{Pt, Ir}/Ce1-xRuxO2, catalysts were prepared to be used in the hydrogen production from the ethanol steam reforming reaction. Initially, the catalytic supports, Ce1-xRuxO2, were synthesized by the sol–gel process. Later, the Pt/Ce0.97Ru0.03O2 and Ir/Ce0.97Ru0.03O2 catalysts were produced through incipient wetness impregnation using high purity compounds as sources of Pt or Ir. These systems were characterized by means of SEM, XRD, TEM, and specific surface area measurements. The catalysts were tested in the ethanol steam reforming reaction at stoichiometric conditions (water/ethanol = 3) in a continuous flow fixed–bed quartz microreactor under atmospheric pressure in the temperature range of 300–600 °C. From the results, it follows that the support itself acts as a catalyst for the reaction. The catalytic support (Ce0.97Ru0.03O2) and the catalytic species (Pt, Ir) exhibit sustained conversion during the studied interval of temperature. It was observed that at 600 °C, Pt/Ce0.97Ru0.03O2 and Ir/Ce0.97Ru0.03O2 achieve a (5 H2/ethanol) molar ratio. Stability tests revealed that Pt/Ce0.97Ru0.03O2 and Ce0.97Ru0.03O2 compounds showed an outstanding performance in the ethanol steam reforming reaction for more than 10 h before being deactivated.