Special Care Unit Research Articles

Empiric Antibiotic Use and the Outcome in Infants at Risk of Early Onset Neonatal Sepsis in a Teaching Hospital in South India: A Retrospective Cohort Study

Background Neonatal sepsis continues to be an important cause of mortality and morbidity in low- and middle-income countries. The identification and early treatment of infants at risk of early-onset neonatal sepsis (EONS) with empiric antibiotics is a preventive strategy. Objectives To study the use of empiric antibiotics in infants at risk for EONS and assess their outcome in terms of the development of sepsis, mortality, and duration of hospital stay. Materials and Methods This retrospective cohort study was done at the Special Newborn Care Unit, GMC Thrissur. The data of babies at risk of EONS over a period of 3 years (2020–2022) was collected. One thousand two hundred and thirty-two babies with at least one risk factor for sepsis, as defined by the National Neonatology Forum (NNF) 2021 guidelines, were enrolled in the study. The antibiotic prescription pattern and the outcomes were measured. Results Empirical antibiotic treatment was received by 61.2% (754/1232) of infants, and of those, 39.5% (298/754) developed EONS. Infants treated with Piperacillin/Tazobactam and Amikacin had a higher incidence of sepsis and mortality than those started on Ampicillin and Gentamicin ( p < .001). In infants less than 32 weeks, the incidence of sepsis increased significantly with increase in number of risk factors ( p < .001). Infants with lower birth weight and gestational age were more susceptible to developing sepsis ( p < .001). EONS was significantly associated with neonatal resuscitation, umbilical vein catheterization, and invasive ventilation ( p < .001). Infants who received empirical antibiotics had a longer hospital stay, with a mean duration of 4.38 days more compared to the no antibiotics group. Conclusion In infants at risk of EONS, the empirical use of antibiotics alone did not show a favorable effect on the incidence of EONS or sepsis-related mortality.

Differences in neonatal adverse outcomes among women with gestational diabetes mellitus managed by diet or medication: a propensity score matched analysis of a population-based sample

Objective Neonatal outcomes in women with and without medically managed gestational diabetes mellitus (GDM) were compared after accounting for differences in maternal baseline characteristics using a propensity score (PS) analysis. Methods Women without preexisting diabetes, delivering singletons during 2010-2017 in a large hospital, were eligible for inclusion. Using nearest-neighbour PS matching, women with non-pharmacological managed GDM were matched with women whose GDM was medically managed. A conditional logistic regression consequently compared the neonatal adverse outcomes between the groups after adjusting for gestational age, induction of labor, birth type, and number of ultrasounds conducted during the pregnancy. Results Of the overall 10028 births, GDM was diagnosed in 930 (9.3%), of whom 710 (76.3%) were successfully matched. The conditional regressions found higher risk of neonatal adverse outcomes in neonates of women with non-pharmacological managed GDM compared to neonates of women with medically managed GDM. These included a higher risk of hypoglycemia (odds ratio (OR) 1.56, 95% confidence interval (CI) 1.03–2.38, p = 0.037), hypothermia (OR 2.29, 95%CI 1.05-5.00, p = 0.037), and birth injuries (OR 3.50, 95%CI 1.62–7.58, p = 0.001), and a higher risk of being small for gestational age (OR 2.06, 95%CI 1.01-4.18, p = 0.046) and being admitted to a special care unit (OR 2.04, 95%CI 1.29-3.21, p = 0.002). Conclusions The increased neonatal morbidity associated with non-medicated GDM identified in our study may indicate that diet and lifestyle changes alone are not sufficient to achieve glycaemic control in some women with GDM. Our findings indicate that gestational diabetes management approach is independently associated with neonatal outcomes.

