Introduction: Kidney failure is a condition of sudden decline in kidney function. Kidney failure occurs when the kidneys are unable to remove metabolic waste from the body or perform their regular functions. Chronic kidney failure is treated by performing long-term hemodialysis which can have an impact on the patient's quality of life. The study aims to determine the relationship between the impact of hemodialysis therapy and the quality of life in chronic kidney disease patients. Methods: The study was correlated with a cross-sectional approach. This study involved 34 patients on hemodialysis and was selected using consecutive sampling. Data were collected by questions and analyzed using the Spearman rho correlation test. Results: Most female patients aged 30-45 years with a duration of hemodialysis therapy over 1 year. Most patients experience the effects of hemodialysis therapy badly. However, their quality of life is good. There is a significant relationship between hemodialysis therapy and the quality of life of patients (0.001). Conclusion: Increasing the provision of counseling related to the impact of hemodialysis therapy and assisting patients to improve their quality of life.
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