Special Protection Research Articles

6-Gingerol activates the Nrf2 signaling pathway to alleviate hydrogen peroxide induced oxidative stress on primary chicken embryo hepatocytes

Oxidative stress affects production performance and meat quality of poultry. 6-gingerol (6-Gin) is the main activity component of ginger, has shown promise in alleviating oxidative stress in broilers, However, the specific protection mechanism of 6-Gin against hepatocytes oxidative damage remains unclear. The primary chicken embryo hepatocytes (CEHs) were damaged and the cell viability was decreased by H2O2, 6-Gin can alleviate the cell injure and oxidative stress. Transcriptomic analysis and further experiments showed that H2O2 significantly suppressed the expression of Nrf2, Keap1, and NQO1, as well as antioxidant enzyme activities, increased inflammatory factors, leading to cell apoptosis. In contrast, 6-Gin effectively reduced these effects by promoting Nrf 2 nuclear translocation and activating the Nrf2 signaling pathway. Furthermore, the protective effects of 6-Gin were eliminated by the Nrf2 inhibitor ML385. In conclusion, 6-Gin exerts antioxidant, anti-inflammatory and anti-apoptotic effects on CEHs through the Nrf2 pathway. This study provides the potential value of 6-Gin for treatment of oxidative stress in broilers.

Criticism Towards the Ruler: Illustrations From the Letter of the Law and the Practice of the Polish Constitutional State

The publication is devoted to several examples of the practice of criticism of the Head of State and executive power in Polish history. The authors have chosen three moments of interest: the first one is the first decade of the “Congress” Polish Kingdom established in 1815, and the second refers to the Second Polish Republic in the period after the coup d’État by Józef Piłsudski in 1926. Finally, the authors refer to some practical aspects of criticism of the authority in the public space in recent times, also recalling the high-profile criminal trial that reached the highest instance – the Supreme Court in 2023. In these examples, the authors focus on aspects of the permissibility of criticism, its specific forms and the reaction of the executive in the early history of the constitutional state and camouflaged criticism of power respectively, through the interwar liberal model of protection of freedom of speech and of the press, which failed in the face of authoritarian changes and the political will to protect the good name of one particular individual; after the death of Piłsudski, the lack of adequate legal protection post mortem was finally “remedied” by a particular repressive law. The last section of the discussion refers to the contemporary Polish state of law, and here the focus is on the faces of criticism and the forms of its suppression. In particular, attention was paid to the problem of the extensive use of means used by the police against criticism particularly unpleasant to the power camp (up to the bizarre action with the hiring of a jib) and the question of maintaining specific protection of the Head of State against defamation in the Criminal Code.

Immune Responses of Club Cells in Fish: A Review

The primary line of defense against pathogens from the environment is often fish epidermis tissue. Nevertheless, little is understood about the physiological mechanisms that underlie the non-specific and/or specific protection that these cells can offer. The exact nature of the relationship between the evolution of ostariophysan fish club cells and chemical warning signals is still unknown and controversial. Fish epidermis layer cells comprise mucus cells, lymphocytes, macrophage cells, cuboidal and squamous epithelial cells, and cells specific to certain fish species. Club cells, also called "alarm cells," are chemical alarms that sound in the event of a potentially hazardous scenario. These cells will burst in the presence of a predator, releasing pheromones that, if the skin is physically damaged, trigger an avoidance and terror reaction. In sturgeon larvae, mucus cells were visible in week 1, but club cells did not appear until week 4. Due to their later development during ontogenesis and after wounding, club cells may not have as much of a protective effect during wound healing as filament or mucus cells. Club cells are mostly found in the epidermis of the skin, and it is thought that when they work in tandem with mucus and goblet cells to fight infections, they serve as the body's first line of defense.

Toward effective protection of victims of human trafficking in mixed migration flows: referral mechanisms shaped on individual need. The Italian experience and the European perspective

