Spearman's Coefficient Research Articles

Evaluating and correlating asphalt binder and mixture fatigue properties considering aging conditions

Asphalt fatigue cracking is a critical distress type for flexible pavement. This study utilized the state of practice binder and mixture cracking tests and parameters to investigate how asphalt binders’ and mixtures’ fatigue performance vary between the different mix designs and evaluate their changes with aging. The potential relationships between the measured binder properties and mixture performance were also explored. Five asphalt mixtures with disparate mix designs were evaluated and three different aging conditioning levels were conducted. The binder tests include the traditional time and frequency sweep and linear amplitude sweep test, while the mixture evaluations include the semi-circular bending and cyclic fatigue test. The results indicate that the different fatigue parameters from the tests can evaluate and rank the mixes differently. The correlation analysis using the Spearman correlation coefficient shows that the mixture cracking parameters that are more predominant by asphalt mixture’s flexibility/brittleness show strong correlations (Spearman coefficient larger than 0.8) with binder cracking indices. The LAS fatigue life-related parameters generally do not correlate well with mixture fatigue indices (Spearman coefficient smaller than 0.6). Furthermore, a prediction model to estimate asphalt mixture’s fatigue performance was developed based on linear regression and Artificial Neural Network (ANN) approach, which only requires the mix design info. and binder fatigue property as the inputs, significantly reducing the time and eliminating the effort in preparing and testing the asphalt mixture specimen for mixture fatigue performance measurement.

Kinesio Taping as an alternative therapy for limited mandibular mobility with pain in female patients with temporomandibular disorders: A randomized controlled trial.

Kinesio Taping (KT) is a non-invasive therapy commonly used in physiotherapy (PT). However, the available data on its effectiveness in patients with symptomatic temporomandibular disorders (TMD) remains scarce and contradictory. The aim of the study was to evaluate the analgesic and myorelaxant effects of KT in TMD patients with limited mandibular mobility. A single-blind randomized controlled trial was conducted among female patients aged 20-45 years with Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) group Ib, using a parallel group design and equal randomization (1:1). All patients underwent surface electromyography (sEMG) of the masseter muscle (MAS), pain intensity was assessed using a Numeric Rating Scale (NRS), and temporomandibular joint mobility was measured before and after 6 and 12 days of treatment. The Perceived Stress Scale (PSS-10) questionnaire was administered on the first and last days of treatment. Statistical analysis was performed using analysis of variance (ANOVA). Mauchly's sphericity test determined changes over time and between groups for variables with a normal distribution. Bonferroni's correction was used for post hoc multiple comparisons. Variables with a non-normal distribution were analyzed using the nparLD package and multiple comparison post hoc test, while correlations were assessed using Spearman's coefficient. Each treatment had a significant effect on the bioelectrical sEMG parameters (p = 0.05). Kinesio Taping had a superior analgesic effect compared to the controls (p < 0.001). The combination of KT with therapeutic exercise (TE) proved to be a more effective therapy for improving the maximal mouth opening (MMO) and reducing perceived stress than monotherapy (p < 0.001). Minimally significant clinical differences were observed for sEMG, MMO and PSS-10 parameters after both therapies. Kinesio Taping combined with TE may be considered an effective complementary noninvasive treatment modality for TMD, either as a stand-alone or as part of the therapeutic process in patients experiencing pain and limited mandibular ROM. Additionally, the use of KT and TE was found to have a beneficial effect on perceived stress levels.

Potential drug-drug interactions analysis in Polish pediatric pneumonology units, including cystic fibrosis patients.

The lack of data on drug-drug interactions in pediatrics represents a relevant problem in making appropriate therapeutic decisions. Our study aimed to investigate the incidence and risk factors for potential drug-drug interactions (pDDIs) in pediatric pneumonology units, including cystic fibrosis patients. We performed a 6-month prospective observational study during which clinical pharmacists, using the Lexicomp Drug Interactions checker, screened medical records to identify pDDIs. Spearman's rank coefficient, logistic regression, and the Mann-Whitney U test were used to identify correlations, analyze risk factors for pDDIs, and compare cystic fibrosis patients with the rest, respectively. Recommendations were provided for the D and X pDDIs categories. Within the 218 patients, 428 pDDIs were identified, out of which 237 were classified as clinically significant. Almost 60% of patients were exposed to at least one relevant interaction. The number of pDDIs correlated with the number of; drugs (rs = 0.53, P < .001), hospitalization length (rs = 0.20, P < .01), and off-label medicines (rs = 0.25, P < .001). According to the multivariate analysis, at least 6 administered medications (OR = 4.15; 95% CI = 2.21-7.78), 4 days of hospitalization (OR = 6.41; 95% CI = 2.29-17.97), and off-label therapy (OR = 3.37; 95% CI = 1.69-6.70) were the risk factor for pDDIs. Despite significant differences in the number of medications taken, comorbidities, and off-label drugs, cystic fibrosis patients were not more exposed to pDDI. Given the lack of data on pDDIs in the pediatric population, the need for close cooperation between clinicians and clinical pharmacists to improve the safety and efficacy of pharmacotherapy is highlighted.

