Specialized Research Institutes Research Articles

Current status and perspectives in environmental oncology.

Cancer stands as a leading global cause of death, with its etiology characterized by complexity and multifaceted factors. Growing research indicates a strong correlation between environmental factors and cancer incidence, underscoring the critical importance of intervening in environmental risk factors to mitigate cancer occurrence. Despite this, specialized research institutions focusing on the intersection of environment and cancer remain scarce, with global investment in cancer prevention significantly trailing behind efforts in diagnosis and treatment. Against the backdrop of rapid global climate change, industrialization, urbanization, aging populations, and the globalization of lifestyles, we proposed the concept of Environmental Oncology (EO) to address these challenges. We discussed the rationale and necessity of developing EO and presented a comprehensive research framework focusing on cancer prevention and treatment. Future EO research will aim to identify cancer causes and implement early prevention strategies using advanced scientific technologies and methods. By emphasizing multidisciplinary collaboration and integrating molecular biology at the micro level, EO will explore the relationship between external and internal environments and cancer. EO will identify potential therapeutic targets by studying the pathways through which environmental exposures lead to carcinogenesis. EO will develop early warning systems and disseminate research findings by collecting big data, employing robust statistical models, and establishing research centers.

РЕЛОКАЦИЯ ПЕРСОНАЛА: НОВЫЕ ВЫЗОВЫ И ВОЗМОЖНОСТИ

Solving the problems of industrial production growth, business scaling, and promotion of new technologies to the regions is impossible without staffing enterprises with qualified workers. At the same time, in the conditions of the modern labor market, it is staffing that becomes one of the main risks in achieving the assigned tasks. One of the ways for enterprises in adapting to the conditions of the modern labor market is personnel relocation. That is why in recent years the issue of the labor mobility and personnel relocation has become the subject of both theoretical and empirical research. Drawing on the analysis and synthesis of statistical data, research results of specialized research institutes, consulting companies, expert opinions, and the experience of Russian companies in the research topic, the authors formulated the concept and characterized the content of the term “personnel relocation”, identified the main factors influencing employee decision-making about relocationю They also shown the main challenges for employers when developing personnel relocation programs and the ways to solve them are shown.

A bibliometric analysis of the research outcome of the Faculty of Medicine, University of Khartoum 2019-2023.

Using two databases, this bibliometric analysis was done for the papers published by the Faculty of Medicine, University of Khartoum (FMUK), from 2019 to 2023. Data were extracted from SCImago for all Sudan, and from PubMed for the publications by FMUK and its associated research centres, the Institute of Endemic Diseases, and the Mycetoma Research Center. The analysis of publications included the count and type of publications, the journals, and national and international collaboration assessment. The publications from FMUK show improvement over time in number and quality, a growth that is significantly influenced by national and international collaboration. These partnerships have proven to be a key driver of FMUK's research output, together with the valuable contributions of the specialized research institutions. However, there is room for improvement in the research output by increasing institutional capacity to support research and scientific communication. The Sudanese Journal of Paediatrics is an example where open access has a positive impact by allowing peripheral journals to be established despite the constraints.

ANALYSIS OF THE POSSIBILITY OF DEVELOPMENT AND IMPLEMENTATION OF A BASIC UNMANNED AIRCRAFT SYSTEM

The term “Basic Unmanned Aircraft System” refers to a comprehensive system encompassing both hardware and software components, forming an integral configuration aimed at unmanned aviation operations.
 The Unmanned Aircraft System, in its fundamental assembly, comprises an intricate interplay of technological components. These components, ranging from cutting-edge hardware to sophisticated software, collaborate harmoniously to execute tasks that were traditionally accomplished by manned aircraft.
 Collaboration between specialized enterprises and research institutions approach holds promise in terms of synergizing the respective expertise of these entities. This symbiotic partnership not only expedites the development process but also introduces the prospect of novel breakthroughs through the fusion of practical experience and theoretical knowledge.
 A paramount consideration is the host of advantages that could potentially be reaped from the realization of the Basic System. One such advantage is the projected increase in production volumes. This, in turn, could significantly bolster the capacity to meet defense orders in a shorter timeframe, thereby enhancing national security endeavors.
 Furthermore, the article delves into the catalytic effect this innovation could have on scientific research, particularly in prioritized domains. The development of the Basic System could potentially serve as a stimulus for intensified scientific inquiry. The complexity of its design necessitates advances in a multitude of scientific fronts, such as materials science, artificial intelligence, and robotics.

