Spatial Rearrangement Research Articles

Inland Shift: Race, Space and Capital in Southern California. By Juan D. De Lara

Inland Shift argues that the logistics economy has reconfigured metropolitan spatial rearrangements as a handmaid to modern capitalism. Juan D. De Lara arrives at this conclusion through the broader interdisciplinary study of racial capitalism. This text builds upon Cedric Robinson’s Black Marxism “by arguing that logistics represents a major rearticulation of modern capitalism” (1). De Lara relies on a multi-scalar analysis of commodity production and consumption to outline how transnational capital movement has reformulated the human geography of Greater Los Angeles. Moreover, he argues that these alterations are informed by local historical contexts, and uses the Inland Empire as a case study to show how “the extended commodity chains of neoliberal economic restructuring created new social and spatial relationships” between and within contemporary global cities (3). His quantitative efforts are deepened by more than 100 interviews, a half-decade of participant observation, and community-based research on Southern California labor history. This approach advances recent scholarship on how capitalism manipulates space to facilitate contemporary race and place making.

Application of Atomic Force Microscopy to Detect Early Osteoarthritis.

Biomechanical properties of cells and tissues not only regulate their shape and function but are also crucial for maintaining their vitality. Changes in elasticity can propagate or trigger the onset of major diseases like cancer or osteoarthritis (OA). Atomic force microscopy (AFM) has emerged as a strong tool to qualitatively and quantitatively characterize the biomechanical properties of specific biological target structures on a microscopic scale, measuring forces in a range from as small as the piconewton to the micronewton. Biomechanical properties are of special importance in musculoskeletal tissues, which are subjected to high levels of strain. OA as a degenerative disease of the cartilage results in the disruption of the pericellular matrix (PCM) and the spatial rearrangement of the chondrocytes embedded in their extracellular matrix (ECM). Disruption in PCM and ECM has been associated with changes in the biomechanical properties of cartilage. In the present study we used AFM to quantify these changes in relation to the specific spatial pattern changes of the chondrocytes. With each pattern change, significant changes in elasticity were observed for both the PCM and ECM. Measuring the local elasticity thus allows for drawing direct conclusions about the degree of local tissue degeneration in OA.

Biochemical changes of the pericellular matrix and spatial chondrocyte organization-Two highly interconnected hallmarks of osteoarthritis.

During osteoarthritis, chondrocytes change their spatial arrangement from single to double strings, then to small and big clusters. This change in pattern has recently been established as an image-based biomarker for osteoarthritis. The pericellular matrix (PCM) appears to degrade together alongside cellular reorganization. The aim of this study was to characterize this PCM-degradation based on different cellular patterns. We additionally wanted to identify the earliest time point of PCM-breakdown in this physiopathological model. To this end, cartilage samples were selected according to their predominant cellular pattern. Qualitative analysis of PCM degradation was performed immunohistochemically by analysing five main PCM components: collagen type VI, perlecan, collagen type III, biglycan, and fibrillin-1 (n = 6 patients). Their protein content was quantified by enzyme-linked immunosorbent assay (127 patients). Accompanying spatial cellular rearrangement, the PCM is progressively destroyed, with a pericellular signal loss in fluorescence microscopy for collagen type VI, perlecan, and biglycan. This loss in protein signal is accompanied by a reduction in total protein content from single strings to big clusters (P < .001 for collagen type VI, P = .003 for perlecan, and P < .001 for biglycan). As a result of an increase in the number of cells from single strings to big clusters, the amount of protein available per cell also decreases for collagen type III and fibrillin-1, where total protein levels remain constant. Biochemical changes of the PCM and cellular rearrangement are thus highly interconnected hallmarks of osteoarthritis. Interestingly, the earliest point in time for a relevant PCM impairment appears to be at the transition to small clusters.

Homeostatic Plasticity Shapes the Retinal Response to Photoreceptor Degeneration.