Importance of Assessing Sarcopenia in Patients with Type 2 Diabetes Mellitus Based on Body Fat Percentage Measured by Dual-Energy X-Ray Absorptiometry in Different Genders.

Growing evidence indicates that there is a close relationship between type 2 diabetes mellitus (T2DM) and sarcopenia, and T2DM patients are often accompanied by obesity. However, research exploring the connection between body fat percentage (BFP) and sarcopenia is currently limited. This was a cross-sectional study that included 676 patients with T2DM over 50 years old. The appendicular skeletal muscle mass index (ASMI), handgrip strength, and 5-time chair stand test (5-TCST) were measured, and sarcopenia was diagnosed according to the Asian Working Group on Sarcopenia (AWGS). Spearman's coefficient was used to evaluate the correlation of BFP and body mass index (BMI) with the diagnostic elements of sarcopenia, and BFP and other relevant covariates were included in the binary logistic regression model. The subgroup performed an interaction test for statistically significant population baseline information. The prevalence of sarcopenia was 18.0% in males and 11.6% in females. Spearman correlation analysis showed that BFP was positively correlated with ASMI in women (R=0.107, P=0.029), but not in men. BFP was negatively correlated with grip strength (male: R= -0.187, P=0.003; female: R=-0.108, P=0.029). There was a positive correlation between BFP and 5-TCST (male: R=0.199, P=0.001; female: R=0.144, P=0.003). After adjusting for confounding factors, BFP was an independent risk factor for sarcopenia (men, OR: 1.33, 95% CI: 1.15-1.54; women, OR: 1.26, 95% CI: 1.13-1.41). This correlation was generally consistent, as demonstrated in further subgroup analyses. High BFP was significantly associated with sarcopenia risk, and this association was independent of gender, age, and BMI.

Correlation of ctDNA and radiographic imaging features derived from 18F-FDG PET/CT for patients with metastatic melanoma treated with immunotherapy.

3057 Background: 18F-FDG PET/CT scans are used to assess tumor response for patients undergoing immunotherapy for metastatic melanoma (MM). Evaluating the relationship between features derived from quantitative medical image analysis and markers in blood samples such as circulating tumor DNA (ctDNA) may present an opportunity to discover imaging and blood biomarkers that can influence future patient care. This study evaluates the correlation of ctDNA and radiographic imaging features derived from FDG PET/CT. Methods: Whole-body FDG PET/CT scans from MM patients between 2014-2020 were retrospectively collected under IRB-approved protocol. Patients received pembrolizumab (n=20), ipilimumab (n=4), nivolumab (n=7), or a combination of ipilimumab and nivolumab (n=19). TRAQinform IQ software (AIQ Solutions) identified and quantified regions of interest suspicious of cancer (lesion-ROI), enabling extraction of imaging features including SUVmax, SUVmean, and SUVtotal in baseline (BL) and follow-up (FU) images and change. Plasma ctDNA concentration (copies/ml) and frequency abundance (FA) were evaluated for the first sample (1) after immunotherapy had started (between baseline and first on-treatment scan), and the next available sample (2). Patients were further grouped by ctDNA mutation for analysis. Correlation between imaging features and ctDNA features was assessed using Spearman coefficient (ρ). Results: The patient cohort included 32 males and 19 females with average age of 62 years (range 23-83). For all 51 patients, moderate correlation was observed in SUVmax,BL with ctDNA copies/ml1 (ρ = 0.48, p&lt;&lt; 0.001) and ctDNA FA1 (ρ = 0.49, p &lt;&lt; 0.001) and in SUVtotal,BL with ctDNA FA1 (ρ= 0.41, p &lt; 0.001). In BRAF mutation patients (N=32), moderate correlations existed between SUVmax,BL with ctDNA copies/ml1 (ρ = 0.49, p = 0.0041 and ctDNA FA1 (ρ = 0.05, p = 0.0035), and SUVtotal,BL with ctDNA copies/ml2 (ρ = 0.42, p = 0.017), ctDNA FA1 (ρ = 0.40, p = 0.023), and ctDNA FA2 (ρ = 0.43, p = 0.012). All the other combinations displayed weak correlations (ρ &lt; 0.39, p &gt; 0.05). Conclusions: This study shows that in patients with MM receiving immunotherapy, quantitative features from blood biomarkers such as ctDNA correlate with FDG PET/CT imaging features. Combining blood biomarkers with imaging features that are spatially localizable may strengthen prognostication in this patient group. Further analysis is being performed with more types of ctDNA mutations.

