Spatial Location Of Objects Research Articles

Neurokinin-2 receptor antagonism in medial septum influences temporal-order memory for objects and forebrain cholinergic activity

In the mammalian brain the neurokinin NK2 receptors are predominantly located in the hippocampus, thalamus, septum and frontal cortex. It has been shown that administration of the NK2 receptor agonist, neurokinin A (NKA), into the medial septum of rats increases extracellular levels of acetylcholine (ACh) in the hippocampus and that NK2 receptor antagonism blocks this increase. Therefore, given the prominent role of hippocampal ACh in information processing, we hypothesized that NK2 receptor antagonism in the medial septum would negatively affect learning and memory via its influence on the cholinergic neurons of the basal forebrain. We investigated the action of local application of the peptidic NK2 receptor antagonist, Bz-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH (1, 10 and 100pmol), into the medial septum on object memory for temporal order and spatial location using an object novelty paradigm. By means of in vivo microdialysis and HPLC analyses, we also examined the influence of NK2 receptor antagonism in the medial septum on ACh in major cholinergic projection areas of the basal forebrain, namely, hippocampus, frontal cortex and amygdala. Results: Injection of vehicle alone into the medial septum impaired memory for temporal order and spatial location of objects. Application of 1pmol of the NK2 receptor antagonist partially reversed this deficit by reinstating memory for temporal order. Injection of 10pmol of the NK2 receptor antagonist into the medial septum decreased levels of ACh in the hippocampus (at 30min post-injection), and frontal cortex (at 30 and 80min post-injection) in comparison to vehicle. However, this apparent decrease was the result of the blockade of a saline-induced increase in ACh levels.

Visual Salience Affects Performance in a Working Memory Task

Many studies of bottom-up visual attention have focused on identifying which features of a visual stimulus render it salient--i.e., make it "pop out" from its background--and on characterizing the extent to which salience predicts eye movements under certain task conditions. However, few studies have examined the relationship between salience and other cognitive functions, such as memory. We examined the impact of visual salience in an object-place working memory task, in which participants memorized the position of 3-5 distinct objects (icons) on a two-dimensional map. We found that their ability to recall an object's spatial location was positively correlated with the object's salience, as quantified using a previously published computational model (Itti et al., 1998). Moreover, the strength of this relationship increased with increasing task difficulty. The correlation between salience and error could not be explained by a biasing of overt attention in favor of more salient icons during memorization, since eye-tracking data revealed no relationship between an icon's salience and fixation time. Our findings show that the influence of bottom-up attention extends beyond oculomotor behavior to include the encoding of information into memory.

Continuous attractors of a class of recurrent neural networks

Recurrent neural networks (RNNs) may possess continuous attractors, a property that many brain theories have implicated in learning and memory. There is good evidence for continuous stimuli, such as orientation, moving direction, and the spatial location of objects could be encoded as continuous attractors in neural networks. The dynamical behaviors of continuous attractors are interesting properties of RNNs. This paper proposes studying the continuous attractors for a class of RNNs. In this network, the inhibition among neurons is realized through a kind of subtractive mechanism. It shows that if the synaptic connections are in Gaussian shape and other parameters are appropriately selected, the network can exactly realize continuous attractor dynamics. Conditions are derived to guarantee the validity of the selected parameters. Simulations are employed for illustration.

The costs of crossing paths and switching tasks between audition and vision

Switching from one functional or cognitive operation to another is thought to rely on executive/control processes. The efficacy of these processes may depend on the extent of overlap between neural circuitry mediating the different tasks; more effective task preparation (and by extension smaller switch costs) is achieved when this overlap is small. We investigated the performance costs associated with switching tasks and/or switching sensory modalities. Participants discriminated either the identity or spatial location of objects that were presented either visually or acoustically. Switch costs between tasks were significantly smaller when the sensory modality of the task switched versus when it repeated. This was the case irrespective of whether the pre-trial cue informed participants only of the upcoming task, but not sensory modality (Experiment 1) or whether the pre-trial cue was informative about both the upcoming task and sensory modality (Experiment 2). In addition, in both experiments switch costs between the senses were positively correlated when the sensory modality of the task repeated across trials and not when it switched. The collective evidence supports the independence of control processes mediating task switching and modality switching and also the hypothesis that switch costs reflect competitive interference between neural circuits.

