Spectral Coherence Research Articles

Tear meniscus particle analysis with anterior segment optical coherence tomography in keratoconus.

To perform tear meniscus particle analysis using anterior segment spectral domain-optical coherence tomography (SD-OCT) and ImageJ software in keratoconus patients. A total of 76 participants (76 eyes) were included in the study. A comprehensive analysis of tear meniscus parameters, including tear meniscus height (TMH), tear meniscus depth (TMD), tear meniscus turbidity (TMT), and percentage of area occupied by particles (PAOP) within the meniscus, was performed in kerataconus patients and healthy controls. TMT was significantly higher in the keratoconus group, while PAOP was significantly lower (P < 0.05). However, TMH and TMD did not show significant differences between the two groups (P > 0.05). There was a negative correlation observed between TMT and PAOP. In binary logistic regression analysis, TMT and Schirmer score were found to be the most influential factors in predicting keratoconus (odds ratio [OR] = 0.995, P = 0.039 and OR = 1.143, P = 0.021, respectively). This study revealed novel findings on analysis of the tear film in keratoconus patients, with higher TMT and lower POAP levels in the keratoconus group compared to the healthy control group.

Intergrader Agreement in Grading Optical Coherence Tomography Morphologic Features in Eyes With Intermediate Nonexudative Age-Related Macular Degeneration.

To determine the reliability of a nine-point summary scale for grading intermediate age-related macular degeneration (AMD) image morphologic features based on the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. Two trained graders independently divided spectral domain-optical coherence tomography (SD-OCT) scans into nine subfields and then graded each subfield for the presence of intraretinal hyperreflective foci (HRF), reticular pseudodrusen (RPD), and incomplete or complete retinal pigment epithelium and outer retinal atrophy (iRORA or cRORA). Grading results were assessed by summing the subfield grades into a nine-point summary score and also by using an eye-level binary grade for presence of the finding in any subfield. Gwet's first-order agreement coefficient (AC1) was calculated to assess intergrader agreement. Images of 79 eyes from 52 patients were evaluated. Intergrader agreement was higher when the OCT grades were summarized with a nine-point summary score (Gwet's AC1 0.92, 0.89, 0.99, and 0.99 for HRF, RPD, iRORA, and cRORA, respectively) compared with the eye-level binary grade (Gwet's AC1 0.75, 0.76, 0.97, and 0.96 for HRF, RPD, iRORA, and cRORA, respectively), with significant differences detected for HRF and RPD. The use of a nine-point summary score showed higher reliability in grading when compared to the binary subfield- and eye-level data, and thus may offer more precise estimation of AMD disease staging. These findings suggest that a nine-point summary score could be a useful means of disease staging by using findings on OCT in clinical studies of AMD.

Sleep stages and brain oscillations: An in-depth analysis using quantitative and mathematical models

This study explores the intricate relationship between sleep stages and brain oscillations, utilizing quantitative EEG analysis and mathematical models. We examine the distinct EEG characteristics of light sleep, deep sleep, and REM sleep, focusing on power spectral density (PSD), coherence, and phase synchronization analyses. The Ising model and Kuramoto model provide frameworks for understanding the synchronization dynamics and phase relationships of neuronal populations across sleep stages. Our findings highlight significant variations in oscillatory activity, coherence, and phase synchronization, offering insights into the neural mechanisms underlying sleep regulation. Additionally, we discuss the implications of these findings for sleep disorders such as insomnia, sleep apnea, and narcolepsy, demonstrating how mathematical models can predict therapeutic outcomes and guide targeted interventions. This comprehensive analysis contributes to the understanding of sleep architecture and the development of novel treatments for sleep disorders.

Coherence evolution of multi-pulse pumped supercontinuum generation in all-normal dispersion fibers.