Surgeon assessment of significant rectal polyps using white light endoscopy alone and in comparison to fluorescence-augmented AI lesion classification

PurposePerioperative decision making for large (> 2 cm) rectal polyps with ambiguous features is complex. The most common intraprocedural assessment is clinician judgement alone while radiological and endoscopic biopsy can provide periprocedural detail. Fluorescence-augmented machine learning (FA-ML) methods may optimise local treatment strategy.MethodsSurgeons of varying grades, all performing colonoscopies independently, were asked to visually judge endoscopic videos of large benign and early-stage malignant (potentially suitable for local excision) rectal lesions on an interactive video platform (Mindstamp) with results compared with and between final pathology, radiology and a novel FA-ML classifier. Statistical analyses of data used Fleiss Multi-rater Kappa scoring, Spearman Coefficient and Frequency tables.ResultsThirty-two surgeons judged 14 ambiguous polyp videos (7 benign, 7 malignant). In all cancers, initial endoscopic biopsy had yielded false-negative results. Five of each lesion type had had a pre-excision MRI with a 60% false-positive malignancy prediction in benign lesions and a 60% over-staging and 40% equivocal rate in cancers. Average clinical visual cancer judgement accuracy was 49% (with only ‘fair’ inter-rater agreement), many reporting uncertainty and higher reported decision confidence did not correspond to higher accuracy. This compared to 86% ML accuracy. Size was misjudged visually by a mean of 20% with polyp size underestimated in 4/6 and overestimated in 2/6. Subjective narratives regarding decision-making requested for 7/14 lesions revealed wide rationale variation between participants.ConclusionCurrent available clinical means of ambiguous rectal lesion assessment is suboptimal with wide inter-observer variation. Fluorescence based AI augmentation may advance this field via objective, explainable ML methods.

Association of tumor-infiltrating lymphocytes (TILs) and immune signatures with PAM50 intrinsic subtyping hormone receptor-positive (HR+)/HER2-negative (HER2-) early breast cancer (BC): A translational analysis of two multicentric neoadjuvant trials.

558 Background: HR+/HER2− BCs are generally described as immunologically cold, with low levels of TILs and PD-L1. Nevertheless, the addition of immunotherapy (ICI) to chemo has been reported to increase pCR rates in high-risk early HR+/HER2– BCs. Assessing the interaction between immune features and tumor biology may identify of a subset of patients (pts) with HR+/HER2− BC that would be the ideal candidates for the combination of chemo and ICI. Methods: Gene-expression data from two multicentric neoadjuvant phase II trials (GIADA, LETLOB) enrolling stage II-IIIA HR+HER2- BC pts was retrieved (Dieci, CCR 2022; Guarneri, JCO 2014). In the GIADA trial, 758 genes were assessed on baseline tumor samples by nCounter (N=43). In the LETLOB trial, gene-expression data (Affymetrix platform) from baseline core-biopsies was available for 66 pts. Intrinsic subtype was assigned using a research-based PAM50 predictor. TILs were evaluated following guidelines. Association of TILs and immune signatures with intrinsic subtyping was assessed by Kruskal-Wallis test. Results: PAM50 subtype distribution (N=109) was 44% Luminal B (LumB), 33% Luminal A (LumA), 18% Basal-like, 5% HER2-enriched (HER2-E). TILs were assessed on 101 samples: median 2 (range 0-100). Basal-like BCs showed higher TILs than other subtypes (p=0.008). No significant difference was observed between LumA and LumB BCs (Table). Basal-like tumors showed higher levels of previously published immune signatures associated with CD8 T-cells (p&lt;0.001), Cytotoxic cells (p&lt;0.001), IFN-gamma (p&lt;0.001), and response to ICI in the GeparNuevo trial (p=0.003) (N=109). PD-1 (p=0.002), PD-L1 (p=0.001), and PD-L2 (p=0.001) genes were also more expressed in Basal-like BCs (evaluable in 43 samples). No significant difference was observed between LumA and LumB tumors. A significant weak to moderate positive correlation was observed between continuous TILs and immune signatures and basal-like PAM50 signature (p&lt;0.001, Spearman coefficient=0.372 for TILs, from 0.354 to 0.648 for immune signatures). Conclusions: PAM50 intrinsic subtyping and TILs/immune signatures capture only partially overlapping information on the biology of HR+/HER2- BCs. Pts with HR+/HER2- BCs simultaneously showing features of biological aggressiveness and enhanced immunogenicity may represent the ideal candidates for the combination of ICI and chemo. [Table: see text]