PHYTOPATHOLOGICAL MONITORING OF DANGEROUS OUTBREAKS DISEASE OF FOREST TREES WITH USE METHOD OF CHANGING RADIAL INCREMENTS IN THE CONDITIONS OF THE POLISKY NATURE RESERVE

PHYTOPATHOLOGICAL MONITORING OF DANGEROUS OUTBREAKS DISEASE OF FOREST TREES WITH USE METHOD OF CHANGING RADIAL INCREMENTS IN THE CONDITIONS OF THE POLISKY NATURE RESERVE

Environmental Approaches for the Benchmarking of International Experience in the Use of Scientific Research in State Strategic Planning for a Sustainable Development

The prospects for sustainable development of the Republic of Kazakhstan and the factors influencing its development are considered as a long-term direction of structural policy, which makes it possible to create and actively develop sustainable development programs, minimize risks, increase competitiveness and open up new opportunities that take into account the negative impact on the environment. In this regard, the paper analyzes the mechanisms of scientific support of state strategic planning in the framework of environmental management, using the scientific potential of the academic environment, taking into account the opinion of the public and the expert community, as well as the creation of specialized research institutes. The results of this study will indicate the ways in which the innovative potential conducted by the public administration could use the potential of science to improve the efficiency of public policies in environment management for a sustainable development.

Results of the implementation of scientific research within the framework of the industry program "Topical Issues of Traumatology and Orthopedics" (1996-2000)

The paper used materials from reports of specialized research institutes and departments of traumatology, orthopedics and military and surgical medical universities. The industry program was carried out by 10 NIITO, as well as MONIKI them. M.F. Vladimirsky, St. Petersburg Research Institute of Prosthetics and 5 departments of traumatology and orthopedics of medical universities - RSMU, St. Petersburg, Samara, Ivanovo and Izhevsk. More than 740 researchers took part in scientific research. Completed 40 contracts.

Condition and growth of pedunculate oak (Quercus robur L.) in irrigated forest belts of Saratov Trans-Volga steppe

The research aim was to establish the regularities of condition and growth of pedunculate oak (Quercus robur L.) in the irrigated forest belts in the steppe of Saratov Trans-Volga Region. The study object is a system of forest shelter belts under conditions of irrigation of dark chestnut soils of Saratov Trans-Volga steppe with tree species of the main and accompanying purpose - pedunculate oak, lanceolate ash (Fracsinus lanceolata L.) and squat elm (Ulmus pumila L.). The research in the field and materials processing were carried out in accordance with the methodology of specialized research institutes and leading scientists in the field of agroforestry. Forest belts located on agricultural land protect crops from the negative effects of drought and dry winds, optimize snow distribution in winter and irrigation regimes for crops during the growing season, and increase the crops productivity. Irrigation has the most important positive effect on growth and condition of tree species in forest belts and, as a result, on durability and reforestation efficiency of forest belts. The studies have shown that the average height and diameter of oak in the. irrigated forest belts mixed with different species are higher than those without irrigation by 15-26% and 34-39%, respectively. The oak growth in height in irrigated areas of forest belts exceeds its growth in height in areas of forest belts without irrigation by 1.5 times. The vital condition of oak in the irrigated forest belts is characterized by the prevalence of “slightly oppressed” (48%) and “healthy” oak trees (40%).

Patterns of runoff formation and erosion under the influence of land and forest strips on the southern chernozem

