Background: Primary Dysmenorrhea refers to painful menstruation without any pelvic pathology. Women with this condition reported that menstruation have a negative impact on their quality of life. To compare the effect of Objective: Spinal thrust Manipulation versus Maitland Mobilization in subjects with primary Dysmenorrhea in terms of pain and Quality of life by using VAS and MOOS Questionnaire. Setting and design: A Randomized controlled study was conducted in tertiary health centre, Belagavi Methods: Forty-two females between 19-25 years of age with Primary Dysmenorrhea were recruited and were randomly allocated in three groups. All groups received hot moist pack and deep transverse massage as a conventional therapy, in addition Group B received spinal thrust manipulation and Group C received Maitland mobilization on their 21st, 23rd and 1st day of menstrual cycle. Patients were assessed at baseline and post intervention using VAS and MOOS Questionnaire. The Intra group analysis showed a Results: considerable amount of change in percentage of VAS in group B and MOOS in group C (p<0.05). Inter group analysis of group A and B showed statistical differences in VAS. Group C showed statistical difference in MOOS score as compare to group A. Post HOC analysis showed no signicant differences in the variables. Conclusion: Spinal thrust manipulation and Maitland mobilization were equally effective in reducing pain and improving quality of life in subjects with primary dysmenorrhea