Spindle Cell Lipoma Research Articles

Angiomyofibroblastoma-Like Tumor of the Inguinal Canal

ngiomyofibroblastoma (AMF) is described as a superficial tumor of the vulva that occurs almost exclusively in the vulvovaginal region. It may also occur on rare occasions in the inguinoscrotal region. The first case was described in 1998, 1 in the form of a mesenchymal tumor of the male genital tract. It was histomorphologically similar to female AMF and to spindle cell lipoma. We report a case of AMF that was confirmed pathologically, along with a review of the cases available in the literature.

Low-Fat and Fat-Free Pleomorphic Lipomas: A Diagnostic Challenge

Pleomorphic lipomas are benign tumors that most commonly present as subcutaneous masses in the head and neck, shoulder, or back region of middle-aged to elderly men. They are related to spindle cell lipomas based on shared cytogenetic aberrations and histologic features. When little or no fat is present, the diagnosis can be challenging. A review of 38 pleomorphic lipomas seen in consultation revealed 7 cases in which fat was present in reduced (<5%) amounts (n = 5) or absent (n = 2). Six of 7 cases were from men with a mean age of 59 years. Excluding 1 case where the site was not specified, they all presented as solitary well-circumscribed subcutaneous masses in the head and neck (n = 3) or shoulder (n = 2) region. The seventh case was an intradermal tumor from the nose of a 48-year-old woman. All displayed pleomorphic and multinucleated floret cells interspersed among bland spindle cells and ropey collagen. They were diffusely immunoreactive for CD34. Referring diagnoses, when provided, included myxofibrosarcoma, giant cell fibroblastoma, and granulomatous rosacea for the tumor from the nose; none considered pleomorphic lipomas. When fat is absent or present in reduced amounts, clinical context and identification of classic nonlipogenic components are essential for the diagnosis of pleomorphic lipomas.

Lipomas of the oral cavity: clinical and histopathologic study of 41 cases in a Brazilian population

This study evaluated the clinical and histopathologic aspects of 41 cases of oral lipomas diagnosed in a Brazilian population. All records from patients diagnosed with oral lipoma between 1970 and 2008 were reviewed. Histological sections were evaluated by light microscopy. There was a predominance of females (2.4:1), with a peak incidence between the sixth and seventh decade. The buccal mucosa was the most affected site (53.7%), followed by the buccal sulcus (14.6%) and tongue (9.8%). Tumor size ranged from 0.5 to 10 cm and the mean reported duration was 48 months. Histologically, the following variants were identified: lipoma (41.5%), fibrolipoma (34.1%), spindle cell lipoma (9.8%), sialolipoma (9.8%), osteolipoma (2.4%), and chondrolipoma (2.4%). Most tumors were well delimited, irrespective of the variant. Lipomas are rare tumors of the oral cavity. The characterization of new variants, such as sialolipomas, and the identification of histological subtypes in already known variants, such as low-fat and fat-free spindle cell lipomas, highlight the importance for careful microscopic evaluation of these tumors, which might be combined with immunohistochemistry in some cases.

Cellular Angiofibroma of Oral Mucosa: Report of Two Cases

Cellular angiofibroma is a benign vascular neoplasm that typically arises in the vulva, perineal, and paratesticular region. Microscopically the lesions exhibit multiple small, non-dilated capillary channels, many of which contain erythrocytes. The endothelial lining cells are prominent, with monomorphic oval nuclei. Interposed among the vessels are both delicate and mature collagen fibers with fibroblastic hypercellularity that is variable in older lesions where sclerosis is prominent. The lesions usually do not recur following simple excision. Recent evidence indicates that cellular angiofibromas may be cytogenetically related to spindle cell lipoma. This represents the first reported instances of cellular angiofibroma in the oral cavity.