Determinants of mechanical birth trauma among live born neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, northwest Ethiopia: A case-control study

Background: The occurrence of birth trauma varies according to the fetal factors, labour and delivery processes and maternal factors. However, there is limited data on the possible factors associated with neonatal birth trauma in our setup. This study aimed to identify the associated factors of birth trauma among live-born neonates in the University of Gondar Comprehensive Specialized Hospital (UoGCSH) Neonatal Intensive Care Unit.
 Method: An unmatched case-control study was conducted among live-born neonates admitted neonatal intensive care unit of UoGCSH over a year from February 1, 2020 to February 1, 2021 G.C. Data was analyzed by SPSS version 20. Descriptive statistics and adjusted Odds Ratio (AOR) with a 95% confidence interval and a p-value of <0.05 was used to identify determinant factors.
 Result: A total of 300 neonates were included with 1:2 ratio of case and controls. The determinant factors of mechanical birth trauma were head circumference (AOR=1.76, 95% CI: 1.26, 2.46), instrumental delivery (AOR=10.65, 95%CI: 2.83, 40.04), malpresentation (AOR=6.31, 95%CI: 1.01, 40.08) and prolonged labour (AOR=1.45, 95%CI: 2.04, 4.49).
 Conclusion: Instrumental delivery, malpresentation, >37cm head circumference, and prolonged duration of labour had statistically a significant association with mechanical birth trauma.

Nursing Homes Adoption of Alzheimer Disease’s Special Care Units: Does it Improve Quality of Care?

Nursing Homes Adoption of Alzheimer Disease’s Special Care Units: Does it Improve Quality of Care?

Nursing Homes’ Alzheimer’s Disease Special Care Units: What are the Drivers of Adoption?

Nursing Homes’ Alzheimer’s Disease Special Care Units: What are the Drivers of Adoption?

Assessing the representativeness of cluster randomized trials: Evidence from two large pragmatic trials in United States nursing homes.

When the randomized clusters in a cluster randomized trial are selected based on characteristics that influence treatment effectiveness, results from the trial may not be directly applicable to the target population. We used data from two large nursing home-based pragmatic cluster randomized trials to compare nursing home and resident characteristics in randomized facilities to eligible non-randomized and ineligible facilities. We linked data from the high-dose influenza vaccine trial and the Music & Memory Pragmatic TRIal for Nursing Home Residents with ALzheimer's Disease (METRICaL) to nursing home assessments and Medicare fee-for-service claims. The target population for the high-dose trial comprised Medicare-certified nursing homes; the target population for the METRICaL trial comprised nursing homes in one of four US-based nursing home chains. We used standardized mean differences to compare facility and individual characteristics across the three groups and logistic regression to model the probability of nursing home trial participation. In the high-dose trial, 4476 (29%) of the 15,502 nursing homes in the target population were eligible for the trial, of which 818 (18%) were randomized. Of the 1,361,122 residents, 91,179 (6.7%) were residents of randomized facilities, 463,703 (34.0%) of eligible non-randomized facilities, and 806,205 (59.3%) of ineligible facilities. In the METRICaL trial, 160 (59%) of the 270 nursing homes in the target population were eligible for the trial, of which 80 (50%) were randomized. Of the 20,262 residents, 973 (34.4%) were residents of randomized facilities, 7431 (36.7%) of eligible non-randomized facilities, and 5858 (28.9%) of ineligible facilities. In the high-dose trial, randomized facilities differed from eligible non-randomized and ineligible facilities by the number of beds (132.5 vs 145.9 and 91.9, respectively), for-profit status (91.8% vs 66.8% and 68.8%), belonging to a nursing home chain (85.8% vs 49.9% and 54.7%), and presence of a special care unit (19.8% vs 25.9% and 14.4%). In the METRICaL trial randomized facilities differed from eligible non-randomized and ineligible facilities by the number of beds (103.7 vs 110.5 and 67.0), resource-poor status (4.6% vs 10.0% and 18.8%), and presence of a special care unit (26.3% vs 33.8% and 10.9%). In both trials, the characteristics of residents in randomized facilities were similar across the three groups. In both trials, facility-level characteristics of randomized nursing homes differed considerably from those of eligible non-randomized and ineligible facilities, while there was little difference in resident-level characteristics across the three groups. Investigators should assess the characteristics of clusters that participate in cluster randomized trials, not just the individuals within the clusters, when examining the applicability of trial results beyond participating clusters.

