Spreadability Test Research Articles

Formulation of aloe vera (Aloe vera (L.) Burm.f.) meat toothpaste and antibacterial activity tests on Streptococcus mutans bacteria

Introduction: Aloe vera (Aloe vera (L.) Burm.f.) is a plant that contains 95% water. The rest is in the form of other active ingredients (essential oils, amino acids, minerals, vitamins, enzymes, and glycoproteins). The type of aloe vera used to make herbal aloe vera is the Barbadensis type, which contains substances for human needs, such as Vitamins A, B1, B2, B6, B12, Vitamin E, and Vitamin C. This plant can also cure diabetes, heart disease, and other diseases. Aloe vera can be formulated into toothpaste preparations because it can improve hygiene and reduce plaque in the mouth. Objective: This study aimed to make a new formulation of (aloe vera (L.) Burm.f.) as a toothpaste preparation and evaluate its antibacterial activity against Streptococcus mutans bacteria. Methods: This study uses an experimental method. In this study, aloe vera was formulated as toothpaste. The physical evaluation carried out included tests for water content, total ash content, water-soluble extract content, ethanol-soluble extract content, acid-insoluble extract content, organoleptic test, oh test, homogeneity test, spreadability test, adhesion test, test viscosity, and foam formation test. Results: Based on the research results, it can be seen that aloe vera flesh has antibacterial activity against Streptococcus mutans bacteria. Conclusion: This research concludes to make a new formulation of (aloe vera (L.) Burm.f.) as a toothpaste preparation and evaluate its antibacterial activity against Streptococcus mutans bacteria.

Formulasi dan Evaluasi Ekstrak Aseton Kulit Putih Semangka Merah Non Biji (Citrullus Vulgaris S) dengan Niacinamide sebagai Gel Pelembab Kulit dengan Uji Kelembapan

This research was carried out with the aim of identifying the content of phytochemical compounds of alkaloids, flavonoids, tannins and saponins in the acetone extract of seedless red watermelon rind (Citrullus vulgaris), knowing the results of evaluating the physical properties of the acetone extract gel of seedless red watermelon rind (Citrullus vulgaris) with niacinamide against various concentrations of moisturizing gel preparations, and comparing the best moisture test concentration on acetone extract gel preparations of seedless red watermelon rind (Citrullus vulgaris) in providing optimal results. This research is a laboratory study of the experimental formulation of acetone extract of seedless red watermelon rind (Citrullus vulgaris) to determine the formulation and concentration of the best extract produced. The research results showed that acetone extract from the white skin of red seedless watermelon (Citrullus vulgaris) contained phytochemical compounds alkaloids, flavonoids, and polyphenol as well as lycopene in the white skin of red seedless watermelon (Citrullus vulgaris). The results of the evaluation of the physical properties of the acetone extract gel of seedless red watermelon rind (Citrullus vulgaris) in the negative control, 2.5% concentration, 5% concentration, and 7.5% concentration met the test requirements but did not meet the spreadability test requirements. And the best concentration of water content test in the acetone extract gel preparation of seedless red watermelon rind (Citrullus vulgaris) in providing optimal results is found in the gel preparation with a concentration of 7.5%.

FORMULASI DAN UJI FISIK SALEP KOMBINASI EKSTRAK PUTRI MALU (Mimosa Pudica) DAN DAUN JARAK PAGAR (Jatropha Curcas)

Indonesia is a tropical country that has the potential to experience skin diseases. The development of drugs from natural ingredients can be used to treat skin diseases. One of the appropriate pharmaceutical preparations for treating skin infections is ointment. Putri Malu (Mimosa Pudica) and Jatropha Leaves (Jatropha Cuscas) are plants that contain flavonoids, alkaloids, saponins, tannins and phenols which have the potential to inhibit bacterial growth. The aim of this research is to formulate an ointment preparation from the extract of putrimalu (mimosa pudica) and jatropha curcas leaves (jatropha curcas) which meets the requirements of an ointment preparation by means of a physical test of the ointment. This type of research was experimental, which was carried out by making 3 ointment formulations combining Putri Malu and Jatropha leaves using the ointment base Vasellin Album and Adeps Lanae. Physically tested ointment preparations include organoleptic tests, homogeneity tests, pH tests, viscosity tests, spreadability tests, and adhesiveness tests. Based on testing of a combination of ointment preparations from the extract of putrimalu (mimosa pudica) and jatropha leaves (jatrooha cuscas) with a base of vasellin album and adeps lanae, the organoleptic results were blackish brown, distinctive odor, semi-solid consistency, homogeneous ointment with a Ph value of 5 and viscosity test. adhesion and spreading power in accordance with ointment preparation standards. The best formulation of the ointment combination of the extract of the mollusk (mimosa pudica) and jatropha curcas (jatropha cusrcas) leaves is formulation 2 with a ratio of (2:2).