Unsupervised video summarization with adversarial graph-based attention network

Video summarization aims to select a subset of video segments that best capture the video storyline. Our study seeks to train an encoder to transform the raw frame features extracted from pre-trained CNN models into representations that embody importance and guide the selection of the video segment. Our main idea is to use graph modeling and attention mechanisms to train the encoder adversarially. The graph representation enables the model to learn the relationship among frames, revealing the intrinsic structure of a video. The attention mechanism allows the model to capture the magnitude of these relationships. In the proposed model, an attention-based encoder is trained using a graph-based generator that reconstructs videos using the encoded features and a discriminator that guides the generator, distinguishing the original and reconstructed video. Thus, by leveraging graph attention and refining mechanisms, the proposed model offers distinct advantages over existing methods, including enhanced summarization accuracy, improved preservation of temporal coherence, and the ability to capture complex semantic linkages within video content. These advancements are substantiated through a comprehensive ablation study, which demonstrates the efficacy of our model using various evaluation metrics — Kendall and Spearman coefficients. The proposed model is evaluated on TVSum and SumMe datasets and achieves results on par with supervised models that used similar encoders and achieved state-of-the-art results compared to other unsupervised models.

Coastal ecological security assessment in Laizhou Bay, China: from the perspective of demographic-social-economic-natural complex ecosystem.

Assessment of ecological security is essential for understanding the status of bay ecosystem and developing appropriate management strategy. Based on the driving force-pressure-state-impact-response (DPSIR) model, the demographic, economic, social, and ecological data of Laizhou Bay and its three neighboring counties were selected for the period from 2015 to 2021. An ecological security evaluation index system of Laizhou Bay containing 26 indicators was established, and the weights of each indicator were determined by the methods of AHP and EWM, and a comprehensive evaluation of the ecological security of Laizhou Bay was carried out by ESI. Correlations between indicators were analyzed by the Spearman's rank coefficient of correlation. The results showed that there were significant correlations between marine conditions and indicators such as population size in the surrounding area, mariculture area, industrial and domestic wastewater discharge, and treatment rate. Overall, from 2015 to 2021, the ecological security of Laizhou Bay showed a favorable trend, from a relatively unsafe level to a generally safe level, and then to a relatively safe level. Through the comprehensive evaluation of the ecological security of Laizhou Bay, we can recognize the utilization of marine resources and ecological carrying capacity, guide the rational development and utilization of marine resources, and promote the sustainable development of the marine economy.

#97 Study of association between post transplant diabetes mellitus (PTDM) and hypomagnesemia