We numerically calculate the coherence of supercontinuum (SC) spectrum generated in all-normal dispersion (ANDi) fibers by multiple picosecond pulses. We show that multi-pulse pumping significantly mitigates the phenomenon of coherence degradation and maintains high spectral coherence over a broader wavelength range compared to the single pumping. It is found that inter-pulse four-wave-mixing (FWM) and stimulated Raman scattering (SRS) significantly contribute to the superior coherence characteristics of the SC. We further discuss the impact of key parameters on the multi-pulse pumped SC. Results indicate that a large temporal interval between pulses reduces spectral broadening efficiency, while closely spaced pulses generate a significant number of incoherent photons, severely degrading spectral coherence. Introducing initial chirp effectively mitigates this coherence degradation. A slight increase in the dispersion parameter notably suppresses the spectral broadening efficiency of the multi-pulse generation. Pulse shape primarily affects the SC shape without significantly impacting the spectral broadening efficiency.

Evaluation of cerebral microcirculation in a mouse model of systemic inflammation.

Perturbations in the microcirculatory system have been observed in neurological conditions, such as Alzheimer's disease or systemic inflammation. However, changes occurring at the level of the capillary are difficult to translate to biomarkers that could be measured macroscopically. We aim to evaluate whether transit time changes reflect capillary stalling and to what degree. We employ a combined spectral optical coherence tomography (OCT) and fluorescence optical imaging (FOI) system to investigate the relation between capillary stalling and transit time in a mouse model of systemic inflammation induced by intraperitoneal injection of lipopolysaccharide. Angiograms are obtained using OCT, and fluorescence signal images are acquired by the FOI system upon intravenous injection of fluorescein isothiocyanate via a catheter inserted into the tail vein. Our findings reveal that lipopolysaccharide (LPS) administration significantly increases both the percentage and duration of capillary stalling compared to mice receiving a 0.9% saline injection. Moreover, LPS-induced mice exhibit significantly prolonged arteriovenous transit time compared to control mice. These observations suggest that capillary stalling, induced by inflammation, modulates cerebral mean transit time, a measure that has translational potential.

Functional states of prelimbic and related circuits during the acquisition of a GO/noGO task in rats.

GO/noGO tasks enable assessing decision-making processes and the ability to suppress a specific action according to the context. Here, rats had to discriminate between 2 visual stimuli (GO or noGO) shown on an iPad screen. The execution (for GO) or nonexecution (for noGO) of the selected action (to touch or not the visual display) were reinforced with food. The main goal was to record and to analyze local field potentials collected from cortical and subcortical structures when the visual stimuli were shown on the touch screen and during the subsequent activities. Rats were implanted with recording electrodes in the prelimbic cortex, primary motor cortex, nucleus accumbens septi, basolateral amygdala, dorsolateral and dorsomedial striatum, hippocampal CA1, and mediodorsal thalamic nucleus. Spectral analyses of the collected data demonstrate that the prelimbic cortex was selectively involved in the cognitive and motivational processing of the learning task but not in the execution of reward-directed behaviors. In addition, the other recorded structures presented specific tendencies to be involved in these 2 types of brain activity in response to the presentation of GO or noGO stimuli. Spectral analyses, spectrograms, and coherence between the recorded brain areas indicate their specific involvement in GO vs. noGO tasks.

A case of accelerated recovery in acute retinal pigment epitheliitis with early methylprednisolone intervention

We present a compelling case of acute retinal pigment epitheliitis (ARPE), also known as Krill’s disease, in a 26-year-old female ophthalmology resident, emphasizing the significance of early intervention and its impact on rapid symptom resolution. Comprehensive ocular examination, fluorescein angiography, and spectral domain-optical coherence tomography were employed for the diagnosis. The patient received pulsed methylprednisolone therapy that was initiated promptly due to professional exigencies. Within 3 days of initiating the methylprednisolone therapy, most of the symptoms, including central scotoma and visual impairment, resolved remarkably. This accelerated recovery challenges the conventional notion of ARPE as a self-limiting condition. The case underscores the importance of individualized treatment strategies in professional contexts, where swift resolution is imperative. Advanced imaging techniques, particularly spectral domain-optical coherence tomography, play a pivotal role in both diagnosis and monitoring the disease progression. Further research is crucial to refine the treatment protocols and unravel the intricacies of ARPE pathophysiology.