The Effectiveness of Sunscreen Cream with Ethanol Extract of Sungkai Leaves (Peronema canescens Jack)

Sungkai (Peronema canescens Jack) (PCL) contains flavonoid compounds that can absorb UV light therefore having the potential to be developed as a raw material for cosmetics that functions as a sunscreen. The research aims to formulate PCL extract into a sunscreen cream. Sungkai leaves are macerated using 96% ethanol solvent. Specific and non-specific parameter tests were carried out on the extract as well as antioxidant tests using the DPPH method and SPF tests using the Mansur method. The results of this research showed that 96% ethanol extract of PCL had a blackish-green color, pH 5.25; the ethanol and water-soluble essence levels were 6.25% and 5.17%. The water content obtained is 27.4%; drying shrinkage is 0.46%; total ash content is 0.12% and acid insoluble ash content is 0.1%. The antioxidant value obtained was 35.06 ppm. Three cream formulations were prepared (FI of 0.1753%, FII of 0.3506%, and FIII of 0.5259%) and evaluated for organoleptic, homogeneity, cream type, viscosity, pH, particle size, and spreadability tests for one month at 25℃ and 40℃. The organoleptic test results of the cream have a soft texture, with varying colors; light green (FI), green (FII), and dark green (FIII) color. Other evaluation test results show that the cream has a pH of 5.16 - 6.73, a spreadability of 6.47 - 8.07 cm, a viscosity of 15466.67 - 38933.33 cPs, a particle size of 9.88 - 16.17 µm and an SPF of 17.68 (FI), 27.46 (FII), and 33.64 (FIII) with ultra protection on all three. PCL extract after being formulated into creams shows high SPF activity with F3 as the best formula. PCL extract can be formulated into a cream form that meets physical and chemical quality parameters.

Geothermal Flora and AgNPs Synergy: A Study on the Efficacy of Lantana camara and Acrostichum aureum-Infused Hand Sanitizers

Hand hygiene is an important factor that needs to be observed in controlling the spread of diseases transmitted through hand-to-hand contact. Synthesis of silver nanoparticles from tembelekan (Lantana camara) and paku laut (Acrostichum aureum) using the green synthesis method has good antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. Therefore, a preparation formulation was made, namely hand sanitizer, which is still rarely used. Formulations that have successfully entered the evaluation stage include organoleptic tests, homogeneity tests, spreadability tests, adhesion tests, viscosity tests, pH tests, accelerated stability tests, and irritation tests. Antibacterial activity was evaluated against bacteria Staphylococcus aureus and Escherichia coli. The hand sanitizer is formulated to contain 5% tembelekan AgNPs (F1); paku laut AgNPs 5% (F2); and a combination of 2.5% paku laut AgNPs and 2.5% tembelekan AgNPs. The resulting hand sanitizer has good organoleptic characteristics, except for the color of the preparation, which changed during the accelerated stability test. Test results for pH, adhesion, spreadability, viscosity, and homogeneity of hand sanitizer meet the requirements of a good test. Irritation tests on ten volunteers showed no irritation reaction. Antibacterial tests show that hand sanitizer has bacterial antibacterial activity with an average ± standard deviation of the inhibition zone Staphylococcus aureus is 6.605±0.459(F1); 6.665±0.615(F2); 6.380±0.282(F3) dan Escherichia coli namely 6.575 ± 0.219 (F1); 6.860 ± 0.155 (F2); 6.810 ± 0.056 (F3). Making hand sanitizer AgNPs-based ingredients from plants can be used as hand sanitizer, but stabilizers are required to prevent color changes during storage.

