Spectrum Of Soft Tissue Tumors Research Articles

Demographic and histopathologic study of soft tissue lesions in a tertiary care hospital in South India

The term soft tissue tumors (STT) encompass a wide range of tumors arising from the mesenchymal tissues. In this study, we have retrospectively analysed the various STTs occurring in the Department of Pathology and included all cases with a confirmed histopathological diagnosis of soft tissue lesions received during the study period of January 2018 – December 2019. These cases were further analysed for the site of the lesion, number of lesions, age and gender of the patients and the results tabulated. A total of 207 cases of soft tissue tumors with confirmed histopathological diagnosis were included in this study. The male: female ratio was 1.1:1. It was observed that most of the soft tissue tumors were seen in the 31-40 years age group (33%) followed by the 41-50 years age group (21%). The most common histopathologic subtype of tumors were of adipocytic origin (61%). Malignant morphology was observed in 2.4% of the cases. Soft tissue tumors are not uncommon tumors and account for 5.2% of cases among the routine histopathological specimens. This study is presented here to understand the demography and the spectrum of soft tissue tumors observed in a tertiary care centre.

Cardiac fibroma: A clinicopathologic study of a series of 12 cases

BackgroundCardiac fibroma (CF) is a rare tumor that has not been widely reported. This study investigated the clinical findings, histologic features, and differential diagnosis of CF. MethodsA total of 12 CF cases were studied and reviewed using hematoxylin and eosin (H&E), special staining and immunohistochemical staining. The ALK gene was tested in 4 cases of cardiac fibroma with significant inflammatory cells. Clinicopathological data were retrospectively analyzed and followed up. ResultsThe cases occurred in six males and six females ranging in age from 0.5 to 55 years (median, 5 years). The tumors were grossly single and solid (1–17 cm; mean 5.6 cm). The clinical signs and symptoms depended largely on the location of the tumor. Microscopically, the CFs observed were composed of monomorphic spindle cells and abundant collagen. The spindle cells demonstrated little or no atypia. The histology of CFs in infants and young children showed some differences from those in adults. Infants and young children with fibromas exhibited cellular types with more inflammatory infiltration. All tumors expressed vimentin markers. Eleven of 12 cases (91.7%) were positive for SMA by immunohistochemistry. ALK immunostaining and ALK-FISH tests showed negative results. Follow-up information was available for all patients. The mean postoperative follow-up was at 3 years (range 2 months–8.8 years). All patients were alive with no evidence of disease. ConclusionsOur study shows that CFs exhibit a wide morphological spectrum of soft tissue tumors with fibroblastic or myofibroblastic differentiation and/or components. Infants and younger pediatric patients with fibromas have tumors that are more hypercellular and more likely to be misdiagnosed with aggressive or malignant lesions than adults. Finally, the data indicate that CF exhibits benign behavior and that local resection is safe and effective.

Axillary fibromatosis with radiological-pathological correlation: a case report and literature review

BackgroundThe term fibromatosis refers to a spectrum of soft tissue tumors resulting from the unbridled proliferation of fibroblasts, with high infiltrative power. It is a rare neoplasm, with an incidence of about 3 cases per million. Most common sites include the abdominal wall and cavity, chest wall, scapular area, and the limbs, rarely affecting the axilla. Imaging plays a major role in surgical planning and clinical follow-up. Differential diagnosis with other soft tissue tumors may be arduous, but a correct evaluation is fundamental.Case presentationA 33-year-old case is reported for the evaluation of a palpable hardened and immobile left axillary nodule. The ultrasound reveals a solid, elongated, heterogeneous, poorly delimited, infiltrative lesion observed in the left axillary hollow, with no detectable flow in the color Doppler mode. At magnetic resonance imaging, the same elongated and expansive lesion was better defined, revealing its irregular contours, alternating areas of hypo- and hyperintense on T2, heterogeneous enhancement, and no signs of signal decay on in- and out-of-phase sequences. Due to its growth and local invasion potential, surgical excision was performed. The microscopic analysis showed long and uniform spindle cell fascicles, with clear cytoplasm and wavy nuclei, arranged in different directions, included in collagen stroma. Immunohistochemistry was positive for nuclear beta-catenin, confirming the diagnosis of fibromatosis.ConclusionImaging methods reflect the heterogeneous nature of the lesion. This study demonstrates the importance of using a multidisciplinary approach in addition to imaging tests and histopathological study for better diagnosis and therapeutic planning. The high infiltrative power always must be reminded of, since it affects young patients and diagnosis delay can lead to mutilating surgeries.

