The main sense of the preventive physical and rehabilitation medicine (PRM) strategy is the development and implementation of medical and social projects, which are based on certain backgrounds, principles, tasks and strategies. The purpose of a quality life formation is to promote the achievement of well-being and health at all levels and for all persons and the main mechanisms of its formation are the creation of conditions for individuals, groups of people, communities and a positive impact on health problems. The disease and its consequences, which disturb the necessary balance of medical, psychological and social components, lead to a change in the quality of a person’s life, to his partial or complete isolation from social life, which causes social disintegration. This necessitates the development and implementation in the health care system of Ukraine of promising preventive rehabilitation/habilitation technologies to improve the quality of life, which includes a person’s assessment of his physical, mental and social well-being. The article deals with modern views on preventive PRM as a disease prevention strategy, which includes the technology and organization of diagnostic and health-improving methods. The modern PRM strategy is determined by the priority of the systemic approach, the use of biopsychosocial models, the focus on the personalization of the individual, and provides for changes in the basic paradigm of the implementation and assessment of rehabilitation measures. Modern technologies in education and training have a positive impact on health promotion, rehabilitation and prevention, medical diagnosis, functional assessment, treatment and rehabilitation management for persons of any age who have experienced limitations in daily functioning due to health conditions. Preventive PRM is person- and functioning-oriented (as opposed to organ- and disease-oriented specialties or specialties that focus on specific age groups) and aims to improve activity, quality of life, improve healthy behaviors, and promote the positive influence of personal and environmental factors on functioning. Preventive PRM allows to manage person’s health. A person does not passively learn about the state of his health, but with the help of modern rehabilitation diagnostic technologies, a multidisciplinary approach, information support, specialists capable of implementing a complex of rehabilitation technologies, gets to know his body, understands what negatively affects his health, and which improves him, and most importantly, learns to manage these processes by himself.