Family involvement in dementia special care units in nursing homes: A qualitative care ethical study into family experiences.

To explore the moral dimension of family experiences with being involved in the care of their loved one with dementia in the nursing home, using the care ethical framework of Tronto. This qualitative study used a care ethical approach in which empirical data and care ethical theory were dialectically related and mutually informing. Fifteen close family members of nursing home residents with dementia were interviewed between February 2020 and October 2020. Forty-two interviews were conducted, based on a semi-structured open-ended design. A thematic narrative approach combined with the five phases of care as defined by Tronto was used to analyse the empirical data. Subsequently, Tronto's identified ethical qualities were used to identify the moral dimension of these empirical findings. We found that in the care process (1) family can find it difficult to recognize their loved one's care needs; (2) both family and staff are reluctant to discuss the allocation of responsibilities with each other; (3) family sometimes feels insecure when it comes to connecting with their loved one; (4) family is often reluctant to provide feedback to staff when they are critical about the care that has been given; and (5) family is generally mild in judging staff, due to staff shortages. The care ethical interpretation of these findings showed that the moral qualities of attentiveness, responsibility, competence, responsiveness, and solidarity are under pressure to a certain extent. Family experiences moral distress during the care process, which hinders family involvement in nursing homes for people with dementia. Nursing home staff can look for and pilot strategies focused on supporting families to act more in accordance with the moral qualities that are under pressure. This can improve family involvement in practice. No Patient/Public Contribution. Nursing home staff paying more attention to families' emotional struggles related to the decline of their loved one, could help families to be more attentive to noticing true care needs of the resident. Both family and nursing home staff should take more often initiatives to evaluate the division of care responsibilities with each other. Nursing home staff should help family connect with their loved one during their visits if they experience difficulties in doing so. Nursing home staff taking more often initiatives to contact family and ask them how they perceive the care for their loved one, can positively affect the responsiveness of both family and staff. It would be helpful if nursing home management could ensure the presence of sufficient and qualified staff so that the first four phases of the care process are not hindered by the lack of staff.

Caracterización clínica y epidemiológica de la enfermedad pulmonar obstructiva crónica

Objective: clinical and epidemiological characterization of patients with chronic obstructive pulmonary disease (COPD). Methods: a retrospective, cross-sectional, descriptive study, which included adult patients with a diagnosis of COPD in a university hospital in Medellín. Data sources were secondary, based on medical records. The Jamovi program was used to perform a univariate analysis. Results and discussion: 552 patients were included. Median age was 76 years with a female predominance (56.7%). Regarding exposure to major respiratory toxic substances implicated in the development of the disease, 24.1% were tobacco smokers and 23% were exposed to biomass smoke. At the time of hospital admission,17.9% were classified as having grade 4 dyspnea; 74.1% received short acting beta-agonists and 60% short-acting antimuscarinics,11.6% required intensive care unit or special care unit admission, and 7.8% died in hospital. Conclusions: under-diagnosis of COPD by spirometry may be related to economic, technological, and trained human resource limitations, which affect adequate diagnosis and management of the disease, as well as patient´s quality of life.

Typology of Dementia-Specific Care Units: A Nationwide Survey Study in Germany.

