Spinal Hemangioma Research Articles

Pure Spinal Epidural Cavernous Hemangioma: A Rare Cause of Thoracic Myelopathy

Cavernous hemangiomas mostly occur in intracranial structures but they also may occur in the spine very rarely. Even if found, spinal hemangiomas are commonly vertebral origin and solely epidural hemangiomas not originating from the vertebral bone are very rare. Our case is a 65-year-old man presented to us with progressive paraparesis from six months with motor power 3/5 in both lower extremities. The pathology was total epidural spinal hemangioma at D9-10 vertebral level with typical myelopathy like presentation. Bang. J Neurosurgery 2024; 13(2): 149-151

Surgical treatment for local recurrence of spinal hemangiomas.

SH is considered to be the most common benign tumor within the human spine. 1-2% of SH get symptomatic with back pain in most cases. Less often, ingrowth of vessels into the spinal canal is seen. In these cases, more invasive surgical treatment is required. Recurrence of SH following surgical treatment is a very rare condition. We present the results of a retrospective chart review, with description of the clinical course of 12 patients with spinal canal invading SH without recurrence and of 5 patients with a recurrent SH. Recurrence was diagnosed 70 months (mean value) after the first procedure. All patients with a recurrent SH had received an incomplete tumor resection as a first treatment. The distribution of gender, age at the diagnosis, levels involved by the tumor, and initial symptoms were comparable in the group of patients with and without recurrence. The patients with recurrent SH were treated with preoperative embolization and en bloc resection or complete piecemeal resection of the affected vertebra. For stabilization, a combined, circumferential fixation was used consisting in a TSM cage filled by bone graft and posterior pedicle screw rod instrumentation in all patients. We followed these patients until 09/ 2023, mean FU 122 months (range 72-184 months). At this time, we found no evidence of tumor recurrence, good clinical conditions in all patients, no signs of implant failure or pseudarthrosis. Thus, radical excision, sufficient stabilization and fusion is considered to be an adequate treatment concept for recurrent SH.

Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review.

(1) Background: this case series and literature review aims to evaluate the efficacy and safety of electrochemotherapy in the management of aggressive spinal hemangiomas, presenting two distinct cases. (2) Methods: we present two cases of spinal aggressive hemangioma which were refractory to conventional treatments and underwent electrochemotherapy. Case 1 involves a 50-year-old female who presented with an aggressive spinal hemangioma of L1, who previously underwent various treatments including surgery, radio-chemotherapy, and arterial embolization. Case 2 describes a 16-year-old female with a T12 vertebral hemangioma, previously treated with surgery and stabilization, who faced limitations in treatment options due to her young age and the location of the hemangioma. (3) Results: in Case 1, electrochemotherapy with bleomycin was administered following the failure of previous treatments and resulted in the reduction of the lesion size and improvement in clinical symptoms. In Case 2, electrochemotherapy was chosen due to the risks associated with other treatments and was completed without any adverse events. Both cases demonstrated the potential of electrochemotherapy as a viable treatment option for spinal hemangiomas, especially in complex or recurrent cases. (4) Conclusions: electrochemotherapy with bleomycin is a promising treatment for aggressive spinal hemangiomas when conventional therapies are not feasible or have failed. Further research is needed to establish definitive protocols and long-term outcomes of electrochemotherapy in spinal hemangioma management.

Surgical strategies in the management of aggressive spinal haemangiomas: Retrospective case series with literature review and a practical treatment algorithm

PurposeWe studied the clinico-radiological features and treatment outcomes of patients with aggressive spinal haemangiomas. MethodsWe undertook a retrospective review of 24 patients with aggressive spinal haemangiomas managed at our centre from 2004 to 2016. The cohort was divided into two groups. Group1 included patients managed from 2004 to 2009 while Group 2 was those treated between 2010 and 2016. Clinicoradiological features and treatment outcomes were studied. ResultsBack pain (24/24) and myelopathy (18/24) were the most common presenting complaints. Over 80% (20/24) of patients, had involvement of the thoracic spine and more than 50% (13/24) had severe spasticity, being Nurick grade 4&5 at presentation. The various treatment modalities used were laminectomy with or without instrumented posterior fusion (10/24), corpectomy with instrumented fusion (10/24) and alcohol injection alone (4/24). Patients who were treated with surgery had significant clinical improvement at follow-up in both groups. Patients who underwent alcohol injection did not have any improvement in symptoms at follow-up. There was a change in our strategy in the later part of the series from a two staged anterior and posterior approach to a single staged posterior-only approach to address vertebral body disease with preoperative angioembolization. ConclusionHaemangiomas are benign lesions with locally aggressive behavior in some cases. Results of conservative approaches such as alcohol injection in management of these lesions are discouraging. Aggressive surgical decompression combined with preoperative adjuncts such as angioembolization with or without stabilization reduces intra operative blood loss and results in good neurological recovery even in patients with severe myelopathy.