Endotracheal Spindle Cell Lipoma Presenting as a Chronic Cough

An elderly gentleman with a chronic cough was found to have a large midtracheal lesion on computed tomography scan. Endotracheal extirpation with an electrocautery snare successfully removed the lesion. Histologic and immunohistochemical analyses revealed the lesion to be a spindle cell lipoma. We provide herein the case presentation and management, the differential diagnosis, and an overview of spindle cell lipoma.

Suprasellar spindle cell lipoma

Spindle cell lipoma of the suprasellar region has not been reported in the literature. We report a case of a 4-year-old male with a suprasellar spindle cell lipoma. The patient presented with headaches and visual disturbances. An imaging study revealed a 4 to 5-mm suprasellar mass that was initially thought to be a lipoma or dermoid cyst. Pathologic examination from the partial resection showed a circumscribed lesion consisting of mature adipose tissue with intermixed uniform spindle cells associated with a mucoid matrix, morphologically consistent with a spindle cell lipoma. The spindle cells and vasculature demonstrated focal positivity with CD34 antibody. There was no evidence of lipoblasts, mitoses, necrosis, or osseous tissue.

Spindle cell lipoma of the esophagus

Esophageal lipomas are benign tumors representing less than 0.5% of all gastrointestinal lipomas. They are typically detected incidentally but occasionally present with local symptoms and rarely with life-threatening complications. We describe a case of a 60-year-old man with progressive dysphagia and weight loss, who presented with several episodes of near asphyxiation secondary to regurgitation and aspiration of the pedunculated mass. Preoperative investigations included a barium meal, esophagoscopy and computerized tomography. The pedunculated lipoma was excised via a cervical approach and found, at final pathology, to be a spindle cell lipoma, a rare variant not previously described in relation to the esophagus.

Spindle cell lipoma in Retzius' space

International Journal of UrologyVolume 16, Issue 2 p. 218-219 Letter to the Editor Spindle cell lipoma in Retzius' space Hidenobu Okuda md , Hidenobu Okuda md Department of Urology, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japanhideokuda1179@yahoo.co.jpSearch for more papers by this author Hidenobu Okuda md , Hidenobu Okuda md Department of Urology, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japanhideokuda1179@yahoo.co.jpSearch for more papers by this author First published: 10 February 2009 https://doi.org/10.1111/j.1442-2042.2008.02204.xCitations: 4Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume16, Issue2February 2009Pages 218-219 RelatedInformation

Extramammary myofibroblastoma in the head and neck region

Mammary myofibroblastoma is a benign mesenchymal tumor of the breast. Extramammary location is very rare and usually occurs along the embryonic milk-line. In this article, we present a case of a woman with an infra-auricular swelling. A diagnosis could not be made on CT scans, so the mass was surgically removed. Histological examination showed spindle cells in clusters, with CD34, desmin, and actin expression. The diagnosis of extramammary myofibroblastoma was made. We describe this case because of the unusual location of this rare tumor. Furthermore, we want to highlight the possible relationship between (extra)mammary myofibroblastoma and spindle cell lipoma (SCL). SCL has a predilection site in the posterior neck. Both tumors show the same clinical behavior, a close histological resemblance, and their cells are both immunoreactive for CD34 and CD10. The loss of RB/13q14 and FKHR/13q14 loci, which is typically found in SCL cells, was also shown in this case.

Spindle Cell Lipoma Involving the Larynx and Lateral Neck Space

Spindle cell lipoma (SCL) is a rare lipoma variant that account for approximately 1.5% of all adipocyte-origin tumors; SCL usually occurs on the posterior neck or shoulder. The histological characteristics of SCL include mature, univacuolar fat cells and fibroblast-like spindle cells in a matrix of collagen and mucoid material. It is important to note that spindle cell lipoma can be mistaken both clinically and histologically for liposarcoma. We report here on a rare case of SCL in a 48-year-old male, and the patient presented with a large right neck mass that involved the lateral neck space and larynx.

