With the advancement of oil and gas exploration and development technology, the development of the world's oil and gas resources is gradually advancing from land and shallow waters to deep waters. During the development of gas wells in deepwater regions, the temperature of the wellbore decreases from the bottom of the well to the wellhead, and therefore, common well conditions of high pressure, low temperature, and the presence of free water are encountered, which can lead to gas hydrate plugging of the pipeline and affect the transportation of natural gas. Simulation of temperature and pressure along the wellbore and identification of gas hydrate-generating zones in the wellbore can be used to take timely preventive measures and minimize losses. In this study, a wellbore gas hydrate generation and prediction model is developed by combining the mass, momentum, and energy conservation equations, and the model is solved by the fourth-order Runge-Kutta method, taking into account the temperature-pressure coupling in the wellbore. The effects of gas production, specific heat capacity, thermal conductivity, tubing size, test duration, and ground temperature gradient on the location of gas hydrate generation and the amount of inhibitor used were analyzed in a case study well in the South China Sea. Some suggestions for practical engineering operations, such as increasing the gas production in moderation and choosing smaller tubing sizes within the acceptable range, were given. The study's results can provide a theoretical basis for flow assurance for hydrocarbon production in the wellbore of deepwater gas wells.