Context. Nonlinear force-free (NLFF) modeling is regularly used to indirectly infer the 3D geometry of the coronal magnetic field, which is not otherwise accessible on a regular basis by means of direct measurements. Aims. We study the effect of binning in time-series NLFF modeling of individual active regions (ARs) in order to quantify the effect of a different underlying spatial sampling on the quality of modeling as well as on the derived physical parameters. Methods. We apply an optimization method to sequences of Solar Dynamics Observatory (SDO) Helioseismic and Magnetic Imager (HMI) vector magnetogram data at three different plate scales for three solar active regions to obtain nine NLFF model time series. From the NLFF models, we deduce active-region magnetic fluxes, electric currents, magnetic energies, and relative helicities, and analyze those with respect to the underlying spatial sampling. We calculate various metrics to quantify the quality of the derived NLFF models and apply a Helmholtz decomposition to characterize solenoidal errors. Results. At a given spatial sampling, the quality of NLFF modeling is different for different ARs, and the quality varies along the individual model time series. For a given AR, modeling at a certain spatial sampling is not necessarily of superior quality compared to that performed with a different plate scale. Generally, the NLFF model quality tends to be higher for larger pixel sizes with the solenoidal quality being the ultimate cause for systematic variations in model-deduced physical quantities. Conclusions. Optimization-based modeling using SDO/HMI vector data binned to larger pixel sizes yields variations in magnetic energy and helicity estimates of ≲30% on overall, given that concise checks ensure the physical plausibility and high solenoidal quality of the tested model. Spatial-sampling-induced differences are relatively small compared to those arising from other sources of uncertainty, including the effects of applying different data calibration methods, those of using vector data from different instruments, or those arising from application of different NLFF methods to identical input data.