Domain-dependent activation during spatial and nonspatial auditory working memory

Visual system has been proposed to be divided into two, the ventral and dorsal, processing streams. The ventral pathway is thought to be involved in object identification whereas the dorsal pathway processes information regarding the spatial locations of objects and the spatial relationships among objects. Several studies on working memory (WM) processing have further suggested that there is a dissociable domain-dependent functional organization within the prefrontal cortex for processing of spatial and nonspatial visual information. Also the auditory system is proposed to be organized into two domain-specific processing streams, similar to that seen in the visual system. Recent studies on auditory WM have further suggested that maintenance of nonspatial and spatial auditory information activates a distributed neural network including temporal, parietal, and frontal regions but the magnitude of activation within these activated areas shows a different functional topography depending on the type of information being maintained. The dorsal prefrontal cortex, specifically an area of the superior frontal sulcus (SFS), has been shown to exhibit greater activity for spatial than for nonspatial auditory tasks. Conversely, ventral frontal regions have been shown to be more recruited by nonspatial than by spatial auditory tasks. It has also been shown that the magnitude of this dissociation is dependent on the cognitive operations required during WM processing. Moreover, there is evidence that within the nonspatial domain in the ventral prefrontal cortex, there is an across-modality dissociation during maintenance of visual and auditory information. Taken together, human neuroimaging results on both visual and auditory sensory systems support the idea that the prefrontal cortex is organized according to the type of information being maintained in WM.

Using bat-modelled sonar as a navigational tool in virtual environments

Bats are able to use active sonar as a mechanism for locating object in three dimensions and for generating spatial maps of their environments. Humans use passive sound cues to detect features of the space they occupy, as well as react to the spatial location of objects which generate sound. The system described in this paper allows free-ranging humans to locate a virtual sound location using active sonar. An emitted pulse, centred on the users head, serves as an intensity and time marker. The return pulse is rendered at the virtual target location and emitted after a time delay corresponding to the two-way path from sender to target and back again. The sonar system is modelled on those of bats, using ultrasonic frequency-modulated signals reflected from simple targets. The model uses the reflectivity characteristics of ultrasound, but the frequency and temporal structure used are scaled, with the speed of sound being set to 8.5 ms −1 to bring the frequency range and temporal resolution within the capabilities of the human auditory system. Orientation with respect to the ensonified target is achieved by time-of-flight time delays to give target range, and binaural location information derived from interaural timing differences, interaural intensity differences, and head-related transfer functions. Subjects performed significantly better at a localization task when given temporal data based on echo delays with an outgoing reference pulse than without a reference pulse. Frequency-modulated signals sweeping from 1.5 kHz–100 Hz over 500 ms provide the best localization cues, and users found them significantly easier to locate than continuous sounds.

Sex differences in object location memory and spatial navigation in Long-Evans rats

In both humans and rodents, males typically excel on a number of tasks requiring spatial ability. However, human females exhibit advantages in memory for the spatial location of objects. This study investigated whether rats would exhibit similar sex differences on a task of object location memory (OLM) and on the watermaze (WM). We predicted that females should outperform males on the OLM task and that males should outperform females on the WM. To control for possible effects of housing environment, rats were housed in either complex environments or in standard shoebox housing. Eighty Long-Evans rats (40 males and 40 females) were housed in either complex (Complex rats) or standard shoebox housing (Control rats). Results indicated that males had superior performance on the WM, whereas females outperformed males on the OLM task, regardless of housing environment. As these sex differences cannot be easily attributed to differences in cognitive style related to linguistic processing of environmental features or to selection pressures related to the hunting gathering evolutionary prehistory of humans, these data suggest that sex differences in spatial ability may be related to traits selected for by polygynous mating strategies.

Auditory and Visual Space Maps in the Cholinergic Nucleus Isthmi Pars Parvocellularis of the Barn Owl

The nucleus isthmi pars parvocellularis (Ipc) is a midbrain cholinergic nucleus that shares reciprocal, topographic connections with the optic tectum (OT). Ipc neurons project to spatially restricted columns in the OT, contacting essentially all OT layers in a given column. Previous research characterizes the Ipc as a visual processor. We found that, in the barn owl, the Ipc responds to auditory as well as to visual stimuli. Auditory responses were tuned broadly for frequency, but sharply for spatial cues. We measured the tuning of Ipc units to binaural sound localization cues, including interaural timing differences (ITDs) and interaural level differences (ILDs). Units in the Ipc were tuned to specific values of both ITD and ILD and were organized systematically according to their ITD and ILD tuning, forming a map of space. The auditory space map aligned with the visual space map in the Ipc. These results demonstrate that the Ipc encodes the spatial location of objects, independent of stimulus modality. These findings, combined with the precise pattern of projections from the Ipc to the OT, suggest that the role of the Ipc is to regulate the sensitivity of OT neurons in a space-specific manner.