Cyclostationarity and real order derivatives in roller bearing fault detection

Abstract Various methods are used in the field of machine diagnostics for recognizing cyclostationarity in signals. The real order derivatives of vibration signals, however, have been rarely reported from the perspective of their effect on the performance of cyclostationarity detection methods. In this paper, we use real order derivatives together with spectral correlation, spectral coherence and squared envelope. Our results suggest that adjusting the order of derivative can enhance the analysis outcome of spectral correlation and squared envelope in particular. Remarkably, the results also suggest that squared envelope, when used alongside real-order derivatives, may replace spectral correlation and spectral coherence. This approach allows obtaining results with reduced computational power, making it advantageous for applications like industrial edge computing, where cost-effective hardware is crucial.

Assessing Choroidal Thickness in Pediatric Patients With Unilateral Strabismic Amblyopia by Using Spectral Domain-Enhanced Depth Imaging-Optical Coherence Tomography.

Objective In this study, we aimed to evaluate the choroidal thickness in patients with unilateral strabismic amblyopia by usingspectral domain-enhanced depth imaging-optical coherence tomography (SD-EDI-OCT) (Heidelberg EngineeringGmbH, Heidelberg, Germany). Methods Twenty-five children with strabismic amblyopia and 20 age- and sex-matched healthy controls were included in this study. Seven sections were obtained, each comprising 25 repetitive images from each section at 200-micron intervals, and measurements were taken from nine different points at vertical and horizontal lines (1 and 3 mm from the subfoveal, superior, inferior, temporal, and nasal regions), centered on the fovea, using SD-EDI-OCT. Choroidal thickness values were obtained by measuring the distance between the basal border of the retinal pigment epithelium and the choroidoscleral border. The Mann-Whitney U test was used to compare choroidal thickness between the amblyopic and the control groups. Results The mean ageof children with amblyopia and that of controls were 8.4 ±2.7 and 9.9 ±3.3 years, respectively (p=0.120). The mean subfoveal choroidal thickness was 372.8 ±78.9 μm in amblyopic eyes and 372.4 ±79.3 μm in the fellow eyes, both of which were thicker than the control eyes (310.9 ±76.3 μm;p<0.05 for each). Similarly, the mean values for the choroidal thickness of the amblyopic children at 1 mm nasal (320 ±86 μm), 1 mm superior (363 ±70 μm), and 3 mm superior (336 ±62 μm) were also significantly thicker than those of the corresponding control eyes (p<0.05 for each). There was a negative correlation between the subfoveal choroidal thickness and axial length (r=-0.332, p=0.005). There were no correlations between the choroidal thickness, age, and visual acuity. Conclusions The choroidal thicknesses of strabismic and fellow eyes were similar in patients with strabismic amblyopia. However, the choroidal thickness of both eyes in strabismic children was significantly thicker than those of the healthy controls. Emmetropization may be defective in both eyes of strabismic amblyopic patients.

Blind cyclostationary fault feature extraction in rolling bearings: a dual adaptive filtering approach

Extracting cyclostationary features from vibration signals is one of the most effective approaches in bearing fault diagnosis. However, current methods require prior knowledge of cycle-frequencies or other statistical information, which constrains their applicability across various scenarios. In this paper, we introduce a novel dual adaptive filtering method, incorporating cycle-frequency estimation to solve the existing problem. The method firstly employs an adaptive line enhancer (ALE) to isolate the first-order cyclostationary signal, thereby the cycle-frequencies can be effectively detected using an exhaustive estimation technique. Subsequently, an adaptive frequency-shift (FRESH) filter is further applied to extract the second-order cyclostationary features from the residual components. The proposed method successfully overcomes the challenge of separating cyclostationary signals without prior knowledge and can be tailored to real-time application scenarios. Besides, the approach distinguishes between the two cyclostationary signal types, effectively resolving any aliasing concerns inherent in their statistical characteristics. The effectiveness of the method is verified through simulation, experiments, and engineering data analysis. It is demonstrated that the method significantly enhances diagnostic accuracy and is more suitable for early fault diagnosis of rolling bearings by estimating spectral coherence on the extracted signals.