Spindle Cell/Pleomorphic Lipoma of the Oropharynx

We report a rare case of spindle cell/pleomorphic lipoma of the oropharynx. A 45-year-old woman presented with a 9-month history of a lump in 2001. A well demarcated polypoid, rubbery mass was found in the left vallecula and was surgically removed. The mass was diagnosed as a spindle cell lipoma. She revisited with the same complaint in 2008. Examination revealed another polypoid mass at the left aryepiglottic fold, near the previous excision site. The excised mass histologically consisted of mature fat cells, numerous bizarre giant cells, and bland spindle cells, features of a typical pleomorphic lipoma. This is the first case of recurrent oropharyngeal spindle cell/pleomorphic lipoma, showing histologic changes during the recurrence. Complete removal and follow-up are necessary for the treatment of this uncommon neoplasm.

Non-infiltrating angiolipoma of the cheek: a case report and review of the literature

Angiolipoma, spindle cell lipoma, mylelolipoma, chondrolipoma and myxolipoma are histologic variants of lipomas arising from fat tissue. Although angiolipoma is the most common tumor in the trunk and extremities of young people, it occurs infrequently in the head and neck region. The authors present the clinical and histological features of a non-infiltrating angiolipoma excised from the cheek of a 22-year old man. Clinical examination showed a soft, mobile, approximately 4 x 3 cm mass that could be palpated anterior to the masseter muscle. The mass was removed by an intraoral approach. Angiolipoma was confirmed on histopathologic evaluation. Lipomas represent about 1 to 5% of all neoplasms of the oral cavity. They are usually painless, soft, round and mobile. The diagnosis is based on both clinical and histologic characteristics. The treatment is surgical excision.

An Atypical Case of Atypical Lipomatous Tumor

A 56-year-old woman was referred to us with an asymptomatic nodule on the thigh. The nodule was about 11x7 cm in diameter with a well-demarcated, smooth, surface. Magnetic resonance imaging showed the intensity of the nodule to be entirely monotonous or partially heterogeneous. Histological examination revealed a proliferation of adipocytes varying considerably in size and including many mono- or multivacuolated lipoblasts. Immunohistochemically, some of the tumor cells were positive for p53 and MDM2. Histologically, the atypical lipomatous tumor, lipoblastoma, spindle cell lipoma, pleomorphic liposarcoma, and hibernoma comprised the list of possible, differential diagnoses. We considered our case to be a variant of atypical lipomatous tumor, although it did not correspond to any of the 4 atypical lipomatous tumor subgroups. There has been no recurrence to date.

Spindle cell lipoma of the aortic valve: a rare cardiac finding

A 64-year-old female presented with a 2-year history of worsening angina. Subsequent investigations revealed aortic valve tumor. The patient had history of hypertension, coronary artery disease, atrial fibrillation, hyperlipidemia, and hyperthyroidism. The patient was nondiabetic, nonsmoker, and had marfanoid features. The tumor was excised, and aortic valve replacement was done using partial sternotomy (minimally invasive). Histology was suggestive of spindle cell lipoma of the aortic valve. Although lipomas have benign pathology and slow growth, they warrant surgical excision in view of possible fatal complications.

ENDOTRACHEAL SPINDLE CELL LIPOMA PRESENTING AS A CHRONIC COUGH

INTRODUCTION: Spindle cell lipoma (SCL) is a rare, benign tumor, usually arising in the subcutaneous tissue of the shoulder and posterior neck of middle-aged and elderly men, although other unusual locations have also been reported. Only two cases of endobronchial lipomas with areas of spindle cell proliferation characteristic of SCL have been documented previously. We report the occurrence of a SCL within the trachea. To our knowledge, this is the first description of a SCL in this location.

