This paper introduces a new approach for interference rejection in direct sequence spread spectrum communication systems based on blind source separation techniques. These techniques strive to separate the interference from the desired signal and as such produce the spread spectrum signal with reduced jammer contamination. The proposed approach is robust under multipath and array imperfections. The paper presents the performance analysis and evaluation of the spread spectrum receiver incorporating the blind source separator. Closed-form expressions of the receiver SNR using the proposed preprocessing scheme are derived. A numerical example, including the bit error rates, is provided to illustrate the effectiveness of the blind source separation-based interference mitigation approach.