Correlation Between Blue Fundus Autofluorescence and SD-OCT Measurements of Geographic Atrophy in Dry Age-Related Macular Degeneration

To compare fundus autofluorescence (FAF) and spectral domain optical coherence tomography (OCT) measurements of geographic atrophy (GA) area and to analyze lesion area changes measured by spectral domain OCT in GATHER1. An assessment reliability analysis using prospective, randomized, double-masked phase 2/3 clinical trial data. GATHER1 examined the efficacy and safety of avacincaptad pegol (ACP) for GA treatment. A post hoc analysis was performed to identify correlations between FAF- and OCT-based measurements of GA. GA area was measured on blue-light FAF images using semiautomatic segmentation software with support from OCT and near-infrared imaging. Machine-learning enhanced, multilayer segmentation of OCT scans were reviewed by human readers, and segmentation errors were corrected as needed. GA area was defined as total RPE loss on cross-sectional B scans. Time points included Months 0, 6, 12, and 18. Additionally, OCT-based GA-area changes between ACP and sham were analyzed. There was a strong correlation (r = 0.93) between FAF and OCT GA area measurements that persisted through 18 months. Mean (SD) differences between OCT and FAF GA measurements were negligible: 0.11 mm2 (1.42) at Month 0, 0.03 mm2 (1.62) at Month 6, -0.17 mm2 (1.81) at Month 12, and -0.07 mm2 (1.78) at Month 18. OCT assessments of GA growth revealed a 30% and 27% reduction at Months 12 and 18, respectively, between ACP and sham, replicating FAF measurements from GATHER1. The strong correlation between blue FAF and OCT measurements of GA area supports OCT as a reliable method to measure GA lesion area in clinical trials.

Effects of slit lamp-delivered retinal laser photobiomodulation in a rat model of choroidal neovascularization

Neovascular age-related macular degeneration, also known as exudative or wet age-related macular degeneration, is the leading cause of blindness in the developed world. Photobiomodulation has the potential to target the up-stream hypoxic and pro-inflammatory drivers of choroidal neovascularization. This study investigated whether photobiomodulation attenuates characteristic pathological features of choroidal neovascularization in a rodent model.Experimental choroidal neovascularization was induced in Brown Norway rats with laser photocoagulation. A custom-designed, slit-lamp-mounted, 670 nm laser was used to administer retinal photobiomodulation every 3 days, beginning 6 days prior to choroidal neovascularization induction and continuing until the animals were killed 14 days later. The effect of photobiomodulation on the size of choroidal neovascular membranes was determined using isolectin-B4 immunohistochemistry and spectral domain-optical coherence tomography. Vascular leakage was determined with fluorescein angiography. The effect of treatment on levels of vascular endothelial growth factor expression was quantified with enzyme-linked immunosorbent assay.Treatment with photobiomodulation was associated with choroidal neovascular membranes that were smaller, had less fluorescein leakage, and a diminished presence of inflammatory cells as compared to sham eyes. These effects were not associated with a statistically significant difference in the level of vascular endothelial growth factor when compared to sham eyes.The data shown herein indicate that photobiomodulation attenuates pathological features of choroidal neovascularization in a rodent model by mechanisms that may be independent of vascular endothelial growth factor.

Macular hole surgery follow-up with spectral domain-optical coherence tomography-guided facedown posturing.