An overview of emerging trends on trafficking of human beings in Italy shows not only an extremely heterogeneous phenomenon but also a complex overlapping of experiences and need of protection of every single victim. In the context of mixed migration flows, persons reaching Italy through the Central Mediterranean and the Balkan routes have often experienced or are at risk of trafficking, and they also apply for international protection upon arrival. Legal categories such as “victims,” “asylum seekers,” and “refugees” are increasingly interconnected and not exhaustive in describing individual experiences and multifaceted vulnerabilities. Against this background, ensuring early identification and assistance for victims of trafficking among asylum seekers is extremely relevant. In Italy, this has led to the development of good practices aimed at implementing the coordination between the asylum and the anti-trafficking systems. In particular, specific Guidelines for Asylum authorities have been adopted to preliminarily identify potential victims of trafficking within the asylum procedure and enable their effective access to protection measures. To comply with specific provisions of the European Trafficking Directive and its transposition into the Italian legal framework, the Guidelines have created a referral mechanism among the asylum authorities and the anti-trafficking system that is unique in the European context. For this reason, the present contribution aims at describing this good practice, its implementation and effects—also at the juridical level—and its limits. Indeed, after the adoption of the instrument, a higher recognition rate of international protection for victims of trafficking has been registered in Italy, both at the administrative and judicial levels; asylum seekers and refugees have also increased their access to the specific protection program for trafficking survivors. In general, the system has strengthened its capacity to fulfill the legal obligation of identifying victims through a multi-agency approach. On the other hand, the ability to conduct screening and preliminary identification of victims of trafficking among asylum seekers is still limited to the “victim model” in terms of gender (women) and form of exploitation (sexual), and to certain stages of the asylum procedure (the first instance before the asylum authorities). With reference to this latter, a comprehensive protection response at the borders is missing despite the political debate on sea and land arrivals to Italy and the recent introduction of border procedures for the assessment of asylum applications. Given the geographical and political centrality of the south-Mediterranean situation in the current migration agenda, the goal of this paper is to analyze the Italian experience on referral mechanisms among trafficking and asylum as an experience that would help to shape future European prospects. The ongoing evolution of mixed migration flows—with particular reference to secondary movement across European countries—and the revised European Directive on trafficking in persons impose the promotion of a reflection on referral mechanisms with a transnational perspective enabling effective protection and the meeting of specific human rights.

An Expert Model Using Deep Learning for Image-based Pest Identification with the TSLM Approach for Enhancing Precision Farming

The rise of digital agriculture has sparked considerable interest in its potential to revolutionize farming practices by integrating of advanced technologies. Unmanned aerial vehicles (UAVs), commonly known as drones, have emerged as a crucial tool in precision agriculture, offering diverse applications for real-world scenarios. This research focuses on harnessing the power of drones in the context of digital agriculture support, particularly in addressing the challenges of crop protection and pest management. The objective is to develop an innovative approach for crop-disease diagnosis using an upgraded Transfer-Driven Self-Adaptive Learning Model (TSLM) that leverages multispectral remote sensing data of drone-captured images to improve pest classification and streamline pesticide application. The study explores nine potent deep neural network models' capabilities for identifying plant diseases using various approaches within the digital agriculture framework. Transfer learning and advanced feature extraction techniques are employed to tailor these deep neural networks to the specific crop protection context. Using of pre-trained deep learning models for feature extraction and fine-tuning enhances the effectiveness of the proposed model. Evaluating the model's performance, precision, sensitivity, specificity, and F1-score metrics are assessed, leading to the discovery that deep feature extraction and Self-Adaptive Learning Model (SLM) classification outperform traditional transfer learning methods. The novelty of this work lies in its application of communication protocols to coordinate a fleet of drones for crop protection within the digital agriculture framework. By combining deep learning techniques with transfer-driven self-adaptive learning, the proposed approach significantly enhances the accuracy and efficiency of pest classification in precision agriculture. The study's findings offer valuable insights into optimizing drone-based technologies to combat plant disease epidemics, thereby contributing to the advancement of digital agriculture and its role in supporting sustainable farming practices.

An Analysis of South Africa's Constitutional and UNCRC-imposed Obligations to Achieve Children's Socio-economic Rights: A Critique

Children require specific protection due to their heightened vulnerability to human rights violations, which can be attributed to several factors such as economic adversity, racial tensions, and armed conflicts. The current situation in South Africa is characterised by a pressing and significant prevalence of severe poverty. The enduring effects of apartheid have contributed to a broad range of socioeconomic challenges inside our deeply divided country. Children are particularly impacted by these issues and experience immediate suffering as a result. In the Republic of South Africa, a significant proportion of the youth population experiences the distressing circumstance of living in poverty. It has been reported that a significant proportion, ranging from 60 to 75 percent, of the youth population in South Africa is experiencing impoverished living conditions. The prevalence of HIV infection and the consequential mortality rates due to AIDS among caretakers have a detrimental effect on the well-being of children. The United Nations Convention on the Rights of the Child (UNCRC) encompasses social, economic, and cultural rights under its provisions. Following the ratification of the UNCRC in June 1995, South Africa is legally obligated to implement the articles pertaining to the rights of children. The formulation and structuring of socio-economic rights and corresponding duties towards children under the South African Constitution were significantly influenced by the UNCRC. The interests of children in South Africa are effectively safeguarded through the provisions enshrined in the Constitution and the duties outlined in the UNCRC. This study assesses the extent to which South Africa has adhered to its constitutional and UNCRC-mandated responsibilities and commitments in order to achieve the socioeconomic rights of children.

