In this paper the dynamic responses of discrete single-layer domes are discussed. As objects of the study, computational models of domes have been analysed. These models differ in the type of their boundary conditions, the grid configuration, and in the height of the spheres. The analysis was conducted in two stages: a modal and a spectral analysis. In the modal analysis, a coefficient of the effective modal mass and the type of natural forms of vibration have been observed. Comparison has been made between CQC and SRSS being two different methods for combining modal contributions, as well as between two other methods of combining modal responses in the direction of seismic effects, namely: SRSS method and the “Rule of 30%”. The purpose of the study is to work out the dynamic response of the discrete single-layer spherical domes.