The main treatment for macular hole (MH) is pars plana vitrectomy, with or without internal limiting membrane (ILM) peeling, followed by gas tamponade and face-down positioning (FDP). This study aims to present the anatomical and visual outcomes following MH repair with optical coherence tomography (OCT)-guided FDP. Thirty-two patients who underwent surgery for idiopathic MH were enrolled. The requirement for the prone position was lifted for those with MH closure observed under gas on postoperative day one OCT. Patients with unclosed MHs were instructed to maintain FDP until the 3rd day. Best-corrected visual acuity at preoperative, postoperative 1st month, and the last visit, closure time post-surgery, duration of prone position, and surgical success rate were recorded. Among the patients, 21 underwent phacovitrectomy + ILM peeling + gas tamponade, while 11 had vitrectomy + ILM peeling + gas tamponade. On postoperative day one, 28 out of 32 MHs closed, with 3 closures on day 3 and one on day 5. There were 18 stage two (56.3%), 13 stage three (40.6%) and 1 stage four (3.1%) MHs. The mean minimum MH diameter was 381.75 ± 68.07 (min 260-max 517) microns. All patients with MH closure time over postoperative day one had non-combined vitrectomy instead of phacovitrectomy. No late complications were observed. OCT-guided FDP approach yields excellent closure rates with no late complications and ensures good patient comfort.

Spectral Domain and Angiography Optical Coherence Tomography in Parkinson’s Disease: Structural And Vascular Changes in the Retina Correlate with Disease Severity and Progression

Background. Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by bradykinesia, resting tremor, and muscle rigidity. Visual disturbances have been also described among non-motor features. Objective. We aimed to investigate the structural and vascular changes in the retinal and choroidal vascular networks, and to assess any relationship with motor and non-motor symptoms (NMS) in PD patients. Methods. Ganglion cell complex (GCC), retinal nerve fiber layer (RNFL), and subfoveal choroidal thickness (SFCT) were examined using spectral domain-optical coherence tomography (SD-OCT). The vessel density (VD) of retinal and choriocapillary vascular networks in macular area and the foveal avascular zone (FAZ) area were evaluated by OCT angiography (OCTA). All patients underwent clinical evaluation using motor section of the Unified PD Rating Scale (UPDRS-III) and the Hoehn and Yahr (HY) scale. Results. A total of 48 eyes from 24 PD patients and 50 eyes from 25 controls were assessed. At SD-OCT, GCC and RNFL were more significantly thin in patients compared to controls. At OCTA exam, PD subjects showed lower values in VD of superficial capillary plexus (SCP) and radial peripapillary capillary plexus in comparison to controls, whereas FAZ area resulted in a significant increase in the patient group. We found a negative correlation between the age at onset and VD of SCP, and between HY score and RNFL thickness and FAZ. UPDRS-III score was negatively correlated with VD of deep capillary plexus. Discussion. The impairment of retinal structure and microvasculature seems to correlate with disease severity and progression in PD. Retinal anomalies can be considered as non-motor manifestations that could occur already in the early stage of the disease.

Numerical Characterization of Prestall Disturbances in a Compressor Stage

Abstract Compared to the subject of rotating stall, less attention has been given to prestall flow disturbances in turbomachinery. This is mostly due to the fact that these phenomena, often referred to as Rotating Instabilities, do not necessarily or distinctly occur in every compressor and usually last for a long period without posing serious threats to stable operation. The present study aims at numerically characterizing prestall disturbances in detail in a compressor stage in which they have been experimentally observed. Full-annulus computational fluid dynamics (CFD) computations employing a hybrid scale-resolving turbulence model are performed and compared against unsteady experimental data. Assessment of specific prestall disturbance metrics, including power spectral density, coherence, and circumferential mode distribution at the rotor clearance, shows that the numerical model is successful in reproducing the unsteady phenomena close to stall inception. Moreover, dynamic mode decomposition is employed to directly link each peak of the unique prestall disturbance spectral signature to spatial structures with a different circumferential order. This procedure is done for both 1D circumferential modes, based on flush-mounted pressure probes, and for 2D surfaces exposing the tip clearance dynamics. The high-resolution numerical model, supplemented with vortex identification criteria and data-driven decompositions, enhances the understanding of prestall disturbances and their associated coherent flow structures.