Impact of Comorbid Pathology and Severity of Clinical Course on Anti-infective Protection in Patients with COVID-19

Objective — to establish and evaluate the impact of comorbid pathology and the severity of the clinical course on the activity of anti-infective protection in patients with coronavirus disease 2019 (COVID-19), based on the analysis of the absolute and relative counts of major immune cell populations in peripheral blood. Materials and methods. A cross-sectional prospective study was conducted involving 204 patients with COVID-19-associated pneumonia of mild, moderate and severe stages. The cohort included 106 (51.97 %) women and 98 (48.03 %) men, with an average age of (55.93 ± 8.75) years. Anti-infective ­protection was studied using comprehensive clinical blood analysis, including the count of major immune-competent cells. Patients were categorised into groups based on comorbi­dity, taking into account the predominant concurrent pathology at the time of examination (endocrine, cardiovascular or other). Results and discussion. More severe COVID-19 cases were characterised by leukopenia, relative and absolute granulocytopenia, neutropenia, a slight hyporegenerative nuclear shift to the right and a reduction in the number of segmented neutrophils by 24.63—34.72 % (p ≤ 0.047—0.009) and eosinophilic granulocytes by 52.94—70.59 % (p ≤ 0.004—0.001). This was accompanied by relative and absolute agranulocytosis due to lymphocytosis (by 20.10—63.33 %; p ≤ 0.05—0.003) and monocytosis (by 40.0—74.12 %; p ≤ 0.046—0.049), indicating an active inflammatory infectious process of viral etiology against a background of decreased resistance and increased activity of the lymphocyte-macrophage link with the beginning of the formation of specific immune protection (cellular and humoral response to coronavirus intervention). Mild cases of COVID-19 showed a higher absolute count of peripheral blood granulocytes (by 48.25 %; p = 0.018), neutrophils, particularly segmented neutrophils and eosinophilic granulocytes, compared to moderate and severe cases (by 32.36—53.18 % (p ≤ 0.049—0.01) and 3.4 times (p ≤ 0.005—0.002)) and the lowest content of monocytes (by 35.41—42.57 %; p ≤ 0.049—0.046). In cases with concurrent endocrine and cardiological pathologies against a background of a more severe clinical course of COVID-19, immunoinflammatory changes intensified due to absolute and relative leukopenia, neutrophilic granulocytopenia, neutropenia, with the presence of relative lymphocytosis and monocytosis, and normal ESR indicators, confirming the inflammatory process of viral etiology, which, in the absence of treatment, may tend to form post-COVID and/or long-term effects of COVID-19 with multisystem involvement. Conclusions. The study found an enhancement of the immunoinflammatory response and an increase in the depletion of cellular factors of non-specific anti-infective protection with the progression of the clinical manifestations of COVID-19, particularly against the backdrop of comorbid endocrine and/or cardiological pathology.

A guide to protection schemes of synchronous generator-based electric grids

Ensuring the reliability of power systems remains a paramount concern for electrical utilities worldwide. The design and implementation of robust protection is crucial for mitigating faults and ensuring uninterrupted power supply. This paper encompasses the protection deployed in electrical utilities. A comprehensive analysis is conducted on the application protection scheme in practice for the protection of major power components. The reliability of protection schemes is enhanced by adopting the of dual & fast protection schemes on the critical power components for swift & reliable clearing of faults. Additionally, this article also investigates the protection strategies employed for slightly lower priority components, including high-speed main and low-speed backup protection schemes. A thorough review for the protection practices for synchronous power generation, transmission, and distribution has been conducted. In this article, the selection of specific protection schemes and the calculation settings for 600 MW synchronous generator-connected lines and transformers are discussed. Additionally, the limitations of traditional protection schemes in safeguarding inverter-based power systems are explored. The paper also highlights areas for future research in the protection of electrical equipment within evolving grid infrastructures. This study will provide valuable insights for researchers and practicing engineers in planning and implementing protection systems for electrical grids, ensuring high levels of reliability and resilience