Abstract Background and Aims New onset diabetes after transplantation (NODAT) or PTDM (Post-transplant Diabetes Mellitus) is associated with increased morbidity, renal graft loss, cardiovascular complications, mortality and increased health care costs. It has been shown that incidence of NODAT is rising in recent years. It is suggested that there is more prominent role of beta cell dysfunction rather than insulin resistance in patients with PTDM. Hypomagnesemia which is commonly seen in post-transplant patients is suggested to have a role in promoting beta cell dysfunction. Emerging modifiable risk factors for PTDM like hypomagnesemia need to be studied which may help to improve its prevalence and outcomes. Method This study was single centre study to assess association of PTDM or NODAT with hypomagnesemia. Other risk factors like body mass index (BMI) &amp;gt;25 kg/m2, higher age and sex of the recipient were also studied. This study was a prospective, non-randomised, comparative, observational study. Duration of the study was from 1st October 2016 to 28th February 2018. Recipients with age &amp;gt; 18 years with at least 2 fasting blood sugar readings of &amp;gt;126 mg/dl or 2 post prandial readings of &amp;gt;200 mg/dl or need for antidiabetic medications beyond 1-month post-transplant were studied as PTDM or NODAT. Patients with deceased donor transplant, second kidney transplant, simultaneous other organ transplant, active Hepatitis C infection, active cytomegalovirus infection, patients with acute rejection, patients with polycystic kidney disease and patients with basiliximab induction were excluded. Results After applying exclusion and exclusion criteria, 98 patients were studied in total. Among 98 patients around 40 patients developed PTDM. When assessed independently higher age of the patient (age more than 50 years) was associated with PTDM (p = .030) while sex of the recipient was not associated with PTDM (P = .188). BMI &amp;gt;25 kg/m2 was significantly associated with PTDM at 1 month (p = .0001), 2 month (p &amp;lt; .0001), 3 month (p &amp;lt; .0001), 6 month (p &amp;lt; .0001), 9 month (p = .0001) and 12 month (p = .003) post-transplant. No statistical difference between doses of steroids were seen in patients with or without PTDM. All 98 patients received tacrolimus as part of their immunosuppressant regime. Time varying serum tacrolimus trough levels were not associated with PTDM and was removed as confounder by using univariate cox proportional hazard model (p = 0.691). After univariate and subsequently multivariate logistic regression analysis only hypomagnesemia was significantly associated with PTDM (p = .0001). After using univariate and subsequently multivariate cox proportional hazard model to study time varying risk factors, both hypomagnesemia (HR, 0.099; 95% CI, 0.016-0.624, p = .014) and BMI &amp;gt;25 kg/m2 (HR, 3.435; 95% CI, 1.657-7.119, p = .001) were associated with PTDM. Significantly a greater number of patients with lower magnesium levels developed PTDM early as compared to patients with normal magnesium levels (Spearman's coefficient of rank correlation (rho) = 0.53; 95% CI, 0.261-0.722, p = .0004). Conclusion Hypomagnesemia and overweight are modifiable risk factors significantly associated with PTDM even after removing confounding factors. Early development of PTDM in patient with hypomagnesemia further corroborates its role. Active interventions should be sought to control hypomagnesemia and overweight which may improve the morbidity and mortality of kidney transplant patients in long run.

Multiple Forms of Resistance to the Phomopsis Stem Canker Pathogens Diaporthe helianthi and D. gulyae in Sunflower.

Phomopsis stem canker of cultivated sunflower (Helianthus annuus L.) can be caused by multiple necrotrophic fungi in the genus Diaporthe, with Diaporthe helianthi and D. gulyae being the most common causal agents in the United States. Infection begins at the leaf margins and proceeds primarily through the vasculature, progressing from the leaf through the petiole to the stem, resulting in formation of brown stem lesions centered around the petiole. Sunflower resistance to Phomopsis stem canker is quantitative and genetically complex. Due to the intricate disease process, resistance is possible at different stages of infection, and multiple forms of defense may contribute to the overall level of quantitative resistance. In this study, sunflower lines exhibiting field resistance to Phomopsis stem canker were evaluated for stem and leaf resistance to multiple isolates of D. helianthi and D. gulyae in greenhouse experiments, and responses to the two species were compared. Additionally, selected resistant and susceptible lines were evaluated for petiole transmission resistance to D. helianthi. Lines with distinct forms of resistance were identified, and results indicated that responses to stem inoculation were strongly correlated (Spearman's coefficient 0.598, P < 0.001) for the two fungal species, while leaf responses were not (Spearman's coefficient 0.396, P = 0.076). These results provide a basis for genetic dissection of distinct forms of sunflower resistance to Phomopsis stem canker and will facilitate combining different forms of resistance to potentially achieve durable control of this disease in sunflower hybrids.