The purpose of the study is to establish the regularities of the formation of maximum flow rates and erosion under the influence of forests, forest strips and agricultural lands in the steppe of the Volga upland. The research methodology was based on the recommendations of specialized research institutes and scientists of Russia. Snow water supply, runoff, maximum runoff modulus, erosion undergo significant changes under the influence of agricultural land, forest strips and forests. Forest strips and forest reduce the coefficients of spring and stormwater runoff in comparison with agricultural land by 5.0-13.5 times. Accordingly, the indicators of the maximum flow modulus are 17.6 - 157 times. The parameters of the drain module are necessary for the creation of discharge erosion control structures. Erosion under the influence of forest strips in fields with non-fallow crop rotation cultivation technology and from forest lands takes permissible sizes of less than 0.3 t/ ha for soils A+ B < 0.5 m. Dump technology, in addition to forest strips, requires the use of additional agrotechnical techniques, for example, mulched crevice. From the complex variety of the impact of natural and anthropogenic factors on erosion, the coefficient and modulus of surface runoff, the degree of protection of the soil by land are the predominant ones. Regression-correlation analysis notes a close relationship between erosion, surface runoff parameters and applied forest strips with determination coefficients 082-0.96. Long-term studies on slopes 3-5o allowed us to recommend: distances between forest strips 300 m- 250 m; non-fallow technology of crop rotation cultivation.

Значение создания региональных энциклопедических изданий по библиотечному делу в развитии библиотечной политики в Украине

The article deals with a new direction of research and publishing activities in Ukraine, such as the creation of regional branch encyclopedic publications. The author, focusing on the fact that this is mainly a local history direction and more than 70 editions have already been prepared, emphasizes that this work is gradually developing in the field of librarianship. Тhus, an important event in generalizing the experience of the development of the theory and practice of librarianship in Ukraine is the preparation and publication in electronic format of the nationwide “Ukrainian Library Encyclopedia” (UBE), which since 2010 has been created largely by the staff of the Yaroslav the Wise National Library of Ukraine. Leading librarians and practitioners of many scientific, public and specialized libraries, specialized universities and research institutes take part in the implementation of this project. Every year, the preparation of the UBE finds an increasing resonance in the professional circles of library specialists. Thanks to the work on the creation of this branch encyclopedia, new information about many outstanding figures in librarianship is introduced into the historical and scientific circulation; new directions of studying the history of libraries are developing, new terms of library science, new directions of library activity are characterized. To date, UBE has already published about 900 articles.

History of hygiene, microbiology and epidemiology in the art of small forms: the past and the present

For the first time, more than 700 award, anniversary and commemorative badges reflecting the history of hygiene, microbiology and epidemiology were systematized and analyzed. The following directions are identified for studying the history of these medical specialties and educational and scientific disciplines with the help of epigraphy: 1) outstanding figures of hygiene, microbiology and epidemiology; 2) hygienic and epidemiological congresses, congresses and other forums; 3) specialized research institutions; 4) educational institutions and faculties of universities that train specialists in the field of hygiene, microbiology and epidemiology; 5) pathogens and vectors of infectious diseases; 6) methods of detecting microorganisms and treating infections; 7) the COVID-19 pandemic. The study showed that during the XX and XXI centuries a large number of badges (awards and commemorative) were issued, reflecting selected pages of the history of hygiene, microbiology and epidemiology. These faleristic objects related to the art of small forms are full-fledged primary sources for studying the history of these areas of medicine and objects for the collections of state, municipal and departmental museums of medical subjects. Signs with portraits of outstanding hygienists, microbiologists and epidemiologists can be used to study and illustrate their life and activities, contribution to science and perpetuate their memory. Epigraphy on the presented signs can help both in establishing the time of a particular fact or event in the past (for example, the dates of the life and activity of an outstanding scientist; the time, place and subject of the scientific forum, the opening date of the research institute, educational institution, faculty or department, etc.), and the specifics of conducting scientific research in the field of hygiene, microbiology and epidemiology (pathogens and vectors of diseases; concepts, devices and research methods, methods of diagnosis and prevention of infectious diseases, etc.).

Bibliometric analysis of diabetes Economics Evaluation Literature

Objective To describe the current status of diabetes economics evaluation research through bibliometric analysis and provide information for medical researchers and policy makers. Method In the Web of Science platform, bibliometric analysis and visualization technologies with the DDA and Pajek's tools were used to analyze the publication year and journals, countries, core authors and research hotspots of the literatures of diabetes economics evaluation published since 1980. Result The earliest literature in this field was published in 1980 and the number of literatures has increased rapidly since 2002. Nearly 20% of the literatures on diabetes economics evaluation were published in the top 15 journals and 150 core authors were found in this field. The developed countries had outstanding performance on diabetes economics evaluation. The institutions with the highest number of publications were Harvard University and University of London. In the co-occurrence network constructed by keywords, there were 4 subject concepts: “Evaluation of Diabetes Economics”, “Diabetes Self-management and Drug Treatment”, “Diabetes Prevention and Early Warning”, “Diabetes Related Metabolic Diseases” and “Diabetes Screening Indicators”. Conclusion The research of diabetes economics evaluation has developed rapidly since 2000. There have been some specialized journals, core authors and research institutions with global influence in this field. The developed countries, such as the United States and the United Kingdom, play an important role in the international cooperation on diabetes economics evaluation., but there is still less focused research hotspots.