Инструменты правовой охраны интеллектуальной собственности при осуществлении внешнеторговой деятельности

The article reviews special aspects of protection of intellectual property. The authors analyze approaches of some countries to protection of certain IP items, legal regimes. The paper highlights that it is reasonable to take into account cultural, linguistic aspects of the respective state, mindset of the local population in carrying out export activities. The paper studies special aspects of license agreements entered into in carrying out export activities. It is noted that recent evolution of information and communications technologies has substantially improved opportunities of control over outsourced activities or processes whether in one or several remote national or international locations, which has made outsourcing a more attractive option of international activities in many other spheres. The article studies special aspects of the TRIPS Agreement that introduces not only procedural provisions of review of disputes including the ones associated with violation of rights to intellectual property that bind states, but also specific right protection mechanisms to be directly applied by courts of the states that are parties to the Agreement.

A Protocol of Prevention and Protection Measures on New Occupational Risk Factors in Green Jobs in Italian Workplaces

The Green Transition aims to protect the health of our planet through changes at the economic, political, and social levels while also having a significant impact on the world of work through the creation of sustainable occupations, referred to as ‘Green Jobs’. The aim of our research was to identify the new emerging occupational risks associated with Green Jobs and to propose a protocol to promote the adoption of more appropriate prevention and protection measures. Starting with a few keywords chosen by the authors, we conducted a narrative review of the scientific articles published in the literature. The results obtained show that the new occupational risks emerging in the activities involved in the green transition are mainly related to the introduction of new materials or new technologies and to modes of production processes. These risks may pose a danger to those exposed to them on a daily basis, causing damage to health. Our protocol proposal calls for a more careful and adequate risk assessment for Green Jobs, providing specific training on these issues for new professionals in the sector and introducing specific prevention and protection measures for the different occupational risks analysed in the workplace. By adopting these recommendations in the workplace and conducting in-depth research on these issues, it will be possible to contribute to the improvement of prevention and protection for these new emerging occupational risks, achieving a positive economic impact and better safety conditions for workers.

Two-Way Perspectives and Attitudes about Environmentally Friendly Agro-Food Production and Consumption: An Empirical Survey for Greece

Relying on pesticides to safeguard crops has led to pest resistance and detrimental environmental and health consequences. Many integrated pest management programs focus on producers’ decision-making processes when selecting and implementing pest management interventions. Alternative approaches such as integrated pest management and biological control have been implemented to address these challenges, with Greece as the research area. A quantitative study was oriented to consumers and producers to investigate their views on the effectiveness of pesticides, aiming to assess whether these perspectives influence their attitudes toward adopting pest management practices. Primary data were gathered through structured questionnaires to consumers and producer associations (focusing on tomatoes, olives, and citrus fruits) and analyzed through multivariate methods. The findings unveiled varying preferences and concerns regarding plant protection tools, with considerations such as product effectiveness, method awareness, and sustainability. Specifically, the study revealed aspects like the popularity and demand for specific plant protection tools, the knowledge of these experts about products and pest control methods, and their stance on sustainable agriculture and environmental aspects of pest control.

Согласие на причинение вреда как потенциальное обстоятельство, исключающее преступность деяния: к вопросу о содержании понятия

The problem of consent to injury raises almost the largest number of discussions in the Russian criminal law theory. Although the social relations need the respective legal regulation, the criminal law has no provision to determine legality of causing an injury upon the victim’s consent. The concept of consent to injury is the critical aspect of the problem under consideration. In this article, the author analyzes classical and contemporary approaches to defining the named concept and the list of its attributes and concludes that the consent to injury as a circumstance that excludes the criminal nature of the act is a will of a person that is formed based on personal interest gives rise to permissive criminal relations and is aimed at performance of an act by another person leading to socially relevant changes in a specific criminal law protection object owned by the consent subject. The conclusions presented in the article can be used as a theoretical basis for studies of conditions of acknowledging an injury caused upon the victim’s consent as legal, and in law making activities at design of respective legal provisions on consent to injury as a circumstance that excludes the criminal nature of the act.

Identification of key areas for ecological restoration of territorial space based on ecological security pattern analysis: A case study of the Taihu Lake city cluster.