Dementia-specific care units vary in their organizational characteristics and are difficult to compare in empirical studies. Based on a representative sample of care units in German nursing homes, we present a typology of organizational characteristics focusing on dementia-specific care structures. We also examine the relationships between organizational types and the provision of nonpharmacological interventions for people with dementia. Data were collected in a Germany-wide survey of a stratified randomized sample of 134 care units using a standardized questionnaire administered during telephone interviews with nursing home administrators or their representatives. The typology was developed based on a factor analysis of mixed data and a hierarchical cluster analysis. We identified 4 types of care units: Dementia Care Units (DCUs; n = 40), Dementia Special Care Units (DSCUs; n = 17), Usual Separated Care Units (n = 58), and Usual Incorporated Care Units (n = 19). All care unit types clearly differed in their organizational characteristics. The specialization of DSCUs was agreed upon with cost bearers and included admission criteria, higher costs, and better staff conditions. Dementia Care Units without specialization did not have these characteristics. Three of seven nonpharmacological interventions were associated with the DSCUs and two with DCUs, but not with the other care unit types. Researchers can use the typology to define and describe care units in empirical studies and improve the understanding and comparability of the context. A clear definition of care units also improves international comparisons.

Treatment of patients with major burn injury in the Burn Unit, Far Eastern District Medical Center of Federal Medical Biological Agency, Russia

The present study involves an analysis of treatment results of the severe burn patients of the Burn Unit, Far Eastern District Medical Center in 2020–2022. The paper describes a clinical case of comprehensive intensive treatment of a patient with major burn injury (80% body surface area burned). The study indicates a vital importance of the fastest evacuation of severely burned patients to a special care unit and adequate intensive therapy to be carried out during transportation. This enables an invasive surgical approach to be adopted, including effective early removal of necrotic tissues, leading to a reduction in the number of complications and improvement of treatment outcomes. The recovery of patients with major burn injury highly correlates with total availability of medication and instruments, individual management of patients, and active rehabilitation measures.

EVALUATION OF MORBIDITY AND MORTALITY OF THE NEWBORN ADMITTED TO SPECIAL NEWBORN CARE UNIT

Objectives: Under the facility-based newborn care scheme (FBNC), special newborn care units (SNCUs) are being established in India with the primary motto of reducing the neonatal mortality rate (NMR). Methods: The present study was a retrospective study conducted for 2 years to gain knowledge of the functioning of SNCU, and its morbidity and mortality pattern of sick newborn attending were evaluated in the present research. The study was conducted at SNCU, SVRRGGH, Tirupati. The total admissions were male, referrals from outside facilities, and low birth-weight newborns. Results: The overall leading cause of admissions was birth asphyxia-related morbidity (BA) (24%), infections (22.2%), followed by respiratory distress syndrome (RDS) (15.3%). The causes of mortality were BA (33.2%), followed by RDS (27%) and infections (16.4%). The case fatality rates of RDS (45%) were the highest, followed by meconium aspiration syndrome (40%) and BA (35.6%). Although morbidity was high, case-fatality rate of infections (16.4%) was low. Conclusion: This study has highlighted the deficiencies at SNCU influencing the outcome of admitted newborns, thus guiding steps for improvisation.

Feasibility, Sustainability, and Effectiveness of the Implementation of "Facility-Team-Driven" Approach for Improving the Quality of Newborn Care in South India.

The primary objective of the study was to assess the feasibility and sustainability of the implementation of the point of care quality improvement (POCQI) methodology for improving the quality of neonatal care at the level 2 special newborn care unit (SNCU). Additional objective was to evaluate the effectiveness of the quality improvement (QI) and preterm baby package training model. This study was conducted in a level-II SNCU. The study period was divided into baseline; intervention and sustenance phases. The primary outcome i.e., feasibility was defined as completion of training for 80% or more health care professionals (HCPs) through workshops, their attendance in subsequent review meetings and, successful accomplishment of at least two plan-do-study-act (PDSA) cycles in each project. Of the total, 1217 neonates were enrolled during the 14 mo study period; 80 neonates in the baseline, 1019 in intervention and 118 in sustenance phases. Feasibility of training was achieved within a month of initiation of intervention phase; 22/24 (92%) nurses and 14/15 (93%) doctors attended the meetings. The outcomes of individual projects suggested an improvement in proportion of neonates being given exclusive breast milk on day 5 (22.8% to 78%); mean difference (95% CI) [55.2 (46.5 to 63.9)]. Neonates on any antibiotics declined, proportion of any enteral feeds on day one and duration of kangaroo mother care (KMC) increased. Proportion of neonates receiving intravenous fluids during phototherapy decreased. The present study demonstrates the feasibility, sustainability, and effectiveness of a facility-team-driven QI approach augmented with capacity building and post-training supportive supervision.