Uji Efektivitas Gel Ekstrak Daun Jarak Pagar (Jatropha Curcas L.) sebagai Penyembuhan Luka Sayat

Indonesia is known for having abundant biological riches and many plants that can be used as medicine. One of the medicinal plants that is often used by Indonesian people is Jatropha curcas leaves. Jatropha plants are currently used as traditional medicine to treat wounds. One common medication used for cuts is povidone iodine which is effective against bacterial infections. However, povidone iodine also has side effects such as irritation, toxic reactions and burning skin. Jatropha leaves have strong antioxidant activity, so it is necessary to innovate in wound treatment using natural ingredients in the form of gel preparations. The gel preparation was chosen because it is practical, not sticky, easily absorbed by the skin, and works directly on wound tissue. The aim of this study was to assess how well a gel made from ethanol extract of jatropha leaves accelerates the healing of cut wounds in white mice. Jatropha curcas leaves were extracted using the maceration method using 96% ethanol as the solvent. Gel stability testing was carried out organoleptically, homogeneity test and spreadability test. Jatropha leaf extract gel was tested on mice that had been given incisions 1.4 cm long with formulations of 10%, 15% and 20% jatropha leaf extract concentrations. Observations were carried out for seven days. Research findings showed that giving white rats gel containing jatropha leaf extract significantly accelerated their ability to repair wounds

Antimicrobial gel with silver vanadate and silver nanoparticles: antifungal and physicochemical evaluation.

Aim: To develop a β-AgVO3 gel and evaluate its physicochemical stability and antifungal activity against Candida albicans. Materials & methods: The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO3. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion. Results: The MIC was 62.5μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO3 concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO3 gel with 20xMIC. Conclusion: The β-AgVO3 gel showed physicochemical stability and antifungal activity.

FORMULASI DAN EVALUASI FISIK SEDIAAN PASTA GIGI EKSTRAK DAUN BELUNTAS DENGAN VARIASI KONSENTRASI GLISERIN

Beluntas leaves (Pluchea indica) are a plant that has alkaloid, tannin and flavonoid compounds so it can be used as an antibacterial against streptococcus mutans which causes dental caries with an inhibitory power of 13.9 mm at a concentration of 5% (strong). Beluntas leaves can be developed into a toothpaste preparation. The aim of this research was to determine the formulation and physical evaluation of beluntas leaf extract toothpaste preparations with varying glycerin concentrations.Making beluntas leaf extract using the maceration method with 96% solvent ethanol ratio 1:10. Making toothpaste with varying glycerin concentrations, F1(5%), F2(7.5%), F3(10%). Physical evaluation of toothpaste preparations includes organoleptic, homogeneity, pH, high foam, spreadability and viscosity.Organoleptic tests of the three formula has a distinctive menthol odorhave the same odor, semi form solid and dark green color. The homogeneity test results F1= not homogeneous, F2= homogeneous, F3= homogeneous. Toothpaste pH test results F1 = 7.22 ± 0.10, F2 = 7.38 ± 0.12, F3 = 8.20 ± 0.35. The results of the toothpaste viscosity test were 9814.8 ± 0.55 cps, F2 = 9812.9 ± 0.59 cps, F3 =9811, 7±0.74 cps. The spreadability test results of toothpaste were F1=2.92±0.09 cm, F2=2.94±0.34 cm, F3=3.20±0.21 cm. Test results for toothpaste foam height F1 = 5.67 ± 0.67 mm, F2 = 5.67 ± 0.34 mm, F3 = 7.00 ± 0.33 mm. Based on the results of the One Way Anova test and the Kruskal Wallis test, it was concluded that variations in glycerin concentration had a significant effect on the spreadability, pH and viscosity tests.

Repellent Activity Testing of an Essential Oil Gel Preparation of Cinnamon (Cinnamomun Burmanii) Bark) And Kaffir Lime Peel (Citrus Hytrix) Against Aedes Aegypti Mosquitoes