Теоретичні та експериментальні методи визначення характеристик міцності лопаток турбін при термомеханічному навантаженні

The subject of this article is the methods of research and evaluation of the properties of turbine blades of a cooled structure under thermomechanical loading. The purpose of the article is to review the world achievements of leading enterprises and research institutions in the issue of fatigue tests of turbine blades under complex loading (cyclic temperature exposure, dynamic and static loading), as well as an overview of the state of this topic at SE "Ivchenko-Progress" and suggestions for its further studying. As a result of the analysis of publications and scientific articles, it can be concluded that specialized research institutes and leading aircraft engine-building enterprises from the end of the twentieth century are studying the properties of turbine blades in the conditions of their operation as part of an engine. In world practice, there are calculated and experimental methods for thermomechanical testing of turbine blades. These tests are aimed at determining the most damaging loads, establishing the flight cycle modes at which these loads are recorded. As a result, it was found that the greatest threat to the strength of the turbine blades is carried by transient modes of engine operation, which are short in time (measured in seconds), but at which there is a change in the parameters of the temperature field, loads from axial and centrifugal forces. And it is the cycling of these parameters that leads to a decrease in the cyclic durability of the turbine blades, especially of the cooled structure (the presence of perforations, internal cooling channels, and other structural elements leads to a complication of the volumetric stress state of the blades). The article analyzes various crystallographic structures of blades and their relationship with the volumetric stress state; examples of studies that were carried out at SE "Ivchenko-Progress" and their results are given, which emphasize the need for further experiments in the field of assessing strength characteristics under complex cyclic loading. An example of an installation for testing blade joints and samples of gears is considered, which can be adapted for testing blades with three-component loading (temperature, dynamic loads, and imitation of the effect of centrifugal forces). It is concluded that when using exclusively computational methods, it is impossible to reliably estimate the level of stresses and their distribution since the calculations are limited by the boundary conditions, which are set according to the capabilities of a particular computational model. Summing up, it can be noted that it is advisable to start assessing the strength of blades under thermomechanical loading with several series of tests of samples of blade material to study the effect of temperature and power cycles of loads, the effect of the orientation of the load vector concerning the crystallographic orientation of the blade. It is noted that tests of full-scale blades under thermomechanical loading are also important since the features of the volumetric stress state of the material during real operation of the blades as part of an engine are not reproduced during testing of samples. The above entails the development of methods and specialized installations for thermomechanical testing.

ІННОВАЦІЙНИЙ РОЗВИТОК ЛІСОВОГО КОМПЛЕКСУ РЕСПУБЛІКИ КОМИ: СТАН І ПЕРСПЕКТИВИ

Global manufacturers of timber products and specialized research institutes are actively developing innovative materials and improving production processes. The fastest growing groups include innovative packaging materials, innovative building materials, biodegradable polymers and biofuels. The aim of the article is to form a theoretical and methodological basis for the innovative development of the forestry complex of the Komi Republic. The subject of the research is theoretical and methodological aspects of innovative development of the forestry complex. Methods used in the study: historical method, methods of verification of theoretical positions (morphological analysis of the content and relationship of categories, principles and laws, assessment of the correspondence of historical facts to theoretical hypotheses), methods of analysis and synthesis, induction and deduction, logical method (hypothetical and axiomatic approaches), comparison method. Research hypothesis. The innovative development of the forestry complex in Russia is associated with forest chemistry. In particular, tall oil rosin and tall oil fatty acids in the markets of Russia and Asia are considered the most priority segments for Russian manufacturers. Presentation of the main material. Analysis of the current state of the forestry complex of the Komi Republic revealed an extremely low level of innovation activity. Over the years after the collapse of the Soviet Union, development proceeded along the extensive path of increasing the production and export of forest products of primary and secondary levels of redistribution, and the share of innovative products in the commodity and industry structure was measured at the level of statistical error. Originality and practical value of the research. The production of innovative products of the second generation is a promising direction for the development of the timber processing industry in the Komi Republic. The main ones are: bioconversion of cellulose-containing raw materials; biomass torrefaction technology based on plant waste; production of sulphate turpentine; highly active preparations for agriculture from pine needles. Conclusions of the study. It is planned to implement these directions by increasing the output of products with high added value, organizing new production of innovative products, commissioning medium and small innovative enterprises for the production of wood flour, biosorbents and other products, and developing regional wooden housing construction.