Homeostatic plasticity stabilizes input and activity levels during neural development, but whether it can restore connectivity and preserve circuit function during neurodegeneration is unknown. Photoreceptor degeneration is the most common cause of blindness in the industrialized world. Visual deficits are dominated by cone loss, which progresses slowly, leaving a window during which rewiring of second-order neurons (i.e., bipolar cells) could preserve function. Here we establish a transgenic model to induce cone degeneration with precise control and analyze bipolar cell responses and their effects on vision through anatomical reconstructions, invivo electrophysiology, and behavioral assays. In young retinas, we find that three bipolar cell types precisely restore input synapse numbers when 50% of cones degenerate but one does not. Of the three bipolar cell types that rewire, two contact new cones within stable dendritic territories, whereas one expands its dendrite arbors to reach new partners. In mature retinas, only one of four bipolar cell types rewires homeostatically. This steep decline in homeostatic plasticity is accompanied by reduced light responses of bipolar cells and deficits in visual behaviors. By contrast, light responses and behavioral performance are preserved when cones degenerate in young mice. Our results reveal unexpected cell type specificity and a steep maturational decline of homeostatic plasticity. The effect of homeostatic plasticity on functional outcomes identify it as a promising therapeutic target for retinal and other neurodegenerative diseases.

Fibonacci array-based focused acoustic camera for estimating multiple moving sound sources

Multiple moving sound sources’ aliasing problem occurs in many fields. The number and relative position of these sources provide critical information for further signal processing. However, estimating the number and relative position under aliasing of multiple moving sound sources is challenging. In this study, the Fibonacci sequence was applied to design a novel two-dimensional Fibonacci array, which has lower maximum sidelobe level than other typical array structures in a certain frequency scope. Conventional beamforming was utilized as an acoustic camera for stationary sound source localization by two-dimensional spatial scanning. Unlike the acoustic camera, a spatiotemporal map (STM) method was developed to estimate the number and relative position of multiple moving sound sources through spatial scanning and temporal focusing. STM is called focused acoustic camera because of the spatiotemporal information extraction of dynamic sources. A deconvolution approach called clean STM (CSTM) was created to estimate the spatiotemporal parameters for further signal processing and to overcome the influence of array pattern on STM. CSTM was combined with two-dimensional time-varying spatial filtering rearrangement and harmonic product spectrum-based sparse filtering enhancement. Consequently, a systematic technique solution was developed to be potentially applied in wayside acoustic bearing fault diagnosis systems. Simulation and experimental cases verified the effectiveness of the proposed method and the systematic technique solution.

Measuring the impacts of suburbanization with ecological footprint calculations

In this paper we present a complex Ecological Footprint (EF) analysis of one of the largest metropolitan regions in post-socialist East Central Europe, the Budapest Metropolitan Region. Our overall goal is to use both top-down and bottom-up approaches and measure the changes of footprint at a metropolitan scale between 2003 and 2013. Our specific objective is to explore how the spatial rearrangements of wealth, density and consumption influence the spatiotemporal changes of EF. The top-down (compound) calculations indicate growing footprint values both in Hungary and in the Budapest Metropolitan Region in the investigated period. However, household-level hybrid (component-based) calculations revealed decreasing footprint values for Hungary both in absolute and relative terms, and a growth for the metropolitan region. This finding suggests growing income disparities within the country. The indirect (consumption embedded) components of EF findings show that in the core city footprint values are higher due to higher disposable income. However, there is a gradual catching up in the suburban zone as younger and more affluent households arrive. On the other hand, direct per capita footprint values decreased in Budapest and grew in the suburbs between 2003 and 2013, mainly due to a higher heating footprint.

Structural Insight into [NiFe] Hydrogenase Maturation by Transient Complexes between Hyp Proteins.