Upper eyelid tumour

Abstract Purpose To describe the clinical and histologic features of a rare eyelid tumour. Methods A 56‐year‐old male patient presented with a nodular subcutaneous tumour in his right upper eyelid close to the eye brow. The lesion had been present for 2 years; there was no pain or inflammation but a slow increase in size. No other significant ocular abnormality was noted, and the patient's general health was good without any medication. On MRI, the tumour presented as a circumscribed non‐infiltrating pseudocystic mass, 20mm in diameter in size and located in the subcutis. Results Histopathology showed a loose myxoid stroma with low cellularity and occasional small blood vessels. A distinct capsule or pseudocapsule was not identified. Near the periphery some fat lobules were seen. The mucoid ground substance stained lightly with Alcian blue. The tumour cells were sparsely distributed throughout the tumour without any particular pattern; most appeared spindle‐shaped with an inconspicuous nucleus and no mitotic figures. Several mast cells were identified. Together with immunohistochemical findings (CD34+, SMA‐, Desmin‐), the diagnosis of myxoid spindle cell lipoma was made. Conclusion To our knowledge, no tumour has been documented in the literature that was histologically really similar to the one present in our patient. There was only very little normal adipose tissue, and a floret‐like nuclear pattern typical for pleomorphic lipoma (but also seen occasionally in normal orbital fat) was not observed. Even though the distinction from other lesions might in some cases be somewhat academic the differential diagnosis includes herniated orbital fat, other lipoma variants such as myolipoma and the hitherto mentioned pleomorphic lipoma, other myxoid tumours, and obiously malignant lesions such as (especially myxoid) liposarcoma.

Spindle cell lipoma of the vestibule of the nose

Spindle cell lipoma of the vestibule of the nose

Bilateral multiple spindle cell lipomas of the tongue

Spindle cell lipoma (SCL) typically occurs in elderly men as a solitary lesion in the posterior neck and back, but less commonly also involves the oral cavity. Here, we describe a rare case of bilateral multiple SCLs of the tongue. The patient was a 72-year-old Japanese man with multiple painless soft nodules in the bilateral margins of the tongue. The patient was not obese, and had used alcohol moderately for more than 40 years. A clinical diagnosis of multiple tongue lipomas was made. The tumors were resected surgically, and they exhibited the histopathological features of SCL, composed of mature fat cells, collagen-forming CD34-positive spindle cells, and sparse mast cells. This suggests that differential diagnosis of intraoral multiple lipomatous nodules should include not only lipomatosis but also multiple SCLs, notwithstanding the rare incidence of the latter.

Medallion-like dermal dendrocyte hamartoma in a 36-year-old male

Medallion-like dermal dendrocyte hamartoma in a 36-year-old male

Frequent Detection of Androgen Receptors in Spindle Cell Lipomas: An Explanation for This Lesion's Male Predominance?

Spindle cell lipoma (SCL) is a tumor with marked male predilection. We discovered one SCL that exhibited strong immunoreactivity for androgen receptors (ARs) in the spindle cells. The hypothesis was that ARs in SCLs would not be rare and that all or nearly all SCLs would be AR positive, perhaps explaining its male predominance. Twenty-eight cases of SCL (22 men, 6 women) and a control group of 20 conventional lipomas (10 men, 10 women) were stained with monoclonal AR antibody (1: 150; Dako, Carpinteria, Calif) using the Ventana Discovery. Only nuclear reactivity was considered positive, as noted in prostate controls. Cell types (fat, spindle cells) and extent of staining were recorded as rare, considered negative, focal (1+), or diffuse (2+/3+). All 22 cases of SCL in men were positive for ARs. Twenty showed diffuse (2+/3+) reactivity mainly in the spindle cells. Of the 6 SCLs in women, 1 was AR negative, 1 showed a 3+ reaction in the spindle cells, and 4 had weak (1+) staining of spindle cells. Overall, 96% of SCLs were AR positive, including 83% of SCLs in women. Seventy percent of conventional lipomas showed positive staining in fat, but only 2 showed 2+ staining. In the rest, staining was rare or weak (1+). Nearly all SCLs exhibited AR reactivity. However, the presence of ARs in a substantial percentage of ordinary lipomas and in SCLs in females mitigates against the hypothesis that AR reactivity alone can explain the marked male predominance of SCL.