Stratum Corneum Hydration Measurements with a Bluetooth Wireless Probe: A Real-Life Study at Home Compared to Measurements under Laboratory Conditions

Introduction: Non-invasive measurement of the stratum corneum hydration (SCH) with capacitance-based instrumentation is established in dermatological and cosmetic studies. We wanted to test the reliability of non-invasive self-measurements for SCH performed under real-life conditions by volunteers with a Bluetooth-based (wireless) probe Corneometer® (CM 825i) transmitting the data via a smartphone application to a central server. Probes and smartphones communicated using Bluetooth Low Energy. Data from the smartphone were securely transferred to a remote server in a different country with TLS encryption using HTTPS protocols. CM 825i values were correlated with the established CM 825 under laboratory conditions. The primary endpoint was the correlation of the two probes. Secondary endpoints were the coefficient of variation (CV) and delta values (before and after treatment). Methods: Eighteen healthy volunteers (f: 8; m: 10) participated in the prospective observational study. The real-world home use of the wireless CM 825i was performed before and after treatments with base cream DAC for 7 days. Results: Both instruments showed a significant and relevant correlation (p < 0.0001; Spearman coefficient of r = 0.8647). CM 825i and CM 825 differentiate significantly between normal and high SCH. Both devices showed comparable robustness in repeated measurements with a CV between 5.6% and 9.2%. Conclusion: We could show a significant correlation between both devices and a comparable differentiation between low and high SCH and comparable CVs. The real-life use demonstrated adequate acquiring and transmitting of in vivo data to a smartphone and subsequently transmitting to the secure server with low numbers of missed transmissions (<0.2%) and missed measurements (<5%).

Correlation between sustainability and smartness indicators in Brazilian cities: insights from the 5SenSu model

To face the growing challenges of urbanization, urban management models grounded in the principles of sustainability and smart cities are being proposed. Despite their acknowledged importance, these models are often misunderstood or improperly applied due to a lack of thorough conceptualization, and they are frequently viewed as interchangeable. The aim of this study is to verify whether a correlation exists between indicators of sustainability and smartness in cities. For a sample of 130 Brazilian cities, their Sustainability Synthetic Indicator of System (SSIS) was computed using the Five-Sector Sustainability Model (5SenSu) and data sourced from the ‘Mandala ODS’ framework. Data concerning smart city were directly sourced from the ‘Connected Smart Cities’ framework. Results show that the 5SenSu model emerges as an alternative multicriteria method, epistemologically grounded in a conceptual model capable of quantifying the sustainability of cities. This approach enables quantitative diagnostics, rankings, and benchmarks, providing information to support decision-making processes. Moreover, the correlation analyses employed reveal a moderate linear correlation (Pearson coefficient of −0.61) and a moderate rank-order correlation (Spearman coefficient of −0.59) between sustainability and smartness. Hence, it would be premature to assume that a city deemed smart would automatically be sustainable, or vice versa. Acknowledging the existing limitations, this study contributes to discussions on the conceptual understanding and quantification through indicators of sustainable and smart cities, providing information for shaping effective public policies aimed at fostering more sustainable urban environments.

Decreased antioxidant capacity in children with diabetic ketoacidosis

Objective. To analyze the levels of antioxidant enzyme superoxide dismutase (SOD) and glutathione peroxidase (GP) against the background of diabetic ketoacidosis (DKA) in type 1 diabetes mellitus (DM) children and adolescents. Materials and methods. The study involved examination of 74 children: 50 DKA children (study group) and 24 relatively healthy children (control group). The study group children were divided into two subgroups: subgroup 1 included children with DKA against the background of type 1 DM onset (n=27), subgroup 2 consisted of children with DKA against the background of chronic type 1 DM (n=23). SOD and GP concentrations in blood plasma were determined in all children by enzyme immunoassay. The reliability between the data was estimated using the Mann-Whitney test, Kruskal-Wallis test and Spearman coefficient. Results. A significant decrease in SOD and GP in children with DKA was revealed as follows: 13130 [13005–18255] Pg/ml and 50.085 [42.02–70.325] Ng/ml, compared to controls: 16415 [13370–19935] Pg/ml and 84.695 [52.49–144.5] Ng/ml, respectively. Minimal SOD and GP were noted in patients with DKA at the background of chronic type 1 DM, compared to DM onset children. The study indicates a reliable correlation between age, duration of the disease, number of DKA in the history and low values of SOD and GP. Conclusion. Decreased antioxidant capacity was found in children with DKA in type 1 DM. SOD and GP can be considered in pediatric practice as markers of oxidative stress in DKA. In addition, an early detection of SOD and GP contributes to the efficient therapy of DKA in children and adolescents.

Relationships between job satisfaction, occupational burnout and rationing of care among intensive care unit nurses.