Dengue fever is still a disease that dominates, especially in the Papua region. To overcome this, it is necessary to modify preparations based on medicinal plants as mosquito repellents, one of which is gel preparations. This study aims to determine the repellent activity test of essential oil gel preparations of Cinnamon Bark (Cinnamomum burmannii) and Kaffir Lime Peel (Citrus Hystrix) against the Aedes aegypti mosquito. The method used in this research uses experimental methods. This research was conducted in April - November 2022. This research used two formulations, namely cinnamon bark and kaffir lime peel (FI) formulations which were compared with formulation preparations in the form of a base without active substances (FII). The tests carried out were physical quality tests and repellent tests on the Aedes aegypti mosquito. The research results show that based on physical quality tests, it is known that FI has a distinctive odor, slightly yellowish white color and a thick shape. Meanwhile, FII has the distinctive smell of patchouli oil, milky white color and thick shape. In the homogeneity test on FI and FII it was found to be homogeneous and fulfilled the requirements. In the adhesion and spreadability tests on FI and FII it was found that they met the requirements. In the pH test, the pH of FI and FII has a pH value of 7 and meets the requirements. In the repellent test using arm-in-cage with 3 replications using 20 Aedes aegypti mosquitoes. The formulas tested were FI and FII and observations made were by recording the number of mosquitoes that landed after using the repellent for 15, 30, 60, 120, 240 and 360 minutes. The research results showed that in the 15th minute the protection power was 88.3%, in the 30th minute the protection power was 88.3%, in the 60th minute the protection power was 72.3%, in the 120th minute the protection power was 67, 1%, in the 240th minute the protection power was 51.5%, and in the 360th minute the protection power was 47.7%. Based on the research results, it can be concluded that the essential oil formulation of cinnamon bark and Kaffir lime peel is efficacious as a repellent.

Formulation and Evaluation of Herbal Hair Serum

In daily life, there is a rising demand for cosmetics and are used by a large number of individuals annually. Humanity employs a variety of goods to accentuate elegance and attractiveness in order to appear youthful and endearing. Therefore, cosmetics are essential to human survival. Because of the perception that herbal cosmetics are safer and have fewer adverse effects, they are utilized extensively these days. One of the main bodily components that serve as a protective appendage is hair. The spreadability test and stability test results were all assessed. It was the development of a daily-use herbal hair serum is the main objective of this study. To achieve this, a range of herbs will be employed, and the ideal formulation will be determined by evaluating the cosmetic serum’s qualities. Three different cosmetic serum formulations (H1, H2, and H3) with different excipient concentrations have been developed. Physical properties, pH, homogeneity test, and viscosity ensured that every parameter fulfilled the norms and was in good condition. Herbal compositions have been shown to be useful in improving hair consistency.

Effect of Vacuum Brazing Conditions of Inconel 718 Superalloy Sheets on Microstructure and Mechanical Properties of Joints

Vacuum furnace brazing is one of the most commonly used joining processes in the aerospace industry, utilized in the manufacturing of the complex components of turbine jet engines, working in both their cold and hot sections. The modern aerospace industry demands continuous improvement of production processes to enhance the engine performance, while ensuring its reliability. Therefore, a better understanding of the processes that shape the properties of engine assemblies joints is crucial. This paper presents an analysis of the influence of key brazing process parameters – brazing time and gap width – on the microstructure and mechanical properties of Inconel 718 superalloy joints obtained with the Palnicro 36M filler alloy. The analysis was conducted basing on results from SEM/EDS analysis and peel, shear and spreadability tests.

Physicochemical Characteristics and SPF Value of Kepok Banana Corm Extract Cream

Banana Corm is banana plant waste that has not been utilized optimally and contains flavonoids which have the potential as natural UV repellents. This study aims to determined the physical-chemical characteristics and preferences of respondents as well as the SPF value of kepok banana corm extract creams. Three cream formulations were carried out using concentration variants of 10% (F1), 20% (F2) and 30% (F3) with physical property tests including organoleptic tests, cream type tests, homogeneity tests, spreadability tests, centrifugation tests and SPF value. The test results show that the three formulations have different colors and aromas and are o/w cream types and have a homogeneous texture. All formulas meet the skin's pH range. In the test results there was a significant difference (p<0.05) in the order of highest spreading power in diameter F3 (5.725 ± 0.01 cm) × F2 (5.24 ± 0.2 cm) × F1 (5.24 ± 0.092 cm ), whereas for the centrifugation test results there was no phase separation in the supply. The results of respondents' preferences for cream showed that the overall cream preparation formula is acceptable and liked by respondents. Based on the research results, it can be concluded that the banana bongol extract cream meets the physical quality requirements based on predetermined parameters and the banana bongol extract cream can be accepted by respondents. Cream with variations in banana weevil concentration of 10%, 20% and 30%, obtained an SPF value in the maximum protection category