Deficiencies of Rule-Based Technology-Generated Antibiograms for Specialized Care Units.

The objective of this study was to compare the pathogens and susceptibilities of the current automated, rule-based technology (RBT) antibiogram with one manually collected through chart review with additional rules applied. This study was a two-year, retrospective cohort study and included all bacterial cultures within the first 30 days from patients admitted to a single Burn Center. The current RBT antibiogram served as the control, and new antibiogram versions were created using additional rules and compared to the control. Six-hundred fifty-seven patients were admitted (61% excluded for lack of cultures). 59% had at least one hospital-acquired risk factor, with over one-third having recent illicit drug use and one-third having a recent hospitalization. Of the 410 cultures included, 57% were Gram-negative, and half were from wound infections. Sensitivities were significantly different when comparing the manual and the RBT version after including factors such as days since admission, presence of hospital-acquired risk factors, or previous antibiotic courses. Recommended empiric Gram-negative antibiotics changed from double coverage to a single β-lactam with >90% susceptibility. The susceptibilities between the first and subsequent courses were dramatically different. Before developing an antibiogram or interpreting the output, it is important to consider which automated criteria are utilized, especially for units with extended lengths of stay.

Feedback from the homelike transformation of a special care unit

The article presents the entire project process of a residential transformation of a special care unit as well as the results of a post-occupancy evaluation. Initially, an ethnographic immersion and a consultation phase made has highlighted the various problems and issues which were the basis of the architectural project. Once the rehabilitation works was done and after a period of use of the new spaces, we wanted to assess the effects of this spatial transformation through a new immersion and a survey of users (residents, families, caregivers). Observation shows good appropriation of living spaces and participation of residents in daily life, as well as a reduction in behavioral disturbances. Caregivers expressed great satisfaction with their new work environment, better involvement and a change in their representations on residents. The families expressed great enthusiasm and satisfaction, especially because of the reduction of their feeling of guilt due to the placement of their loved one in the institution. It seems that all these improvements are linked to the fact that this new environment qualified of "beautiful", "homelike" is a source of well-being and appeasement. However, the creation of a domestic environment implies the acceptance of a risk-taking, not always assumed, which generates fear to some caregivers, what ends with prohibitions towards residents. Beyond architectural aspects, creating the conditions for people to feel at home involves thinking about values and support methods.

Neutrophil-lymphocyte ratio as a predictor of delirium tremens in hospitalized patients with alcohol withdrawal.

Delirium Tremens (DT) is a severe form of alcohol withdrawal that can be fatal if not recognized early and treated appropriately. In our study, we aimed to determine the role of Neutrophil-Lymphocyte ratio (NLR), a marker of systemic inflammation, in predicting the development of DT. This retrospective study was conducted in an alcohol and drug treatment center between March 2017 and March 2020. A total of 212 patients with a diagnosis of alcohol use disorder who were admitted to a special care unit after alcohol withdrawal were included. Blood tests were collected within 24 hours of the patients' admission. Comparisons were made according to whether the patients developed DT during the hospitalization. DT was diagnosed in 24.1% of the patients. It was determined that higher NLR level (odds ratio [OR]: 4.38, 95%CI: 2.58-7.43) and history of DT (OR: 1.33, 95%CI: 1.23-11.73) are independent risk factors for the development of DT in the logistic regression analysis. The optimal cut-off value of NLR in predicting DT was 2.67 (sensitivity: 82.4%, specificity: 88.8%). The ROC curve of NLR showed a larger area under the curve (AUC) than the curves of other systemic inflammation markers. NLR is a simple, practical and inexpensive marker that can predict the development of DT in patients with alcohol withdrawal syndrome.