Epitheloid Haemangioma of Spine - A Rare Case Report and Review of Literature

Introduction: Epitheloid hemangioma (EH) of spine is a rare vascular disease. Haemangiomas are tumours typically composed of thin walled blood vessels, of which EH is an infrequent variation. The exact incidence of EH is not known. EH, though is considered to be benign disease it can be locally aggressive. EH most commonly affects the integumentary system. IT most commonly involves liver, lungs and bones. Here we report a 25 years old male with complete work up for EH including clinical data, MRI spine, surgical, histopathological information and adjuvant radiation therapy following surgical management. In addition to the case report, we reviewed literature on EH of bones. Case Report: A 25 years old male came to our emergency department with complaints of severe lower back pain. He also complained of difficulty in walking for the past 3 months. MRI Lumbosacral (LS) with whole spine screening was done 1 month back and it showed Multifocal vertebral lesions involving D4, D5, D6 vertebra predominantly in posterior elements, expansion of the transverse processes and involvement of costochondral junction, left 5th rib with extensive soft tissue component indenting on the pleura. He was seen by Neurosurgery team at our hospital and was planned for surgical decompression and stabilisation of D4-D6 vertebrae. He underwent D3 to D6 laminectomy and stabilization under general anaesthesia. Final histopathology along with IHC correlation was suggestive of Epitheloid Hemangioma. Case was discussed in our hospital multidisciplinary tumor board and was planned for adjuvant radiotherapy (RT). Then he received adjuvant radiotherapy total dose (TD) 45 Gray (Gy) to D3-D6 region. Post treatment 6 months, his power is improved and is near normal. Conclusion: To summarize our case appears as a typical features of EH like young male patient, lytic lesions with sclerotic rim, IHC confirmation

Saf torasik spinal epidural kavernöz hemanjiom (SEKH)

Cavernous hemangiomas (CHs) can be found in all intracranial structures, especially in the brain parenchyma. Most spinal hemangiomas are of vertebral origin. Spinal cavernous hemangiomas that do not hold the vertebrae are called "pure" types. Pure spinal epidural cavernous hemangiomas (SECHs) are very rare and account for approximately 4% of all epidural lesions. Here is a case of pure thoracic SECH detected in a 42-year-old female patient with progressive paraparesis and sensory loss below the T8 sensory dermatome for the last 2 months presented. Cavernous hemangioma should not be forgotten among the options in the differential diagnosis of spinal epidural tumors.

Second Case of Tumors Associated With Heterozygous NTHL1 Variant

Homozygous mutations to NTHL1 are known to increase cancer risk, particularly in the colon and breast. NTHL1 tumor syndrome (NTS) is an autosomal recessive genetic condition. Little is known about the cancer risk in patients who have heterozygous NTHL1 mutations. We previously published a case of benign tumors associated with a heterozygous NTHL1 mutation. In this second case, we present a patient with a heterozygous NTHL1 mutation who developed a gastrointestinal stromal tumor, pilocytic astrocytoma, tall cell papillary thyroid cancer, invasive ductal papilloma, spinal nerve sheath tumors, and spinal hemangiomas. Here, we show that heterozygous NTHL1 mutations may increase cancer risk and may even manifest similarly to NTS.

The Long-Term Outcome in a Cohort of 52 Patients With Symptomatic Intramedullary Spinal Cavernous Hemangioma After Microsurgery and Emergency Rescue Surgery.

