For the purpose of providing the scientific insights to combustion characteristics of spray jet, numerical calculations of reacting and non-reacting spray cases are performed for ECN (engine combustion network) Spray A (n-dodecane spray combustion) which coupled finite chemistry combustion model PaSR and detailed chemical reaction kinetics based on OpenFOAM. The applicability and accuracy of the spray model is verified in the non-reacting spray case, and it is found that the predicted spray characteristics such as the penetration length of liquid and vapor and the mixture fraction are in good agreement with the test results. The two processes of low-temperature reaction and high-temperature ignition experienced by n-dodecane spray ignition are analyzed in reacting spray case, and it is found that the low-temperature reaction continues to exothermic before high-temperature ignition, and continues to proceed stably after high-temperature ignition, which promotes high-temperature ignition and flame stability. Finally, the effects of different fuel injection pressures on ignition delay time and flame lift-off length are studied.