Rewarming rate of hypothermic neonates in a low-resource setting: a retrospective single-center study.

Hypothermic neonates need to be promptly rewarmed but there is no strong evidence to support a rapid or a slow pace of rewarming. This study aimed to investigate the rewarming rate and its associations with clinical outcomes in hypothermic neonates born in a low-resource setting. This retrospective study evaluated the rewarming rate of hypothermic inborn neonates admitted to the Special Care Unit of Tosamaganga Hospital (Tanzania) in 2019-2020. The rewarming rate was calculated as the difference between the first normothermic value (36.5-37.5°C) and the admission temperature, divided by the time elapsed. Neurodevelopmental status at 1 month of age was assessed using the Hammersmith Neonatal Neurological Examination. Median rewarming rate was 0.22°C/h (IQR: 0.11-0.41) in 344/382 (90%) hypothermic inborn infants, and was inversely correlated to admission temperature (correlation coefficient -0.36, p < 0.001). Rewarming rate was not associated with hypoglycemia (p = 0.16), late onset sepsis (p = 0.10), jaundice (p = 0.85), respiratory distress (p = 0.83), seizures (p = 0.34), length of hospital stay (p = 0.22) or mortality (p = 0.17). In 102/307 survivors who returned at follow-up visit at 1 month of age, rewarming rate was not associated with a potential correlate of cerebral palsy risk. Our findings did not show any significant association between rewarming rate and mortality, selected complications or abnormal neurologic exam suggestive of cerebral palsy. However, further prospective studies with strong methodological approach are required to provide conclusive evidence on this topic.

Patient Safety Incident Reporting and Learning Guidelines Implemented by Health Care Professionals in Specialized Care Units: Scoping Review.

Implementing Patient Safety Incident Reporting and Learning (PSIRL) guidelines is critical in guiding clinical practice and improving clinical outcomes in specialized care units (SCUs). There is limited research on the evidence of the implemented PSIRL guidelines in SCUs at the global level. This review aims to map the evidence of PSIRL guidelines implemented by health care professionals in specialized care units globally. A scoping review methodology, according to Joanna Briggs Institute, was adopted. The eligibility criteria were guided by the Population, Concept, and Context (PCC) framework, with the Population including health care professionals, the Concept including PSIRL guidelines, and the Context including specialized units globally. Papers written in English were searched from relevant databases and search engines. The PRISMA-ScR (Preferred Reporting Items for Scoping Reviews and Meta-Analyses extension for Scoping Reviews) checklist for used. The 13 selected studies were published from 2003 to 2023. Most articles are from the Netherlands and Switzerland (n=3), followed by South Africa (n=2). The nature of implemented PSIRL guidelines was computer-based (n=11) and paper-based incident reporting (n=2). The reporting system was intended for all the health care professionals within the specialized units, focusing on patients, staff members, and families. The outcomes of implemented incident reporting guidelines were positive, as evidenced by improved reporting of incidents, including medication errors (n=8) and decreased rate of incidents and errors (n=4). Furthermore, 1 study showed no change (n=1) in implementing the incident reporting guidelines. The implementation of reporting of patient safety incidents (PSIs) in specialized units started to be reported around 2002; however, the frequency of yearly publications remains very low. Although some specialized units are still using multifaceted interventions and paper reporting systems in reporting PSIs, the implementation of electronic and computer-based reporting systems is gaining momentum. The effective implementation of an electronic-based reporting system should extend into other units beyond critical care units, as it increases the reporting of PSIs, reducing time to make an informed reporting of PSIs and immediate accessibility to information when needed for analysis. The evidence on the implementation of PSI reporting guidelines in SCUs comes from 5 different continents (Asia, Africa, Australia, Europe, and North America). However, the number identified for certain countries within each continent is very minimal.