Rationing of nursing care is referred to as overlooking aspects of required patient care. Its result is incomplete or delayed services provided to the patient. Anesthesia nurses employed in an intensive care unit are exposed to a significant workload. Particularly heavy is the psychological burden leading in many cases to the onset of burnout syndrome and a decrease in job satisfaction. Was to determine the relationship between occupational burnout, job satisfaction and rationing of care among anesthesia nurses employed in intensive care units. The study group consisted of 477 anesthesia nurses employed in intensive care units in Poland. The study was conducted between December 2022 and January 2023. The research tools were BERNCA-R questionnaire, Job Satisfaction Scale questionnaire and Maslach Burnout Inventory questionnaire, which were distributed to selected hospitals with a request to be forwarded to intensive care units and completed. In the statistical analysis, correlations were calculated using Spearman's rho coefficient, reporting the intensity of the relationship and its positive or negative direction. The analysis was performed using the IBM SPSS 26.0 package with the Exact Tests module. The mean score of the BERNCA questionnaire was 1.65 ± 0.82. The mean score of occupational burnout was 60.82 ± 10.46. The level of emotional exhaustion, which significantly affects occupational burnout, was 26.39 ± 6.07, depersonalization was 14.14 ± 3.21 and lack of personal achievement was 20.29 ± 4.70. All the scores obtained exceeded the threshold of 50% of total points, which indicates the presence of occupational burnout at a significant level. The job satisfaction of the nurses surveyed was above mean at 23.00 ± 5.2 out of 35 total points. The results proved that there is a statistically significant, although with a weak strength of association, correlation between occupational burnout and rationing of care by anesthesia nurses. As the limitation of anesthesia nurses' ability to perform certain activities increases, their job satisfaction decreases. In a work environment that is conducive to nurses, there are fewer job responsibilities that are unfulfilled. Therefore, it is essential to create a friendly work environment for nursing staff that will promote the provision of services at the highest possible level.

Strong Correlation Between Standing Long-Leg Radiographs and CT Scans in Measuring Coronal Knee Alignment.

The objective of this study was to evaluate the correlation in measurements of the lower-limb coronal alignment between long-leg radiographs (LLRs) and computed tomography (CT) scanograms that were made during preoperative planning for robotic-arm-assisted knee arthroplasty. On the basis of published evidence demonstrating a good correlation between these imaging modalities in measuring the lower-limb mechanical axis, we hypothesized that there would be no significant differences between the 2 in the present study. This multicenter cohort study across 3 tertiary centers included 300 patients undergoing primary robotic-arm-assisted total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) for whom LLRs and CT scanograms were available preoperatively. The study involved measuring the medial proximal tibial angle (MPTA), lateral distal femoral angle (LDFA), hip-knee-ankle angle (HKA), joint line obliquity (JLO), joint-line convergence angle (JLCA), and arithmetic HKA (aHKA). The aHKA represents a method for estimating constitutional alignment using angles that are unaffected by joint-space narrowing. Strong correlations (p < 0.001) between the imaging modalities were found for the HKA (correlation coefficient, 0.912), aHKA (0.883), MPTA (0.820), LDFA (0.871), and JLO (0.778). A weaker correlation was observed for the JLCA in valgus knees as compared with varus knees (Spearman coefficients, 0.412 and 0.518, respectively). Regression models demonstrated that the degree of agreement was associated with the preoperative intra-articular deformity and the positioning of the lower limb during the CT scan (i.e., the lower-limb rotational angle). An initial JLCA within ±5° was associated with higher agreement. We observed a strong correlation between LLRs and CT scanograms that were made during the preoperative planning stage of robotic-arm-assisted knee arthroplasty, implying that CT scanograms can reliably be utilized to estimate the coronal alignment of the knee, potentially replacing the need for LLRs. Nevertheless, to attain a higher degree of agreement, it is crucial to ensure appropriate radiographic positioning of the lower limb. Additionally, surgeons must remain vigilant regarding potential discrepancies in cases involving substantial deformities. Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

Relationships between diameter growth and functional wood anatomy in Eucalyptus globulus clones

