoplasms

Clinical evaluation of serum squamous cell carcinoma-related antigen levels in patients with malignant neoplasms

顎・口腔疾患患者に対してのへん平上皮癌関連抗原ＴＡ‐４（ＳＣＣ抗原）の検索

Squamous cell carcinoma related antigen TA-4 (SCC-Ag) was examined by radio immunoassay in 33 patients with oral and maxillofacial lesions.In nine of 10 patients with untreated malignant tumors, there were detected high positive levels of antigen. The average data of them showed 2.97 ± 1.09 ng/ml.After treatment, 12 patients who had no recurrences or metastasis showed relatively low positive levels, such as the average of 2.31 ± 0.83 ng/ml. However, in benign tumors, cysts and other diseases with the exception of malignant tumors, there were detected lower than standard levels (2.0 ng/ml) or TA-4.TA-4 (SCC-Ag) appears useful for diagnosing and monitoring to learn the recurrence of metastasis of patients with oral and maxillofacial malignant tumors.