[NiFe] hydrogenases catalyze reversible hydrogen production/consumption. The core unit of [NiFe] hydrogenase consists of a large and a small subunit. The active site of the large subunit of [NiFe] hydrogenases contains a NiFe(CN)2CO cluster. The biosynthesis/maturation of these hydrogenases is a complex and dynamic process catalyzed primarily by six Hyp proteins (HypABCDEF), which play central roles in the maturation process. HypA and HypB are involved in the Ni insertion, whereas HypC, D, E, and F are required for the biosynthesis, assembly, and insertion of the Fe(CN)2CO group. HypE and HypF catalyze the synthesis of the CN group through the carbamoylation and cyanation of the C-terminus cysteine of HypE. HypC and HypD form a scaffold for the assembly of the Fe(CN)2CO moiety.Over the last decades, a large number of biochemical studies on maturation proteins have been performed, revealing basic functions of each Hyp protein and the overall framework of the maturation pathway. However, it is only in the last 10 years that structural insight has been gained, and our group has made significant contributions to the structural biology of hydrogenase maturation proteins.Since our first publication, where crystal structures of three Hyp proteins have been determined, we have performed a series of structural studies of all six Hyp proteins from a hyperthermophilic archaeon Thermococcus kodakarensis, providing molecular details of each Hyp protein. We have also determined the crystal structures of transient complexes between Hyp proteins that are formed during the maturation process to sequentially incorporate the components of the NiFe(CN)2CO cluster to immature large subunits of [NiFe] hydrogenases. Such complexes, whose crystal structures are determined, include HypA-HypB, HypA-HyhL (hydrogenase large subunit), HypC-HypD, and HypC-HypD-HypE. The structures of the HypC-HypD, and HypCDE complexes reveal a sophisticated process of transient formation of the HypCDE complex, providing insight into the molecular basis of Fe atom cyanation. The high-resolution structures of the carbamoylated and cyanated forms of HypE reveal a structural basis for the biological conversion of primary amide to nitrile. The structure of the HypA-HypB complex elucidates nucleotide-dependent transient complex formation between these two proteins and the molecular basis of acquisition and release of labile Ni. Furthermore, our recent structure analysis of a complex between HypA and immature HyhL reveals that spatial rearrangement of both the N- and C-terminal tails of HyhL will occur upon the [NiFe] cluster insertion, which function as a key checkpoint for the maturation completion. This Account will focus on recent advances in structural studies of the Hyp proteins and on mechanistic insights into the [NiFe] hydrogenase maturation.

Nucleosome Assembly State Governs Histone H3 Tail Conformation and Dynamics

Accessibility of the human genome must be dynamically modulated for proper gene control. As such, the structure of chromatin undergoes continual temporal and spatial rearrangements during which nucleosomes, the basic structural unit of chromatin, are reorganized and DNA is repositioned around the nucleosome core. The canonical nucleosome consists of two copies each of the histones H2A, H2B, H3 and H4. Recent evidence suggests that subnucleosomal species lacking the standard number of histones exist in cells, at least as transcriptional and remodeling intermediates. Altering the composition of nucleosomes may serve as a mechanism of chromatin regulation. We recently found that the H3 tails exist in a dynamic ensemble of states within the nucleosome core particle, collapsed onto the core DNA. This results in inhibition of binding by a model histone reader domain in the absence of other nuclear factors. We sought to investigate the effects of removing one or both H2A/H2B dimers on the conformational ensemble of the H3 tails. In this study, we demonstrate that the conformation of the H3 tails is sensitive to the assembly state of the nucleosome core particle (NCP). Solution NMR studies demonstrate that the H3 tails experience distinct environments between octasomes (canonical nucleosomes), hexasomes (lacking one dimer), and tetrasomes (lacking both dimers). These studies additionally demonstrate that the accessibility of the H3 tails is influenced by the assembly state of the NCP. Altogether, these studies suggest that nucleosome assembly state is another mechanism of modulating histone tail conformation and accessibility, with implications in chromatin signaling and remodeling.

Phenylglyoxal inhibition of the mitochondrial F1FO-ATPase activated by Mg2+ or by Ca2+ provides clues on the mitochondrial permeability transition pore

Phenylglyoxal (PGO), known to cause post-translational modifications of Arg residues, was used to highlight the role of arginine residues of the F1FO-ATPase, which may be crucial to yield the mitochondrial permeability transition pore (mPTP). In swine heart mitochondria PGO inhibits ATP hydrolysis by the F1FO-ATPase either sustained by the natural cofactor Mg2+ or by Ca2+ by a similar uncompetitive inhibition mechanism, namely the tertiary complex (ESI) only forms when the ATP substrate is already bound to the enzyme, and with similar strength, as shown by the similar K'i values (0.82 ± 0.07 mM in presence of Mg2+ and 0.64 ± 0.05 mM in the presence of Ca2+). Multiple inhibitor analysis indicates that features of the F1 catalytic sites and/or the FO proton binding sites are apparently unaffected by PGO. However, PGO and F1 or FO inhibitors can bind the enzyme combine simultaneously. However they mutually hinder to bind the Mg2+-activated F1FO-ATPase, whereas they do not mutually exclude to bind the Ca2+-activated F1FO-ATPase. The putative formation of PGO-arginine adducts, and the consequent spatial rearrangement in the enzyme structure, inhibits the F1FO-ATPase activity but, as shown by the calcium retention capacity evaluation in intact mitochondria, apparently favours the mPTP formation.