A combination of suprachoroidal injection of triamcinolone using a custom-made needle and intravitreal Ziv-aflibercept every eight weeks to manage naïve/denovo central DME: a single-center retrospective case series

BackgroundPrevious studies have shown promising effects of combining intravitreal bevacizumab and suprachoroidal injection of triamcinolone acetonide in treating DME. However, further research is needed.ObjectiveTo assess the efficacy and safety of combining both intravitreal Ziv-aflibercept and suprachoroidal injection of triamcinolone acetonide using a custom-made needle in naïve and de novo central diabetic macular edema (DME) patients every eight weeks for 24 weeks.MethodsCentral macular thickness was measured via spectral domain-optical coherence tomography, and best-corrected visual acuity was measured via a Snellen chart at baseline and at 4, 8, 12, 16, and 24 weeks postinjection. Additionally, cataract progression, intraocular pressure (IOP), and ocular safety were analyzed.ResultsA total of 10 eyes of 6 patients were treated with suprachoroidal injections of triamcinolone acteonid combined with an intravitreal injection of Ziv-aflibercept. Vision improved from 0.69 log minimum angle of resolution (MAR) at baseline to 0.39 log MAR after treatment. Central macular thickness significantly decreased from 462.3 ± 166 μm at baseline to 362.7 ± 77.6 μm at 24 weeks postinjection.ConclusionSuprachoroidal injection of triamcinolone using a custom-made needle with the intravitreal agent Ziv-aflibercept to treat de novo/naïve central DME has favorable outcomes and adequate safety results. Moreover, this study demonstrated the benefit of adapting the previous treatment combination for extending the interval between anti-VEGF treatments from 4 to 8 weeks, which could prevent further expenses, especially in low-income countries.However, large multicenter randomized clinical trials with longer follow-up periods are needed to assess this treatment route, especially in low-income and resourced countries.

Giant ocular surface squamous neoplasia evaluated by spectral domain-optical coherence tomography

Giant ocular surface squamous neoplasia (OSSN) is difficult to manage due to extensive surface involvement and postsurgical complications. Preoperative evaluation by spectral domain-optical coherence tomography (SD-OCT) can aid in detecting the limits in the needed tissue excision, residual corneal bed, and epithelial transition in all quadrants of the limbus. We present a case of giant OSSN managed surgically with preoperative SD-OCT evaluation for excision with margin clearance and minimal complications. The postoperative period was uneventful with a clear cornea without limbal stem cell deficiency and recurrence.

Psychophysical, electrofunctional, and morphological evaluation in naïve neovascular AMD patients treated with intravitreal anti-VEGF.

The aim of this study was to investigate the retinal morpho-functional characteristics of patients with neovascular wet age-related macular degeneration (nAMD) treated with intravitreal injection (IV) of aflibercept (AFL). The study was conducted on 35 patients previously diagnosed with type 1 nAMD who received a fixed-dosing regimen of aflibercept injections over 12 months. The goal was to assess trends in visual abilities over time by measuring visual acuity (VA), contrast sensitivity (CS), visual evoked potentials (VEPs), and spectral domain-optical coherence tomography (SD-OCT). The same psychophysical, electro-functional, and morphological tests administered at baseline (T0) were repeated 4 to 8 weeks after the last aflibercept injection (Tn), resulting in a total of six examinations. At Tn, all subjects exhibited improved VA for both far and near distances compared to values detected at T0. Similarly, VEP amplitude and latency values at Tn showed a greater P100 improvement than those observed at T0. Additionally, the CS examination at Tn demonstrated improvement, particularly at high spatial stimulation frequencies. The Tn SD-OCT results highlighted a reduction in macular thickness compared to T0 values. This exploratory research indicates that intravitreal injections of AFL, following a fixed-dosing regimen, represent a valuable therapeutic approach for enhancing visual performance. This conclusion is supported by comprehensive statistical analysis of psychophysical, electro-functional, and morphological examinations within the same group of patients with nAMD, as demonstrated for the first time.