BackgroundSurgery is the mainstay treatment for patients with symptomatic intramedullary spinal cavernous hemangioma (ISCH), however the time of surgical intervention remains controversial. In this study, we proposed emergency rescue surgery (ERS) for patients in deteriorative type. The prognostic factors of patients with ISCH after microsurgery and the clinical effect of ERS were analyzed.MethodsFrom January 2013 to November 2019, 52 patients with symptomatic ISCH treated by microsurgical treatment were collected, ranging in age from 17 to 66 years old (mean: 45.8 ± 13.5 years). The course of the disease ranged from 2 days to 20 years. Of 52 lesions, 17 lesions were in the cervical segment, 25 in the thoracic segment, and 10 in the lumbosacral segment; while seven cases were at the ventral surface, 25 cases at the dorsal surface, and 20 cases at the central spinal cord. The sagittal diameter ranged from 1 to 58 mm (median: 17.3 mm). The transverse diameter ratio ranged from 20 to 80% (median: 50.7%). Thirty-two patients were diagnosed as deteriorative type and 22 were treated by ERS.ResultsAt 12 months after surgery, all patients were followed up, and no residual or recurrence was found in all patients. Twenty-five patients (48.1%) showed spinal cord functional improvement after surgery; 25 (48.1%) had no functional change; 2 (3.8%) got worse. For deteriorative patients, ERS group had a significantly higher improvement rate than the non-ERS group (χ2 = 5.393, P = 0.02); For all 52 patients, the factors as a lesion at the ventral surface (Z = 10.453, P = 0.015), or lumbosacral segment (χ2 = 9.259, P = 0.010) and longer course of disease (Z = −2.021, P = 0.043) were potential risks in functional recovery in univariate analysis; and in multiple-factor analysis, the lesion at the lumbosacral segment (OR = 4.004, 95% CI: 1.341~11.961, P = 0.013) was the independent risk factors for the functional recovery.ConclusionsMicrosurgical resection is safe and effective for symptomatic ISCH. The ERS is an effective way to improve deteriorative patients' spinal cord function at long-term follow-up. The lesion at the lumbosacral segment is one of the poor prognostic factors.

Баллонная кифопластика в хирургическом лечении агрессивных гемангиом позвоночника (обзор литературы)

Introduction Aggressive vertebral hemangiomas occur in 10–11.5 % of the working-age population that determines social significance of the disease. Percutaneous vertebroplasty technique is normally used for the treatment of aggressive spinal hemangiomas. Cement leakage is the most common complication during vertebroplasty (40–87. 5 %). Balloon kyphoplasty is associated with a low incidence of cement leakage. Objective We aimed to analyze literature and summarize information on balloon kyphoplasty used to treat aggressive spinal hemangiomas. Material and methods The original literature search was conducted on key resources including PubMed and GoogleScholar. Literature searches included both Russian and English studies based on keywords. Results and discussion The article presents the main results of balloon kyphoplasty used as a standalone procedure and in combination with other methods of surgical treatment of aggressive spinal hemangiomas. The use of balloon kyphoplasty was shown to reduce the risk of extraspinal cement leakage. However, this aspect is represented by a small number of scientific publications in the current medical literature that emphasizes the relevance of the topic raised. Conclusion Despite the variety of available treatment options, the optimal management strategy remains controversial for aggressive forms of vertebral hemangiomas. There are no well-defined criteria and indications reported recently to be included into a well-structured algorithm for of balloon kyphoplasty in the treatment of aggressive spinal hemangiomas, and therefore the debatable questions need further investigation.

Outcomes of nephron sparing surgery and cortical sparing adrenalectomy in the management of Von Hippel\u2013Lindau syndrome

BackgroundThe management of Von Hippel–Lindau syndrome (VHLS) is multidisciplinary. The urologist is involved in treating the renal, epididymal tumors and often adrenal pheochromocytoma. Preservation of renal and adrenal function is a challenge. We present 17 cases of VHLS in a tertiary care center in South India.MethodsA retrospective review of the patients who underwent surgical treatment under urology for VHLS from January 2009 to November 2018 was conducted. The demographic data, the spectrum of manifestation, treatment, change in glomerular filtration rate, adrenal insufficiency, and recurrence-free survival were analyzed.ResultsThere were 17 patients diagnosed with VHLS. The median age of diagnosis was 39 years (range 23–41). The spectrum of clinical manifestation was: multifocal RCC (88%), pancreatic cysts/tumors (70%), cerebellar hemangioblastoma (59%), retinal angiomas (47%), epididymal cysts/tumors (47%), pheochromocytomas (41%), and spinal hemangiomas (30%). There were seven patients with ten pheochromocytoma lesions. Three underwent cortical sparing and seven total adrenalectomies; 13 patients underwent nephron sparing surgery (NSS), of which seven patients had bilateral tumors. The median duration of follow-up was 6.5 years (range 2–12 years). Following NSS, seven patients had a local recurrence, and one developed pancreatic metastasis. Two patients (11%) were lost to follow-up. Renal function was preserved in all patients at the last follow-up, and there was no postoperative adrenal crisis or mortality.ConclusionNephron sparing surgery and cortical sparing adrenalectomy are the treatment of choice for multifocal RCC and pheochromocytomas in patients with VHLS providing good oncological outcomes and preservation of renal and adrenal function.

