The development of a scientific framework for performance-based seismic engineering requires, among other steps, the evaluation of ground motion intensity measures at a site and the characterization of their relationship with suitable engineering demand parameters (EDPs) which describe the performance of a structure. In order to be able to predict the damage resulting from earthquake ground motions in a structural system, it is first necessary to properly identify ground motion parameters that are well correlated with structural response and, in turn, with damage. Since structural damage during an earthquake ground motion may be due to excessive deformation or to cumulative cyclic damage, reliable methods for estimating displacement demands on structures are needed. Even though the seismic performance is directly related to the global and local deformations of the structure, energy-based methodologies appear more helpful in concept, as they permit a rational assessment of the energy absorption and dissipation mechanisms that can be effectively accomplished to balance the energy imparted to the structure. Moreover, energy-based parameters are directly related to cycles of response of the structure and, therefore, they can implicitly capture the effect of ground motion duration, which is ignored by conventional spectral parameters. Therefore, the identification of reliable relationships between energy and displacement demands represents a fundamental issue in both the development of more reliable seismic code provisions and the evaluation of seismic vulnerability aimed at the upgrading of existing hazardous facilities. As these two aspects could become consistently integrated within a performance-based seismic design methodology, understanding how input and dissipated energy are correlated with displacement demands emerges as a decisive prerequisite. The aim of the present study is the establishment of functional relationships between input and dissipated energy (that can be considered as parameters representative of the amplitude, frequency content and duration of earthquake ground motions) and displacement-based response measures that are well correlated to structural and non-structural damage. For the purpose of quantifying the EDPs to be related to the energy measures, for comprehensive range of ground motion and structural characteristics, both simplified and more accurate numerical models will be used in this study for the estimation of local and global displacement and energy demands. Parametric linear and nonlinear time-history analyses will be performed on elastic and inelastic SDOF and MDOF systems, in order to assume information on the seismic response of a wide range of current structures. Hysteretic models typical of frame force/displacement behavior will be assumed for the local inelastic cyclic response of the systems. A wide range of vibration periods will be taken into account so as to define displacement, interstory drift and energy spectra for MDOF systems. Various scalar measures related to the deformation demand will be used in this research. These include the spectral displacements, the peak roof drift ratio, and the peak interstory drift ratio. A total of about 900 recorded ground motions covering a broad variety of condition in terms of frequency content, duration and amplitude will be used as input in the dynamic analyses. The records are obtained from 40 earthquakes and grouped as a function of magnitude of the event, source-to-site condition and site soil condition. In addition, in the data-set of records a considerable number of near-fault signals is included, in recognition of the particular significance of pulse-like time histories in causing large seismic demands to the structures.