Aim of study: We aimed to 1) analyze the variability of wood hydraulic anatomical traits in 10 clones of E. globulus Labill. with different growth rates, and 2) determine whether the magnitude of diameter growth affects the relationships between anatomical variables and diameter at breast height (DBH). Area of study: 25-year-old common garden trial in Balcarce, Buenos Aires, Argentina. Material and methods: We measured vessel diameter and number per unit area in transverse histological sections of stem wood, and calculated the proportion of vessel lumens, vessel composition (S), and theoretical specific hydraulic conductivity (Ks) of 10 E. globulus clones of high (HG) and low (LG) mean growth rates (measured as DBH) under field conditions. Main results: There was a difference in the range of variability in hydraulic anatomy between HG and LG clones, with LG clones showing a wider range. HG clones had wood with larger and fewer vessels and higher S compared to LG clones, with similar Ks between both growth groups. No clear or strong trends were observed between wood anatomy and DBH within the HG and LG groups, but across all clones a high correlation (Spearman coefficient r; p&lt;0.001) was observed between vessel number ‒ DBH (r= -0.68), and S ‒ DBH (r= 0.74). These correlations were driven by contrasting mean values of both growth groups. Research highlights: Commercial E. globulus clones present a relatively large variation in anatomical and hydraulic strategies. However, in contrast to what is postulated for various woody species, there was no clear relationship between theoretical hydraulic efficiency and individual diameter growth rate in the genotypes studied.

Association between Physical Activity Level, Body Composition, and Phase Angle in University Students from Bioelectrical Impedance Analysis (BIA).

Background: The aim of this study is to determine the relationship between selected components of body composition and the phase angle specified by bioelectrical impedance analysis, depending on the level of physical activity among students. Materials and Methods: The study group consisted of 484 university students from Krosno. The diagnostic survey method (IPAQ-SF), measurements of highs, and analysis of body composition components (BIA) were used. The relationship between variables was determined using the χ2 test, the V-Kramer coefficient, and Spearman's rho coefficient. Results: University students in physical education demonstrated the highest level of physical activity and the lowest incidence of excessive body mass. Among the participants, 28.1% did not engage in any physical activity, or their level was insufficient. The PhA level was correlated with lean body mass and muscle mass. The correlation between higher levels of PA and PhA values was statistically significant, as was the relationship between self-assessment of physical fitness and the level of PA determined by IPAQ-SF. Conclusions: Preventive actions and educational programs, especially about spending leisure time in active ways, should be particularly targeted at students of disciplines with a significant amount of sedentary classes.

Correlation of Fourier transform infrared spectroscopy data for optimizing Gramicidin production in corn kernel aqueous stream

In this work, an aqueous corn kernel stream (CKS) fermented in the presence of Aneurinibacillus aneurinilyticus was subjected to an extraction process with phosphate buffer saline (PBS) to evaluate the conditions that promote the production of Gramicidin (GR) in this aqueous stream. To do so, a fast and simple technique was used based on Fourier Transform Infrared Spectroscopy (FTIR) analysis combined with a statistical correlation treatment of the spectra in comparison with a standard spectrum of Gramicidin A (GR-A) and Gramicidin S (GR-S). The correlation analysis employed made it possible to obtain a similarity index using Pearson (PP) and Spearman (PS) coefficients for pairs of FTIR transmittance spectra, associated to different fermentation conditions. More favorable PPand PS similarity indices were obtained for pairs with GR-S rather than GR-A when compared with the samples under evaluation, observing that production of GR-S was promoted under high concentration of CKS (400 g/L) with similarity index of 0.752 and 0.813 for PPand PS, respectively, considering the FTIR spectra between 400 and 4000 cm−1, whereas low concentration of CKS (100 g/L) provided non favorable correlation factors (PP similarity indices lower than 0.4). The same behavior was observed when the study was considered between 1450 and 1750 cm−1 corresponding with the interval absorbance of amide I, amide II, and ammonium dominate bands in GR-S. Finally, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) corroborated this correlation study, proving that FTIR could be an interesting tool for establishing the optimal conditions of biotechnological processes.

Developing and validating an assessment tool to measure climate change knowledge among middle school students: preliminary findings in a Spanish context

Considering the crucial role of education in offering mitigation and adaptation strategies for climate change, there is a clear need for objective tools to assess its impact on the understanding of the issue among secondary school students. This paper describes the methodological design used to build and validate an instrument that explores secondary education students’ climate change knowledge. The design is organized into several steps: literature and document review; item design; Expert judgment; pilot testing; and instrument quality criteria analysis. Thus, a questionnaire comprising 27 4-points Likert scale items was designed. Two rounds of pilot testing and statistical analyses were conducted on the difficulty indexes, factor analysis, Spearman coefficient (flit-half method), and alpha coefficient. The result is an instrument with a degree of feasibility, validity and reliability suitable for comparative research as was found in a Spanish macro-study involving 6398 secondary school students. Preliminary results for the Spanish context are offered.