Spectrum of soft tissue tumors: A two year clinicopathological study at tertiary level hospital

Introduction: Soft tissue sarcomas account for less than 1% of overall human burden of malignant tumors. Our study was conducted in a tertiary care hospital in konaseema region to identify various histological patterns of the soft tissue tumors along with their relation to age, sex and site. Materials and Methods: 215 cases of soft tissue tumors were analysed both retrospectively and prospectively for two years during January 2015 to January 2017. A careful histopathological examination was done with clinical correlation. Results: In a span of two years, we received 215 soft tissue tumors, 179 cases (83.2%) were benign in nature, 18 (8.3%) cases were of intermediate grade malignancy and 18 (8.3%) were malignant. Males were affected more than females. The most common site was lower extremities. Conclusion: A vigilant Histopathological examination using Hematoxylin and Eosin stain (H&E) with clinical correlation is still an important tool and gold standard in diagnosing various patterns of soft tissue tumors. Keywords: Soft tissue sarcoma, Benign, Malignant, Hematoxylin and Eosin stain.

Morphological spectrum of soft tissue tumors in a tertiary care hospital affiliated with a teaching institute: A 4 years retrospective study

Aims and Objectives: 1) To study the morphological spectrum of soft tissue tumors in detail on the basis of both histopathological features and recent WHO classification and 2) To study the relative frequencies of Benign, Intermediate and Malignant tumors along with their locations, age groups of presentation and gender ratio. Materials and Methods: The present 4 years retrospective study was conducted at the department of Pathology, GMERS Medical College-Junagadh from January 2015 to December 2018. It includes 105 cases of soft tissue tumors that presented and diagnosed at our institute on both clinical and pathological basis. Results: Out of 105 cases, 101 (96.19%) were benign, only one (0.95%) was intermediate & 3 (2.86%) were malignant in nature. The commonest age group was 41-50 years & M: F ratio was 1.56:1. Among benign tumors, adipocytic tumors constituted majority of the cases (78.22%) followed by vascular tumors (7.92%). Both upper & lower extremities were found to be the commonest location for such tumors. Conclusion: Soft tissue tumors are diagnosed on the basis of gross & light microscopic features in majority of the cases. However, in certain cases of malignancies or sarcomas, ancillary techniques like special histochemical staining & IHC become quite helpful in diagnosis. Keywords: Peripheral Neuroblastic tumors, Neuroblastoma, Ganglioneuroblastoma, Ganglioneuroma, Immunohistochemistry.

Common Soft Tissue Tumors Involving the Hand with Histopathological Correlation.

Soft tissue tumors involving the hand are common and most often benign. It is important to know the spectrum of soft tissue tumors of the hand and understand the typical as well as atypical imaging features are seen on different imaging modalities. The imaging features are largely determined by the tumor histopathology; thus, the basic idea about the tumor histopathology will always be useful. This article intends to focus on a comprehensive approach including demographics, clinical presentation, and imaging findings required to diagnose the tumor definitely or narrow the differentials. This article discusses common soft tissue tumor mimics of the hand as well, however, excludes the bone tumors for the sake of brevity.