Radiofrequency ablation may improve the beneficial results of vertebroplasty for vertebral hemangiomas: analysis of 46 patients

ABSTRACT Objectives To evaluate the effect of vertebroplasty (VP) alone or combined therapy of radiofrequency ablation (RFA) with vertebroplasty on pain relief with visual analog scale (VAS) and Oswestry Disability Index (ODI) scores in vertebral hemangiomas. Methods Forty-six patients with hemangiomas were evaluated retrospectively: 20 males and 26 females were included. In group 1 (n = 25) only VP was performed, while RFA+VP were performed in the same treatment session in group 2 (n = 21). Radiological diagnosis was performed with X-ray, CT-scan and MRI images in all patients. The intensity of pain was assessed with the VAS together with the assesment of life quality with the ODI. The assesments were performed before, at first day, at first month and 6 months after treatment. Results There was no significant difference between mean preprocedural VAS and ODI scores, but a significant decrease was seen in postprocedural VAS and ODI scores between group 1 and 2, when compared with the preprocedural values. Although lack of a statistically significant difference in long term results, mean VAS score was 3.7 for group 1, while it was 1.8 for group 2, and the mean ODI score was 38 for group 1, and 22.48 for group 2 at 6th month assesment. Discussion Although minimally invasive percutaneous techniques are indicated as other modalities are ineffective or contraindicated, combining RFA with vertebral augmentation provide prevention of mechanical loading pain, and prevention of somatic pain in patients with spinal hemangiomas.

Spinal Hemangioma in Pregnancy: A Case Report

Background: Hemangiomas of bone are localized benign tumors composed of fully developed adult blood vessels. Vertebral hemangiomas are present without symptoms in approximately 10% of the population and more common in females. It is usually located in the lower thoracic and lumbar vertebra and are often multifocal. Infrequently these benign lesions may cause local or radicular pain and neurological deficits ranging from myeloradiculopathy to paralysis. The physiological vascular, hemodynamic and hormonal changes in pregnancy act to enlarge a preexisting hemangioma and most of these changes peak in the third trimester. The most important contributing factor is the increase in venous pressure resulting from mechanical obstruction of blood flow from the paravertebral veins into the inferior vena cava by the gravid uterus. Objective: To study the outcome of management of a case of spinal hemangioma during pregnancy. Case report: A 26-years-old pregnant female patient attended the Department of Orthopedic Surgery at the International Medical Center Hospital, Jeddah, Saudi Arabia, suffering from a severe lower limb paresis and loss of sphincteric control and diagnosed with spinal hemangioma. An intervention was done during pregnancy to prevent further complications by decompressing the spinal cord. Post-delivery, the main surgery was performed to prevent the recurrence. Conclusion: The management of spinal hemangiomas in pregnant women can be done in the following two steps. The First step is short-timed, less bloody intervention to decompress the mass to prevent further damage and complications. The second step is to perform the main surgery post-delivery when the condition permits.

Percutaneous vertebroplasty with or without sclerotherapy for the treatment of symptomatic spinal haemangiomas: study of clinical safety and efficacy

Purpose : To illustrate safety and efficacy of percutaneous vertebroplasty (either solely performed or in combination to alcohol sclerotherapy) for treatment of symptomatic, aggressive vertebral haemangiomas in a series of consecutive patients. Material and Methods : Institutional database research from 1/1/2010 until 31/8/2020 identified 25 patients with 31 symptomatic, aggressive vertebral haemangiomas suffering from pain with or without neurologic compromise underwent percutaneous vertebroplasty either solely performed or in combination to alcohol sclerotherapy. When haemangioma was restrained to the vertebral body, percutaneous vertebroplasty was performed as the only treatment technique. When an epidural component was also present causing pressure effects upon the spinal sac, sclerotherapy was additionally performed with alcohol injection at the level of the vertebral pedicles. CT scan assessed implant distribution the morning post therapy and MRI was performed 6 months post. Numeric Visual pain scores (NVS) prior- and post-treatment were compared using Paired Samples t-Test and Wilcoxon Signed Rank Test. Results : Mean pain score prior to any therapy was 8.52 ± 1.388 NVS units. Mean pain score at 12 months post therapy was 1.68 ± 2.445 NVS units. There was a mean reduction of 6.84 ± 3.145 NVS units. The comparison of the patients’ self-reported outcomes concerning pain reduction and mobility improvement prior and post therapy was considered statistically significant (p<0.001). No complication was noted. Conclusions : Percutaneous vertebroplasty (either solely performed or in combination to alcohol sclerotherapy) seems to be a safe and efficient technique for the treatment of symptomatic, aggressive vertebral haemangiomas resulting in significant pain reduction and mobility improvement. Proper patient selection is a prerequisite for high success rate.

