This study aimed to determine the effect of application of foliar spray and drenching of nano urea on growth and survival of mango grafts cv. Alphonso. The experiment was laid out in Randomized Block Design with three replications and twelve treatments to assess various concentrations of nano urea at College of Horticulture, Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth, Dapoli, Ratnagiri, Maharashtra, India. Treatments applied as a foliar spray and drenching of nano urea at different rates in which treatment of foliar application of nano urea at 1500 ppm showed best performance in survival percentage (95.11 %), graft height (44.99 cm), number of shoots (1.90), number of leaves (31.13), relative growth rate (0.0059 cm/cm/day), dry weight of root (13.44 g) and tap root length (27.10 cm). However, drenching treatment of nano urea at 1500 ppm showed good results in graft girth (10.60 mm) and treatment of foliar spray of nano urea at 500 ppm were found best for total leaf area (654.52 cm2). Among all the nano urea treatments, foliar spray of nano urea at 1500 ppm was the best owing to highest survival and better growth of mango grafts cv. Alphonso.