Epidemiological and histopathological analysis of soft tissue tumors of the hand - 9 years of experience from a single center

Objectives: The spectrum of soft tissue tumors of the hand is wide. The type of tumor can vary based on demographic factors, such as a patient’s gender and age. Furthermore, certain tumors arise more commonly in particular locations on the hand. This study aimed to determine the incidence and recurrence rates of soft tissue tumors of the hand and to discuss the most common types of tumors based on tumoral parameters, demographic data, and histopathological findings with a brief review of the literature. Methods: We analyzed the clinical data and the pathology reports of all patients who underwent surgery in our hand and microsurgery department between January 1, 2007, and January 1, 2016. We evaluated the demographic data, surgical information, tumor type, size and location, histopathological diagnoses and immunohistochemical findings. We also determined the recurrence rates of the patients after a 2-year follow up. Results: In our center, 302 surgical resections were performed between January 1, 2007, and January 1, 2016. Ganglion, which is a pseudotumoral lesion, was the most common space occupying lesion (n=102, 34%). Of the 302 resections, 66% were tumoral cases (n=200). Giant cell tenosynovial tumor (n=55, 27.5%) was the most common benign tumor, followed by glomus tumor (n=34, 17%), pyogenic granuloma (n=15, 7.5%), and cystic hygroma (n=14, 7%). Conclusion: In accordance with the literature, in the present study, most of the patients (99%) that underwent surgery had benign diagnoses. Synovial sarcoma was the only malignant tumor observed in the study population.

A Clinicopathological Spectrum of Soft Tissue Tumors in a Tertiary Care Centre with Emphasis on Role of Immunohistochemistry in Diagnosis of Soft Tissue Tumors

A Clinicopathological Spectrum of Soft Tissue Tumors in a Tertiary Care Centre with Emphasis on Role of Immunohistochemistry in Diagnosis of Soft Tissue Tumors

Histopathological Spectrum of Soft Tissue Tumors in Rural Population

Histopathological Spectrum of Soft Tissue Tumors in Rural Population

Histopathological Spectrum of Soft tissue tumors in a rural Tertiary Care teaching hospital

Histopathological Spectrum of Soft tissue tumors in a rural Tertiary Care teaching hospital

Spectrum of soft tissue tumors based on histomorphology

Spectrum of soft tissue tumors based on histomorphology

Pediatric low-grade fibromyxoid sarcoma mimicking ossifying fibromyxoid tumor: adding to the diagnostic spectrum of soft tissue tumors with a bony shell

We describe a case of superficial low-grade fibromyxoid sarcoma (LGFMS) in a 12-year-old boy, confirmed by the detection of FUS-CREB3L2 fusion transcripts by reverse-transcription polymerase chain reaction and FUS rearrangement with fluorescence in situ hybridization, which had morphological features similar to ossifying fibromyxoid tumor (OFMT), including an almost complete rim of mature, metaplastic bone. LGFMS and OFMT can appear morphologically similar, with bland ovoid cells within a fibrous to myxoid matrix. Both can occur superficially; and whereas MUC4 immunoreactivity is characteristic of LGFMS, this can also be seen in some OFMTs. As the morphological spectrum of LGFMS is wide, we highlight the potential for diagnostic confusion with OFMT, which is clinically pertinent as most OFMTs behave in a benign manner whereas LGFMS is a malignant neoplasm with a propensity for local recurrence and a significant metastatic rate.

Molecular strategies for detecting chromosomal translocations in soft tissue tumors (Review)

Approximately one third of soft tissue tumors are characterized by chromosomal aberrations, in particular, translocations and amplifications, which appear to be highly specific. The identification of fusion transcripts not only supports the diagnosis, but provides the basis for the development of novel therapeutic strategies aimed at blocking the aberrant activity of chimeric proteins. Molecular biology, and in particular, cytogenetic and qualitative and quantitative polymerase chain reaction technologies, allow with high efficiency and specificity, the determination of specific fusion transcripts resulting from chromosomal translocations, as well as the analysis of gene amplifications. In this review, various molecular techniques that allow the identification of translocations and consequent fusion transcripts generated are discussed in the broad spectrum of soft tissue tumors.