Multitemporal Mosaicing for Sentinel-3/FLEX Derived Level-2 Product Composites

The increasing availability of remote sensing data raises important challenges in terms of operational data provision and spatial coverage for conducting global studies and analyses. In this regard, existing multitemporal mosaicing techniques are generally limited to producing spectral image composites without considering the particular features of higher-level biophysical and other derived products, such as those provided by the Sentinel-3 (S3) and Fluorescence Explorer (FLEX) tandem missions. To relieve these limitations, this article proposes a novel multitemporal mosaicing algorithm specially designed for operational S3-derived products and also studies its applicability within the FLEX mission context. Specifically, we design a new operational methodology to automatically produce multitemporal mosaics from derived S3/FLEX products with the objective of facilitating the automatic processing of high-level data products, where weekly, monthly, seasonal, or annual biophysical mosaics can be generated by means of four processes proposed in this work: 1) operational data acquisition; 2) spatial mosaicing and rearrangement; 3) temporal compositing; and 4) confidence measures. The experimental part of the work tests the consistency of the proposed framework over different S3 product collections while showing its advantages with respect to other standard mosaicing alternatives. The source codes of this work will be made available for reproducible research.

Local order and cluster formation in model fluids with competing interactions: a simulation and theoretical study.

In a preliminary study [Phys. Chem. Chem. Phys., 2017, 19, 15247], we have recently documented an elusive mechanism underlying the cluster formation in model fluids with microscopic competing interactions (hard-sphere two-Yukawa). This mechanism consists in a tiny rearrangement of a distant correlation peak in the local density profile. For weak attractions, this peak contributes to the shallow, long-wave oscillation typical of such fluids; as the attraction strengthens, such a portion progressively disengages from the long-range behaviour, and moving backwards takes on the character of a new shell of neighbours, falling beyond the existing ones at shorter distances. This "reversal of trend" - despite its tiny size, in comparison with the overall aspect of the density profile - is shown to precisely occur at the onset of clustering. The scope of the present study is twofold. In the first instance, we positively assess our preliminary finding. To this aim we have studied by Monte Carlo simulations different families of two-Yukawa fluids, under the same conditions investigated in the original paper, namely fixed temperature, high fluid-density and increasingly attractive strength. Apparently, the reversal of trend in spatial correlations sets as a sensitive criterion to identify the clustering threshold, complementing other common indicators, based on the modifications undergone by the low-wavevector peak in the structure factor. Secondly, we document the accuracy of the Hypernetted Chain theory in predicting the spatial rearrangement under scrutiny. This evidence paves the way to an extended investigation of the observed phenomenology by the complementary use of theoretical and simulation tools.

Adaptive Liquid Interfacially Assembled Protein Nanosheets for Guiding Mesenchymal Stem Cell Fate.

There is a growing interest in the development of dynamic adaptive biomaterials for regulation of cellular functions. However, existing materials are limited to two-state switching of the presentation and removal of cell-adhesive bioactive motifs that cannot emulate the native extracellular matrix (ECM) in vivo with continuously adjustable characteristics. Here, tunable adaptive materials composed of a protein monolayer assembled at a liquid-liquid interface are demonstrated, which adapt dynamically to cell traction forces. An ultrastructure transition from protein monolayer to hierarchical fiber occurs through interfacial jamming. Elongated fibronectin fibers promote formation of elongated focal adhesion structures, increase focal adhesion kinase activation, and enhance neuronal differentiation of stem cells. Cell traction force results in spatial rearrangement of ECM proteins, which feeds back to alter stem cell fate. The reported biomimetic adaptive liquid interface enables dynamic control of stem cell behavior and has potential translational applications.

A Spectral Filter Array Camera for Clinical Monitoring and Diagnosis: Proof of Concept for Skin Oxygenation Imaging.

