The pitch-diameter ratio is an important design indicator affecting the separation performance of spirals. Based on the numerical simulation method, this paper systematically investigated the variation of flow hydrodynamic parameters in the spiral concentrator with the regulation of the pitch-diameter ratio. The radial distribution and variation trend of hematite and quartz particles with different particle sizes are further analyzed. Additionally, the separation indices of hematite and quartz with different particle size combinations were predicted. The results show that the tangential velocity, maximum radial velocity, velocity shear rate, and Reynolds number of fluid in each region decrease with the increase of the pitch-diameter ratio. The range of laminar flow gradually expands as the pitch-diameter ratio increases. There are significant differences in depth of water, ratio of inward and outward flows, and secondary flow velocity in different regions. Some flow hydrodynamic parameters at the inner trough reach relative equilibrium at a pitch-diameter ratio of 0.675. Hematite and quartz particles form a selective distribution in the trough surface, which comprehensively reflects the density effect, particle size effect, following flow effect of fine particles, and the effect of interstitial trickling of high-density fine particles. Fine hematite and coarse quartz form a large amount of misplaced material, and there is a corresponding mixing area. With the increase in pitch-diameter ratio, coarse and fine hematite particles migrate inward and outward, respectively. With the increase in pitch-diameter ratio, the misplaced amount of quartz on the inner trough decreases, but the outward migration distance of coarse quartz is smaller. Increasing the pitch-diameter ratio is beneficial to the separation of combined feedings of coarse hematite and quartz but unfavorable to that of fine hematite and quartz. The maximum separation efficiency of coarse hematite and fine quartz can reach 85.74%, and the iron grade of the inner product can reach 65.96% when the pitch-diameter ratio is 0.675 and the splitter location is 115 mm. The changing trend of separation indices in this feeding is closely related to the variation of fluid parameters and the change in the radial distribution of single mineral particles. The research results can provide references for the structural design of spirals, the selection of feed particle size, and the adjustment of splitter location.