Objective: To compare the number of detections of diffuse axonal injury (DAI) lesions between CT and MRI routine sequences (T1WI, T2WI, FLAIR) and special sequences (DWI, SWI). There is no difference in the detection rate of hemorrhagic lesions and non-hemorrhagic lesions with diffuse axonal injury, and more clinically valuable diagnostic methods are obtained to improve the clinical understanding of the detection and disease of diffuse axonal injury. Methods: The paper collected 37 cases of clinical data and imaging data of patients with diffuse axonal injury clinically diagnosed from March 2017 to January 2019 in our hospital. The patients underwent CT scan of the Department of Radiology in our hospital within 72 hours after the injury, and MRI was performed one week after admission according to the stable condition. The imaging data was obtained from the radiology consciousness readings. Results: A total of 37 patients underwent imaging studies. The number of missed CT scans in the brainstem was relatively small compared with other locations, and the number of missed diagnosis of lesions in the cerebellum was higher. In the conventional MRI sequence, FLAIR detected the most lesions, and the difference between the number of lesions detected by T1WI and T2WI was statistically significant (χ2 = 22.930, P = 0.011 < 0.05). Among the special sequences, the number of SWI lesions was the highest, and the difference between DWI and SWI was statistically significant (χ2 = 13.090, P = 0.002 < 0.05). The number of detected CT, FLAIR and SWI was compared. The number of SWI detected was the most, and the difference was statistically significant (χ2 = 19.634, P = 0.033 < 0.05). DWI had the highest detection rate for hemorrhagic lesions, followed by FLAIR (χ2 = 188.168, P < 0.001). SWI had the highest detection rate for hemorrhagic lesions, followed by DWI (χ2 = 1363.452, P < 0.001). Conclusion: The most common number of lesions detected in patients with DAI is the SWI sequence. For the detection of hemorrhagic lesions, SWI has obvious advantages. In non-hemorrhagic lesions, the detection rate of DWI is significantly higher than other sequences. Therefore, it can be said that the DWI and SWI sequences provide an important imaging basis for the definitive diagnosis of DAI, and have high application value.