The emerging technology of spectral filter array (SFA) cameras has great potential for clinical applications, due to its unique capability for real time spectral imaging, at a reasonable cost. This makes such cameras particularly suitable for quantification of dynamic processes such as skin oxygenation. Skin oxygenation measurements are useful for burn wound healing assessment and as an indicator of patient complications in the operating room. Due to their unique design, in which all pixels of the image sensor are equipped with different optical filters, SFA cameras require specific image processing steps to obtain meaningful high quality spectral image data. These steps include spatial rearrangement, SFA interpolations and spectral correction. In this paper the feasibility of a commercially available SFA camera for clinical applications is tested. A suitable general image processing pipeline is proposed. As a ’proof of concept’ a complete system for spatial dynamic skin oxygenation measurements is developed and evaluated. In a study including 58 volunteers, oxygenation changes during upper arm occlusion were measured with the proposed SFA system and compared with a validated clinical device for localized oxygenation measurements. The comparison of the clinical standard measurements and SFA results show a good correlation for the relative oxygenation changes. This proposed processing pipeline for SFA cameras shows to be effective for relative oxygenation change imaging. It can be implemented in real time and developed further for absolute spatial oxygenation measurements.

Spatial organization of thylakoid network in higher plants

ABSTRACTAn intricate network of internal plastid membrane is formed in chloroplasts during plant ontogenesis. The network develops directly from a simple membrane system in proplastids or through a paracrystalline tubular prolamellar body (PLB) in etioplasts. A complex spatial structure of PLB interconnected with porous prothylakoids (PTs) is formed when the seedling growth proceeds without light. Upon illumination, PLB transforms through a multistage process into a lamellar system of stacked (grana) and loosely arranged (stroma) thylakoids. The chloroplast thylakoid network, the site of photochemical reactions, is one of the most important as well as most complicated membrane systems in nature. Thus, extensive studies on its possible spatial rearrangements are important for a better understanding of the crucial role of the thylakoid structure in the regulation of photosynthesis. Complementary structural methods are necessary to provide a complex image of spatial thylakoid arrangement. Therefore, in this review, we describe the results obtained by methods using both fixed and in vivo samples. The main goal of this review is to present the state of research on the three-dimensional (3D) structure of internal plastid membrane network, its spatial arrangement during plant ontogenesis and its modifications caused by different factors. Influence of different membrane components on the formation of the thylakoid network shape is also described. Additionally, we summarize recent 3D structural results in the field of thylakoid dynamics induced by environmental factors, especially of light-triggered changes related to rearrangements of the photosynthetic complexes.

Protein Misfolding Thermodynamics.

It is known that protein misfolding is governed by the hydrophobic effect of solutes at hydrophobic amino acid side chains. The hydrophobic force of nonaqueous solutes acts as a driving force for the spatial rearrangement of protein side chains, whose structural transitions need to be regulated in both time and space. Smaller hydrophobic solutes exert more effect at protein side chains, which involves the clustering of proteins into misfolded shapes. The consequences of misfolding are loss of protein function, gain of toxic function, or both. This is a physical process, whose result has been directly linked to a large number of human diseases.

Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet.

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains to be fully elucidated. Compelling evidence suggests that boosting mitochondrial function may represent a valuable therapeutic tool to improve insulin sensitivity. Mitochondria are highly dynamic organelles, which adapt to short- and long-term metabolic perturbations by undergoing fusion and fission cycles, spatial rearrangement of the electron transport chain complexes into supercomplexes and biogenesis governed by peroxisome proliferator-activated receptor γ co-activator 1α (PGC 1α). However, these processes appear to be dysregulated in type 2 diabetic individuals. Herein, we describe the mechanistic link between mitochondrial dysfunction and insulin resistance in skeletal muscle alongside the intracellular pathways orchestrating mitochondrial bioenergetics. We then review current evidence on nutritional tools, including fatty acids, amino acids, caloric restriction and food bioactive derivatives, which may enhance insulin sensitivity by therapeutically targeting mitochondrial function and biogenesis.

Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit

SUMMARYResilience of neural circuits has been observed in the persistence of function despite neuronal loss. In vision, acuity and sensitivity can be retained after 50% loss of cones. While neurons in the cortex can remodel after input loss, the contributions of cell-type-specific circuits to resilience are unknown. Here, we study the effects of partial cone loss in mature mouse retina where cell types and connections are known. At first-order synapses, bipolar cell dendrites remodel and synaptic proteins diminish at sites of input loss. Sites of remaining inputs preserve synaptic proteins. Second-order synapses between bipolar and ganglion cells remain stable. Functionally, ganglion cell spatio-temporal receptive fields retain center-surround structure following partial cone loss. We find evidence for slower temporal filters and expanded receptive field surrounds, derived mainly from inhibitory inputs. Surround expansion is absent in partially stimulated control retina. Results demonstrate functional resilience to input loss beyond pre-existing mechanisms in control retina.