Spinal cord vascular diseases

Spinal vascular malformations include various entities, including spinal dural arteriovenous (AV) fistulas, acquired malformations and cavernous hemangiomas, and spinal arteriovenous malformations. AV fistula refers to aspinal cord vascular malformation in which there is a short-circuit connection between adural artery and aperimedullary vein superficial to the myelon. The condition is relatively rare, initial clinical symptoms are often misinterpreted, and adefinitive diagnosis is often delayed by 12months or more. However, early diagnosis is important to prevent progression of clinical symptoms, which may include paraplegia. Early magnetic resonance imaging (MRI) is helpful, showing intramedullary edema in the T2-weighted sequences and superficial, markedly dilated veins. Treatment consists of ligation of the AV fistula, either surgically or by embolization. Cavernous hemangiomas, consisting of alarge number of closely located immature blood vessels, are also relatively rare and have alow risk of bleeding (approximately 0.2-0.5%). Venous hemorrhage may also occur, resulting in clinical symptoms (including paraplegia).

Hemangioma of the Lumbar Spine Involving the Spinous Process: A Rare Case Report and Review of the Literature.

Hemangiomas of the spine are usually benign and asymptomatic. They can cause devastating complications such as pathological fractures of the spine and neurological disability. This report documents an atypical location of a hemangioma in a lumbar spinous process, in combination with a spondylolisthesis at the same level, which makes it even more uncommon. Surgery can be effective and safe and can significantly improve patient outcomes. Moreover, prior embolization can prevent acute hemorrhage in addition to providing careful diagnosis and evaluation.

High-Grade Spinal Hemangioma: A National Cancer Database Analysis

Spinal hemangiomas are common primary tumors of the vertebrae. Although these tumors are most frequently benign and asymptomatic, they can rarely exhibit aggressive growth and invasion into neighboring structures. Treatment for these aggressive variants is controversial, often involving surgery, chemotherapy, and/or radiotherapy. This study sought to investigate current trends affecting overall survival (OS) using the National Cancer Database (NCDB) and to formulate treatment recommendations. The National Cancer Database was queried for spinal hemangiomas between 2004 and 2016. A Cox proportional hazards model was used to perform multivariate regression analysis of survival. Survival curves for comparative visualization of demographic and treatment factors were generated using a semiparametric Cox approach. A cohort of 102 patients with histologically confirmed spinal hemangiomas was identified in the database. Mean OS was 1.94 years. Administered treatments included partial surgical resection (n= 17), radical resection (n= 14), chemotherapy (n= 34), and radiotherapy (n= 56). Multivariate analysis revealed associations between decreased OS and advanced age (>65 years) and presence of metastasis. Cox survival analysis further revealed improved OS in patients who received surgical treatment and higher radiation dose. This retrospective analysis finding that treatment with surgical resection and/or radiotherapy is associated with increased OS constitutes the largest cohort of patients with aggressive vertebral hemangiomas to date. Given that the mean OS of the study cohort was 1.94 years, our findings suggest that the optimal treatment regimen to maximize survival should consist of early surgical resection with adjuvant high-dose radiotherapy.

Vertebral Hemangiomas: Polka-dot and Corduroy Sign

Clinical Image Vertebral hemangiomas are mal-formative benign tumours consisting of newly formed normal blood vessels without arteriovenous shunt. It has two main histopathological types, cavernous and capillary angiomas. The exact etiology of spinal hemangiomas genesis is not well understood yet, a well-known characteristic of these lesions includes a vascular proliferation of capillaries, subsequently leads to displacement of bone and in rarer cases erosion into the spinal canal. In 1% of cases, the tumour can be locally aggressive, revealed by neurological complications thus requiring a surgical intervention. The development of this vascular malformation causes osteolysis of cancellous bone and its replacement by coarse, sclerotic trabeculae surrounded by fatty marrow or vascular spaces, creating a vertically striated appearance (Figures 1A and 1B) due to thickening of the bony trabeculae. This radiological aspect isreferred to as the jail bar sign, also known as the corduroy sign. The polka-dot sign is the result of the same phenomenon happening in vertebral intraosseous hemangiomas. It is the axial equivalent of the corduroy sign seen on sagittal and coronal images. On CT scan the dots are white on a black fatty background bearing a likeness to a polka-dot pattern (Figure 1C). Keywords: Vertebral hemangiomas, Polka-dot sign, Corduroy sign Declaration of Interests: The authors declare that they have no competing interests.