Evaluation of Emulgel and Nanostructured Lipid Carrier-Based Gel Formulations for Transdermal Administration of Ibuprofen: Characterization, Mechanical Properties, and Ex-Vivo Skin Permeation

In transdermal applications of nonsteroidal anti-inflammatory drugs, the rheological and mechanical properties of the dosage form affect the performance of the drug. The aim of this study to develop emulgel and nanostructured lipid carrier NLC-based gel formulations containing ibuprofen, evaluate their mechanical properties, bioadhesive value and ex-vivo rabbit skin permeability. All formulations showed non-Newtonian pseudoplastic behavior and their viscosity values are suitable for topical application. The particle size of the nanostructured lipid carrier system was found to be 468 ± 21 nm, and the encapsulation efficiency was 95.58 ± 0.41%. According to the index of viscosity, consistency, firmness, and cohesiveness values obtained as a result of the back extrusion study, E2 formulation was found to be more suitable for transdermal application. The firmness and work of shear values of the E2 formulation, which has the highest viscosity value, were also found to be the highest and it was chosen as the most suitable formulation in terms of the spreadability test. The work of bioadhesion values of NLC-based gel and IBU-loaded NLC-based gel were found as 0.226 ± 0.028 and 0.181 ± 0.006 mJ/cm2 respectively. The percentages of IBU that penetrated through rabbit skin from the Ibuactive-Cream and the E2 were 87.4 ± 2.11% and 93.4 ± 2.72% after 24 h, respectively. When the penetration of ibuprofen through the skin was evaluated, it was found that the E2 formulation increased penetration due to its lipid and nanoparticle structure. As a result of these findings, it can be said that the NLC-based gel formulation will increase the therapeutic efficacy and will be a good alternative transdermal formulation.Graphical

Preparation, characterization, and in vitro evaluation of microemulsion based cream formulations for the topical treatment of acne vulgaris

AbstractBy lowering the significant adverse effects of traditional medications, this study intends to create cream formulations based on microemulsions that contain extract from Allium sativum L. for the treatment of acne vulgaris. Characterization experiments were carried out on the developed cream formulations based on microemulsions. Textural profile analysis and spreadability tests were conducted. Furthermore, cell culture studies and toxicity analysis were performed. As a result, the pH and viscosity values of the developed formulations were found between 6.43 ± 0.00 and 6.66 ± 0.01, and between 13.90 ± 0.080 and 137.20 ± 8.02 P, respectively. The highest‐performing empty and loaded cream formulations in terms of spreadability and textural profile analysis were those with the highest beeswax content. The highest‐performing empty and loaded cream formulations in terms of spreadability and textural profile analysis were those with the highest beeswax content. According to the visual physical evaluation of the formulations, it was observed that the developed formulations were neat, smooth, and homogeneous. The optimum formulation developed was non‐cytotoxic, which maintained cell viability by over 90%. Additionally, the skin irritation experiment was also non‐irritant with a relative cell viability of 92.6%. In conclusion, the developed A. sativum extract‐loaded microemulsion‐based cream formulations appear to be promising formulations for the acne vulgaris treatment, without malodors.

Physical Characteristics of Lip Cream Preparations with Natural Coloring Beetroot Extract (Beta Vulgaris L.)

Introduction: Cosmetics are a primary need for women to help them appear more attractive, one of the lip coloring cosmetics that is currently in great demand among consumers is lip cream. Lip cream is a liquid lipstick preparation that can moisturize the lips for a long time compared to solid form and produces a more even color on the lips. Lip cream coloring ingredients can be obtained from synthetic dyes and natural dyes. The coloring (pigment) found in red beets is betalain which can be used as an antioxidantMethods: The research method is experimental. This research was carried out to formulate beetroot (Beta vulgaris L.) extract as a natural coloring for lip cream preparations. The independent variable in this research is beetroot (Beta vulgaris L.) extract as a natural coloring and the dependent variable is the physical characteristics of lip cream including organoleptic (shape, color and odor), pH, homogeneity and spread ability. Data analysis is descriptive.Results: The results of this research show that the lip cream preparation has the characteristics of being in a semi-solid form, with a purplish red color, and a distinctive rose smell. The color and smell did not change until day 7. The pH test showed a pH of 3.39 on day 1 and 5.49 on day 7. The homogeneity test showed it was homogeneous until day 7. The spreadability test showed that it could be spread with an average spreadability of 5 cm.Conclusion: This research shows that the lip cream color is dark or thick red in the preparation, organoleptic test, pH test, spreadability is in accordance with the desired design.