Progress in Understanding Spatial Coordinate Systems in the Primate Brain

A new study in this issue of Neuron shows that when monkeys reach to a visual target, neurons in the dorsal premotor cortex compare the location of the target, the hand, and the point of visual fixation. The neurons therefore encode space through a combination of eye-centered and hand-centered coordinates.

Mislocalization of Perceived Saccade Target Position Induced by Perisaccadic Visual Stimulation

The perceptual localization of objects flashed at the time of a saccade often shows large spatial distortions. These perisaccadic mislocalizations exhibit different spatial patterns depending on the experimental condition. In darkness, when only extraretinal information is available, mislocalization is spatially uniform. In light and when visual references are available, mislocalization is directed toward the saccade target, resembling a compression of visual space. These patterns are derived from measurements of the absolute perceived position of the flashed object in egocentric space. Here, we report that also the perceived location of the saccade target is altered when an object is flashed perisaccadically. The mislocalization of the target depends on the presentation time of the flashed object and is directed toward the position of the flash. The resulting compression of the relative distance between target and flash is similar in darkness and in light and can also be found during fixation. When the localization of the flashed object is described relative to the perceived location of the saccade target, spatial compression becomes similar in many experimental conditions. We therefore suggest that perisaccadic compression relies on an encoding of relative spatial locations of objects rather than on localizations in egocentric space.

Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects

The ventral visual stream processes information about the identity of objects ('what'), whereas the dorsal stream processes the spatial locations of objects ('where'). There is a corresponding, although disputed, distinction for the ventrolateral and dorsolateral prefrontal areas. Furthermore, there seems to be a distinction between the anterior and posterior medial temporal lobe (MTL) structures in the processing of novel items and new spatial arrangements, respectively. Functional differentiation of the intermediary mid-line cortical and temporal neocortical structures that communicate with the occipitotemporal, occipitoparietal, prefrontal, and MTL structures, however, is unclear. Therefore, in the present functional magnetic resonance imaging (fMRI) study, we examined whether the distinction among the MTL structures extends to these closely connected cortical areas. The most striking difference in the fMRI responses during visual presentation of changes in either items or their locations was the bilateral activation of the temporal lobe and ventrolateral prefrontal cortical areas for novel object identification in contrast to wide parietal and dorsolateral prefrontal activation for the novel locations of objects. An anterior-posterior distinction of fMRI responses similar to the MTL was observed in the cingulate/retrosplenial, and superior and middle temporal cortices. In addition to the distinct areas of activation, certain frontal, parietal, and temporo-occipital areas responded to both object and spatial novelty, suggesting a common attentional network for both types of changes in the visual environment. These findings offer new insights to the functional roles and intrinsic specialization of the cingulate/retrosplenial, and lateral temporal cortical areas in visuospatial cognition.

Impaired spatial coding within objects but not between objects in prosopagnosia

Patients with prosopagnosia from occipitotemporal lesions have impaired perception of the configuration of facial features. This may be an example of impaired "within-object" spatial coding, which others propose to be distinct from "between-object" spatial coding. To determine whether the prosopagnosic deficit in perceiving spatial configuration was specific to within-face and not between-face spatial coding and whether the deficit was face-selective or extended to objects other than faces. Six prosopagnosic patients were tested using an oddity paradigm in which they detected which of three simultaneously seen stimuli was an altered target. In the "within-face" task, the target face had altered interocular distance or mouth position. In the "between-face" task, the target face was located farther away from the other two. In the "within-object" task, the stimulus was a two-dot pattern, and the target pattern had altered interdot distance. Spatial judgments were impaired within faces for all six patients and within the two-dot pattern for five of six patients. However, all six had normal between-face spatial perception. Impaired perception of spatial relations in prosopagnosia is selective to the spatial structure within individual objects and spares the perception of spatial location of objects. It is not specific to faces. It reveals a process involved in analyzing object structure, consistent with the patients' deficits in recognizing facial identity, and illustrates a different type of "visuospatial" defect.

Influence of object spatial location and task complexity on children's use of their preferred hand depending on their handedness consistency.

The goal of the present study was to compare the use of the preferred versus the nonpreferred hand in children performing two tasks of different levels of complexity, in various positions in space. Right-handed and left-handed consistent children were compared to their inconsistent counterparts. The results showed that the general tendency to use one's preferred hand to grasp an object is more or less pronounced depending on the object's spatial location and the task's complexity. The children used their preferred hand more often even when the object was presented contralaterally, and did so to a greater extent during the more complex task. Inconsistent-handers were more likely to shift to using their nonpreferred hand when the object was presented to this hand's side. Finally, we found that the influence of handedness consistency on hand use for the spatial positions varied with the complexity of the task. These results favor a view of handedness as a dynamic process in which motor preferences interact with task demand, probably through task-related attention.

Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans

A number of studies in rodents and monkeys report a distinction between the contributions of the hippocampus and perirhinal cortex to memory, such that the hippocampus is crucial for spatial memory whereas the perirhinal cortex has a pivotal role in perception and memory for visual objects. To determine if there is such a distinction in humans, we conducted a functional magnetic resonance imaging study to compare the medial temporal lobe responses to changes in object identity and spatial configurations of objects. We found evidence for the predicted distinction between hippocampal and perirhinal cortical activations, although part of the hippocampus was also activated by identification of novel objects. Additionally, an anterior-posterior activation gradient emerged inside the hippocampus and parahippocampal cortex. The anterior hippocampus, perirhinal cortex and anterior parahippocampal cortex are involved in perception of contextually novel objects, whereas the posterior hippocampus and posterior parahippocampal cortex are involved in processing of novel arrangements of familiar objects. These results demonstrate that there is a functional dissociation between processing of novel object identities and new spatial locations of objects among the subregions of medial temporal lobe structures in humans also.

P49 Novel marine compounds — antitumor or genotoxic: Role of endpoint biomarkers

We investigated the immediate and lasting effect of social instability stress in adolescence [SS: daily 1 h isolation and change of cage partner postnatal days (P) 30–45] on cell proliferation in the hippocampus and on spatial memory using an object spatial location (SL) test. Female rats were treated with bromodeoxyuridine (BrdU) P43–45, and on P49, SS had reduced cell hippocampal cell proliferation/survival compared to controls as indicated by BrdU immunoreactive cell counts (p = 0.009), and did not differ in Ki67 immunoreactive cell counts (p = 0.15) from CTL. A separate group of SS and CTL rats were tested at P47 and P48, and again at P72 and P73 on the SL test using 1 and 8 h retention intervals. SS and CTL females did not differ in adolescence, but CTL had better memory than SS as adults (p = 0.03). The better memory performance of CTL rats is not due to differential investigation of objects during the familiarization pre-tests or by differential locomotor activity. The lasting memory reduction and reduced cell proliferation/survival in SS rats is consistent with the hypothesis that ongoing development of the hippocampus renders the adolescent particularly vulnerable to chronic social stress.

Mother-Child Conversation Styles and Children's Laboratory Memory for Narrative and Nonnarrative Materials

The study reported here was designed to examine influences of mothers' early conversational styles on children's episodic memory for events experienced outside of the mother-child relationship. Fifty-three 3-, 4-, 5-, and 6-year-old children participated in picture-book interaction tasks with their mothers and with an unfamiliar investigator. Conversational messages were coded for their narrative and paradigmatic content. The children were also administered cued- and free-recall laboratory tasks for object names, object locations, animal facts, and story narratives. Reliable correlations were found between mothers' and children's levels of narrative talk in the mother-child picture-book task and between children's levels of narrative talk with mother and with an unfamiliar investigator. Recall analyses showed that the younger children's levels of narrative talk during picture-book tasks with mothers were positively related to the children's laboratory recall for story materials, unrelated to laboratory recall of object names and animal facts, and negatively related to laboratory recall for the spatial locations of objects. Connections between conversation styles and recall proficiency were less apparent and not reliable for the 5- and 6-year-old children in the sample. Differences between these age effects and those found in research on children's autobiographical memory are discussed.

Motion distorts perceived depth

Two important tasks that the visual system has to perform are determining the direction of motion and the spatial location of objects. It has recently been shown that the perceived location of an object moving in the frontal-plane is displaced along the direction of motion (e.g. Nature 397 (1999) 610; Vision Research 31 (1991) 1619). The aim of the present study is to examine the extent of this interaction between motion and perceived location. The observers’ task was to indicate which of two vertically separated moving stimuli was closer. The two stimuli were presented at various relative disparity offsets. The stimuli consisted of moving dot patterns (optic-flow) that simulated either fronto-parallel motion (all the dots moved one direction) or motion in depth. Motion of the dots towards the centre of the stimulus simulated object motion away from the observer and motion of the dots away from the centre of the stimulus simulated object motion towards the observer. Results indicate that motion-in-depth information can bias perceived stereoscopic-based depth. Simulated motion towards the observer made the object appear closer to the observer than the depth signalled by the disparity information and simulated motion away from the observer made it seem further away. The results of this study, when combined with those of previous studies, show that motion can distort our entire three dimensional representation of space.