Scientific support of small fruit growing in Russia and prospects for its development.

It is possible to achieve the target indices of the Russian Doctrine of Food Security (self-sufficiency in fruits and berries should be at least 60 %) by combining the competencies of science and business. At present, hundreds of varieties of small fruit crops are included in the State Register of Breeding Achievements Admitted for Use. Domestic breeders have obtained substantial results; the share of their assortment is 79-100 %. Federal Research Center of Horticulture (Moscow) (101 pcs.), Federal Altai Research Center of Agrobiotechnology (Barnaul) (85 pcs.), Michurin Federal Research Center (Michurinsk) (42 pcs.) are the leaders in the number of created hybrids and varieties. Over the past five years, 133 new breeding achievements of traditional small fruit crops have been submitted to the State variety testing, the originators of which are research institutions, private companies and individuals. The creation of modern seed-breeding (nursery-breeding) centers (SBC) on the basis of leading specialized research institutions is expected to be the solution to the problems of modern breeding and nursery breeding and to give impetus to the development of domestic small fruit growing. The research programs of the SBC involve an integrated approach that combines the knowledge and capabilities of researchers from different disciplines, the concentration of a complex analytical instrument base in the Centers of collective use, the using of biotechnological and molecular genetic research, along with traditional methods of breeding. An analysis of the achievements in small fruit growing in research institutions under the jurisdiction of the Ministry of Science and Higher Education of the Russian Federation revealed a huge scientific potential (genetic collections, hybrid funds) for creating competitive commercial varieties and technologies for their cultivation by establishing plantations with certified planting material in accordance with international requirements. Information from literary sources indicates that one of the main criteria for the value of varieties is resistance to harmful viral diseases. The cultivation of such varieties will reduce the cost of producing planting material for small fruit crops of the highest quality categories. In the near future, the most relevant areas for the breeding of small fruit crops will be: breeding for resistance to the most harmful viruses, winter hardiness, increased transportability and long-term post-harvest storage of fruits, suitability for mechanized cultivation, high content of biologically active substances.

Scientific support of small fruit growing in Russia and prospects for its development

It is possible to achieve the target indices of the Russian Doctrine of Food Security (self-sufficiency in fruits and berries should be at least 60 %) by combining the competencies of science and business. At present, hundreds of varieties of small fruit crops are included in the State Register of Breeding Achievements Admitted for Use. Domestic breeders have obtained substantial results; the share of their assortment is 79–100 %. Federal Research Center of Horticulture (Moscow) (101 pcs.), Federal Altai Research Center of Agrobiotechnology (Barnaul) (85 pcs.), Michurin Federal Research Center (Michurinsk) (42 pcs.) are the leaders in the number of created hybrids and varieties. Over the past five years, 133 new breeding achievements of traditional small fruit crops have been submitted to the State variety testing, the originators of which are research institutions, private companies and individuals. The creation of modern seed-breeding (nursery-breeding) centers (SBC) on the basis of leading specialized research institutions is expected to be the solution to the problems of modern breeding and nursery breeding and to give impetus to the development of domestic small fruit growing. The research programs of the SBC involve an integrated approach that combines the knowledge and capabilities of researchers from different disciplines, the concentration of a complex analytical instrument base in the Centers of collective use, the using of biotechnological and molecular genetic research, along with traditional methods of breeding. An analysis of the achievements in small fruit growing in research institutions under the jurisdiction of the Ministry of Science and Higher Education of the Russian Federation revealed a huge scientific potential (genetic collections, hybrid funds) for creating competitive commercial varieties and technologies for their cultivation by establishing plantations with certified planting material in accordance with international requirements. Information from literary sources indicates that one of the main criteria for the value of varieties is resistance to harmful viral diseases. The cultivation of such varieties will reduce the cost of producing planting material for small fruit crops of the highest quality categories. In the near future, the most relevant areas for the breeding of small fruit crops will be: breeding for resistance to the most harmful viruses, winter hardiness, increased transportability and long-term post-harvest storage of fruits, suitability for mechanized cultivation, high content of biologically active substances.

