Biophile microelements (copper, zinc, manganese, iron, nickel) and heavy metals (lead, cadmium) in the aerial part of Artemisia frigida Willd. and Artemisia jacutica Drob. of Russian (areas of the Republic of Buryatia) and Mongolian flora was presented in this paper. The quantitative content of the elements in the samples collected in 2008, 2015–2018 was studied using atomic absorption method performed on a SOLAAR M6 after preliminary decomposition by dry mineralization, and inductively coupled plasma atomic emission method (ICP) on a Profile Plus spectrometer after decomposition of samples in the MARS 6 microwave system. The content of the same elements in the aerial part of the same species of Artemisia varied in a wide range, which was consistent with the literature data. In addition, the Principle component analysis of the elemental composition of A. frigida and A. jacutica was presented in this paper. The biplot showed the impact of forest fires that took place on the territory of Buryatia in 2015. So this year was characterized by a high concentration of lead, cadmium, nickel, copper and iron in studied samples. Also, the biplot showed the elements content versus plant species. In general, the content of toxic (lead, cadmium, nickel) and vital elements (copper, zinc, iron, manganese) was within the normal concentration. Therefore, the aerial part of A. frigida and A. jacutica of Buryatian (Russia) and aimaks (Mongolia) flora can be considered as promising plant raw materials for using in medical practice.