Применение ингибиторов ангиогенеза при экссудативно-геморрагической хориоретинопатии (клинический случай)

Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is a rare condition characterized by retinal and choroidal changes observed in the periphery of the fundus. Most cases are asymptomatic. Due to the dark color and prominence of the retina in the periphery, this disease is often mistaken for choroidal melanoma. Material and methods. This article presents a clinical case report of a patient, a 77-yearold female, presented with sudden vision deterioration in her left eye and was diagnosed with PEHCR. Standard ophthalmic examinations including visual acuity, tonometry, ophthalmoscopy, spectral optical coherence tomography, ultrasonography, color Doppler imaging, and fluorescein angiography were performed. Following diagnosis, the patient received intravitreal injections of brolucizumab for treatment. Results. Significant improvement was observed in the patient's condition following antiVEGF therapy, with reduced retinal thickness and intraretinal cystic cavities in the macular region, as well as decreased neovascular membrane activity. Repeat injections further improved the patient's visual acuity and reduced peripheral retinal changes. Conclusion. PEHCR is a rare disease of the peripheral retina and choroid, which is often asymptomatic but can mimic serious life-threatening diseases, so it is important to correctly diagnose this disease using a multimodal approach to avoid misdiagnosis and determine treatment strategies. Keywords: peripheral exudative hemorrhagic chorioretinopathy, pseudomelanoma, аntivascular endothelial growth factor

Morphological differences of the neuroretinal rim between temporally tilted and non-tilted optic discs in healthy eyes

This study aimed to compare morphological differences of the neuroretinal rim between the temporally tilted and non-tilted optic discs in healthy eyes. We prospectively enrolled participants aged 20–40 years with temporally tilted or non-tilted optic discs. The optic nerve head parameters were analyzed using spectral domain-optical coherence tomography. The angle between the Bruch’s membrane opening (BMO) plane and BMO-minimum rim width (BMO-MRW) was termed “BMO-MRW angle”. Peripapillary retinal nerve fiber layer thickness (pRNFLT) and BMO-based parameters were compared between the temporally tilted and non-tilted disc groups. As a result, 55 temporally tilted disc eyes and 38 non-tilted disc eyes were analyzed. Global pRNFLT, global BMO-MRW, and total BMO-minimum rim area (BMO-MRA) were similar between the two groups (p = 0.138, 0.161, and p = 0.410, respectively). In the sectoral analysis, temporally tilted disc group exhibited thicker BMO-MRW in the temporal sector (p = 0.032) and thinner in the nasal superior and nasal sectors (p = 0.025 and p = 0.002, respectively). Temporally tilted disc group showed larger BMO-MRA in the temporal, temporal superior, and temporal inferior sectors (p < 0.001, p < 0.001, and p < 0.016, respectively), alongside a higher BMO-MRW angle in the temporal sector and lower in the nasal superior and nasal sectors. In conclusion, the neuroretinal rim, represented by BMO-MRW and BMO-MRA, showed morphological differences between temporally tilted and non-tilted optic discs in healthy eyes. BMO-MRW and BMO-MRA showed temporalization in the same manner as pRNFLT in the temporally tilted disc eyes. The BMO-MRW angle showed that in temporally tilted disc eyes, optic nerve fibers met the BMO plane steeply in the nasal sector and gently in the temporal sector than in non-tilted disc eyes, suggesting potential stress region of optic nerve fibers in temporally tilted disc eyes.