ПОЛІТИКА РОЗБУДОВИ ФАРМАЦЕВТИЧНОЇ ІНДУСТРІЇ В НІМЕЧЧИНІ: УРОКИ ДЛЯ УКРАЇНИ

Показано еволюцію розбудови хіміко-фармацевтичної індустрії Німеччини від запозичення технологій до ендогенних інновацій та перетворення на глобального лідера. Обґрунтовано, що уряд країни сприяв розвитку нової галузі через нарощування бюджетних асигнувань на підготовку наукових і виробничих кадрів; субсидування дослідницьких робіт; дотування транспортних перевезень та сировини. Показано, що формування великих компаній забезпечило економію на масштабі та прискорило розвиток; створення спеціалізованих дослідницьких інститутів під патронатом влади започаткувало державно-приватне партнерство у фінансуванні досліджень, галузеві асоціації сприяли мобілізації громадськості на підтримку галузі, а компетентні менеджери компаній та участь представників індустрії у політиці разом з видатними державними діячами забезпечили узгоджені дії з посилення її інноваційного потенціалу. Культивування національної свідомості, що придбання німецьких товарів є запорукою добробуту держави, визначило споживчі уподобання й стало потужним стимулом для розширення поставок на внутрішній ринок. Запровадження високих митних тарифів на готові лікарські засоби забезпечило захист нової індустрії на етапі становлення. Тісна співпраця банків з фармацевтичними компаніями сприяла реалізації інвестиційно-інноваційних проєктів та зовнішній експансії. Створення картелів хімічними та фармацевтичними компаніями стало інституційною відповіддю на безпрецедентний феномен індустріалізації та наздоганяючого розвитку Німеччини. Виявлено, що на сучасному етапі Уряд Німеччини через національні та регіональні програми продовжує сприяти розвитку технологічного та інноваційного потенціалу фармацевтики. Обґрунтовано доцільність запровадження в Україні механізмів ендогенізації розвитку виробництва лікарських засобів і медичних виробів, а також розширення продажів на внутрішньому ринку через запровадження преференцій при публічних закупівлях у контексті захисту суттєвих інтересів безпеки та здоров’я нації.

History Pages of the National Medical Research Center of Rehabilitation and Balneology

In 2021 the National medical research center of rehabilitation and balneology (NMIC RK) marks one hundred years. This is one of the specialized scientific institutions created in the country in the first years of the existence of Soviet power. From the first months of the reign of Soviet power, it became obvious that the resort business was at a new stage of development. Under Nicholas II, as with his predecessors, resort business was treated as something secondary, philanthropic. Only with the advent of socialism was a resort business in the USSR of the 1920s. acquired important state significance. First of all, it was decided to create in a short time the necessary number of specialized research institutes. Within a few years, a network of special institutions for the scientific support of resort business was created. One of the first was the NMIC RK. The history of this Center is unique, but still little studied. The purpose of the study is to, based on archival materials and publications, characterize the history of the Center, identify its role in the development of balneology. Resortology of the USSR has become an independent multi-industry sphere. the Centre has made a significant contribution to this through its scientific achievements and high efficiency. Scientists of the NMIC RK tried to keep up with the demands of the authorities and worked for the benefit of the population and economy of the country. the center faced a number of problems after the change of the country's political structure in the 1990s, but this did not prevent it from maintaining the scientific potential and professionalism of its employees, modernizing the logistics, improving the quality of work and introducing the results of research into the practice of the country's resort business.

Detection of acquired von Willebrand syndrome after ventricular assist device by total thrombus-formation analysis system.