Surgical management of aggressive hemangiomas of the spine

Our objective is to describe the surgical management and outcomes following surgical intervention for aggressive spine hemangiomas. Patients from 2005 to 2018 with an aggressive hemangioma of the cervical, thoracic, lumbar spine and sacrum treated surgically at a tertiary referral academic medical center were included in this study. The hospital pathology department database was used to identify patients with a diagnosis of aggressive hemangioma. Patient demographics, medical history, operative procedure, adjunct treatment, early and late complications, and recurrence were analyzed using the Fischer exact test with significance set at p < 0.05 Ten patients met inclusion criteria for the study. The average follow up was 11 months. Eight out of ten patients had aggressive hemangioma of the thoracic spine. Seven of the ten patients presented with back or leg pain. The most common surgery was laminectomy at the site of the lesion (70%). 40% of patients underwent a spinal fusion, with two of these patients receiving concurrent intra-operative vertebroplasty. Three patients underwent post-operative radiation therapy. Five complications were noted among three individuals. There were three perioperative complications, deep venous thrombosis, renal insufficiency, one surgical site infection, and two postoperative complications, both revisions. There were no recurrences. Surgical intervention for aggressive spine hemangiomas is an effective treatment with relatively low complication and recurrence rates.

An Unusual Long Segment Spinal Epidural Cavernous Hemangioma: A Case Report

Spinal epidural hemangioma, mostly cavernous, is a rare lesion with many radiological mimics that has diagnostic difficulty. They can extend from one to multiple vertebral levels and may or may not be associated with vertebral hemangiomas. We are reporting a case of young adult presenting with features of compressive myelopathy. Plain and contrast-enhanced magnetic resonance imaging showed a large spinal epidural lesion extending from C7 to D10 vertebral levels with extension into adjacent neural foramina and paravertebral spaces. There were also signal changes in bodies and posterior elements of dorsal vertebrae. A provisional diagnosis of lymphoma was made. The patient was operated for decompression and histopathological diagnosis of cavernous hemangioma was made. As in our case, a review of literature shows that epidural cavernous hemangioma of spine may extend to multiple vertebral levels and difficult to diagnose on pre-operative imaging. However, such a long segment epidural cavernous hemangioma has not been reported in literature. Furthermore, we should be aware of these rare lesions to include it in our differential diagnosis the spinal epidural lesions for early diagnosis and management.

Surgical treatment of aggressive hemangiomas of the transitional cervical-thoracic spine in children (сlinical observations, preliminary results)

Introduction. Vertebral hemangioma is a common pathology, in which 3.7% cases are aggressive. One of the pathogenetic factors contributing to the growth of vertebral hemangioma is mechanical overload. The transitional parts of the spine are the most loaded. Lesions of the transitional cervical-thoracic spine by hemangioma are rare (2%–4% of all vertebral hemangiomas). A common treatment for aggressive hemangiomas is puncture vertebroplasty. Currently, the number of pediatric patients with vertebral hemangiomas has increased, with an incidence close to 8% for individuals aged below 18 years. Exaggeration of the possibilities of conservative treatment for hemangiomas in children often leads to unsatisfactory results. Clinical research on this problem is relevant due to the lack information about the surgical tactics in aggressive spinal hemangiomas in children.&#x0D; Clinical observation. Two patients aged 15 and 17 years old with aggressive hemangiomas of the transitional cervical-thoracic spine underwent operation with the use of open-puncture vertebroplasty. There were no postoperative complications, and good preliminary results were obtained.&#x0D; Discussion. Various approaches in the treatment of aggressive hemangiomas of the transitional cervical-thoracic spine in children, including open-puncture vertebroplasty, were presented and analyzed.&#x0D; Conclusion. Due to the limited information about surgical treatment for pediatric vertebral hemangiomas, the presented clinical cases of surgical treatment for aggressive hemangiomas of the transitional cervical-thoracic spine may be of interest to a wide audience.