In this study, the Weather Research and Forecasting model coupled with chemistry (WRF-Chem) is employed to simulate a dust process in Northwest China during May 2018. The model's ability to simulate the dust process in Northwest China is firstly evaluated using various satellite-retrieved and observational data, including satellite-retrieved aerosol optical depth (AOD), extinction coefficient and dust index, as well as observational wind field, precipitation and particulate matter with particle size below 10 mic (PM10) mass concentration at surface. The four-dimensional assimilation method is also used to optimize meteorological data and effectively improve the simulation of the dust process. The comparisons between the simulations based on five dust emission schemes within WRF-Chem and the observations show that, the Shao01 scheme overall has good performance in simulating the emission flux, the spatial pattern of source region, as well as the spatiotemporal variation of dust mass concentration, during this dust process. In comparison to Shao01, the GOCART AFWA and Shao04 schemes can also produce quite similar spatial pattern of dust source region, but tend to overestimate or underestimate dust emission and mass concentration. The Shao11 scheme fails to simulate the dust process since the importance of the fully disturbed particle size distribution is omitted. It is also noted that the GOCART scheme can well reproduce dust emission processes under weak wind erosion but underestimate dust emission flux under strong wind erosion. In addition, the GOCART scheme has produced some spurious emissions and thus blurred the distribution of dust source region. The Shao01 simulation was found to reasonably reproduce the spatial distribution and magnitude of the satellite-retrieved AOD and vertical profile of extinction coefficient, as well as the PM10 mass concentration at surface. Northwest China is covered by mountains, basins, deserts and other landforms, thus the complex terrain is one of the key factors to influence the dust process over the region. Our study shows that after being emitted, the airborne dust transported toward the east and west. The dust to the east was diffused rapidly, but the portion toward the west was blocked and accumulated at the edges of the mountains and thus produced dust weather characterized by high dust concentration and long lifetime. The dust accumulated at the edges of the mountains could reach an altitude of more than 6 km due to wind and thermal effect, and finally arrive at Tibetan Plateau and eastern China.