Distributed neural activity during object, spatial and integrated processing in humans

Information about the form and the spatial location of objects is seamlessly integrated during visual perception. We used event-related potentials (ERPs) to explore neural activity related to processing form, location or the combination of both kinds of features. Healthy subjects performed three versions of a ‘match-to-sample’ task: a two-object task, a two-location task and an integrated object–location task. Responses were quickest and most accurate during the integrated task, slower and less accurate in the two-location task and slowest and least accurate in the two-object task. ERPs locked to the ‘sample’ stimulus at encoding, and to the ‘target’ stimulus during feature comparison differentiated between tasks. ‘Sample’ stimulus ERPs exhibited task-specific posterior cortical involvement in processing distinct visual features. ‘Target’ stimulus ERPs revealed task-related differences in features associated with frontal lobe mediated attentional processes: an early latency P300 showed increased amplitude during the integrated task. Results from this experiment support the view that distinct neural circuits mediate form vs. location processing and that form–location integration engages both pathways and upregulates frontal–parietal association networks.

Vagueness and Rough Location

This paper deals with the representation and the processing of information about spatial objects with indeterminate location like valleys or dunes (objects subject to vagueness). The indeterminacy of the location of spatial objects is caused by the vagueness of the unity condition provided by the underlying human concepts valley and dune. We propose the notion of rough, i.e., approximate, location for representing and processing information about indeterminate location of objects subject to vagueness. We provide an analysis of the relationships between vagueness of concepts, indeterminacy of location of objects, and rough approximations using methods of formal ontology. In the second part of the paper we propose an algebraic formalization of rough location, and hence, a formal method for the representation of objects subject to vagueness on a computer. We further define operations on those representations, which can be interpreted as union and intersection operations between those objects. The discussion of vagueness of concepts, indeterminacy of location, rough location and the relationships between these notions contributes to the theory about the ontology of geographic space. The formalization presented can provide the foundation for the implementation of vague objects and their location indeterminacy in GIS.

Rat spatial memory tasks adapted for humans: characterization in subjects with intact brain and subjects with selective medial temporal lobe thermal lesions.

In the present paper we describe five tests, 3 of which were designed to be similar to tasks used with rodents. Results obtained from control subjects, patients with selective thermo-coagulation lesions to the medial temporal lobe and results from non-human primates and rodents are discussed. The tests involve memory for spatial locations acquired by moving around in a room, memory for objects subjects interacted with, or memory for objects and their locations. Two of the spatial memory tasks were designed specifically as analogs of the Morris water task and the 8-arm radial-maze tasks used with rats. The Morris water task was modeled by hiding a sensor under the carpet of a room (Invisible Sensor Task). Subjects had to learn its location by using an array of visual cues available in the room. A path integration task was developed in order to study the non-visual acquisition of a cognitive representation of the spatial location of objects. In the non-visual spatial memory task, we blindfolded subjects and led them to a room where they had to find 3 objects and remember their locations. We designed an object location task by placing 4 objects in a room that subjects observed for later recall of their locations. A recognition task, and a novelty detection task were given subsequent to the recall task. An 8-arm radial-maze was recreated by placing stands at equal distance from each other around the room, and asking subjects to visit each stand once, from a central point. A non-spatial working memory task was designed to be the non-spatial equivalent of the radial maze. Search paths recorded on the first trial of the Invisible Sensor Task, when subjects search for the target by trial and error are reported. An analysis of the search paths revealed that patients with lesions to the right or left hippocampus or parahippocampal cortex employed the same type of search strategies as normal controls did, showing similarities and differences to the search behavior recorded in rats. Interestingly, patients with lesions that included the right parahippocampal cortex were impaired relative to patients with lesions to the right hippocampus that spared the parahippocampal cortex, when recall of the sensor was tested after a 30 min delay (Bohbot et al. 1998). No differences were obtained between control subjects and patients with selective thermal lesions to the medial temporal lobe, when tested on the radial-maze, the non-spatial analogue to the radial-maze and the path integration tasks. Differences in methodological procedures, learning strategies and lesion location could account for some of the discrepant results between humans and non-human species. Patients with lesions to the right hippocampus, irrespective of whether the right parahippocampal cortex was spared or damaged, had difficulties remembering the particular configuration and identity of objects in the novelty detection of the object location task. This supports the role of the human right hippocampus for spatial memory, in this case, involving memory for the location of elements in the room; learning known to require the hippocampus in the rat.