Coupling point defects and potential energy surface exploration

The free and potential energy surfaces (F/PES) of atomistic systems contain important information regarding structural stability that is crucial in the development of new materials and devices. An effective method for navigating the energy surface can help to realize new synthesis pathways, fabrication techniques, and aid in the prediction of complex atomic structures. In most physical systems, an accurate exploration of the most stable atomic configurations in the FES can be computationally prohibitive using traditional, temperature dependent Monte-Carlo and dynamics based techniques due to the large spatial rearrangements and long time scales involved. In this work, we demonstrate the role of point defect (PD) mediated processes in navigating the PES by implementing PD transformations in a conventional PES exploration technique in order to enable shortcuts in finding the global energy minimum. Using the standard minima-hopping method as a means of sampling the PES, we discuss the details of a point defect mediated Minima-Hopping (PDMH) approach. We study the necessity of incorporating classification and biasing techniques during the search, such as a funnel characterization procedure with an accompanying super-basin history list. An example of our method is demonstrated on fullerene clusters starting from known, nearby low energy configurations. The results show that our method can enable pathways toward the global minimum energy configuration where an optimized MH calculation could not. The implications of such a method are discussed along with future areas of development.

Path-Dependent Preparation of Complex Micelle Packings of a Hydrated Diblock Oligomer.

Small-angle X-ray scattering analyses reveal that the hydrated diblock oligomer n-C16H23(OCH2CH2)20-OH (C16E20 or Brij 58) forms lyotropic liquid crystals (LLCs) exhibiting face-centered cubic (FCC), body-centered cubic (BCC), Frank–Kasper (FK) A15, and cylindrical (HI) morphologies over the concentration range 30–65 wt % amphiphile. Heating LLCs comprising 54–59 wt % C16E20 drives the temperature-dependent phase transition sequence: A15 → BCC → HI. However, rapidly quenching the resulting HI phase from 70 to 25 °C initially forms a BCC phase that isothermally transforms into a complex, tetragonal FK σ phase comprising 30 quasispherical micelles. The metastability of this micellar σ phase is shown to depend on the sample cooling rate, thermal quench depth, and isothermal annealing temperature. We rationalize the preference for the A15 structure at 25 °C in terms of minimizing unfavorable water/hydrophobic contacts, while maximizing local particle sphericity. The symmetry breaking transition kinetics in these micellar LLCs apparently stem from the temperature-dependent activation barriers for phase nucleation and growth, which are intimately coupled to the time scales for micelle reconfiguration by amphiphile chain exchange and their spatial rearrangement. These findings highlight how thermal processing influences nucleation and growth of the self-assembled morphologies of intrinsically reconfigurable, soft spherical particles.

Exciton‐ and Polaron‐Induced Reversible Dipole Reorientation in Amorphous Organic Semiconductor Films

AbstractThe quantum efficiency of organic light‐emitting diodes (OLEDs) employing thermally activated delayed fluorescence (TADF) highly depends on the S1−T1 energy gaps (ΔEST) of the emitters. However, the ΔEST values determined in solution or even in organic thin films through a static approach continuously fail in predicting device performance. Herein, by systematically investigating the time‐resolved emission spectra of several TADF emitters in various matrixes and the dielectric spectra of the matrixes, it is demonstrated that molecular organic semiconductors can undergo reversible and irreversible spatial rearrangements within a few dozen nanoseconds in an electric field created by a polarized charge‐transfer state and can in turn lower the excited‐state energy. In contrast to solution solvation, the polarized microenvironment in films can last for tens of microseconds or more after removing the electric field, leading to a narrowing and a broader distribution of ΔEST. In TADF OLEDs, the large dipole moment of emitter‐based polarons is key for reducing the ΔEST of subsequently generated excitons by inducing the dipole orientation of the surrounding molecules. Understanding the so‐called solid‐state solvation with a dynamic approach can provide deeper insight into the working mechanism in organic semiconductor devices.