Pengalaman Kepala Ruangan dalam Mengelola Ruang Rawat Inap pada Masa Pandemi Covid-19

Nurses are a milestone in achieving quality and professional health services. Since Covid-19 was declared a global pandemic, the Mangusada Hospital formed a special care unit, the Covid-19 Isolation Room. Hospitals, through line managers, are required to be able to prepare service management to comply with national health protocol standards while still prioritizing health and safety in the prevention and control of Covid-19 transmission. The purpose of this study was to describe the experience of the head of the room in managing inpatient rooms during the Covid-19 pandemic at the Mangusada Hospital in 2021. This research used a qualitative and phenomenological approach with data collection methods using in-depth interview techniques on March 1- April 30, 2021, at the Mangusada Hospital. Determination of the sampling technique using purposive sampling with a sample of 7 main participants and six triangulation participants. Data analysis in this study was carried out using the method of Colaizzi. The study resulted in 5 themes, namely, 1) changes in the function and management of the room, 2) anxiety, 3) adequate support, 4) limited facilities and infrastructure, and 5) hope that the pandemic will end soon. Based on the research results, the head of the room needs to understand and carry out management functions to support service in the inpatient room, which is his responsibility and expected to improve planning and human resources in the ward during the Covid-19 pandemic.

Need of a specialised care unit for patients with morbid obesity

Need of a specialised care unit for patients with morbid obesity

Seizure Rates Across Pathologically-Confirmed Dementia Subtypes (P3-6.005)

<h3>Objective:</h3> Taking advantage of a large autopsy series of uniformly pathologically-characterized persons with dementia (PWD), our goal was to determine the seizure occurrence rate for different types of pathologically confirmed dementia subtypes. <h3>Background:</h3> The incidence of seizures in PWD is higher than in persons without dementia. However, evidence of this is based on studies that included clinically-diagnosed all-cause dementia, pathologically-diagnosed Alzheimer’s Disease (AD), or clinically-diagnosed subtypes of dementia without pathological confirmation. <h3>Design/Methods:</h3> Retrospective review of clinical and autopsy records among all veterans who died while in a VA-based Special Dementia Care Unit and whose families consented to brain autopsy was conducted. <h3>Results:</h3> Of the 335 veterans, the majority (n = 327, 97.61%) were male with an average age of 78 years at death (SD=7.62). The average age at first reported symptom was 71 (SD=8.28). Overall, 57 (17%) veterans had evidence of new-onset seizures after the date of their dementia diagnosis and were thus considered to have dementia-related seizures. Of those with AD-only neuropathology (n=121), 26 (21.5%) had developed seizures and accounted for 45.6% of all the dementia-related seizure cases. In addition, most of the remaining cases of dementia-related seizures (n=26, 45.6%) showed evidence of AD pathology and in addition to another comorbid pathology. The remaining five (8.8%) were diagnosed with Frontotemporal Dementia and/or Traumatic Brain Injury. <h3>Conclusions:</h3> Dementia-related seizures are common and are associated with AD pathology. Even among pathologically mixed dementias, seizure prevalence was driven by AD pathology. Diagnosis of seizures in patients with dementia may reflect underlying AD pathology, regardless of clinical presentation. The development of dementia-related seizures should raise the possibility of underlying AD pathology and thus could have implications for treatment response. <b>Disclosure:</b> An immediate family member of Dr. Moo has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Taylor and Francis. Dr. Moo has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Smith Mirabella Blake. Dr. Moo has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Cambridge Medical Experts. The institution of Dr. Moo has received research support from VA HSR&amp;D. The institution of Dr. Moo has received research support from VA Office of Rural Health. Prof. Shirk has received personal compensation for serving as an employee of Hologic. The institution of Prof. Shirk has received research support from Alzheimer’s Association. The institution of Prof. Shirk has received research support from VA. The institution of Prof. Shirk has received research support from NIA. Dr. Baumann has nothing to disclose. Dr. Sullivan has nothing to disclose.