AimsBleeding is a serious complication in patients with continuous‐flow left ventricular assist device (CF‐LVAD). Acquired von Willebrand syndrome (AVWS; type 2A) develops because of high shear stress inside the pumps and is a cause of bleeding complication. Although von Willebrand factor (vWF) multimer analysis is useful for diagnosing AVWS, it is only performed in specialized research institutes. A novel microchip flow chamber system, the total thrombus‐formation analysis system (T‐TAS), is a point‐of‐care system to evaluate the thrombus‐formation process and useful for monitoring platelet thrombus‐formation capacity in patients receiving antiplatelet therapy and the diagnosis and evaluation of the clinical severity of von Willebrand disease type 1. However, little is known about the association between AVWS and platelet thrombus‐formation capacity evaluated by T‐TAS in patients with CF‐LVAD. We aimed to evaluate the utility of T‐TAS for easy detection of AVWS in patients with CF‐LVAD.Methods and resultsWe simultaneously evaluated the vWF large multimers and T‐TAS parameters in four consecutive patients with axial‐type CF‐LVAD and eight control patients treated with aspirin and warfarin. vWF large multimer index was defined as the proportion of large multimers in total vWF derived from a normal control plasma. T‐TAS analyses different thrombus‐formation processes using two microchips with different thrombogenic surfaces. PL24‐AUC10 levels in the platelet (PL) chip are highly sensitive for platelet functions, while AR10‐AUC30 levels in the atheroma (AR) chip allow the assessment of the overall haemostatic ability. vWF large multimer index and T‐TAS parameters were decreased in all patients with CF‐LVAD. The mean PL24‐AUC10 level (5.4 ± 2.9 vs. 219 ± 67; P < 0.01), AR10‐AUC30 level (338 ± 460 vs. 1604 ± 160; P < 0.01) and vWF large multimer index (49 ± 11% vs. 112 ± 27%; P < 0.01) were significantly lower in the patients with CF‐LVAD than in control patients. One patient showed changes in T‐TAS levels before and after implantation of CF‐LVAD. PL24‐AUC10 and AR10‐AUC30 levels decreased from 438.1 to 5.0 and from 1667.9 to 1134.3, respectively.ConclusionsIn patients with CF‐LVAD, the platelet thrombus‐formation capacity was extremely impaired because of AVWS, and T‐TAS parameters could detect the presence of AVWS. T‐TAS can be used for easy detection of AVWS as a point‐of‐care testing. Further studies with a large sample size are needed to validate our results in several LVAD models and evaluate the prognostic value of bleeding complications and thromboembolism in patients with LVAD.

The effect of image search, social influence characteristics and anthropomorphism on purchase intention in mobile shopping

Purpose: The purpose of this study is to review the previous studies on the characteristics of the image search service provided by using artificial intelligence, the social impact characteristics, and the moderating effect of perceived anthropomorphism, and conduct empirical analysis to identify the constituent factors affecting purchase intention. To clarify. Through this, I tried to present theoretical and practical implications. Research design, data, and methodology: Research design was that characteristics of image search service (ubiquity and information quality) and social impact characteristics (subjective norms, electronic word of mouth marketing) are affected by mediation of satisfaction and flow, therefore, control of perceived anthropomorphism have an effect on purchase intention to increase. For analysis, research conducted literature review, and developed questionnaires, so that EM firm which is a specialized research institute has collected data. This was conducted on 410 people between the 20s and 50s who have mobile shopping experiences. SPSS Statistics 23 and AMOS 23 had been used to perform necessary analysis such as exploratory factor analysis, reliability analysis, feasibility analysis, and structural equation modeling based on this data. Results: first, ubiquity, information quality and subjective norms were found to have a positive effect on purchase intention through satisfaction and flow parameters. Second, satisfaction and flow were found to have a mediating effect between ubiquity, information quality, and subjective norms and purchase intentions. However, there was no mediating effect between eWOM information and purchase intention. Third, perceived anthropomorphism was found to have a moderating effect between information quality and satisfaction, and it was found that there was no moderating effect on the relationship between information quality and flow. Conclusions: The information quality of image search services using artificial intelligence has a positive effect on satisfaction, and it has been found that there is a positive moderate effect of perceived anthropomorphism in this relationship, which may be an academic contribution to the distribution science utilizing artificial intelligence. Therefore, it is possible to propose a distribution strategy that improves purchase intention by utilizing image search service and anthropomorphism in practical business and providing a more enjoyable immersive experience to customers.