Abstract The Karangsambung-Karangbolong National Geopark (GNKK) is administratively located in Kebumen Regency, Central Java Province, Indonesia. The GNKK area has an area of 543,599 km2 which includes 12 sub-districts with 117 villages. The morphology of the GNKK area consists of hills, valleys, and plains to the coast. The morphology of hills and mountains is an area that is prone to landslides. Assessment of physical, social, and economic vulnerability needs to be carried out so that disaster risk analysis and mitigation can be carried out in the future. The aims of this study are 1. To determine the spatial distribution of physical, social, and economic vulnerabilities in the Karangsambung Karangbolong National Geopark Area, 2. To analyze the physical, social, and economic vulnerability to landslides in the Karangsambung Karangbolong National Geopark Area. Assessment of physical, social, and economic vulnerability using the Spatial Multi-Criteria Evaluation (SMCE) method. The results of the main study of the GNKK area have high, moderate, and low classes of physical, social, and economic vulnerability to landslides. However, most GNKK areas are classified as moderate. The community’s social conditions in each village significantly affect the areas prone to frequent landslides. The strategy for disaster mitigation by a landslide is increasing human resources for disaster knowledge with disaster mitigation training and using infrastructures such as installing landslide-prone signs and trigger lines.