Formulation and development of herbal gel for wound healing

Herbal gel is a solid, jelly-like substance that can have properties ranging from soft and weak to hard and tough preparation. It is used topically for a variety of purposes, such as protectants, antiseptics, and antimicrobials. Herbal formulations means a dosage form consisting of one or more herbs or processed herbs in specified quantities to provide specific nutritional, cosmetic benefits meant for use to diagnose, treat, mitigate diseases of human beings or animals, alter the structure or physiology of human beings or animals. The aim of herbal treatment is usually to produce persisting improvements in well-being. Practitioners often talk in terms of trying to treat the “underlying cause” of disease and may prescribe herbs aimed at correcting patterns of dysfunction rather than targeting the presenting symptoms. Gel-based products absorb into the skin easily, leave little to no residue on the skin, and prevent greasiness. Moisturizing benefit, Acne, Ageing, treat sunburn, hydration, cooling effect, long lasting, Compatible with sensitive skin type. Moringa oleifera is a tree with antioxidants and also anti-inflammatory properties. Its health benefits may range from speeding up wound healing. The herbal gel was prepared by using heat add the required amount of all the ingredients and stirred it continuously up to 10 to 15 minute to form a homogenous mass of gel. This gel was formulate by using suitable ingredients like, Maringa seed oil, olive oil, aloe-Vera gel This gel is honey, Garlic extract. In different properties the herbal gel was evaluated by different parameters such as a pH measurement, viscosity test skin irritation test, physical appearance, spread ability test and net content.

Development of an Anti-Acne Facial Wash Gel With Cassia alata L. Leaf Extract

Acne is a skin disease that is often encountered. Acne can be caused by various factors, including bacterial infection. To prevent acne, keep facial skin clean using facial wash. Using facial wash made from synthetic substances can cause more significant side effects than natural ingredients, so research is needed on natural ingredients that can be used as anti-acne agents. One natural ingredient that has antibacterial activity is ketepeng leaf (Cassia alata L.). This research aims to formulate a facial wash gel preparation from ketepeng leaf extract and test its antibacterial activity against Staphylococcus aureus bacteria. This research is experimental research starting from making extracts, dosage formulation, evaluating the physical properties of the dosage (stability test, organoleptic test, homogeneity test, pH test, viscosity test, spreadability test, and foamability test), skin irritation test, hedonic test and antibacterial activity against Staphylococcus aureus bacteria. The research results showed that the inhibition zone produced by formula 1 was 9,73mm, formula 2 was 10,33mm, and formula 3 was 13,18mm. This research concludes that Ketepeng leaf can be used as an active ingredient in anti-acne facial wash gel preparations because the Ketepeng leaf extract facial wash gel preparation meets the requirements for evaluating good physical properties and has antibacterial activity against Staphylococcus aureus bacteria in each formula.

Dosage Evaluation and Antioxidant Activity Test of Lotion of Ethanol Extract of Belimbing Wuluh Leaf (Averrhoa Bilimbi L.)

