Squamous Cell Carcinoma Of Penis Research Articles

EGFR overexpression in invasive squamous cell carcinoma of the penis.

e15078 Background: Squamous cell carcinoma of penis (SCCP) is an uncommon malignancy. The published literature on its biology and treatment is limited. Traditional treatments like standard chemothe...

Carcinoma verrucoso de pene desarrollado sobre un liquen plano: ¿una auténtica lesión preneoplásica?

Up to 30% of squamous cell carcinomas of the penis arise from a lichen sclerosus, but very few reports in which lichen planus was the preexisting lesion have been published. We report a male with verrucous carcinoma of penis that developed in an area of lichen planus. A 53-year-old male presented with an exophytic tumor on the glans penis that had been present for about 6 months. The lesion developed in a previously biopsied area of lichen planus hypertrophicus. After excision, histological diagnosis was verrucous carcinoma. The development of any subtype of squamous cell carcinoma of penis in a lichen planus can be coincidental, or a neoplastic transformation of lichen planus can take place.

Carcinoma verrucoso de pene desarrollado sobre un liquen plano. ¿una auténtica lesión preneoplásica?

Introductionup to 30% of squamous cell carcinomas of the penis arise from a lichen sclerosus, but very few reports in which lichen planus was the preexisting lesion have been published. We report a male with verrucous carcinoma of penis that developed in an area of lichen planus. Clinical casea 53-year-old male presented with an exophytic tumor on the glans penis that had been present for about 6 months. The lesion developed in a previously biopsied area of lichen planus hypertrophicus. After excision, histological diagnosis was verrucous carcinoma. Commentthe development of any subtype of squamous cell carcinoma of penis in a lichen planus can be coincidental, or a neoplastic transformation of lichen planus can take place.

Predicting inguinal metastases in cancer penis

Objective: Is it possible to predict inguinal metastasis in penile cancer? Materials and Methods: This is a retrospective analysis of 90 cases of squamous cell carcinoma of penis. The analysis involved a study of archival specimens by a single consultant pathologist. The grade and depth of invasion of the primary tumor was studied. We tried to establish a correlation with clinical positivity as determined by physical examination, grade of primary tumor, depth of invasion and inguinal lymph node metastasis. Results: Metastatic status was known in 44 of 64 patients with clinically palpable inguinal nodes and 18 of 26 with clinically negative nodes. Of 62, 27 had lymph node metastasis in which 16 were poorly differentiated primary tumor. Inguinal lymph node metastasis was seen in six of nine (66.66%) when depth of invasion was more than 8 mm. Conclusions: In well-differentiated tumors with less than 3mm depth of invasion, active surveillance of the node could be recommended. In the rest, it may be wise in our country to offer prophylactic modified inguinal lymphadenectomy to avoid progression of disease from loss to follow-up. Morbidity can be reduced with a modified inguinal lymph node dissection in a majority and also by using principles of plastic surgery in the remainder.

Adjuvant Treatment Using Bleomycin in Squamous Cell Carcinoma of Penis: Study of 19 Cases

Nineteen patients with squamous cell carcinoma of the penis had surgical treatment or a combination of surgery and radiation. They also had chemotherapy using bleomycin as a single agent or in combination with vincristine and methotrexate. The total doses of bleomycin varied between 89 mg/m2 and 212 mg/m2. The best results were obtained in well differentiated carcinomas.