The identification of key areas for ecological restoration of national land space based on the ecological security pattern is an important way to balance environmental protection and social development in the new era. With the Taihu Lake city cluster as the study area, we identified the ecological source from both structural and functional aspects, and used the minimum cumulative resistance model to identify the ecological corridors on the basis of constructing the resistance surface. Coupled the landscape ecological risk evaluation, we determined the appropriate width of each ecological corridor in the study area, identified the key restoration zones through the circuit theory. Then, we constructed the ecological security pattern of "six zones and four belts" and controlled by zoning. The results showed that the 32 ecological source areas in the Taihu Lake city cluster presented a spatial pattern of "more in the east and less in the west-mountains and lakes are connected" and 70 ecological corridors were concentrated in the west and the center. The suitable width of most of the ecological corridors was 1500-2000 m. The ecological restoration zones of the national land space were concentrated in the eastern part of the Lake Taihu, Changxing County, and Liyang City. According to the characteristics of the study area and the actual situation of the restoration area, we proposed specific protection and restoration measures, such as protecting the core ecological source, optimizing and restoring the important corridors, and reasonably planning land use of the ecological pinch points and obstacle points.

Intervention and Diversion Program Implementation for the Children in Conflict with the Law in Pangasinan

Juvenile delinquency is of a global concern, members of the United Nations (UN), including the Philippines, remain committed to funding research, programs, and initiatives to combat juvenile delinquency and provide positive outcomes for youth, their families, and their communities, as well as raising awareness and ensuring the proper implementation of the juvenile justice system. There are now a plethora of international mechanisms in place that provide specific protection to youths in the juvenile justice system, such as diversion and intervention, which will be the focus of the paper. Data and statistics on children in conflict with the law and, in particular, the status of children on intervention and diversion are both lacking in the country. For the establishment of appropriate policies and initiatives aimed at improving juvenile justice and protecting the rights of children in confrontation with the law, this is essential. The aim of this paper is to assess the implementation of the diversion and intervention programs for CICL as stipulated in the Juvenile Justice Welfare Act of 2006 otherwise known as RA 9344.

Enhanced Carbon Accumulation in China's New Coastal Wetlands Over the 21st Century

AbstractWetlands formed by natural sediment deposition account for a large proportion of new coastal lands, and these new wetlands usually have active ecosystems and obvious ecological effects. However, previous studies largely overlooked this sediment‐caused wetland expansion, and the spatiotemporal variation in these wetlands and future response to sea‐level rise (SLR) have not been determined. Here, we employed satellite observations to quantify the seaward expansion of coastal lands in China over the past two decades. A total land expansion of 6,651 km2 was found, and wetlands and artificial surfaces dominated, accounting for 32% and 25%, respectively. Subsequently, we utilized an integrated model to estimate the response of these new wetlands to SLR in the 21st century, that is, we estimated the wetland gain from sediment deposition and loss due to SLR. The results indicate that under the current condition of sediment availability, the area of China's new coastal wetlands is projected to increase by 200%–261% compared to that in 2020 based on four SLR scenarios, despite the unavoidable impact of SLR. These increases are accompanied by the continuous enhancement of carbon accumulation. Wetland changes are influenced by factors such as sediment deposition, SLR and storm surges, as well as the continued effect of local natural and anthropogenic factors. These results show the importance of understanding the ecological effects of new wetlands and constructing specific protection measures for sustainable development.

Escherichia coli Activate Extraintestinal Antibody Response and Provide Anti-Infective Immunity.

The effects of intestinal microflora on extraintestinal immune response by intestinal cytokines and metabolites have been documented, but whether intestinal microbes stimulate serum antibody generation is unknown. Here, serum antibodies against 69 outer membrane proteins of Escherichia coli, a dominant bacterium in the human intestine, are detected in 141 healthy individuals of varying ages. Antibodies against E. coli outer membrane proteins are determined in all serum samples tested, and frequencies of antibodies to five outer membrane proteins (OmpA, OmpX, TsX, HlpA, and FepA) are close to 100%. Serum antibodies against E. coli outer membrane proteins are further validated by Western blot and bacterial pull-down. Moreover, the present study shows that OstA, HlpA, Tsx, NlpB, OmpC, YfcU, and OmpA provide specific immune protection against pathogenic E. coli, while HlpA and OmpA also exhibit cross-protection against Staphylococcus aureus infection. These finding indicate that intestinal E. coli activate extraintestinal antibody responses and provide anti-infective immunity.