<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p><em>This study aims to make and evaluate the lotion formula from ethanol extract of star fruit leaves (Averrhoa bilimbi L.) and test the antioxidant activity of the lotion. The research method used is experimental, making lotions and testing antioxidant activity from July to October 2023 at the Semi-Solid Preparation Technology Laboratory, Department of Pharmacy, Poltekkes Kemenkes Medan, and Research Laboratory, University of North Sumatra. In the preparation stage, star fruit leaf simplisia was extracted by maceration using a 95% ethanol solvent. The lotion formula was made with ingredients such as PEG 4000, stearyl alcohol, glycerin, sodium lauryl sulfate, coconut oil, nipagin, and distillate water, with varying concentrations of ethanol extract of star fruit leaves. The formulation was evaluated through organoleptic, homogeneity, pH, spreadability, and viscosity tests. The results showed that the lotion produced had a homogeneous shape and aroma to the concentration of ethanol extract. In addition, the pH of the lotion is also within the safe range for human skin. The spreadability test showed the lotion's ability to spread on the skin, which met the requirements for lotions with spreadability values between 5 and 7 cm. The viscosity of the lotion was also by the set standards. Stability tests were conducted to monitor the physical and chemical changes of the lotion over four weeks. The results showed that lotions with 1% and 3% ethanol extract concentrations were stable during the study period. However, the 5% concentration experienced inhomogeneity changes in the third week. In conclusion, lotion with ethanol extract of star fruit leaves at 1% and 3% concentration can produce a good and stable formula. However, the antioxidant activity of the lotion is still in the weak to moderate category. This research contributes to developing plant-based natural cosmetic products for skin care.</em><em></em></p><p><em> </em></p></td></tr></tbody></table></div><p><strong><em>Keywords: Antioxidant Activity, Belimbing Wuluh, Ethanol Extract, Evaluation, Lotion</em></strong></p>

Formulation, physical characterization, and antibacterial activity of modifications of Bawang Dayak Eleutherine bulbosa (Mill.) Urb. anti-acne cream

IntroductionSeveral studies have reported the ability of Bawang Dayak cream to inhibit Cutibacterium acnes, but the lack of specific formulations has led to its ineffectiveness. This is indicated by a smaller inhibition zone and the predominant scent of the plant. Therefore, this study aims to assess the physical characteristics and antibacterial activity of two modified formulations of Bawang Dayak anti-acne cream. MethodsTwo modified formulations of Bawang Dayak anti-acne cream were prepared, namely M1 (containing peppermint water) and M2 (comprising peppermint water, cinnamon extract, and honey). Each formulation had four concentrations: 5% (F1), 10% (F2), 15% (F3), and 20% (F4). The physical characteristics were then examined. The antibacterial activity test was carried out using the disc-diffusion method against acne-causing bacteria. ResultsThe addition of peppermint water to the cream formula masked the odour of Bawang Dayak. All the formulas examined met the requirements of the homogeneity, pH, and spreadability tests. However, the adhesion test showed that only F2 and F4 of M2 met the requirement. The results also showed that M1 had better antibacterial activity compared to M2. ConclusionsThis study found that all the formulas observed passed the homogeneity, pH, and spreadability tests. Only F2 and F4 of M2 met the requirements of the adhesion tests. M1 exhibited superior antibacterial activity compared to the M2. F1 of M1 showed the highest antibacterial activity against Staphylococcus epidermidis. Further investigation was needed to evaluate the effectiveness of M2 against S. epidermidis and Staphylococcus aureus, as well as assess the stability.

Formulation and Evaluation of Physical Quality of Peel-Oof Masks of Essential Oils of Galam Kalimantan Plants

The Kalimantan galam plant (Melaleuca cajuputi subsp cajuputi) has been used for generations but its use is very limited, only as wooden piles which form the basis of buildings in swamps (cerucuk), pillars for building construction, stakes (supports for newly planted seedlings) and siring. Street. The use of galam essential oil as an active ingredient in peel-off mask preparations can be efficacious in reducing inflammation and infection of acne or other skin problems. Facial masks in the form of peel-off itself have many advantages, namely their practical use and are easy to remove or lift like elastic membranes compared to conventional masks which leave residue. This study aims to design a peel-off mask formulation by utilizing the active ingredient in the essential oil of the galam plant. The preparations were then tested for physical quality requirements including organoleptic tests, homogeneity tests, pH tests, drying time tests, spreadability and adhesion tests. The results of the tests that have been carried out include the extraction of essential oils as the active substance. The yield of essential oil obtained was 0.12%. Organoleptic quality tests showed changes in color, smell and shape in the three formulations. The homogeneity test for formulas I and II remained homogeneous, while for formula III the consistency changed to 2 layers. The pH test showed that all formulations met the pH requirements for topical preparations, namely 4-8. The drying time test for formula I was more difficult to remove, formula II was not too stiff while formula III was stiffer. Spreadability test on formulas I, II and III 5-7 cm. The gel viscosity test decreased and the adhesion test on formulation I was easily released, formulas II and III were not easily released while the irritation test of 30 people did not experience redness in 3 formulas.