A rotor open-phase imbalance protection for variable speed pumped storage unit based on rotation transformation fault component ratio

Doubly-fed variable speed pumped storage unit (VSPSU) adopts slip ring injection AC excitation mode, and its rotor side structure is complex and prone to open-phase faults. It is very important to configure specific open-phase imbalance protection to ensure its safe operation. Traditional doubly-fed motors only stay in the state monitoring stage for rotor electrical imbalance, which cannot meet the requirements of large-capacity VSPSU for fast, real-time, and high-reliability protection. Therefore, this paper proposes a VSPSU rotor open-phase imbalance protection method based on the rotation transformation fault component ratio (FCR). The fundamental frequency component and fault characteristic component of the stator current space vector are extracted by rotation transformation and FCR is calculated, and then different protection action modes are divided according to the amplitude of FCR. To realize the engineering application, a microcomputer protection algorithm suitable for the proposed protection method is further proposed, and then a complete microcomputer protection scheme is formed. Simulation and experiment results show that the proposed protection scheme has high sensitivity and fast action speed. At the same time, the proposed algorithm can be directly embedded in the existing microcomputer protection device to meet the needs of engineering applications.

The co-design of housing welfare for “Dopo di Noi” of people with disabilities

In Italy Law 112/16, known as Law Dopo di Noi, introduced specific protections in our system to promote the deinstitutionalisation of people with disabilities, allocating economic resources to Regions to realise new housing welfare infrastructures and initiatives to support autonomous living paths, in view of the family support loss and in respect of the individual “Progetto di Vita” (Life project) of people with disabilities. This paper reports results of a research promoted by “Dipartimento per le Politiche in Favore delle Persone con Disabilità” of the Presidency of Council of Ministers, in which tools to support the co-design of housing interventions aimed at social inclusion were elaborated, for the future of people with disabilities.

Legal Ramifications of Employing AI-Generated Logos as Brand Identities: A Juridical Examination

The utilization of Artificial Intelligence (AI) technology is experiencing rapid expansion in contemporary times. Within the domain of trademark law, a logo serves as a visual identity utilized to distinguish a product or service from its competitors. The utilization of a logo as a brand identity is afforded specific legal protections pursuant to Indonesian Law No. 20/2016 concerning Trademarks. A pivotal consideration pertains to discerning the rightful owner of the rights to the logo created by AI. Is it the proprietor of the AI software employed in crafting the logo, or is it the proprietor of the company or individual who commissioned the logo? The method employed in this research is a normative juridical approach, which scrutinizes the application of legal principles or norms. The approaches employed in this research encompass conceptual and statutory analyses. The objective of this research pertains to understanding the Legal Implications of Utilizing Artificial Intelligence-Generated Logos as Brand Identities, and serving as a reference material for subsequent legal inquiries, particularly those related to the advancement of artificial intelligence. The majority of regulations concerning copyright and ownership of artistic works still hinge upon Copyright Law No. 28/2014. Despite its enactment, the Copyright Law remains bereft of provisions safeguarding works generated by Artificial Intelligence. In the realm of AI or artificial intelligence, there are instances where AI applications inadvertently generate trademark logos bearing visual resemblance to other trademark logos. Such resemblances have the potential to bewilder consumers and undermine the authenticity of a brand.

Implementing preventive healthcare strategies in early intervention

In recent years, efforts to promote early intervention for children with developmental delays have been made to prevent further pathological invasion in children. Early rehabilitation through early screening not only enhances treatment effectiveness but also significantly reduces the pain and damage caused by diseases to families. In the concept of preventive healthcare strategies, it can be divided into three stages and five levels: (1) Primary prevention: can be divided into two levels, health promotion, and specific protection. (2) Secondary prevention: providing early treatment through early screening. (3) Tertiary prevention: mainly aimed at restoring the maximum function of disabilities caused by diseases, only causing minimal restrictions on personal function, and can be divided into two levels, limitation of disability, and rehabilitation treatment. In this article, besides exploring the causes of early childhood developmental disorders, the author combines preventive healthcare strategies to propose the differentiated application of early intervention in the three stages of preventive healthcare. This article reviews the current situation and challenges in Taiwan, and proposes possible responses based on scholars' views and personal opinions, aiming to enhance the quality of early intervention services provided by interdisciplinary teams.